- Min.Order :10 Milligram
- Purity: 98% 99%
- Payment Terms : L/C,D/A,D/P,T/T
Keywords
MK-0773 606101-58-0 SARM
Quick Details
- Appearance:
- Application:androgen receptor modulator
- PackAge: 5mg 10mg 25mg
- ProductionCapacity:|Metric Ton|Day
- Storage: -20℃
- Transportation:by sea or by air
Superiority:
MK-0773 is a selective androgen receptor modulators (SARMs) that binds to AR with an IC50 of 6.6 nM. IC50: 6.6 nM (AR)
The IC50 of MK-0773 binding to AR is increased 3.5-fold in the presence of 25% rat serum and 13-fold in the presence of 25% human serum, indicating that it binds to serum proteins. The affinity of MK-0773 for AR across species is evaluated using COS cells transfected with AR, and IC50 values are very similar in four species (rat, 0.50 nM; dog, 0.55 nM; rhesus, 0.45 nM; human, 0.65 nM).
MK-0773 (6 and 80 mg/kg, s.c.) produces exposure-related stimulatory effects on cortical BFR and LBM in the OVX rat model. MK-0773 (5, 15, and 80 mg/kg, s.c.) increases seminal vesicle weights, and has reduced effects on the prostate. The partial agonism and tissue selectivity of MK-0773 does not translate into differential effects on lipid metabolism in OVX rats.
Details:
Yichang shangnuoder Biomedical Technology Co., Ltd. was registered and established in September 2018, located in the national biomedical incubator of Yichang City, Hubei Province (Chengdong u Valley). It is a comprehensive high-tech enterprise integrating R & D, production and sales of pharmaceutical raw materials and intermediates.
The company has a 400 square meter standard chemical synthesis laboratory, advanced production equipment, and a strong R & D team composed of several senior technical researchers with bachelor's degree and master's degree. It has established the "production, teaching and research" cooperation mode with some universities in Yichang, Wuhan and Shanghai. The company is mainly engaged in the R & D and production of new chemical drugs, high-end chemicals and pharmaceutical intermediates, and has applied for 12 patents in key technology fields.
Since its establishment, the company has been adhering to the business philosophy of "innovation driven, efficiency first, professional guidance, first-class service", continuously providing high-quality products and services to customers at home and abroad, providing services throughout Wuhan, Hangzhou, Shanghai, Shenzhen and other regions, accumulating rich business resources. After years of technical development, the company can provide customers with mature and stable high-level pharmaceutical raw materials, intermediate R & D, manufacturing and other professional services.
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