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Hangzhou Maytime Bio-Tech Co.,Ltd.

We are Top Manufacturer for Sofosbuvir intermediates and Sofosbuvir API ,With competitive price and good quality. Appearance:off-white to white powder Storage:store in well closed container Package:export worthy package Application:for Sofosb

Top manufacturer of Sofosbuvir intermediate 863329-66-2

Cas:863329-66-2

Min.Order:1 Kilogram

Negotiable

Type:Other

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Hunan Wistar Imp. & Exp. Co., Ltd.

The company serves as a key global supplier of statins intermediates, which has a solid industrial foundation in the field of statins for lipid-lowering drugs, and holds a leading position in the market. Leveraging extensive experience in research an

Quality Manufacturer Supply High Purity 863329-66-2 Fast Shipping

Cas:863329-66-2

Min.Order:25 Kilogram

Negotiable

Type:Trading Company

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Simagchem Corporation

Welcome to Simagchem, your partner in China as a premier supply of bulk specialty chemicals for industry and life science. We introduce experienced quality product and exceptional JIT service with instant market intelligence in China to benefit our

High quality 2'-deoxy-2'-fluoro-2'-C-methyluridine supplier in China

Cas:863329-66-2

Min.Order:1 Metric Ton

Negotiable

Type:Manufacturers

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Hangzhou Dingyan Chem Co., Ltd

Items Standard Result Assay (Ursolic acid) 98%min 98.22% ----------------------------------------------------------------

High purity 863329-66-2 Iron carbonate

Cas:863329-66-2

Min.Order:1 Gram

FOB Price: $100.0 / 500.0

Type:Trading Company

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Wuhan Fortuna Chemical Co.,Ltd

Unique advantages of 2'-deoxy-2'-fluoro-2'-C-methyluridine Cas 863329-66-2 Guaranteed purity High quality & competitive price Quality control Fast feedback Prompt shipment Appearance:White powder Storage:cool dry place Package:10

Hebei yanxi chemical co.,LTD.

Hebei yanxi chemical co. LTD. has expanded a compositive entity from initially only as a small manufacturer. The company dedicated to the development, production and marketing of chemicals. After many years of efforts, we have established stable

2'-deoxy-2'-fluoro-2'-C-methyluridine

Cas:863329-66-2

Min.Order:1 Metric Ton

FOB Price: $1.0 / 2.0

Type:Manufacturers

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Hangzhou Think Chemical Co. Ltd

(2'R)-2'-Deoxy-2'-fluoro-2'-methyluridine CAS No.:863329-66-2 Name: (2'R)-2'-Deoxy-2'-fluoro-2'-methyluridine Synonyms: RO 2433; PSI-6206; 1-((2R,3R,4R,5R)-3-Fluoro-4-hydroxy-5-(hydroxymeth

High purity (2'R)-2'-Deoxy-2'-fluoro-2'-methyluridine CAS No.:863329-66-2

Cas:863329-66-2

Min.Order:1 Kilogram

FOB Price: $2.0

Type:Other

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Henan Allgreen Chemical Co.,Ltd

Good quality Good price Promptly delivery Appearance:white powder Storage:dry dondition Package:According to the demand of customer Application:intermediate Transportation:According to the demand of customer Port:shanghai

863329-66-2 2'-deoxy-2'-fluoro-2'-C-methyluridine

Cas:863329-66-2

Min.Order:1 Kilogram

Negotiable

Type:Manufacturers

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Ality Chemical Corporation

The above product is Ality Chemical's strong item with best price, good quality and fast supply. Ality Chemical has been focusing on the research and production of this field for over 14 years. At the same time, we are always committed to providi

Factory Supply (2'R)-2'-deoxy-2'-fluoro-2'-methyluridine

Cas:863329-66-2

Min.Order:1

Negotiable

Type:Other

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Xi'an Xszo Chem Co., Ltd.

1. Factory price and high quality must be guaranteed, base on 8 years of production and R&D experience2. Free samples will be provided,ensure specifications and quality are right for customer3. Customers will receive the most professional technical s

High Quality 99% 863329-66-2 2'-deoxy-2'-fluoro-2'-C-methyluridine Manufacturer

Cas:863329-66-2

Min.Order:1 Gram

FOB Price: $0.1

Type:Manufacturers

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Enke Pharma-tech Co.,Ltd. (Cangzhou, China )

Cangzhou Enke Pharma Tech Co.,ltd. is located in Cangzhou City, Hebei province ,where is a famous petroleum chemical industry city in China. Enke Pharma a high-tech enterprise ,and we are dedicated to developing and manufacturing new api, intermedi

2'-deoxy-2'-fluoro-2'-C-methyluridine

Cas:863329-66-2

Min.Order:1 Kilogram

FOB Price: $5.0

Type:Manufacturers

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Dayang Chem (Hangzhou) Co.,Ltd.

As a leading manufacturer and supplier of chemicals in China, DayangChem not only supply popular chemicals, but also DayangChem’s R&D center offer custom synthesis services. DayangChem can provide different quantities of custom synthesis

Sofosbuvir intermediate in stock

Cas:863329-66-2

Min.Order:1 Kilogram

FOB Price: $3.0

Type:Lab/Research institutions

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Chemwill Asia Co., Ltd.

Our main production base is located in Xuzhou industry park. We are certified both to the ISO 9001 and ISO 14001 Standards, have a safety management system in place.Our R&D team masters core technology for process-design of target building block

(2'R)-2'-Deoxy-2'-fluoro-2'-methyluridine

Cas:863329-66-2

Min.Order:5 Kiloliter

FOB Price: $1.2 / 5.0

Type:Manufacturers

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Hubei DiBo chemical co., LTD

Name:2'-deoxy-2'-fluoro-2'-C-methyluridine CAS NO:863329-66-2 Grade:Medical scientific research and export Molecular formula:C10H13FN2O5 Molecular weight:260.2220 Product Quality 12 years of chemical raw materials Mature operati

2'-deoxy-2'-fluoro-2'-C-methyluridine/ CAS:863329-66-2/ raw material/ high-quality

Cas:863329-66-2

Min.Order:25 Kilogram

FOB Price: $2.0 / 3.0

Type:Other

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Henan Tianfu Chemical Co., Ltd.

Our company was built in 2009 with an ISO certificate. In the past 5 years, we have grown up as a famous fine chemicals supplier in China and we had established stable business relationships with Samsung,LG,Merck,Thermo Fisher Scientific and so o

TIANFU CHEM 2'-deoxy-2'-fluoro-2'-C-methyluridine

Cas:863329-66-2

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

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Leader Biochemical Group

About Product Technical Details

China Largest factory Manufacturer Supply 2'-deoxy-2'-fluoro-2'-C-methyluridine CAS 863329-66-2

Cas:863329-66-2

Min.Order:1 Kilogram

FOB Price: $1.0 / 3.0

Type:Lab/Research institutions

inquiry

LIDE PHARMACEUTICALS LIMITED

Advantage : LIDE PHARMACEUTICALS LTD. is a mid-small manufacturing-type enterprise, engaged in pharmaceutical intermediates of R&D, custom-made and production, and also involving trading chemicals for export. We have established the R&amp

1-((2R,3R,4R,5R)-3-Fluoro-4-hydroxy-5-(hydroxymethyl)-3-methyltetrahydrofuran-2-yl)pyrimidine-2,4(1H,3H)-dione

Cas:863329-66-2

Min.Order:1 Gram

FOB Price: $1.0

Type:Lab/Research institutions

inquiry

Jinan Finer Chemical Co., Ltd

Product Description Product website: http://www.finerchem.com/pro01en/id/218.html Product Name (2'R)-2'-Deoxy-2'-fluoro-2'-methyluridine

(2'R)-2'-Deoxy-2'-fluoro-2'-methyluridine

Cas:863329-66-2

Min.Order:1 Gram

FOB Price: $34.0

Type:Lab/Research institutions

inquiry

Hebei Nengqian Chemical Import and Export Co., LTD

Our advantages: 1, High quality with competitive price: 1) Standard:BP/USP/EP/Enterprise standard 2) All Purity≥99% 3) We are manufacturer and can provide high quality products with factory price. 2, Fast and safe delivery 1) Parcel can be sent

2'-deoxy-2'-fluoro-2'-C-methyluridine

Cas:863329-66-2

Min.Order:1 Kilogram

FOB Price: $9.0 / 99.0

Type:Trading Company

inquiry

Zhuozhou Wenxi import and Export Co., Ltd

WITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et

New production CAS 863329-66-2 with best quality

Cas:863329-66-2

Min.Order:1 Kilogram

FOB Price: $139.0 / 210.0

Type:Trading Company

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Henan Sinotech Import&Export Corporation

Product name (2'R)-2'-Deoxy-2'-fluoro-2'-methyluridine Synonyms RO 2433;PSI-6206 CAS No. 863329-66-2

(2'R)-2'-Deoxy-2'-fluoro-2'-methyluridine

Cas:863329-66-2

Min.Order:1 Kilogram

FOB Price: $1.0

Type:Other

inquiry

Hubei Langyou International Trading Co., Ltd

Advantages: Hubei XinRunde Chemical Co., Ltd is a renowned pharmaceutical manufacturer. We can offer high quality products at competitive price in quick delivery with 100% custom pass guaranteed. Never stop striving to offer our best serv

863329-66-2 API Manufacturer Sofobuvir Intermediates

Cas:863329-66-2

Min.Order:10 Gram

Negotiable

Type:Other

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Hefei TNJ chemical industry co.,ltd

1. We are one of the domestic largest manufacturers of API; 2. We are always the supplier of products with higher quality and at more competitive price; 3. We are supplier of safe and ecofriendly products ; 4. We provide stable supply and

Manufacturer of 2'-deoxy-2'-fluoro-2'-C-methyluridine at Factory Price

Cas:863329-66-2

Min.Order:25 Kilogram

Negotiable

Type:Trading Company

inquiry

Shanghai Upbio Tech Co.,Ltd

1.No Less 8 years exporting experience. Clients can 100% received goods 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Upbio is Specialized

Uridine, 2'-deoxy-2'-fluoro-2'-methyl-, (2'R)- 863329-66-2

Cas:863329-66-2

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

HANWAYS CHEMPHARM CO.,LIMITED

Wuhan hanweishi Pharmchem Co., Ltd(Hanways chempharm) is a specialized company concentrating on the R&D, production, marketing and technical service of APIs and pharmaceutical intermediates. The leading products range are APIs, Hormones, Peptides

Sofosbuvir Intermediate CAS 863329-66-2

Cas:863329-66-2

Min.Order:100 Kilogram

FOB Price: $1.0 / 5.0

Type:Trading Company

inquiry

Baoji Guokang Healthchem co.,ltd

Our company has been in existence for 10 years since its establishment. We have our own unique team. The company integrates independent research and development, production and sales. We have established famous brands at home and abroad. At prese

2'-deoxy-2'-fluoro-2'-C-methyluridine 99%

Cas:863329-66-2

Min.Order:1 Kilogram

FOB Price: $120.0 / 145.0

Type:Trading Company

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Qingdao Beluga Import and Export Co., LTD

2'-deoxy-2'-fluoro-2'-C-methyluridine CAS: 863329-66-2 Qingdao Belugas Import and Export Co., Ltd. is a scientific and technological company integrating research and development, production and trade of chemical intermediates, specializi

2'-deoxy-2'-fluoro-2'-C-methyluridine CAS: 863329-66-2

Cas:863329-66-2

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Shandong Hanjiang Chemical Co., Ltd.

Hello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by emai

Uridine, 2'-deoxy-2'-fluoro-2'-methyl-, (2'R)-

Cas:863329-66-2

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Henan Wentao Chemical Product Co., Ltd.

Henan Wentao Chemical Product Co.,Ltd is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds, which are widely used in the fields of prod

CAS NO.:863329-66-2

Cas:863329-66-2

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Wuhan Han Sheng New Material Technology Co.,Ltd

Our Advantage: high quality with competitive price High quality standard: BP/USP/EP Enterprise standard All purity customized Fast and safe delivery We have reliable forwarder who can help us deliver our goods more fast and safe. We

Factory Supply High Quality CAS 863329-66-2 ,2'-deoxy-2'-fluoro-2'-C-methyluridine

Cas:863329-66-2

Min.Order:10 Kilogram

Negotiable

Type:Trading Company

inquiry

Synthetic route

(2‘R)-2‘-deoxy-2’-fluoro-2-methyluridine-3’,5’-dibenzoate

(2‘R)-2‘-deoxy-2’-fluoro-2-methyluridine-3’,5’-dibenzoate

2'-deoxy-2'-fluoro-2'-methyluridine
863329-66-2

2'-deoxy-2'-fluoro-2'-methyluridine

Conditions
ConditionsYield
With ammonia In methanol at 20℃;100%
With ammonia In methanol at 20℃; for 17h;93%
Stage #1: (2‘R)-2‘-deoxy-2’-fluoro-2-methyluridine-3’,5’-dibenzoate With N-butylamine at 45 - 50℃;
Stage #2: With methanol In tert-butyl methyl ether at 60 - 70℃;
90.7%
C22H41FN2O7Si2

C22H41FN2O7Si2

2'-deoxy-2'-fluoro-2'-methyluridine
863329-66-2

2'-deoxy-2'-fluoro-2'-methyluridine

Conditions
ConditionsYield
With tetramethylammonium fluoride; acetic acid In N,N-dimethyl-formamide at 20℃; for 2h; Time; Inert atmosphere;95%
(2'R)-2'-deoxy-2'-fluoro-2'-methyluridine-3',5'-dibenzoate

(2'R)-2'-deoxy-2'-fluoro-2'-methyluridine-3',5'-dibenzoate

2'-deoxy-2'-fluoro-2'-methyluridine
863329-66-2

2'-deoxy-2'-fluoro-2'-methyluridine

Conditions
ConditionsYield
With ammonia In methanol at 0 - 15℃; for 27h;94%
((2R,3R,5R)-3-acetoxy-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-4-fluoro-4-methyltetrahydrofuran-2-yl)methyl acetate

((2R,3R,5R)-3-acetoxy-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-4-fluoro-4-methyltetrahydrofuran-2-yl)methyl acetate

2'-deoxy-2'-fluoro-2'-methyluridine
863329-66-2

2'-deoxy-2'-fluoro-2'-methyluridine

Conditions
ConditionsYield
With ammonia In methanol at 5 - 25℃; for 26h;92.5%
C24H20N2O7
944476-43-1

C24H20N2O7

2'-deoxy-2'-fluoro-2'-methyluridine
863329-66-2

2'-deoxy-2'-fluoro-2'-methyluridine

Conditions
ConditionsYield
With potassium fluoride; 2,3,5,6,8,9,11,12,14,15-decahydro-1,4,7,10,13,16-benzohexaoxacyclooctadecin In N,N-dimethyl-formamide; toluene for 5h; Reflux;92.3%
C10H15FN2O5

C10H15FN2O5

2'-deoxy-2'-fluoro-2'-methyluridine
863329-66-2

2'-deoxy-2'-fluoro-2'-methyluridine

Conditions
ConditionsYield
With manganese(IV) oxide In toluene at 20℃; for 2h;91%
N-(1-((2R,3R,4R,5R)-3-fluoro-4-hydroxy-5-(hydroxymethyl)-3-methyltetrahydrofuran-2-yl)-2-oxo-1,2-dihydropyrimidin-4-yl)benzamide
874638-98-9

N-(1-((2R,3R,4R,5R)-3-fluoro-4-hydroxy-5-(hydroxymethyl)-3-methyltetrahydrofuran-2-yl)-2-oxo-1,2-dihydropyrimidin-4-yl)benzamide

2'-deoxy-2'-fluoro-2'-methyluridine
863329-66-2

2'-deoxy-2'-fluoro-2'-methyluridine

Conditions
ConditionsYield
With sodium hypochlorite; tetra(n-butyl)ammonium hydrogensulfate In tetrahydrofuran at 0 - 30℃; for 24h;85%
1-((6aR,8R,9aS)-2,2,4,4-tetraisopropyl-9-methylenetetrahydro-6H-furo[3,2-f][1,3,5,2,4]trioxadisilocin-8-yl)-pyrimidine-2,4(1H,3H)-dione
102789-14-0

1-((6aR,8R,9aS)-2,2,4,4-tetraisopropyl-9-methylenetetrahydro-6H-furo[3,2-f][1,3,5,2,4]trioxadisilocin-8-yl)-pyrimidine-2,4(1H,3H)-dione

2'-deoxy-2'-fluoro-2'-methyluridine
863329-66-2

2'-deoxy-2'-fluoro-2'-methyluridine

Conditions
ConditionsYield
With potassium hydrogensulfate; hydrogen fluoride In 1,2-dichloro-ethane at 0℃; for 2h;82%
C19H39FO5Si2

C19H39FO5Si2

uracil
66-22-8

uracil

2'-deoxy-2'-fluoro-2'-methyluridine
863329-66-2

2'-deoxy-2'-fluoro-2'-methyluridine

Conditions
ConditionsYield
Stage #1: uracil With ammonium sulfate; 1,1,1,3,3,3-hexamethyl-disilazane In chlorobenzene Reflux;
Stage #2: C19H39FO5Si2 With tin(IV) chloride In chlorobenzene at 50℃;
Stage #3: With tetrabutyl ammonium fluoride In tetrahydrofuran at 55 - 60℃; Reagent/catalyst; Solvent;
72%
(2R,3R,4R,5R)-5-(4-benzamido-2-oxopyrimidin-1(2H)-yl)-2-((benzoyloxy)methyl)-4-fluoro-4-methyltetrahydrofuran-3-yl benzoate
817204-32-3

(2R,3R,4R,5R)-5-(4-benzamido-2-oxopyrimidin-1(2H)-yl)-2-((benzoyloxy)methyl)-4-fluoro-4-methyltetrahydrofuran-3-yl benzoate

2'-deoxy-2'-fluoro-2'-methyluridine
863329-66-2

2'-deoxy-2'-fluoro-2'-methyluridine

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 87 percent / aq. HOAc / 12 h / Heating
2: 100 percent / NH3 / methanol / 20 °C
View Scheme
Multi-step reaction with 2 steps
1: acetic acid / water / 5 h / 110 °C
2: ammonia; methanol / 30 h / 20 °C
View Scheme
Multi-step reaction with 2 steps
1: acetic acid / water / 90 - 105 °C
2: sodium methylate / methanol / Reflux
View Scheme
3',5'-O-dibenozyl-2'deoxy-2'-fluoro-2'-C-methyl-N4-benzoylcytidine

3',5'-O-dibenozyl-2'deoxy-2'-fluoro-2'-C-methyl-N4-benzoylcytidine

2'-deoxy-2'-fluoro-2'-methyluridine
863329-66-2

2'-deoxy-2'-fluoro-2'-methyluridine

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: water; acetic acid / 20 h / 110 °C
2: ammonia / methanol / 27 h / 0 - 15 °C
View Scheme
((2R,3R,4R)-3-(benzoyloxy)-4-fluoro-5-hydroxy-4-methyltetrahydrofuran-2-yl)methyl benzoate

((2R,3R,4R)-3-(benzoyloxy)-4-fluoro-5-hydroxy-4-methyltetrahydrofuran-2-yl)methyl benzoate

2'-deoxy-2'-fluoro-2'-methyluridine
863329-66-2

2'-deoxy-2'-fluoro-2'-methyluridine

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1.1: dmap / 1.5 h / -20 °C / Inert atmosphere
2.1: N,O-bis-(trimethylsilyl)-acetamide / chlorobenzene / 2 h / 80 °C
2.2: 16 h / 65 °C
3.1: acetic acid / water / 5 h / 110 °C
4.1: ammonia; methanol / 30 h / 20 °C
View Scheme
Multi-step reaction with 4 steps
1: N-ethyl-N,N-diisopropylamine / toluene / 1 h / -5 - 0 °C
2: tin(IV) chloride; N,O-bis-(trimethylsilyl)-acetamide / acetonitrile / Reflux
3: acetic acid / water / 90 - 105 °C
4: sodium methylate / methanol / Reflux
View Scheme
Multi-step reaction with 4 steps
1: N-chloro-succinimide; triphenylphosphine / dichloromethane / 1 h / 0 - 15 °C / Inert atmosphere
2: tin(IV) chloride / chlorobenzene / 75 °C
3: formic acid / water / 7.5 h / 25 - 100 °C
4: ammonia / 20 h / 0 - 15 °C
View Scheme
((2R,3R,4R)-3-benzoyloxy-4-fluoro-4-methyl-5-oxo-tetrahydrofuran-2-yl)methyl benzoate
874638-80-9

((2R,3R,4R)-3-benzoyloxy-4-fluoro-4-methyl-5-oxo-tetrahydrofuran-2-yl)methyl benzoate

2'-deoxy-2'-fluoro-2'-methyluridine
863329-66-2

2'-deoxy-2'-fluoro-2'-methyluridine

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1.1: lithium tri-t-butoxyaluminum hydride / tetrahydrofuran / -20 °C / Inert atmosphere
2.1: dmap / 1.5 h / -20 °C / Inert atmosphere
3.1: N,O-bis-(trimethylsilyl)-acetamide / chlorobenzene / 2 h / 80 °C
3.2: 16 h / 65 °C
4.1: acetic acid / water / 5 h / 110 °C
5.1: ammonia; methanol / 30 h / 20 °C
View Scheme
Multi-step reaction with 5 steps
1: sodium bis(2-methoxyethoxy)aluminium dihydride / dichloromethane / -20 - -15 °C / Inert atmosphere
2: N-ethyl-N,N-diisopropylamine / toluene / 1 h / -5 - 0 °C
3: tin(IV) chloride; N,O-bis-(trimethylsilyl)-acetamide / acetonitrile / Reflux
4: acetic acid / water / 90 - 105 °C
5: sodium methylate / methanol / Reflux
View Scheme
Multi-step reaction with 4 steps
1.1: Red-Al(OCH2CF3) / dichloromethane / 0.5 h / -10 °C
1.2: 16 h / -10 - 20 °C
2.1: ammonium sulfate / chlorobenzene / 1.5 h / 20 °C
2.2: 10 h / 70 °C
3.1: acetic acid / water / 20 h / Reflux
4.1: ammonia; methanol / 27 h / 0 - 15 °C
View Scheme
Multi-step reaction with 5 steps
1: diisobutylaluminium hydride / dichloromethane / 2.5 h / Inert atmosphere
2: N-chloro-succinimide; triphenylphosphine / dichloromethane / 1 h / 0 - 15 °C / Inert atmosphere
3: tin(IV) chloride / chlorobenzene / 75 °C
4: formic acid / water / 7.5 h / 25 - 100 °C
5: ammonia / 20 h / 0 - 15 °C
View Scheme
Multi-step reaction with 5 steps
1.1: aluminium / dichloromethane; 2,2,2-trifluoroethanol; toluene / 0 - 10 °C
2.1: triphenylphosphine; diethylazodicarboxylate / toluene / 0 - 30 °C
3.1: ammonium sulfate; 1,1,1,3,3,3-hexamethyl-disilazane / chlorobenzene / 90 - 100 °C
3.2: 65 - 70 °C
4.1: acetic acid / water / Reflux
5.1: N-butylamine / 45 - 50 °C
5.2: 60 - 70 °C
View Scheme
(2R,3R,4R,5R)-5-acetoxy-2-((benzoyloxy)methyl)-4-fluoro-4-methyl-tetrahydrofuran-3-yl benzoate
874638-93-4

(2R,3R,4R,5R)-5-acetoxy-2-((benzoyloxy)methyl)-4-fluoro-4-methyl-tetrahydrofuran-3-yl benzoate

2'-deoxy-2'-fluoro-2'-methyluridine
863329-66-2

2'-deoxy-2'-fluoro-2'-methyluridine

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1.1: N,O-bis-(trimethylsilyl)-acetamide / chlorobenzene / 2 h / 80 °C
1.2: 16 h / 65 °C
2.1: acetic acid / water / 5 h / 110 °C
3.1: ammonia; methanol / 30 h / 20 °C
View Scheme
C14H11Cl6FN2O7

C14H11Cl6FN2O7

2'-deoxy-2'-fluoro-2'-methyluridine
863329-66-2

2'-deoxy-2'-fluoro-2'-methyluridine

Conditions
ConditionsYield
With methanol; ammonia at 20℃; for 0.75h;139 mg
1-(2'-C-methyl-β-D-arabinofuranosyl)uracil
114262-49-6

1-(2'-C-methyl-β-D-arabinofuranosyl)uracil

2'-deoxy-2'-fluoro-2'-methyluridine
863329-66-2

2'-deoxy-2'-fluoro-2'-methyluridine

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: pyridine; dmap / dichloromethane / 17 h / 20 °C / Inert atmosphere
2: ethanaminium,N-(difluoro-λ4-sulfanylidene)-N-ethyl-,tetrafluoroborate; triethylammonium dihydrofluoride / dichloromethane / 1 h / 20 °C / Inert atmosphere
3: ammonia; methanol / 0.75 h / 20 °C
View Scheme
Multi-step reaction with 3 steps
1: pyridine
2: diethylamino-sulfur trifluoride / dichloromethane
3: ammonia / methanol
View Scheme
1-(2'-C-methyl-β-D-arabinofuranosyl)uracil
114262-49-6

1-(2'-C-methyl-β-D-arabinofuranosyl)uracil

A

2'-deoxy-2'-fluoro-2'-methyluridine
863329-66-2

2'-deoxy-2'-fluoro-2'-methyluridine

B

1-((2R,4S,5R)-4-hydroxy-5-(hydroxymethyl)-3-methylenetetrahydrofuran-2-yl)pyrimidine-2,4(1H,3H)-dione
119410-95-6

1-((2R,4S,5R)-4-hydroxy-5-(hydroxymethyl)-3-methylenetetrahydrofuran-2-yl)pyrimidine-2,4(1H,3H)-dione

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: dichloromethane / 2.5 h / 20 °C / Inert atmosphere
2: triethylamine; triethylamine tris(hydrogen fluoride); ethanaminium,N-(difluoro-λ4-sulfanylidene)-N-ethyl-,tetrafluoroborate / dichloromethane / 4 h / 20 °C / Inert atmosphere
View Scheme
(2R,3R,4S,5R)-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-4-hydroxy-4-methyl-2-((2,2,2-trifluoroacetoxy)methyl)tetrahydrofuran-3-yl 2,2,2-trifluoroacetate

(2R,3R,4S,5R)-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-4-hydroxy-4-methyl-2-((2,2,2-trifluoroacetoxy)methyl)tetrahydrofuran-3-yl 2,2,2-trifluoroacetate

2'-deoxy-2'-fluoro-2'-methyluridine
863329-66-2

2'-deoxy-2'-fluoro-2'-methyluridine

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: triethylamine; triethylamine tris(hydrogen fluoride); ethanaminium,N-(difluoro-λ4-sulfanylidene)-N-ethyl-,tetrafluoroborate / dichloromethane / 4 h / 20 °C / Inert atmosphere
2: pyridine; dmap / dichloromethane / 17 h / 20 °C / Inert atmosphere
3: ethanaminium,N-(difluoro-λ4-sulfanylidene)-N-ethyl-,tetrafluoroborate; triethylammonium dihydrofluoride / dichloromethane / 1 h / 20 °C / Inert atmosphere
4: ammonia; methanol / 0.75 h / 20 °C
View Scheme
(2R,3R,4S,5R)-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-4-hydroxy-4-methyl-2-((2,2,2-trifluoroacetoxy)methyl)tetrahydrofuran-3-yl 2,2,2-trifluoroacetate

(2R,3R,4S,5R)-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-4-hydroxy-4-methyl-2-((2,2,2-trifluoroacetoxy)methyl)tetrahydrofuran-3-yl 2,2,2-trifluoroacetate

A

2'-deoxy-2'-fluoro-2'-methyluridine
863329-66-2

2'-deoxy-2'-fluoro-2'-methyluridine

B

1-((2R,4S,5R)-4-hydroxy-5-(hydroxymethyl)-3-methylenetetrahydrofuran-2-yl)pyrimidine-2,4(1H,3H)-dione
119410-95-6

1-((2R,4S,5R)-4-hydroxy-5-(hydroxymethyl)-3-methylenetetrahydrofuran-2-yl)pyrimidine-2,4(1H,3H)-dione

C

1-(2'-C-methyl-β-D-arabinofuranosyl)uracil
114262-49-6

1-(2'-C-methyl-β-D-arabinofuranosyl)uracil

Conditions
ConditionsYield
Stage #1: (2R,3R,4S,5R)-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-4-hydroxy-4-methyl-2-((2,2,2-trifluoroacetoxy)methyl)tetrahydrofuran-3-yl 2,2,2-trifluoroacetate With triethylamine tris(hydrogen fluoride); triethylamine; ethanaminium,N-(difluoro-λ4-sulfanylidene)-N-ethyl-,tetrafluoroborate In dichloromethane at 20℃; for 4h; Inert atmosphere;
Stage #2: With water
A 42 %Spectr.
B 37 %Spectr.
C 8 %Spectr.
C27H25FO8S

C27H25FO8S

2'-deoxy-2'-fluoro-2'-methyluridine
863329-66-2

2'-deoxy-2'-fluoro-2'-methyluridine

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: tin(IV) chloride; N,O-bis-(trimethylsilyl)-acetamide / acetonitrile / Reflux
2: acetic acid / water / 90 - 105 °C
3: sodium methylate / methanol / Reflux
View Scheme
(2R)-2-deoxy-2-fluoro-2-methyl-α/β-D-erythro-pentofuranosyl chloride-3,5-dibenzoate

(2R)-2-deoxy-2-fluoro-2-methyl-α/β-D-erythro-pentofuranosyl chloride-3,5-dibenzoate

2'-deoxy-2'-fluoro-2'-methyluridine
863329-66-2

2'-deoxy-2'-fluoro-2'-methyluridine

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1.1: ammonium sulfate / chlorobenzene / 1.5 h / 20 °C
1.2: 10 h / 70 °C
2.1: acetic acid / water / 20 h / Reflux
3.1: ammonia; methanol / 27 h / 0 - 15 °C
View Scheme
Multi-step reaction with 3 steps
1: tin(IV) chloride / chlorobenzene / 75 °C
2: formic acid / water / 7.5 h / 25 - 100 °C
3: ammonia / 20 h / 0 - 15 °C
View Scheme
C24H22N2O7

C24H22N2O7

2'-deoxy-2'-fluoro-2'-methyluridine
863329-66-2

2'-deoxy-2'-fluoro-2'-methyluridine

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: potassium fluoride; 2,3,5,6,8,9,11,12,14,15-decahydro-1,4,7,10,13,16-benzohexaoxacyclooctadecin / N,N-dimethyl-formamide / 5 h / Reflux
2: manganese(IV) oxide / toluene / 2 h / 20 °C
View Scheme
C21H20N2O6

C21H20N2O6

2'-deoxy-2'-fluoro-2'-methyluridine
863329-66-2

2'-deoxy-2'-fluoro-2'-methyluridine

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 1,8-diazabicyclo[5.4.0]undec-7-ene / ethanol / 4 h / Reflux
2: potassium fluoride; 2,3,5,6,8,9,11,12,14,15-decahydro-1,4,7,10,13,16-benzohexaoxacyclooctadecin / N,N-dimethyl-formamide; toluene / 5 h / Reflux
View Scheme
Multi-step reaction with 3 steps
1: N,N-dimethyl-formamide / 2 h / 75 °C
2: potassium fluoride; 2,3,5,6,8,9,11,12,14,15-decahydro-1,4,7,10,13,16-benzohexaoxacyclooctadecin / N,N-dimethyl-formamide / 5 h / Reflux
3: manganese(IV) oxide / toluene / 2 h / 20 °C
View Scheme
3’,5’-O-benzoyl-2,2’-anhydrouridine
31616-01-0

3’,5’-O-benzoyl-2,2’-anhydrouridine

2'-deoxy-2'-fluoro-2'-methyluridine
863329-66-2

2'-deoxy-2'-fluoro-2'-methyluridine

Conditions
ConditionsYield
Multi-step reaction with 6 steps
1: tetrabutylammomium bromide; sodium hydrogencarbonate / dichloromethane / 50 °C
2: 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; sodium hypochlorite / dichloromethane / 0 - 20 °C
3: 2-methyltetrahydrofuran / -78 - -40 °C
4: sodium hydrogencarbonate; phosphoramide; bis(phenyl) carbonate / 150 °C
5: tetrabutyl ammonium fluoride / chlorobenzene / Reflux
6: monomethanolamine / 24 h / 25 - 30 °C
View Scheme
3’,5’-dibenzoyluridine
54618-11-0

3’,5’-dibenzoyluridine

2'-deoxy-2'-fluoro-2'-methyluridine
863329-66-2

2'-deoxy-2'-fluoro-2'-methyluridine

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1: 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; sodium hypochlorite / dichloromethane / 0 - 20 °C
2: 2-methyltetrahydrofuran / -78 - -40 °C
3: sodium hydrogencarbonate; phosphoramide; bis(phenyl) carbonate / 150 °C
4: tetrabutyl ammonium fluoride / chlorobenzene / Reflux
5: monomethanolamine / 24 h / 25 - 30 °C
View Scheme
C23H18N2O8

C23H18N2O8

2'-deoxy-2'-fluoro-2'-methyluridine
863329-66-2

2'-deoxy-2'-fluoro-2'-methyluridine

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: 2-methyltetrahydrofuran / -78 - -40 °C
2: sodium hydrogencarbonate; phosphoramide; bis(phenyl) carbonate / 150 °C
3: tetrabutyl ammonium fluoride / chlorobenzene / Reflux
4: monomethanolamine / 24 h / 25 - 30 °C
View Scheme
C24H22N2O8

C24H22N2O8

2'-deoxy-2'-fluoro-2'-methyluridine
863329-66-2

2'-deoxy-2'-fluoro-2'-methyluridine

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: sodium hydrogencarbonate; phosphoramide; bis(phenyl) carbonate / 150 °C
2: tetrabutyl ammonium fluoride / chlorobenzene / Reflux
3: monomethanolamine / 24 h / 25 - 30 °C
View Scheme
Conditions
ConditionsYield
Multi-step reaction with 7 steps
1: pyridine / 24 h / 20 °C
2: lithium tri-t-butoxyaluminum hydride / tetrahydrofuran / -40 - -20 °C
3: triethylamine / ethyl acetate / 0 - 20 °C
4: ammonium sulfate; 1,1,1,3,3,3-hexamethyl-disilazane; urethane; tin(IV) chloride / 60 - 70 °C / Inert atmosphere
5: potassium carbonate; phosphoramide / 150 °C
6: tetrabutyl ammonium fluoride / chlorobenzene / Reflux
7: monomethanolamine / 24 h / 25 - 30 °C
View Scheme
Multi-step reaction with 7 steps
1: pyridine / 24 h / 20 °C
2: lithium tri-t-butoxyaluminum hydride / tetrahydrofuran / -40 - -20 °C
3: Vilsmeier reagent / dichloromethane; ethyl acetate / 35 - 40 °C
4: ammonium sulfate; 1,1,1,3,3,3-hexamethyl-disilazane; urethane; tin(IV) chloride / chlorobenzene / 60 - 70 °C
5: potassium carbonate; phosphoramide / 150 °C
6: tetrabutyl ammonium fluoride / chlorobenzene / Reflux
7: monomethanolamine / 24 h / 25 - 30 °C
View Scheme
Multi-step reaction with 4 steps
1.1: dmap / acetonitrile / 15 - 20 °C
2.1: triethylamine hydrofluoride; triethylamine / tetrahydrofuran / Reflux
3.1: lithium tri-t-butoxyaluminum hydride / tetrahydrofuran / 0.5 h / -20 - 0 °C
3.2: 20 °C
4.1: 1,1,1,3,3,3-hexamethyl-disilazane; ammonium sulfate / chlorobenzene / Reflux
4.2: 50 °C
4.3: 55 - 60 °C
View Scheme
(3R,4R,5R)-5-((benzoyloxy)methyl)-3-methyl-2-oxotetrahydrofuran-3,4-diyl dibenzoate
7392-74-7

(3R,4R,5R)-5-((benzoyloxy)methyl)-3-methyl-2-oxotetrahydrofuran-3,4-diyl dibenzoate

2'-deoxy-2'-fluoro-2'-methyluridine
863329-66-2

2'-deoxy-2'-fluoro-2'-methyluridine

Conditions
ConditionsYield
Multi-step reaction with 6 steps
1: lithium tri-t-butoxyaluminum hydride / tetrahydrofuran / -40 - -20 °C
2: triethylamine / ethyl acetate / 0 - 20 °C
3: ammonium sulfate; 1,1,1,3,3,3-hexamethyl-disilazane; urethane; tin(IV) chloride / 60 - 70 °C / Inert atmosphere
4: potassium carbonate; phosphoramide / 150 °C
5: tetrabutyl ammonium fluoride / chlorobenzene / Reflux
6: monomethanolamine / 24 h / 25 - 30 °C
View Scheme
Multi-step reaction with 6 steps
1: lithium tri-t-butoxyaluminum hydride / tetrahydrofuran / -40 - -20 °C
2: Vilsmeier reagent / dichloromethane; ethyl acetate / 35 - 40 °C
3: ammonium sulfate; 1,1,1,3,3,3-hexamethyl-disilazane; urethane; tin(IV) chloride / chlorobenzene / 60 - 70 °C
4: potassium carbonate; phosphoramide / 150 °C
5: tetrabutyl ammonium fluoride / chlorobenzene / Reflux
6: monomethanolamine / 24 h / 25 - 30 °C
View Scheme
(3R,4R,5R)-5-((benzoyloxy)methyl)-2-hydroxy-3-methyltetrahydrofuran-3,4-diyl dibenzoate

(3R,4R,5R)-5-((benzoyloxy)methyl)-2-hydroxy-3-methyltetrahydrofuran-3,4-diyl dibenzoate

2'-deoxy-2'-fluoro-2'-methyluridine
863329-66-2

2'-deoxy-2'-fluoro-2'-methyluridine

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1: triethylamine / ethyl acetate / 0 - 20 °C
2: ammonium sulfate; 1,1,1,3,3,3-hexamethyl-disilazane; urethane; tin(IV) chloride / 60 - 70 °C / Inert atmosphere
3: potassium carbonate; phosphoramide / 150 °C
4: tetrabutyl ammonium fluoride / chlorobenzene / Reflux
5: monomethanolamine / 24 h / 25 - 30 °C
View Scheme
Multi-step reaction with 5 steps
1: Vilsmeier reagent / dichloromethane; ethyl acetate / 35 - 40 °C
2: ammonium sulfate; 1,1,1,3,3,3-hexamethyl-disilazane; urethane; tin(IV) chloride / chlorobenzene / 60 - 70 °C
3: potassium carbonate; phosphoramide / 150 °C
4: tetrabutyl ammonium fluoride / chlorobenzene / Reflux
5: monomethanolamine / 24 h / 25 - 30 °C
View Scheme
2'-deoxy-2'-fluoro-2'-methyluridine
863329-66-2

2'-deoxy-2'-fluoro-2'-methyluridine

tert-butyldimethylsilyl chloride
18162-48-6

tert-butyldimethylsilyl chloride

1-((2R,3R,4R,5R)-5-((tert-butyldimethylsilyloxy)methyl)-3-fluoro-4-hydroxy-3-methyl-tetrahydrofuran-2-yl)pyrimidine-2,4(1H,3H)-dione
1160557-97-0

1-((2R,3R,4R,5R)-5-((tert-butyldimethylsilyloxy)methyl)-3-fluoro-4-hydroxy-3-methyl-tetrahydrofuran-2-yl)pyrimidine-2,4(1H,3H)-dione

Conditions
ConditionsYield
In pyridine at 20℃; for 24h;100%
With pyridine; 1-methyl-1H-imidazole at 0 - 5℃; for 3h;100%
With pyridine; 1H-imidazole In N,N-dimethyl-formamide at 0 - 20℃; for 12h; Inert atmosphere;93%
2'-deoxy-2'-fluoro-2'-methyluridine
863329-66-2

2'-deoxy-2'-fluoro-2'-methyluridine

acetic anhydride
108-24-7

acetic anhydride

((2R,3R,5R)-3-acetoxy-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-4-fluoro-4-methyltetrahydrofuran-2-yl)methyl acetate

((2R,3R,5R)-3-acetoxy-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-4-fluoro-4-methyltetrahydrofuran-2-yl)methyl acetate

Conditions
ConditionsYield
With pyridine at 0 - 20℃; for 2h;100%
With dmap; triethylamine at 20℃; for 2h;81%
With dmap at 20℃; for 2h;81%
2'-deoxy-2'-fluoro-2'-methyluridine
863329-66-2

2'-deoxy-2'-fluoro-2'-methyluridine

(S)-2-[((S)-(2,3,4,5,6-pentafluorophenoxy)(phenoxy)phosphoryl)amino]propionic acid isopropyl ester
1334513-02-8

(S)-2-[((S)-(2,3,4,5,6-pentafluorophenoxy)(phenoxy)phosphoryl)amino]propionic acid isopropyl ester

sofosbuvir
1190307-88-0

sofosbuvir

Conditions
ConditionsYield
With pyridine; aluminum (III) chloride In dichloromethane at 20℃; Reagent/catalyst; Temperature;97.5%
With 2,6-dimethylpyridine; dimethylaluminum chloride In tetrahydrofuran; hexane at 0 - 45℃; for 20h;86%
Stage #1: 2'-deoxy-2'-fluoro-2'-methyluridine With 3,3-diphenyl-2-propenal; tert-butylmagnesium chloride In tetrahydrofuran at -5 - 5℃; for 19h; Inert atmosphere;
Stage #2: (S)-2-[(S)-((2,3,4,5,6-pentafluorophenoxy)(phenoxy)phosphoryl)amino]propionic acid isopropyl ester In tetrahydrofuran Reagent/catalyst;
86.2%
2'-deoxy-2'-fluoro-2'-methyluridine
863329-66-2

2'-deoxy-2'-fluoro-2'-methyluridine

C17H20ClN2O5P

C17H20ClN2O5P

sofosbuvir
1064684-44-1

sofosbuvir

Conditions
ConditionsYield
With N-ethyl-N,N-diisopropylamine; zinc(II) chloride In tetrahydrofuran at 55 - 60℃; Inert atmosphere;96.4%
2'-deoxy-2'-fluoro-2'-methyluridine
863329-66-2

2'-deoxy-2'-fluoro-2'-methyluridine

(S)-2-[((S)-(2,3,4,5,6-pentafluorophenoxy)(phenoxy)phosphoryl)amino]propionic acid isopropyl ester
1334513-02-8

(S)-2-[((S)-(2,3,4,5,6-pentafluorophenoxy)(phenoxy)phosphoryl)amino]propionic acid isopropyl ester

(S)-2-{(R)-[(2R,3R,4R,5R)-5-(2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-4-fluoro-3-hydroxy-4-methyltetrahydrofuran-2-ylmethoxy](phenoxy)phosphorylamino}propionic acid isopropyl ester
1190308-01-0

(S)-2-{(R)-[(2R,3R,4R,5R)-5-(2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-4-fluoro-3-hydroxy-4-methyltetrahydrofuran-2-ylmethoxy](phenoxy)phosphorylamino}propionic acid isopropyl ester

Conditions
ConditionsYield
Stage #1: 2'-deoxy-2'-fluoro-2'-methyluridine With isopropyl magnesium chloride lithium chloride complex In tetrahydrofuran at -60℃; for 1h;
Stage #2: (S)-2-[(S)-((2,3,4,5,6-pentafluorophenoxy)(phenoxy)phosphoryl)amino]propionic acid isopropyl ester In tetrahydrofuran at -50℃; for 1h; Temperature; Reagent/catalyst;
95%
Stage #1: 2'-deoxy-2'-fluoro-2'-methyluridine With tert-butylmagnesium chloride In tetrahydrofuran at 0℃; for 1.16667h; Inert atmosphere;
Stage #2: (S)-2-[(S)-((2,3,4,5,6-pentafluorophenoxy)(phenoxy)phosphoryl)amino]propionic acid isopropyl ester In tetrahydrofuran at 5 - 20℃; for 10h; Inert atmosphere;
76%
2'-deoxy-2'-fluoro-2'-methyluridine
863329-66-2

2'-deoxy-2'-fluoro-2'-methyluridine

1-[(2R,3R,4R,5S)-3-fluoro-4-hydroxy-5-(iodomethyl)-3-methyloxolan-2-yl]-1,2,3,4-tetrahydropyrimidine-2,4-dione
1365257-00-6

1-[(2R,3R,4R,5S)-3-fluoro-4-hydroxy-5-(iodomethyl)-3-methyloxolan-2-yl]-1,2,3,4-tetrahydropyrimidine-2,4-dione

Conditions
ConditionsYield
Stage #1: 2'-deoxy-2'-fluoro-2'-methyluridine With 1H-imidazole; triphenylphosphine In tetrahydrofuran at 20℃; for 0.333333h; Inert atmosphere;
Stage #2: With iodine In tetrahydrofuran at 20℃; for 18.5h; Inert atmosphere;
94%
With pyridine; iodine; triphenylphosphine In tetrahydrofuran at 20℃; for 12h;85%
With pyridine; iodine; triphenylphosphine In tetrahydrofuran at 20℃; for 12h;85%
2'-deoxy-2'-fluoro-2'-methyluridine
863329-66-2

2'-deoxy-2'-fluoro-2'-methyluridine

4,4'-dimethoxytrityl chloride
40615-36-9

4,4'-dimethoxytrityl chloride

5'-O-(4,4'-dimethoxytrityl)-2'-deoxy-2'-fluoro-2'-C-methyluridine
1244762-79-5

5'-O-(4,4'-dimethoxytrityl)-2'-deoxy-2'-fluoro-2'-C-methyluridine

Conditions
ConditionsYield
With pyridine at 0 - 20℃; for 8h;93%
With dmap; triethylamine In ethyl acetate at 50℃; for 3h; Inert atmosphere;88.9%
With pyridine In N,N-dimethyl-formamide
With pyridine In dichloromethane at 0℃; for 4h;
2'-deoxy-2'-fluoro-2'-methyluridine
863329-66-2

2'-deoxy-2'-fluoro-2'-methyluridine

(R)-2-((R)-(2,3,4,5,6-pentafluorophenoxy)phenoxyphosphorylamino)propionic acid isopropyl ester

(R)-2-((R)-(2,3,4,5,6-pentafluorophenoxy)phenoxyphosphorylamino)propionic acid isopropyl ester

C22H29FN3O9P

C22H29FN3O9P

Conditions
ConditionsYield
With 1,8-diazabicyclo[5.4.0]undec-7-ene In tetrahydrofuran at 0℃;92%
2'-deoxy-2'-fluoro-2'-methyluridine
863329-66-2

2'-deoxy-2'-fluoro-2'-methyluridine

(S)-2-[(2,3,4,5,6-pentafluorophenoxy)phenoxyphosphorylamino]propionic acid isopropyl ester
1256490-52-4

(S)-2-[(2,3,4,5,6-pentafluorophenoxy)phenoxyphosphorylamino]propionic acid isopropyl ester

sofosbuvir
1064684-44-1

sofosbuvir

Conditions
ConditionsYield
Stage #1: 2'-deoxy-2'-fluoro-2'-methyluridine With tert-butylmagnesium chloride; lithium chloride In tetrahydrofuran at 0 - 5℃; for 1h; Inert atmosphere;
Stage #2: (S)-2-[(2,3,4,5,6-pentafluorophenoxy)phenoxyphosphorylamino]propionic acid isopropyl ester In tetrahydrofuran at -10 - -5℃; for 24h;
90.5%
With tert-butylmagnesium chloride In tetrahydrofuran at -20 - 20℃; Inert atmosphere;61.4%
Stage #1: 2'-deoxy-2'-fluoro-2'-methyluridine With tert-butylmagnesium chloride In tetrahydrofuran at 20℃; for 0.5h;
Stage #2: (S)-2-[(2,3,4,5,6-pentafluorophenoxy)phenoxyphosphorylamino]propionic acid isopropyl ester In tetrahydrofuran at 20℃; for 72h;
2'-deoxy-2'-fluoro-2'-methyluridine
863329-66-2

2'-deoxy-2'-fluoro-2'-methyluridine

(R)-2-((R)-(2,3,4,5,6-pentafluorophenoxy)phenoxyphosphorylamino)propionic acid isopropyl ester

(R)-2-((R)-(2,3,4,5,6-pentafluorophenoxy)phenoxyphosphorylamino)propionic acid isopropyl ester

((S)-(((2R,3R,4R,5R)-5-(2,4-dioxo-3,4-dihydro-pyrimidin-1(2H)-yl)-4-fluoro-3-hydroxy-4-methyl-tetrahydrofuran-2-yl)methoxy)(phenoxy)phosphoryl)-D-alanine isopropyl ester

((S)-(((2R,3R,4R,5R)-5-(2,4-dioxo-3,4-dihydro-pyrimidin-1(2H)-yl)-4-fluoro-3-hydroxy-4-methyl-tetrahydrofuran-2-yl)methoxy)(phenoxy)phosphoryl)-D-alanine isopropyl ester

Conditions
ConditionsYield
With triethylamine; magnesium chloride In tetrahydrofuran at 40℃; for 2.5h;89%
2'-deoxy-2'-fluoro-2'-methyluridine
863329-66-2

2'-deoxy-2'-fluoro-2'-methyluridine

C18H17F5NO5P

C18H17F5NO5P

sofosbuvir
1190307-88-0

sofosbuvir

Conditions
ConditionsYield
Stage #1: 2'-deoxy-2'-fluoro-2'-methyluridine; C18H17F5NO5P With N-ethyl-N,N-diisopropylamine; magnesium chloride In tetrahydrofuran at 30 - 40℃;
Stage #2: With hydrogenchloride In tetrahydrofuran; water for 0.5h; Reagent/catalyst; Temperature; Solvent;
88%
Stage #1: 2'-deoxy-2'-fluoro-2'-methyluridine With tert-butylmagnesium chloride In tetrahydrofuran at -5 - 30℃; for 1h; Inert atmosphere;
Stage #2: C18H17F5NO5P In tetrahydrofuran at 10 - 15℃;
67.5%
2'-deoxy-2'-fluoro-2'-methyluridine
863329-66-2

2'-deoxy-2'-fluoro-2'-methyluridine

C17H20ClN2O5P

C17H20ClN2O5P

sofosbuvir
1064684-44-1

sofosbuvir

Conditions
ConditionsYield
With N-ethyl-N,N-diisopropylamine; zinc(II) chloride In tetrahydrofuran at 55 - 60℃; Inert atmosphere;84.6%
2'-deoxy-2'-fluoro-2'-methyluridine
863329-66-2

2'-deoxy-2'-fluoro-2'-methyluridine

1,3-Dichloro-1,1,3,3-tetraisopropyldisiloxane
69304-37-6

1,3-Dichloro-1,1,3,3-tetraisopropyldisiloxane

C22H41FN2O7Si2
1256490-55-7

C22H41FN2O7Si2

Conditions
ConditionsYield
Stage #1: 2'-deoxy-2'-fluoro-2'-methyluridine; 1,3-Dichloro-1,1,3,3-tetraisopropyldisiloxane In pyridine at 20℃; for 16h;
Stage #2: With water; trifluoroacetic acid In tetrahydrofuran at 0℃; for 6h;
84%
2'-deoxy-2'-fluoro-2'-methyluridine
863329-66-2

2'-deoxy-2'-fluoro-2'-methyluridine

(S)-2-[[(S)-(1,1'-biphenyl-4-oxy)(pentafluorophenoxy)phosphoryl]amino]propionic acid isopropyl ester

(S)-2-[[(S)-(1,1'-biphenyl-4-oxy)(pentafluorophenoxy)phosphoryl]amino]propionic acid isopropyl ester

(S)‐2‐[[[(1,1’‐biphenyl-4-yloxy)][((2R,3R,4R,5R)‐5‐(2,4‐dioxo‐3,4‐dihydropyrimidin-1(2H)-yl)‐4‐fluoro‐3‐hydroxy‐4-methyltetrahydrofuran-2-yl)methoxy]-(S)-phosphoryl]amino]propionic acid isopropyl ester

(S)‐2‐[[[(1,1’‐biphenyl-4-yloxy)][((2R,3R,4R,5R)‐5‐(2,4‐dioxo‐3,4‐dihydropyrimidin-1(2H)-yl)‐4‐fluoro‐3‐hydroxy‐4-methyltetrahydrofuran-2-yl)methoxy]-(S)-phosphoryl]amino]propionic acid isopropyl ester

Conditions
ConditionsYield
Stage #1: 2'-deoxy-2'-fluoro-2'-methyluridine With tert-butylmagnesium chloride In tetrahydrofuran at -10 - 5℃; for 1h; Inert atmosphere; Large scale;
Stage #2: (S)-2-[[(S)-(1,1'-biphenyl-4-oxy)(pentafluorophenoxy)phosphoryl]amino]propionic acid isopropyl ester at 5 - 10℃; Large scale;
81.72%
Stage #1: 2'-deoxy-2'-fluoro-2'-methyluridine In tetrahydrofuran at -10 - 5℃; for 1h; Inert atmosphere;
Stage #2: (S)-2-[[(S)-(1,1'-biphenyl-4-oxy)(pentafluorophenoxy)phosphoryl]amino]propionic acid isopropyl ester In tetrahydrofuran at 5 - 10℃; Inert atmosphere;
Stage #1: 2'-deoxy-2'-fluoro-2'-methyluridine With tert-butylmagnesium chloride In tetrahydrofuran at -10 - 5℃; for 1h; Inert atmosphere; Large scale;
Stage #2: (S)-2-[[(S)-(1,1'-biphenyl-4-oxy)(pentafluorophenoxy)phosphoryl]amino]propionic acid isopropyl ester In tetrahydrofuran at 5 - 10℃; Inert atmosphere; Large scale;
Stage #1: 2'-deoxy-2'-fluoro-2'-methyluridine With tert-butylmagnesium chloride In tetrahydrofuran at -10 - 5℃; for 1h; Inert atmosphere;
Stage #2: (S)-2-[[(S)-(1,1'-biphenyl-4-oxy)(pentafluorophenoxy)phosphoryl]amino]propionic acid isopropyl ester In tetrahydrofuran at 5 - 10℃;
2'-deoxy-2'-fluoro-2'-methyluridine
863329-66-2

2'-deoxy-2'-fluoro-2'-methyluridine

C17H20ClN2O5P

C17H20ClN2O5P

sofosbuvir
1190307-88-0

sofosbuvir

Conditions
ConditionsYield
With N-ethyl-N,N-diisopropylamine; zinc(II) chloride In tetrahydrofuran; water at 55℃; for 20h; Reagent/catalyst; Concentration;80%
2'-deoxy-2'-fluoro-2'-methyluridine
863329-66-2

2'-deoxy-2'-fluoro-2'-methyluridine

(S)-2-[(S)-(2,3,4,5,6-pentafluoro-phenoxy)-phenoxy-phosphorylamino]propionic acid isopropyl ester
1337529-56-2

(S)-2-[(S)-(2,3,4,5,6-pentafluoro-phenoxy)-phenoxy-phosphorylamino]propionic acid isopropyl ester

sofosbuvir
1190307-88-0

sofosbuvir

Conditions
ConditionsYield
Stage #1: 2'-deoxy-2'-fluoro-2'-methyluridine With magnesium chloride In tetrahydrofuran at 25 - 30℃; for 2h; Inert atmosphere;
Stage #2: (S)-2-[(S)-(2,3,4,5,6-pentafluoro-phenoxy)-phenoxy-phosphorylamino]propionic acid isopropyl ester In tetrahydrofuran at 25 - 30℃; Reagent/catalyst;
80%
2'-deoxy-2'-fluoro-2'-methyluridine
863329-66-2

2'-deoxy-2'-fluoro-2'-methyluridine

C17H20ClN2O5P

C17H20ClN2O5P

sofosbuvir
1064684-44-1

sofosbuvir

Conditions
ConditionsYield
With N-ethyl-N,N-diisopropylamine; zinc(II) chloride In tetrahydrofuran at 55 - 60℃; Inert atmosphere;76.9%
2'-deoxy-2'-fluoro-2'-methyluridine
863329-66-2

2'-deoxy-2'-fluoro-2'-methyluridine

(S)-pentafluorophenylphenyl-(1-(2-methylbenzyloxy)propan-2-yl)phosphoramidate

(S)-pentafluorophenylphenyl-(1-(2-methylbenzyloxy)propan-2-yl)phosphoramidate

C27H33FN3O8P

C27H33FN3O8P

Conditions
ConditionsYield
Stage #1: 2'-deoxy-2'-fluoro-2'-methyluridine With tert-butylmagnesium chloride In tetrahydrofuran at 0 - 30℃; for 1h; Inert atmosphere;
Stage #2: (S)-pentafluorophenylphenyl-(1-(2-methylbenzyloxy)propan-2-yl)phosphoramidate In tetrahydrofuran at 0 - 25℃; for 10h; Inert atmosphere;
76%
2'-deoxy-2'-fluoro-2'-methyluridine
863329-66-2

2'-deoxy-2'-fluoro-2'-methyluridine

C17H20ClN2O5P

C17H20ClN2O5P

sofosbuvir
1064684-44-1

sofosbuvir

Conditions
ConditionsYield
With N-ethyl-N,N-diisopropylamine; zinc(II) chloride In tetrahydrofuran at 55 - 60℃; Inert atmosphere;73.1%
2'-deoxy-2'-fluoro-2'-methyluridine
863329-66-2

2'-deoxy-2'-fluoro-2'-methyluridine

C17H20BrN2O5P

C17H20BrN2O5P

sofosbuvir
1064684-44-1

sofosbuvir

Conditions
ConditionsYield
With N-ethyl-N,N-diisopropylamine; zinc(II) chloride In tetrahydrofuran at 55 - 60℃; Inert atmosphere;69.2%
2'-deoxy-2'-fluoro-2'-methyluridine
863329-66-2

2'-deoxy-2'-fluoro-2'-methyluridine

(S)-2-[(S)-(4-nitro-phenoxy)-phenoxy-phosphorylamino]propionic acid isopropyl ester
1256490-31-9

(S)-2-[(S)-(4-nitro-phenoxy)-phenoxy-phosphorylamino]propionic acid isopropyl ester

sofosbuvir
1190307-88-0

sofosbuvir

Conditions
ConditionsYield
Stage #1: 2'-deoxy-2'-fluoro-2'-methyluridine With tert-butylmagnesium chloride In tetrahydrofuran at 20℃; for 1h;
Stage #2: (S)-2-[(S)-(4-nitro-phenoxy)-phenoxy-phosphorylamino]propionic acid isopropyl ester In tetrahydrofuran at 20℃; for 48h;
67.6%
Stage #1: 2'-deoxy-2'-fluoro-2'-methyluridine With tert-butylmagnesium chloride In tetrahydrofuran at 20 - 50℃; for 21h;
Stage #2: (S)-2-[(S)-(4-nitro-phenoxy)-phenoxy-phosphorylamino]propionic acid isopropyl ester In tetrahydrofuran at 20℃; for 60.25h;
40%
Stage #1: 2'-deoxy-2'-fluoro-2'-methyluridine With 1-methyl-pyrrolidin-2-one In tetrahydrofuran for 0.166667h;
Stage #2: With tert-butylmagnesium chloride In tetrahydrofuran at 20℃; for 0.166667h;
Stage #3: (S)-2-[(S)-(4-nitro-phenoxy)-phenoxy-phosphorylamino]propionic acid isopropyl ester at 55℃; for 2.5h;
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