• Name

  Terconazole

• EINECS 267-751-6
• CAS No. 67915-31-5
• Article Data1
• CAS DataBase
• Density 1.35g/cm³
• Solubility
• Melting Point 126.3 ºC
• Formula C26H31 Cl2 N5 O3
• Boiling Point 681.8°Cat760mmHg
• Molecular Weight 532.47
• Flash Point 366.2°C
• Transport Information
• Appearance
• Safety 26
• Risk Codes 36/37/38-53
• Molecular Structure
• Hazard Symbols Xi
• Synonyms Piperazine,1-[4-[[2-(2,4-dichlorophenyl)-2-(1H-1,2,4-triazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy]phenyl]-4-(1-methylethyl)-,cis-; (?à)-Terconazole; Fungistat;Gyno-Terazol; NSC 331942; R 42470; Terazol; Terazol Cream & Suppositories;Terconazole; Tercospor; Termayazole; Triaconazole
• PSA 64.88000
• LogP 4.46560

Synthetic route

67914-86-7

cis-[2-(2,4-dichlorophenyl)-2-(1H-1,2,4-triazol-1-ylmethyl)-1,3-dioxolan-4-yl]methyl methanesulfonate

67914-97-0

4-(4-hydroxyphenyl)-1-(1-methylethyl)piperazine

67915-31-5

(+/-)-Terconazole

Conditions

Conditions	Yield
With sodium hydride 1.) Me2SO, 1 h, 2.) Me2SO, 80 deg C, 4 h; Yield given. Multistep reaction;

38869-47-5

4-(p-methoxyphenyl)piperazine dihydrochloride

67915-31-5

(+/-)-Terconazole

Conditions

Conditions	Yield
Multi-step reaction with 3 steps 1: H2, NaOAc / 10percent Pd/C / methanol 2: 85 percent / 48percent HBr / Heating 3: 1.) NaH / 1.) Me2SO, 1 h, 2.) Me2SO, 80 deg C, 4 h View Scheme

61397-56-6

(+/-)-cis-[2-(bromomethyl)-2-(2,4-dichlorophenyl)-1,3-dioxolane-4-yl]methyl benzoate

67915-31-5

(+/-)-Terconazole

Conditions

Conditions	Yield
Multi-step reaction with 3 steps 1: 1.) NaH, 3.) aq. NaOH 2: 87 percent / pyridine 3: 1.) NaH / 1.) Me2SO, 1 h, 2.) Me2SO, 80 deg C, 4 h View Scheme

67914-85-6

cis-2-(2,4-dichlorophenyl)-2-(1H-1,2,4-triazol-1-ylmethyl)-1,3-dioxolane-4-methanol

67915-31-5

(+/-)-Terconazole

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: 87 percent / pyridine 2: 1.) NaH / 1.) Me2SO, 1 h, 2.) Me2SO, 80 deg C, 4 h View Scheme

84499-46-7

4-(4-methoxyphenyl)-1-(1-methylethyl)piperazine

67915-31-5

(+/-)-Terconazole

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: 85 percent / 48percent HBr / Heating 2: 1.) NaH / 1.) Me2SO, 1 h, 2.) Me2SO, 80 deg C, 4 h View Scheme

Terconazole Chemical Properties

Terconazole Specification