p-(2-Methoxyethyl) phenol supplier

Name
p-(2-Methoxyethyl) phenol
EINECS 260-354-9
CAS No. 56718-71-9
Article Data21
CAS DataBase
Density 1.06 g/cm³
Solubility 8.42g/L at 20℃
Melting Point 42-45 °C(lit.)
Formula C₉H₁₂O₂
Boiling Point 239.9 °C at 760 mmHg
Molecular Weight 152.193
Flash Point 97.8 °C
Transport Information
Appearance White Powder
Safety 26-36
Risk Codes 36/37/38
Molecular Structure
Hazard Symbols Xi
Synonyms Phenol,p-(2-methoxyethyl)- (6CI,7CI);4-(2-Methoxyethyl)phenol;p-Hydroxyphenethyl methyl ether;4-(2-methoxyethyl)-phenol;
PSA 29.46000
LogP 1.58110

Synthetic route

: 32136-81-5
alpha-methoxy-4-hydroxyacetophenone

: 56718-71-9
4-(2-methoxyethyl)phenol

Conditions

Conditions	Yield
With hydrogen; palladium on activated charcoal In ethanol under 2327.2 Torr; for 4h;	96%
With hydrogen under 3000.3 Torr; Pressure; Heating;	80%
With hydrogen; acetic acid; palladium on activated charcoal
With H2; acetic acid; palladium-carbon	0.54 g (3.6 mmol=61%)

: 4-hydroxyphenyl glyoxal dimethylacetal

: 56718-71-9
4-(2-methoxyethyl)phenol

Conditions

Conditions	Yield
palladium-carbon In hydrogenchloride; methanol	70%
With hydrogen; palladium-carbon In hydrogenchloride; methanol	59%
With hydrogen; palladium-carbon In methanol	53%
With hydrogenchloride; hydrogen; palladium-carbon In methanol	47%

: 501-94-0
p-hydroxyphenethyl alcohol

: 56718-71-9
4-(2-methoxyethyl)phenol

Conditions

Conditions	Yield
With sulfuric acid In methanol	40%
In methanol	31%
Multi-step reaction with 3 steps 1: ethanol / 9 h / Heating 2: 1.) NaH / 1.) THF, reflux, 30 min; 2.) THF, reflux, 6 h 3: H2 / 10percent Pd/C / ethanol / 24 h / 3102.9 Torr / Ambient temperature View Scheme

: 4-(2-methoxyethenyl)phenol

: 56718-71-9
4-(2-methoxyethyl)phenol

Conditions

Conditions	Yield
With hydrogen In ethyl acetate at 50℃; under 30402 Torr; for 16h;	10 g

: 67-56-1
methanol

: 28145-35-9
4-(2-chloroethyl)phenol

: 56718-71-9
4-(2-methoxyethyl)phenol

Conditions

Conditions	Yield
With sodium methylate at 50℃; for 7h; Reagent/catalyst;	92%

: 98627-35-1
1-(benzyloxy)-4-(2-methoxyethyl)benzene

: 56718-71-9
4-(2-methoxyethyl)phenol

Conditions

Conditions	Yield
With palladium on activated charcoal; hydrogen In tetrahydrofuran at 20℃; under 3000.3 Torr; for 24h;	82%
With hydrogen; palladium on activated charcoal In ethanol under 3102.9 Torr; for 24h; Ambient temperature;
With palladium 10% on activated carbon; hydrogen under 37503.8 Torr; for 3h;	38.6 g

: 953422-33-8
2-(4'-hydroxyphenyl)ethyl methyl carbonate

: 616-38-6
carbonic acid dimethyl ester

: 56718-71-9
4-(2-methoxyethyl)phenol

Conditions

Conditions	Yield
With Amberlyst 15 for 36h; Reflux;	95%

: 501-94-0
p-hydroxyphenethyl alcohol

: 144-55-8
sodium hydrogencarbonate

: 56718-71-9
4-(2-methoxyethyl)phenol

Conditions

Conditions	Yield
In methanol	65%

: 67-56-1
methanol

: 4-((3H-diazirin-3-yl)methyl)phenol

: 56718-71-9
4-(2-methoxyethyl)phenol

Conditions

Conditions	Yield
at 20℃; for 2h; Inert atmosphere; UV-irradiation;	57%

: 14140-15-9
4-(2-bromoethyl)phenol

: 124-41-4
sodium methylate

: 56718-71-9
4-(2-methoxyethyl)phenol

Conditions

Conditions	Yield
In methanol at 20℃; for 3h;	79%
With methanol

: 501-94-0
p-hydroxyphenethyl alcohol

poly(styrene-co-divinylbenzene)-supported methyl sulfonate, loading rate of SO3Me: ca. 4.0 mmol/g: poly(styrene-co-divinylbenzene)-supported methyl sulfonate, loading rate of SO3Me: ca. 4.0 mmol/g

A: 702-23-8
2-(4-Methoxyphenyl)ethanol

B: 56718-71-9
4-(2-methoxyethyl)phenol

Conditions

Conditions	Yield
With potassium carbonate In acetonitrile for 24h; Heating;	A 82% B 9%

...Expand

: 60-18-4
L-tyrosine

: 56718-71-9
4-(2-methoxyethyl)phenol

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: ammonia; [bis(acetoxy)iodo]benzene / methanol / 2 h / 0 - 20 °C / Inert atmosphere 2: 2 h / 20 °C / Inert atmosphere; UV-irradiation View Scheme

: 35424-81-8
L-<15N>tyrosine

: 56718-71-9
4-(2-methoxyethyl)phenol

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: ammonia; [bis(acetoxy)iodo]benzene; potassium hydroxide / methanol / 2 h / 0 °C 2: 2 h / 20 °C / Inert atmosphere; UV-irradiation View Scheme

: 61439-59-6
2-(4-benzyloxyphenyl)ethanol

: 56718-71-9
4-(2-methoxyethyl)phenol

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: 1.) NaH / 1.) THF, reflux, 30 min; 2.) THF, reflux, 6 h 2: H2 / 10percent Pd/C / ethanol / 24 h / 3102.9 Torr / Ambient temperature View Scheme
Multi-step reaction with 2 steps 1: potassium hydroxide / dimethyl sulfoxide / 20 °C 2: palladium on activated charcoal; hydrogen / tetrahydrofuran / 24 h / 20 °C / 3000.3 Torr View Scheme

: 108-95-2
phenol

: 56718-71-9
4-(2-methoxyethyl)phenol

Conditions

Conditions	Yield
Multi-step reaction with 3 steps 1: 50 percent / AlCl3 / various solvent(s) / 5 h / 70 °C 2: 90 percent / methanol / 24 h / Ambient temperature 3: 96 percent / H2 / 10percent Pd/C / ethanol / 4 h / 2327.2 Torr View Scheme
Multi-step reaction with 3 steps 1: aluminum (III) chloride 2: methanol / pH 8 3: hydrogen / 3000.3 Torr / Heating View Scheme

: 2491-38-5
2-bromo-1-(4'-hydroxyphenyl)-1-ethanone

: 56718-71-9
4-(2-methoxyethyl)phenol

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: methanol 2: H2; AcOH / Pd/C View Scheme

: 99-93-4
4-Hydroxyacetophenone

: 56718-71-9
4-(2-methoxyethyl)phenol

Conditions

Conditions	Yield
Multi-step reaction with 3 steps 1: CuBr2 / ethyl acetate 2: methanol 3: H2; AcOH / Pd/C View Scheme

: 6305-04-0
p-hydroxyphenacyl chloride

: 56718-71-9
4-(2-methoxyethyl)phenol

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: 90 percent / methanol / 24 h / Ambient temperature 2: 96 percent / H2 / 10percent Pd/C / ethanol / 4 h / 2327.2 Torr View Scheme

: 82099-82-9
Acetic acid 4-(2-methoxy-ethyl)-phenyl ester

: 56718-71-9
4-(2-methoxyethyl)phenol

Conditions

Conditions	Yield
With sodium hydroxide In ethanol for 4h; Heating;
With sodium hydroxide

: 60-12-8
2-phenylethanol

ZnCl2: ZnCl2

: 56718-71-9
4-(2-methoxyethyl)phenol

Conditions

Conditions	Yield
Multi-step reaction with 4 steps 2: NaOH 3: H2O2, HCOOH 4: NaOH View Scheme
Multi-step reaction with 6 steps 1: 207 g / pyridine / benzene / 5 h / 25 - 30 °C 2: 218 g / aluminium chloride / CH2Cl2 / 6 h / Ambient temperature 3: 71 g / sodium hydroxide / ethanol / 5 h / Heating 4: sodium hydroxide / dimethylsulfoxide / 4 h / 50 - 60 °C 5: 88 percent formic acid, cc. sulfuric acid, 35 percent hydrogen peroxide / acetic anhydride / 3 h / 40 - 50 °C 6: sodium hydroxide / ethanol / 4 h / Heating View Scheme

Yield

Multi-step reaction with 4 steps
2: NaOH
3: H2O2, HCOOH
4: NaOH
View Scheme

Multi-step reaction with 6 steps
1: 207 g / pyridine / benzene / 5 h / 25 - 30 °C
2: 218 g / aluminium chloride / CH2Cl2 / 6 h / Ambient temperature
3: 71 g / sodium hydroxide / ethanol / 5 h / Heating
4: sodium hydroxide / dimethylsulfoxide / 4 h / 50 - 60 °C
5: 88 percent formic acid, cc. sulfuric acid, 35 percent hydrogen peroxide / acetic anhydride / 3 h / 40 - 50 °C
6: sodium hydroxide / ethanol / 4 h / Heating
View Scheme

: 99215-51-7
1-<4-(1-hydroxyethyl)phenyl>ethanone

: 56718-71-9
4-(2-methoxyethyl)phenol

Conditions

Conditions	Yield
Multi-step reaction with 3 steps 1: NaOH 2: H2O2, HCOOH 3: NaOH View Scheme
Multi-step reaction with 3 steps 1: sodium hydroxide / dimethylsulfoxide / 4 h / 50 - 60 °C 2: 88 percent formic acid, cc. sulfuric acid, 35 percent hydrogen peroxide / acetic anhydride / 3 h / 40 - 50 °C 3: sodium hydroxide / ethanol / 4 h / Heating View Scheme

: 93205-89-1
4-methoxyethylacetophenone

: 56718-71-9
4-(2-methoxyethyl)phenol

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: H2O2, HCOOH 2: NaOH View Scheme
Multi-step reaction with 2 steps 1: 88 percent formic acid, cc. sulfuric acid, 35 percent hydrogen peroxide / acetic anhydride / 3 h / 40 - 50 °C 2: sodium hydroxide / ethanol / 4 h / Heating View Scheme

: 106-48-9
4-chloro-phenol

: 56718-71-9
4-(2-methoxyethyl)phenol

Conditions

Conditions	Yield
Multi-step reaction with 4 steps 1.1: potassium carbonate / N,N-dimethyl-formamide / 1 h / 80 °C 1.2: 1 h / 105 °C 2.1: magnesium; iodine / 2-methyltetrahydrofuran / 2 h / Reflux 3.1: sodium hydroxide / toluene; water / 2 h 3.2: 2 h 4.1: palladium 10% on activated carbon; hydrogen / 3 h / 37503.8 Torr View Scheme
Multi-step reaction with 4 steps 1.1: sulfuric acid / toluene / 16 h / -10 - 0 °C 2.1: magnesium / tetrahydrofuran / 16 h / 65 - 72 °C / Inert atmosphere 2.2: 0 - 10 °C / Inert atmosphere 3.1: thionyl chloride; N,N-dimethyl-formamide / toluene / 2 h / 55 - 60 °C 4.1: sodium methylate / 7 h / 50 °C View Scheme

: 586-78-7
para-nitrophenyl bromide

magnesium: magnesium

: 56718-71-9
4-(2-methoxyethyl)phenol

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: 1.) Et3N, 2.) H2 / 1/2.) 5percent Pd/C / 1.) toluene, 120 deg C, 16 h, 2.) toluene, 85 deg C, 150 psi, 45 min 2: 1.) NaNO2, 50percent H2SO4, 2.) urea / 1.) H20, 5 deg C, 15 min, 2.) H2O, 100 - 105 deg C, 1 h View Scheme

: 73823-79-7
β-(4-acetylphenyl)ethyl acetate

: 56718-71-9
4-(2-methoxyethyl)phenol

Conditions

Conditions	Yield
Multi-step reaction with 4 steps 1: 71 g / sodium hydroxide / ethanol / 5 h / Heating 2: sodium hydroxide / dimethylsulfoxide / 4 h / 50 - 60 °C 3: 88 percent formic acid, cc. sulfuric acid, 35 percent hydrogen peroxide / acetic anhydride / 3 h / 40 - 50 °C 4: sodium hydroxide / ethanol / 4 h / Heating View Scheme

: 103-45-7
acetic acid phenethyl ester

: 56718-71-9
4-(2-methoxyethyl)phenol

Conditions

Conditions	Yield
Multi-step reaction with 5 steps 1: 218 g / aluminium chloride / CH2Cl2 / 6 h / Ambient temperature 2: 71 g / sodium hydroxide / ethanol / 5 h / Heating 3: sodium hydroxide / dimethylsulfoxide / 4 h / 50 - 60 °C 4: 88 percent formic acid, cc. sulfuric acid, 35 percent hydrogen peroxide / acetic anhydride / 3 h / 40 - 50 °C 5: sodium hydroxide / ethanol / 4 h / Heating View Scheme

: 7700-27-8
4-chlorophenyl benzyl ether

: 56718-71-9
4-(2-methoxyethyl)phenol

Conditions

Conditions	Yield
Multi-step reaction with 3 steps 1.1: magnesium; iodine / 2-methyltetrahydrofuran / 2 h / Reflux 2.1: sodium hydroxide / toluene; water / 2 h 2.2: 2 h 3.1: palladium 10% on activated carbon; hydrogen / 3 h / 37503.8 Torr View Scheme

: 18995-35-2
4-tert-butoxychlorobenzene

: 56718-71-9
4-(2-methoxyethyl)phenol

Conditions

Conditions	Yield
Multi-step reaction with 3 steps 1.1: magnesium / tetrahydrofuran / 16 h / 65 - 72 °C / Inert atmosphere 1.2: 0 - 10 °C / Inert atmosphere 2.1: thionyl chloride; N,N-dimethyl-formamide / toluene / 2 h / 55 - 60 °C 3.1: sodium methylate / 7 h / 50 °C View Scheme

: 60876-70-2
4-tert-butoxybromobenzene

: 56718-71-9
4-(2-methoxyethyl)phenol

Conditions

Conditions	Yield
Multi-step reaction with 3 steps 1.1: magnesium / tetrahydrofuran / 6 h / 65 - 72 °C / Inert atmosphere 1.2: 0 - 10 °C / Inert atmosphere 2.1: thionyl chloride; N,N-dimethyl-formamide / toluene / 2 h / 55 - 60 °C 3.1: sodium methylate / 7 h / 50 °C View Scheme

: 106-41-2
4-bromo-phenol

: 56718-71-9
4-(2-methoxyethyl)phenol

Conditions

Conditions	Yield
Multi-step reaction with 4 steps 1.1: sulfuric acid / toluene / 16 h / -10 - 0 °C 2.1: magnesium / tetrahydrofuran / 6 h / 65 - 72 °C / Inert atmosphere 2.2: 0 - 10 °C / Inert atmosphere 3.1: thionyl chloride; N,N-dimethyl-formamide / toluene / 2 h / 55 - 60 °C 4.1: sodium methylate / 7 h / 50 °C View Scheme

: 56718-71-9
4-(2-methoxyethyl)phenol

: 244768-32-9
4-[(4-chloro-2-pyrimidinyl)amino]benzonitrile

: 1448695-92-8
4-{4-[4-(2-methoxylethyl)phenoxy]pyrimidin-2-ylamino}benzonitrile

Conditions

Conditions	Yield
Stage #1: 4-(2-methoxyethyl)phenol With potassium carbonate In N,N-dimethyl-formamide at 20℃; for 0.166667h; Inert atmosphere; Stage #2: 4-[(4-chloro-2-pyrimidinyl)amino]benzonitrile In N,N-dimethyl-formamide at 80℃; Inert atmosphere;	98.4%

: 110-15-6
succinic acid

: 56718-71-9
4-(2-methoxyethyl)phenol

: 75-31-0
isopropylamine

: 106-89-8
epichlorohydrin

: metoprolol succinate

Conditions

Conditions	Yield
Stage #1: 4-(2-methoxyethyl)phenol; epichlorohydrin With sodium hydroxide In water at 30 - 40℃; for 5h; Stage #2: isopropylamine In water at 20 - 30℃; for 5h; Stage #3: succinic acid In acetone at 20 - 35℃; Temperature; Solvent;	97.8%

...Expand

: 6637-53-2, 144252-21-1, 144252-22-2
3-hydroxy-3-phenyl-2,3-dihydro-isoindol-1-one

: 56718-71-9
4-(2-methoxyethyl)phenol

: 3-(2-hydroxy-5-(2-methoxyethyl)phenyl)-3-phenylisoindolin-1-one

Conditions

Conditions	Yield
Stage #1: 3-hydroxy-3-phenyl-2,3-dihydro-isoindol-1-one With methanesulfonic acid In cyclohexane at 25℃; for 0.166667h; Betti Reaction; Stage #2: 4-(2-methoxyethyl)phenol In cyclohexane at 80℃; for 16h; Betti Reaction;	97%

: 4-(4-chloro-6-methyl-pyrimidin-2-ylamino)-benzonitrile

: 56718-71-9
4-(2-methoxyethyl)phenol

: 1448695-99-5
4-{6-methyl-4-[4-(2-methoxylethyl)phenoxy]pyrimidin-2-ylamino}benzonitrile

Conditions

Conditions	Yield
Stage #1: 4-(2-methoxyethyl)phenol With potassium carbonate In N,N-dimethyl-formamide at 20℃; for 0.166667h; Inert atmosphere; Stage #2: 4-(4-chloro-6-methyl-pyrimidin-2-ylamino)-benzonitrile In N,N-dimethyl-formamide at 80℃; Inert atmosphere;	96.2%

: 56718-71-9
4-(2-methoxyethyl)phenol

: 106-89-8
epichlorohydrin

: 56718-70-8
2-[4-(2'-methoxyethyl)phenoxymethyl]oxirane

Conditions

Conditions	Yield
With sodium hydroxide at 85 - 90℃; pH=8; Temperature; pH-value; Flow reactor;	95.2%
With sodium hydroxide at 90 - 115℃; under 1500.15 - 2250.23 Torr; pH=9; Flow reactor;	95.2%
With sodium hydroxide In water at 40 - 45℃; for 3 - 5h;	93%

: 56718-71-9
4-(2-methoxyethyl)phenol

: 106-95-6
allyl bromide

: 80448-05-1
3-[4-(2-methoxyethyl)phenoxy]propylene

Conditions

Conditions	Yield
With potassium carbonate In acetone Reflux;	87%
With potassium carbonate In acetone for 7h; Heating;	85%

: 64-18-6
formic acid

: 56718-71-9
4-(2-methoxyethyl)phenol

: 4-(2-Methoxyethyl)phenyl formate

Conditions

Conditions	Yield
With tetrakis(triphenylphosphine) palladium(0); sodium acetate; acetic anhydride at 20℃; for 12h; Inert atmosphere;	87%

: 56718-71-9
4-(2-methoxyethyl)phenol

: C14H19N2O2S(1+)*F6P(1-)

: 4-(2-methoxyethyl)phenyl-4-methylbenzenesulfonate

Conditions

Conditions	Yield
With DBN In acetonitrile at 80℃; for 4h;	84%

: 1644-11-7
1,1,1,2,3,3-hexafluoro-2-(heptafluoropropoxy)-3-[(trifluorovinyl)oxy]propane

: 56718-71-9
4-(2-methoxyethyl)phenol

: 1-(2-methoxy-ethyl)-4-[1,1,2-trifluoro-2-(1,1,2,3,3,3-hexafluoro-2-heptafluoropropyloxy-propoxy)-ethoxy]-benzene

Conditions

Conditions	Yield
With potassium hydroxide Addition;	78%

: 64-18-6
formic acid

: 591-50-4
iodobenzene

: 56718-71-9
4-(2-methoxyethyl)phenol

: 4-(2-methoxyethyl)phenyl benzoate

Conditions

Conditions	Yield
With palladium diacetate; acetic anhydride; triethylamine; 4,5-bis(diphenylphos4,5-bis(diphenylphosphino)-9,9-dimethylxanthenephino)-9,9-dimethylxanthene In toluene at 80℃; for 12h; Inert atmosphere;	78%

...Expand

: 67843-74-7
(S)-epichlorohydrin

: 56718-71-9
4-(2-methoxyethyl)phenol

A: 105780-38-9
(2S)-2-{[4-(2-Methoxyethyl)phenoxy]methyl}oxirane

B: 133397-54-3
(R)-2-{[4-(2-methoxyethyl)phenoxy]methyl}oxirane

Conditions

Conditions	Yield
With potassium carbonate In acetonitrile for 14h; Reflux; optical yield given as %ee;	A n/a B 75%

...Expand

: 56718-71-9
4-(2-methoxyethyl)phenol

: (S,S,S)-triglycidyl isocyanurate

: 1333949-81-7
(S)-5-((4-(2-methoxyethyl)phenoxy)methyl)oxazolidin-2-one

Conditions

Conditions	Yield
With potassium hydroxide In 4-methyl-2-pentanone at 110 - 115℃; for 2 - 3h; Large scale reaction;	75%

: 51594-55-9
(R)-(-)-epichlorohydrin

: 56718-71-9
4-(2-methoxyethyl)phenol

A: 105780-38-9
(2S)-2-{[4-(2-Methoxyethyl)phenoxy]methyl}oxirane

B: 133397-54-3
(R)-2-{[4-(2-methoxyethyl)phenoxy]methyl}oxirane

Conditions

Conditions	Yield
With potassium carbonate In acetonitrile for 14h; Reflux; optical yield given as %ee;	A 73% B n/a

...Expand

: 56718-71-9
4-(2-methoxyethyl)phenol

: 140645-28-9
(4S)-N-tert-butoxycarbonyl-4-[[(4'-methylbenzenesulfonyl)oxy]methyl]-2,2-dimethyl-1,3-oxazolidine

: 935547-68-5
4(R)-4-((4-(2-methoxyethyl)phenoxy)methyl)-2,2-dimethyloxazolidine-3-carboxylic acid tert-butyl ester

Conditions

Conditions	Yield
Stage #1: 4-(2-methoxyethyl)phenol With sodium hydride In N,N-dimethyl-formamide at 20℃; Stage #2: (4S)-N-tert-butoxycarbonyl-4-[[(4'-methylbenzenesulfonyl)oxy]methyl]-2,2-dimethyl-1,3-oxazolidine In N,N-dimethyl-formamide at 40℃; for 1h;	71%
With sodium hydride In N,N-dimethyl-formamide at 60 - 80℃;
Stage #1: 4-(2-methoxyethyl)phenol With sodium hydride In N,N-dimethyl-formamide at 20℃; for 0.166667h; Stage #2: (4S)-N-tert-butoxycarbonyl-4-[[(4'-methylbenzenesulfonyl)oxy]methyl]-2,2-dimethyl-1,3-oxazolidine In N,N-dimethyl-formamide at 60 - 80℃; for 2h; Further stages.;

: 733747-96-1
1-(6-chloro-5-nitro-pyrimidin-4-yl)-piperidine-4-carboxylic acid ethyl ester

: 56718-71-9
4-(2-methoxyethyl)phenol

: 733748-32-8
1-{6-[4-(2-methoxyethyl)-phenoxy]-5-nitropyrimidin-4-yl}-piperidine-4-carboxylic acid ethyl ester

Conditions

Conditions	Yield
With potassium carbonate In N,N-dimethyl-formamide at 90℃; for 15h;	71%

p-(2-Methoxyethyl) phenol Specification

The 4-(2-Methoxyethyl)-phenol is an organic compound with the formula C₉H₁₂O₂. The systematic name of this chemical is 4-(2-methoxyethyl)phenol. With the CAS registry number 56718-71-9, it is also named as phenol, 4-(2-methoxyethyl)-. The product's categories are Aromatic Phenols; Phenoles and Thiophenoles; Various Metabolites and Impurities; Intermediates & Fine Chemicals; Metabolites & Impurities; Pharmaceuticals; Organic Building Blocks; Oxygen Compounds; Phenols. Besides, it should be stored in a closed cool and dry place. It is an important pharmaceutical intermediate, which is mainly used to produce an effective drug in the treatment of cardiovascular disease.

Physical properties about 4-(2-Methoxyethyl)-phenol are: (1)ACD/LogP: 1.41; (2)ACD/LogD (pH 5.5): 1.41; (3)ACD/LogD (pH 7.4): 1.4; (4)ACD/BCF (pH 5.5): 6.88; (5)ACD/BCF (pH 7.4): 6.87; (6)ACD/KOC (pH 5.5): 138.48; (7)ACD/KOC (pH 7.4): 138.14; (8)#H bond acceptors: 2; (9)#H bond donors: 1; (10)#Freely Rotating Bonds: 4; (11)Polar Surface Area: 18.46 Å²; (12)Index of Refraction: 1.525; (13)Molar Refractivity: 44.06 cm³; (14)Molar Volume: 143.5 cm³; (15)Polarizability: 17.46×10^-24cm³; (16)Surface Tension: 38.8 dyne/cm; (17)Density: 1.06 g/cm³; (18)Flash Point: 97.8 °C; (19)Enthalpy of Vaporization: 49.62 kJ/mol; (20)Boiling Point: 239.9 °C at 760 mmHg; (21)Vapour Pressure: 0.0252 mmHg at 25°C.

Preparation: this chemical can be prepared by 1-(4-hydroxy-phenyl)-2-methoxy-ethanone. This reaction will need reagent H₂, catalyst 10 percent Pd/C and solvent ethanol. The reaction time is 4 hours. The yield is about 96%.

Uses of 4-(2-Methoxyethyl)-phenol: it can be used to produce 1-allyloxy-4-(2-methoxy-ethyl)-benzene by heating. It will need reagent K₂CO₃ and solvent acetone with reaction time of 7 hours. The yield is about 85%.

When you are using this chemical, please be cautious about it as the following:
This chemical is irritating to eyes, respiratory system and skin. When you are using it, wear suitable protective clothing. In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.

You can still convert the following datas into molecular structure:
(1)SMILES: Oc1ccc(cc1)CCOC
(2)InChI: InChI=1/C9H12O2/c1-11-7-6-8-2-4-9(10)5-3-8/h2-5,10H,6-7H2,1H3
(3)InChIKey: FAYGEALAEQKPDI-UHFFFAOYAX
(4)Std. InChI: InChI=1S/C9H12O2/c1-11-7-6-8-2-4-9(10)5-3-8/h2-5,10H,6-7H2,1H3
(5)Std. InChIKey: FAYGEALAEQKPDI-UHFFFAOYSA-N

Product Name

p-(2-Methoxyethyl) phenol

Synthetic route

p-(2-Methoxyethyl) phenol Specification

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