Potassium bisaccharate supplier

Name
Potassium bisaccharate
EINECS 209-402-2
CAS No. 576-42-1
Article Data11
CAS DataBase
Density 1.939g/cm³
Solubility 2.26 grams / 100 ml in water
Melting Point 188oC (dec.)(lit.)
Formula C6H10 O8 . K
Boiling Point 766.4 °C at 760 mmHg
Molecular Weight 248.231
Flash Point 431.2 °C
Transport Information
Appearance white crystalline powder
Safety Moderately toxic by ingestion and intraperitoneal routes. When heated to decomposition it emits acrid smoke and irritating vapors.
Risk Codes
Molecular Structure
Hazard Symbols
Synonyms D-Glucaricacid, monopotassium salt (9CI); Glucaric acid, monopotassium salt, D- (8CI);D-Saccharic acid monopotassium salt; Monopotassium D-glucarate; Potassium acidsaccharate; Potassium bisaccharate; Potassium hydrogen D-glucarate; Potassiumhydrogen saccharate
PSA 158.35000
LogP -4.73550

Synthetic route

: 2280-44-6
D-Glucose

: 576-42-1
D-glucaric acid monopotassium salt

Conditions

Conditions	Yield
With potassium hydroxide; chlorine; potassium bromide; 4-acetylamino-2,2,6,6-tetramethylpiperidine-N-oxyl In water at 0 - 5℃; pH=11.4 - 11.7; Product distribution; Further Variations:; Reagents;	77%

: 50-99-7
D-glucose

A: C6H5O9(3-)*3K(1+)

B: C6H5O9(3-)*3K(1+)

C: 576-42-1
D-glucaric acid monopotassium salt

Conditions

Conditions	Yield
With 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; sodium D-gluconate; potassium hydroxide In water at 5℃; pH=12.2; Electrochemical reaction; optical yield given as %de;	A n/a B n/a C 70%

...Expand

: 6556-12-3
D-Glucuronic acid

: 576-42-1
D-glucaric acid monopotassium salt

Conditions

Conditions	Yield
With peracetic acid; potassium hydroxide; ethylenediaminetetraacetic acid; cyfluthrin; potassium hydrogencarbonate; potassium bromide In water

: 87-73-0
D-glucaric acid

: 576-42-1
D-glucaric acid monopotassium salt

Conditions

Conditions	Yield
Stage #1: D-glucaric acid With potassium hydroxide In water Stage #2: With hydrogenchloride In water pH=3.4; Cooling with ice;	83.2 g

: 492-62-6
alpha-D-glucopyranose

: 576-42-1
D-glucaric acid monopotassium salt

Conditions

Conditions	Yield
With oxygen; potassium hydroxide In water at 50℃; under 750.075 Torr; for 4h;
With platinum on activated charcoal; oxygen; potassium hydroxide at 50℃; under 750.075 Torr; for 4h; pH=4;

: 6027-89-0
L-gulose

: 576-42-1
D-glucaric acid monopotassium salt

Conditions

Conditions	Yield
Stage #1: L-gulose With nitric acid; potassium hydroxide; sodium nitrite pH=Ca. 9 - Ca. 10; Stage #2: With nitric acid at 15 - 30℃; for 12h; pH=Ca. 3 - Ca. 4;

: 576-42-1
D-glucaric acid monopotassium salt

A: 87-73-0
D-glucaric acid

B: 389-36-6
D-Glucaro-1,4-lacton

C: 2782-04-9
D-glucaro-6,3-lactone

Conditions

Conditions	Yield
With H(1+) resin Rexyn 100(H) In water for 3h; lactonization;	A n/a B n/a C 69.1%

...Expand

: 64-17-5
ethanol

: 576-42-1
D-glucaric acid monopotassium salt

A: 45214-05-9
diethyl glucarate

B: (S)-((2S,3R,4R)-3,4-Dihydroxy-5-oxo-tetrahydro-furan-2-yl)-hydroxy-acetic acid ethyl ester

C: 261900-70-3
D-glucarate-6,3-lactone ethyl ester

Conditions

Conditions	Yield
With REXYN 101(H) at 55℃; for 4h;	A n/a B n/a C 58.9%

...Expand

: 67-56-1
methanol

: 576-42-1
D-glucaric acid monopotassium salt

A: 3868-17-5
glucaric acid dimethyl ester

B: 22140-16-5
methyl D-glucarate 1,4-lactone

C: 155976-55-9
Methyl D-glucarate 6,3-lactone

Conditions

Conditions	Yield
With hydrogenchloride for 4h; Heating;	A n/a B 58.89% C n/a
With hydrogenchloride for 4h; Heating;

...Expand

: [Cu4(μ-OH)(μ-α-D-glucose-1-phosphate(2-))2(2,2'-bipyridyl)4(H2O)2](NO3)3*10H2O

: 576-42-1
D-glucaric acid monopotassium salt

: [Cu4(μ-α-D-glucose-1-phosphate(2-))2(μ-D-glucaratoH)2(2,2'-bipyridyl)4](NO3)2*2H2O

Conditions

Conditions	Yield
In water; N,N-dimethyl-formamide K glucarate (2 equiv.) in H2O added to soln. of Cu complex in DMF; stirred for 5 min; solvent removed under reduced pressure; crystd. from MeOH at room temp. for several d; crystals collected; washed with Et2O; dried under vac.; elem. anal.;	49%

: [Cu4(μ-OH)(μ-α-D-glucose-1-phosphate(2-))2(2,2'-bipyridyl)4(H2O)2](NO3)3*10H2O

: 576-42-1
D-glucaric acid monopotassium salt

: ([Cu4(μ-α-D-glucose-1-phosphate(2-))2(μ-D-glucarateH)2(2,2'-bipyridyl)4](NO3)2*8H2O)(n)

Conditions

Conditions	Yield
In N,N-dimethyl-formamide K glucarate (1 equiv.) added to soln. of Cu complex in DMF; stirred for 5 min; solvent removed under reduced pressure; crystd. from MeOH at room temp. for several d; crystals collected; washed with Et2O; dried under vac.; elem. anal.;	34%

: 576-42-1
D-glucaric acid monopotassium salt

: 71-36-3
butan-1-ol

: glucaric acid di-n-butyl ester

Conditions

Conditions	Yield
With Amberlyst-15 at 75℃; for 1.5h; Time;	25%

: 67-56-1
methanol

: 576-42-1
D-glucaric acid monopotassium salt

: 3868-17-5
glucaric acid dimethyl ester

Conditions

Conditions	Yield
With ion-exchange resin + form>

: 64-67-5
diethyl sulfate

: 75-03-6
ethyl iodide

: 576-42-1
D-glucaric acid monopotassium salt

: 109721-79-1
Tetraaethylzuckersaeure-diaethylester

Conditions

Conditions	Yield
(i) aq. NaOH, (ii) /BRN= 1209714/, (iii) /BRN= 505934/, Ag2O; Multistep reaction;

...Expand

: 576-42-1
D-glucaric acid monopotassium salt

: 77-78-1
dimethyl sulfate

: 14307-81-4
tetramethyl-d-saccharic acid

Conditions

Conditions	Yield
(i) aq. NaOH, (ii) /BRN= 635994/; Multistep reaction;

: 576-42-1
D-glucaric acid monopotassium salt

: 77-78-1
dimethyl sulfate

: 74-88-4
methyl iodide

: 102264-45-9
O2,O3,O4,O5-tetramethyl-D-glucaric acid dimethyl ester

Conditions

Conditions	Yield
(i) aq. NaOH, (ii) /BRN= 635994/, (iii) /BRN= 969135/, Ag2O; Multistep reaction;

...Expand

: 576-42-1
D-glucaric acid monopotassium salt

: 74-88-4
methyl iodide

: 102264-45-9
O2,O3,O4,O5-tetramethyl-D-glucaric acid dimethyl ester

Conditions

Conditions	Yield
(i) aq. NH3, AgNO3, (ii) /BRN= 969135/, DMF, (iii) /BRN= 969135/, Ag2O; Multistep reaction;

: 50-00-0
formaldehyd

: 576-42-1
D-glucaric acid monopotassium salt

: 4539-77-9, 7595-91-7, 114006-01-8, 114421-41-9
2,4:3,5-di-O-methylene-D-glucaric acid dimethyl ester

Conditions

Conditions	Yield
With sulfuric acid	4.77 g

: 576-42-1
D-glucaric acid monopotassium salt

: (2R,3S,4S,5S)-5-(2-Amino-ethylcarbamoyl)-2,3,4,5-tetrahydroxy-pentanoic acid methyl ester; hydrochloride

Conditions

Conditions	Yield
Multi-step reaction with 3 steps 1: 69.1 percent / H(1+) resin Rexyn 100(H) / H2O / 3 h 2: 91.7 percent / methanol / 3 h / 95 °C 3: acetyl chloride / 3 h / 20 °C View Scheme

: 576-42-1
D-glucaric acid monopotassium salt

: (2R,3S,4S,5S)-5-(4-Amino-butylcarbamoyl)-2,3,4,5-tetrahydroxy-pentanoic acid methyl ester; hydrochloride

Conditions

Conditions	Yield
Multi-step reaction with 3 steps 1: 69.1 percent / H(1+) resin Rexyn 100(H) / H2O / 3 h 2: 94.9 percent / methanol / 3 h / 95 °C 3: acetyl chloride / 3 h / 20 °C View Scheme

: 576-42-1
D-glucaric acid monopotassium salt

: (2R,3S,4S,5S)-5-(6-Amino-hexylcarbamoyl)-2,3,4,5-tetrahydroxy-pentanoic acid methyl ester; hydrochloride

Conditions

Conditions	Yield
Multi-step reaction with 3 steps 1: 69.1 percent / H(1+) resin Rexyn 100(H) / H2O / 3 h 2: 90.9 percent / methanol / 3 h / 95 °C 3: acetyl chloride / 3 h / 20 °C View Scheme

: 576-42-1
D-glucaric acid monopotassium salt

: 6-[N-(2'-aminoethyl)]-D-glucaramide, sodium salt

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: 69.1 percent / H(1+) resin Rexyn 100(H) / H2O / 3 h 2: 91.7 percent / methanol / 3 h / 95 °C View Scheme

: 576-42-1
D-glucaric acid monopotassium salt

: (2R,3S,4S,5S)-5-(8-Amino-octylcarbamoyl)-2,3,4,5-tetrahydroxy-pentanoic acid methyl ester; hydrochloride

Conditions

Conditions	Yield
Multi-step reaction with 3 steps 1: 69.1 percent / H(1+) resin Rexyn 100(H) / H2O / 3 h 2: 93.8 percent / methanol / 3 h / 95 °C 3: acetyl chloride / 3 h / 20 °C View Scheme

: 576-42-1
D-glucaric acid monopotassium salt

: 6-[N-(4'-aminobutyl)]-D-glucaramide, sodium salt

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: 69.1 percent / H(1+) resin Rexyn 100(H) / H2O / 3 h 2: 94.9 percent / methanol / 3 h / 95 °C View Scheme

: 576-42-1
D-glucaric acid monopotassium salt

: (2R,3S,4S,5S)-5-(10-Amino-decylcarbamoyl)-2,3,4,5-tetrahydroxy-pentanoic acid methyl ester; hydrochloride

Conditions

Conditions	Yield
Multi-step reaction with 3 steps 1: 69.1 percent / H(1+) resin Rexyn 100(H) / H2O / 3 h 2: 90.3 percent / methanol / 3 h / 95 °C 3: acetyl chloride / 3 h / 20 °C View Scheme

: 576-42-1
D-glucaric acid monopotassium salt

: 6-[N-(6'-aminohexyl)]-D-glucaramide, sodium salt

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: 69.1 percent / H(1+) resin Rexyn 100(H) / H2O / 3 h 2: 90.9 percent / methanol / 3 h / 95 °C View Scheme

: 576-42-1
D-glucaric acid monopotassium salt

: (2R,3S,4S,5S)-5-(12-Amino-dodecylcarbamoyl)-2,3,4,5-tetrahydroxy-pentanoic acid methyl ester; hydrochloride

Conditions

Conditions	Yield
Multi-step reaction with 3 steps 1: 69.1 percent / H(1+) resin Rexyn 100(H) / H2O / 3 h 2: 91.5 percent / methanol / 3 h / 95 °C 3: acetyl chloride / 3 h / 20 °C View Scheme

: 576-42-1
D-glucaric acid monopotassium salt

: 6-[N-(8'-aminooctyl)]-D-glucaramide, sodium salt

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: 69.1 percent / H(1+) resin Rexyn 100(H) / H2O / 3 h 2: 93.8 percent / methanol / 3 h / 95 °C View Scheme

: 576-42-1
D-glucaric acid monopotassium salt

: 6-[N-(10'-aminodecyl)]-D-glucaramide, sodium salt

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: 69.1 percent / H(1+) resin Rexyn 100(H) / H2O / 3 h 2: 90.3 percent / methanol / 3 h / 95 °C View Scheme

: 576-42-1
D-glucaric acid monopotassium salt

: 6-[N-(12'-aminododecyl)]-D-glucaramide, sodium salt

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: 69.1 percent / H(1+) resin Rexyn 100(H) / H2O / 3 h 2: 91.5 percent / methanol / 3 h / 95 °C View Scheme

: 576-42-1
D-glucaric acid monopotassium salt

: 156016-05-6
N,N'-dimethyl-D-glucaramide

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: HCl / 4 h / Heating 2: 90.9 percent / methanol; H2O / 2 h / Ambient temperature View Scheme

: 576-42-1
D-glucaric acid monopotassium salt

: Dimethyl 2,3,4,5-tetrakis-O--D-glucarate

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: HCl / 4 h / Heating 2: 1.) acetyl chloride, 2.) 1,1,1,3,3,3-hexamethyldisilazane, pyridine / 1.) MeOH, reflux, 12 h, 2.) r.t., 2 d View Scheme

: 576-42-1
D-glucaric acid monopotassium salt

: Methyl 2,4,5-tris-O--D-glucarate 6,3-lactone

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: HCl / 4 h / Heating 2: 1.) acetyl chloride, 2.) 1,1,1,3,3,3-hexamethyldisilazane, pyridine / 1.) MeOH, reflux, 12 h, 2.) r.t., 2 d View Scheme

: 576-42-1
D-glucaric acid monopotassium salt

: Methyl 2,3,5-tris-O--D-glucarate 1,4-lactone

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: HCl / 4 h / Heating 2: 1.) acetyl chloride, 2.) 1,1,1,3,3,3-hexamethyldisilazane, pyridine / 1.) MeOH, reflux, 12 h, 2.) r.t., 2 d View Scheme
Multi-step reaction with 2 steps 1: HCl / 4 h / Heating 2: 1,1,1,3,3,3-hexamethyldisilazane, pyridine / methanol / Ambient temperature View Scheme

Potassium bisaccharate Chemical Properties

Name: Potassium hydrogen saccharate
Molecular Formula: C₁₂H₁₆KO₁₆Formula Weight: 455.34g/mol
Appearance: White powder.
EINECS: 209-402-2
Synonyms of Potassium hydrogen saccharate (576-42-1): Saccharic acid,monopotassium salt ; Saccharic acid,potassium sal ; Potassium (2R,3S,4S,5S)-2,3,4,5,6-pentahydroxy-6-oxohexanoate ; Potassium d-saccharic ; Potassium bisaccharate ; Potassium acid Saccharic ; Potassium bisaccharate ; Monopotassiumd-glucarate .
Structure of Potassium hydrogen saccharate (576-42-1):

Potassium bisaccharate Toxicity Data With Reference

1.		orl-rat LD:>2360 mg/kg		JAPMA8 Journal of the American Pharmaceutical Association, Scientific Edition. 40 (1951),277.
2.		ipr-rat LD:>2360 mg/kg		JAPMA8 Journal of the American Pharmaceutical Association, Scientific Edition. 40 (1951),277.

Potassium bisaccharate Safety Profile

WGK Germany: 3
RTECS: LZ4291900
Moderately toxic by ingestion and intraperitoneal routes. When heated to decomposition it emits acrid smoke and irritating vapors.

Product Name

Potassium bisaccharate

Synthetic route

Potassium bisaccharate Chemical Properties

Potassium bisaccharate Toxicity Data With Reference

Potassium bisaccharate Safety Profile

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