Urea,N,N'-bis(2-hydroxyethyl)- supplier

Name
N,N'-BIS(2-HYDROXYETHYL)-UREA
EINECS
CAS No. 15438-70-7
Article Data12
CAS DataBase
Density 1.226 g/cm³
Solubility
Melting Point 83 °C
Formula C₅H₁₂N₂O₃
Boiling Point 445.1 °C at 760 mmHg
Molecular Weight 148.162
Flash Point 223 °C
Transport Information
Appearance
Safety
Risk Codes
Molecular Structure
Hazard Symbols
Synonyms NN'-Bis(2-hydroxyethyl)urea;
PSA 81.59000
LogP -0.94800

Synthetic route

: 3422-02-4
N-(benzyloxycarbonyl)aniline

: 141-43-5
ethanolamine

A: 15438-70-7
N,N'-bis(2-hydroxyethyl)urea

B: 3747-47-5
1-(2-hydroxyethyl)-3-phenylurea

Conditions

Conditions	Yield
With 2-(2-Ethoxyethoxy)ethyl benzyl ether In benzyl alcohol	A n/a B 80%
In benzyl alcohol at 140℃; Rate constant; various temp.,time, and conc.;

...Expand

: 868-84-8
S,S-dimethyl dithiocarbonate

: 141-43-5
ethanolamine

A: 497-25-6
dimethylenecyclourethane

B: 15438-70-7
N,N'-bis(2-hydroxyethyl)urea

Conditions

Conditions	Yield
at 60℃; for 15h; Yields of byproduct given;	A n/a B 55%
In methanol at 60℃; for 24h;

...Expand

: 124-38-9
carbon dioxide

: 141-43-5
ethanolamine

A: 497-25-6
dimethylenecyclourethane

B: 15438-70-7
N,N'-bis(2-hydroxyethyl)urea

Conditions

Conditions	Yield
With tetrachloromethane; triethylamine; triphenylphosphine In acetonitrile under 760 Torr; for 20h; Ambient temperature;	A 51% B n/a

...Expand

: 497-25-6
dimethylenecyclourethane

: 141-43-5
ethanolamine

: 15438-70-7
N,N'-bis(2-hydroxyethyl)urea

Conditions

Conditions	Yield
at 150℃; for 4h;	41%

: 83330-75-0
N-(benzyloxycarbonyl)-N-methylaniline

A: 15438-70-7
N,N'-bis(2-hydroxyethyl)urea

B: 62-53-3
aniline

Conditions

Conditions	Yield
In ethanolamine at 140℃; Rate constant; Kinetics; Mechanism; other solvent: ether, various temperatures;

: 13105-54-9
2-hydroxyethyl N-butylcarbamate

: 141-43-5
ethanolamine

A: 1792-17-2
N,N'-di-n-butylurea

B: 15438-70-7
N,N'-bis(2-hydroxyethyl)urea

C: 29346-52-9
1-(2-hydroxyethyl)-3-n-butylurea

Conditions

Conditions	Yield
With caesium carbonate at 100℃; for 0.5h;	A 17 %Chromat. B 12 %Chromat. C 45 %Chromat.

...Expand

: 4663-83-6
β-hydroxyethyl benzylcarbamate

: 141-43-5
ethanolamine

A: 15438-70-7
N,N'-bis(2-hydroxyethyl)urea

B: 1466-67-7
1,3-dibenzylurea

C: 57501-19-6
N-(2-hydroxyethyl)-N'-benzylurea

Conditions

Conditions	Yield
With caesium carbonate at 100℃; for 0.5h;	A 18 %Chromat. B 19 %Chromat. C 35 %Chromat.

...Expand

: 1310688-13-1
1,3-bis(2-((triethylsilyl)oxy)ethyl)urea

: 15438-70-7
N,N'-bis(2-hydroxyethyl)urea

Conditions

Conditions	Yield
With potassium carbonate In methanol at 80℃; for 1h; Inert atmosphere;

: 15438-70-7
N,N'-bis(2-hydroxyethyl)urea

: 75014-24-3
1,3-bis(2-hydroxyethyl)-1-nitrosourea

Conditions

Conditions	Yield
With sodium acetate; dinitrogen tetraoxide In dichloromethane for 1h; Ambient temperature;

: 15438-70-7
N,N'-bis(2-hydroxyethyl)urea

: 108554-72-9
(allyloxy)bis(diisopropylamino)phosphine

: 1163120-83-9
C23H48N4O5P2

Conditions

Conditions	Yield
With pyridinium trifluroacetate In acetonitrile at 18.4 - 25.6℃; for 17 - 18h; Product distribution / selectivity;

: 918826-72-9
C39H77N2O7P

: 15438-70-7
N,N'-bis(2-hydroxyethyl)urea

A: C71H136N4O17P2

B: C38H74N3O10P

Conditions

Conditions	Yield
Stage #1: C39H77N2O7P With acetic acid In acetonitrile at 0 - 25℃; Stage #2: N,N'-bis(2-hydroxyethyl)urea With pyridinium trifluroacetate In acetonitrile at 20℃; for 18h;

...Expand

: 15438-70-7
N,N'-bis(2-hydroxyethyl)urea

: C7H5O2(1-)*C19H10F8I2N2O5

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / tetrahydrofuran / 24 h / 75 °C / Inert atmosphere 2: acetonitrile / 21.84 °C / Inert atmosphere View Scheme

: 15438-70-7
N,N'-bis(2-hydroxyethyl)urea

: C7H5O2(1-)*C19H10F10N2O5

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / tetrahydrofuran / 24 h / 75 °C / Inert atmosphere 2: acetonitrile / 21.84 °C / Inert atmosphere View Scheme

: 15438-70-7
N,N'-bis(2-hydroxyethyl)urea

: C19H10F8I2N2O5*Cl(1-)

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / tetrahydrofuran / 24 h / 75 °C / Inert atmosphere 2: tetrabutyl-ammonium chloride / acetonitrile / 21.84 °C / Inert atmosphere View Scheme

: 15438-70-7
N,N'-bis(2-hydroxyethyl)urea

: C19H10F10N2O5*Cl(1-)

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / tetrahydrofuran / 24 h / 75 °C / Inert atmosphere 2: tetrabutyl-ammonium chloride / acetonitrile / 21.84 °C / Inert atmosphere View Scheme

: 15438-70-7
N,N'-bis(2-hydroxyethyl)urea

: C19H10F8I2N2O5*H2O4P(1-)

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / tetrahydrofuran / 24 h / 75 °C / Inert atmosphere 2: tetrabutylammonium dihydrogen phosphate / acetonitrile / 21.84 °C / Inert atmosphere View Scheme

: 15438-70-7
N,N'-bis(2-hydroxyethyl)urea

: C19H10F10N2O5*H2O4P(1-)

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / tetrahydrofuran / 24 h / 75 °C / Inert atmosphere 2: tetrabutylammonium dihydrogen phosphate / acetonitrile / 21.84 °C / Inert atmosphere View Scheme

: 15438-70-7
N,N'-bis(2-hydroxyethyl)urea

: Br(1-)*C19H10F8I2N2O5

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / tetrahydrofuran / 24 h / 75 °C / Inert atmosphere 2: tetrabutylammomium bromide / acetonitrile / 21.84 °C / Inert atmosphere View Scheme

: 15438-70-7
N,N'-bis(2-hydroxyethyl)urea

: Br(1-)*C19H10F10N2O5

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / tetrahydrofuran / 24 h / 75 °C / Inert atmosphere 2: tetrabutylammomium bromide / acetonitrile / 21.84 °C / Inert atmosphere View Scheme

: 15438-70-7
N,N'-bis(2-hydroxyethyl)urea

: C19H10F8I2N2O5*I(1-)

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / tetrahydrofuran / 24 h / 75 °C / Inert atmosphere 2: tetra-(n-butyl)ammonium iodide / acetonitrile / 21.84 °C / Inert atmosphere View Scheme

: 15438-70-7
N,N'-bis(2-hydroxyethyl)urea

: C19H10F10N2O5*I(1-)

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / tetrahydrofuran / 24 h / 75 °C / Inert atmosphere 2: tetra-(n-butyl)ammonium iodide / acetonitrile / 21.84 °C / Inert atmosphere View Scheme

: 15438-70-7
N,N'-bis(2-hydroxyethyl)urea

: C7H7O3S(1-)*C19H10F8I2N2O5

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / tetrahydrofuran / 24 h / 75 °C / Inert atmosphere 2: acetonitrile / 21.84 °C / Inert atmosphere View Scheme

: 15438-70-7
N,N'-bis(2-hydroxyethyl)urea

: C7H7O3S(1-)*C19H10F10N2O5

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / tetrahydrofuran / 24 h / 75 °C / Inert atmosphere 2: acetonitrile / 21.84 °C / Inert atmosphere View Scheme

: 15438-70-7
N,N'-bis(2-hydroxyethyl)urea

: C19H10F8I2N2O5*HO4S(1-)

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / tetrahydrofuran / 24 h / 75 °C / Inert atmosphere 2: tetra(n-butyl)ammonium hydrogensulfate / acetonitrile / 21.84 °C / Inert atmosphere View Scheme

: 15438-70-7
N,N'-bis(2-hydroxyethyl)urea

: C19H10F10N2O5*HO4S(1-)

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / tetrahydrofuran / 24 h / 75 °C / Inert atmosphere 2: tetra(n-butyl)ammonium hydrogensulfate / acetonitrile / 21.84 °C / Inert atmosphere View Scheme

: 15438-70-7
N,N'-bis(2-hydroxyethyl)urea

: C19H10F8I2N2O5*NO3(1-)

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / tetrahydrofuran / 24 h / 75 °C / Inert atmosphere 2: tetrabutylammonium nitrate / acetonitrile / 21.84 °C / Inert atmosphere View Scheme

: 15438-70-7
N,N'-bis(2-hydroxyethyl)urea

: C19H10F10N2O5*NO3(1-)

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / tetrahydrofuran / 24 h / 75 °C / Inert atmosphere 2: tetrabutylammonium nitrate / acetonitrile / 21.84 °C / Inert atmosphere View Scheme

: 15438-70-7
N,N'-bis(2-hydroxyethyl)urea

: 602-94-8
Pentafluorobenzoic acid

: 1310688-46-0
(carbonylbis(azanediyl))bis(ethane-2,1-diyl) bis(2,3,4,5,6-pentafluorobenzoate)

Conditions

Conditions	Yield
With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In tetrahydrofuran at 75℃; for 24h; Inert atmosphere;	312 mg

Urea,N,N'-bis(2-hydroxyethyl)- Specification

The Urea,N,N'-bis(2-hydroxyethyl)-, with the CAS registry number of 15438-70-7, is also known as NN'-Bis(2-hydroxyethyl)urea. Its molecular formula is C₅H₁₂N₂O₃ and molecular weight is 148.16. What's more, its IUPAC name is 1,3-Bis(2-hydroxyethyl)urea.

Physical properties about the Urea,N,N'-bis(2-hydroxyethyl)- are: (1)ACD/LogP: -2.27; (2)# of Rule of 5 Violations: 0; (3)ACD/LogD (pH 5.5): -2.27; (4)ACD/LogD (pH 7.4): -2.27; (5)ACD/BCF (pH 5.5): 1; (6)ACD/BCF (pH 7.4): 1; (7)ACD/KOC (pH 5.5): 1.39; (8)ACD/KOC (pH 7.4): 1.39; (9)#H bond acceptors: 5; (10)#H bond donors: 4; (11)#Freely Rotating Bonds: 6; (12)Polar Surface Area: 42.01 Å²; (13)Index of Refraction: 1.499; (14)Molar Refractivity: 35.5 cm³; (15)Molar Volume: 120.8 cm³; (16)Surface Tension: 52.6 dyne/cm; (17)Density: 1.226 g/cm³; (18)Flash Point: 223 °C; (19)Enthalpy of Vaporization: 81.13 kJ/mol; (20)Boiling Point: 445.1 °C at 760 mmHg; (21)Vapour Pressure: 8.55E-10 mmHg at 25 °C.

You can still convert the following datas into molecular structure:
(1) SMILES: O=C(NCCO)NCCO
(2) InChI: InChI=1/C5H12N2O3/c8-3-1-6-5(10)7-2-4-9/h8-9H,1-4H2,(H2,6,7,10)
(3) InChIKey: KSYGJAFGQWTAFW-UHFFFAOYAF

Product Name

N,N'-BIS(2-HYDROXYETHYL)-UREA

Synthetic route

Urea,N,N'-bis(2-hydroxyethyl)- Specification

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