- Fischer Peptide Synthesis
-
Fischer Peptide Synthesis
E. Fischer, Ber. 36, 2982 (1903).
Formation of polypeptides by treatment of an α-chloro or α-bromo acyl chloride with an amino acid ester, hydrolysis to the acid and conversion to a new acid chloride which is again condensed with a second amino acid ester, and so on. The terminal chloride is finally converted to an amino group with ammonia:
C. L. A. Schmidt, The Chemistry of the Amino Acids and Proteins (Thomas, Springfield, IL, 1944) p 257; B. Rockland in Amino Acids and Proteins, D. M. Greenberg, Ed. (Charles C. Thomas, Springfield, IL, 1951) p 232; H. D. Springall, The Structural Chemistry of Proteins (New York, 1954) p 24. Cf. Bergmann-Zervas Carbobenzoxy Method.
Prev: Fischer Phenylhydrazine Synthesis
Next: Fischer Oxazole Synthesis - 【Back】【Close 】【Print】【Add to favorite 】
- Related information
- Automated Peptide Synthesizer
- Merrifield Solid-Phase Peptide Synthesis
- Fischer-Tropsch Syntheses
- Fischer-Speier Esterification Method
- Fischer-Hepp Rearrangement
- Fischer Phenylhydrazone and Osazone Reaction
- Fischer Phenylhydrazine Synthesis
- Fischer Oxazole Synthesis
- Fischer Indole Synthesis
- Kiliani-Fischer Synthesis
-
Health and Chemical more >
-
Hot Products
- 959583-61-0 (2S,3S)-3-((tert-Butoxycarbonyl)amino)-2-hydroxy-3-(naphthalen-1-yl)propanoic acid
- 86347-14-0 Medetomidine
- 125-20-2 Thymolphthalein
- 143527-70-2 3,5-Oxazolidinedicarboxylicacid, 2,2-dimethyl-4-phenyl-, 3-(1,1-dimethylethyl) ester, (4S,5R)-
- 15883-20-2 2-Piperidinecarboxamide,N-(2,6-dimethylphenyl)-
- 4443-51-0 Bicyclo[2.2.1]heptane, 2-methoxy-1,7,7-trimethyl-
- 21651-62-7 Cyclopenta[c]pyran-1(4aH)-one,5,6,7,7a-tetrahydro-4,7-dimethyl-, (4aS,7S,7aR)-
- 116539-55-0 2-Thiophenemethanol, a-[2-(methylamino)ethyl]-, (aS)-
- 26898-17-9 DIBENZYLTOLUENE
- 66170-10-3 L-Ascorbicacid, 2-(dihydrogen phosphate), sodium salt (1:3)
- 863329-66-2 2'-deoxy-2'-fluoro-2'-C-methyluridine
- 96-31-1 1,3-Dimethylurea