Uracil Basic information Organic alkali Fluorouracil Chemical property Uses Production methods Product Name: Uracil Synonyms: COATED SAFETY BOTTLE 2,5LWITHOUT CAP ISO;ALUMINIUM CAN WITH HANDLE AND STOPPER;Uracyl;2,6-Dihydroxypyrimidine;2-
Zhangjiagang free Trade Zone Kaida International trade Co., LTD., formerly known as Zhangjiagang Asia Chemical Co., LTD., has been engaged in the production and research of this product for more than 10 years and has rich experience. The company'
Cas:66-22-8
Min.Order:500 Gram
Negotiable
Type:Trading Company
inquiry1. We integrate research and development, production, and sales. A 1800 square meter research and development center,The company has conducted over 50 research and development and technical service projects annually, applied for more than 10 patents,
Product Name:Uracil CAS No.:66-22-8 MF:C4H4N2O2 MW:112.09 Assay : 98% Packaging: 1kg/Bag, 25kg/Drum or depends on your requirements. Shipping: Timely delivery after your payment Superiority : ISO certificate 2. Powerful R & D
Cas:66-22-8
Min.Order:1 Kilogram
Negotiable
Type:Lab/Research institutions
inquiry1.A strong technical force and advanced processing equipments. The quality of the products has been strictly inspected and all kinds of index have reached or exceeded domestic and international standards.2. Now we have established long-term stable re
Items Standard Result Appearance white or almost white crystalline powder,Odorless conform Identification
Cas:66-22-8
Min.Order:1 Kilogram
FOB Price: $25.0 / 30.0
Type:Manufacturers
inquiryWelcome to Simagchem, your partner in China as a premier supply of bulk specialty chemicals for industry and life science. We introduce experienced quality product and exceptional JIT service with instant market intelligence in China to benefit our
Cas:66-22-8
Min.Order:0 Metric Ton
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Type:Manufacturers
inquiryProduct description: Product name Uracil CAS number 66-22-8 Assay ≥99% Appearance White to off-white crystalline powder Capacity 200mt/year Application Pharmaceutical interme
hebei yanxi chemical co., LTD who registered capital of 10 million yuan, nearly to $2 million, we have a pharmaceutical raw materials factory production of pharmaceutical raw materials, and a reagent r&d center, and we do research and developm
Cas:66-22-8
Min.Order:1 Metric Ton
FOB Price: $1.0 / 3.0
Type:Manufacturers
inquiry1. Guaranteed purity; 2. Large quantity in stock; 3. Largest manufacturer; 4. Best service after shipment with email; 5. High quality & competitive price; ...... Appearance:White or almost white crystalline powder Storage:+15℃ to +30°
Cas:66-22-8
Min.Order:25 Kilogram
FOB Price: $30.0 / 55.0
Type:Trading Company
inquiry1. Factory price and high quality must be guaranteed, base on 8 years of production and R&D experience2. Free samples will be provided,ensure specifications and quality are right for customer3. Customers will receive the most professional technical s
Cas:66-22-8
Min.Order:1 Gram
FOB Price: $0.1
Type:Manufacturers
inquiryCangzhou Enke Pharma Tech Co.,ltd. is located in Cangzhou City, Hebei province ,where is a famous petroleum chemical industry city in China. Enke Pharma a high-tech enterprise ,and we are dedicated to developing and manufacturing new api, intermedi
As a leading manufacturer and supplier of chemicals in China, DayangChem not only supply popular chemicals, but also DayangChem’s R&D center offer custom synthesis according to the contract research and development services for the fine c
Cas:66-22-8
Min.Order:1 Kilogram
FOB Price: $3.0 / 6.0
Type:Lab/Research institutions
inquiryOur main production base is located in Xuzhou industry park. We are certified both to the ISO 9001 and ISO 14001 Standards, have a safety management system in place.Our R&D team masters core technology for process-design of target building block
LIDE PHARMACEUTICALS LIMITED is a professional chemicals and APIs leading manufacturer in China. Our core business line covers APIs, Intermediates, Herb extract, etc.
Our company was built in 2009 with an ISO certificate.In the past 5 years, we have grown up as a famous fine chemicals supplier in China and we had established stable business relationships with Samsung,LG,Merck,Thermo Fisher Scientific and so
Cas:66-22-8
Min.Order:1 Metric Ton
Negotiable
Type:Lab/Research institutions
inquiryWith our good experience, we offer detailed technical support and advice to assist customers. We communicate closely with customers to establish their quality requirements. Consistent Quality Our plant has strict quality control in each manufacturin
WITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et
Cas:66-22-8
Min.Order:1 Kilogram
FOB Price: $139.0 / 210.0
Type:Trading Company
inquiryOur Advantage: high quality with competitive price High quality standard: BP/USP/EP Enterprise standard All purity customized Fast and safe delivery We have reliable forwarder who can help us deliver our goods more fast and safe. We
Cas:66-22-8
Min.Order:10 Kilogram
FOB Price: $40.0 / 50.0
Type:Trading Company
inquiryProduct Name Uracil CAS No. 66-22-8 Density 1.5±0.1 g/cm3 Molecular Formula C4H4N2O2 Molecular Weight 112.0
Advantages: Hubei XinRunde Chemical Co., Ltd is a renowned pharmaceutical manufacturer. We can offer high quality products at competitive price in quick delivery with 100% custom pass guaranteed. Never stop striving to offer our best service is
Cas:66-22-8
Min.Order:10 Gram
Negotiable
Type:Other
inquiryAppearance:White to slightly yellow Crystalline Powder Storage:2-8°C, Tightly closed. Dry Package:25kg/drum Application:Pharmaceutical intermediates; organic synthetic Transportation:Express/Sea/Air Port:any port in China
Cas:66-22-8
Min.Order:500 Gram
Negotiable
Type:Lab/Research institutions
inquiryHanways chempharm is a specialized company concentrating on the R&D, production, marketing and technical service of APIs and pharmaceutical intermediates. The marketing department is located in Wuhan. We have two GMP facilities in Hubei Pr
Cas:66-22-8
Min.Order:1 Kilogram
FOB Price: $200.0 / 400.0
Type:Trading Company
inquiry1.No Less 8 years exporting experience. Clients can 100% received goods 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Upbio is Specialized
We are the manufacturers and suppliers of API in China, and warehouse in Germany and USA of California, which can quickly and safely deliver to your address 1.High quality and competitive price. 2.Free sample for your evaluation. 3.Promptly delivery
Cas:66-22-8
Min.Order:10 Gram
FOB Price: $8.8
Type:Trading Company
inquiryOur company has been in existence for 10 years since its establishment. We have our own unique team. The company integrates independent research and development, production and sales. We have established famous brands at home and abroad. At prese
Cas:66-22-8
Min.Order:1 Kilogram
FOB Price: $21.4 / 29.3
Type:Trading Company
inquiryUracil CAS: 66-22-8 Qingdao Belugas Import and Export Co., Ltd. is a scientific and technological company integrating research and development, production and trade of chemical intermediates, specializing in high quality organic intermediates, stero
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Product Detail Minimum Order Qty. 10 Gram
Cas:66-22-8
Min.Order:10 Gram
Negotiable
Type:Trading Company
inquiry1.high quality: quality is life. quality is the most important element for all goods. we have a lab doing research in wuhan china. hplc and nmr is available if needed. 2.reasonable price: we provide high quality products wi
Cas:66-22-8
Min.Order:10 Gram
Negotiable
Type:Lab/Research institutions
inquiryConditions | Yield |
---|---|
With sodium hydroxide; methyloxirane In water at 20℃; | 100% |
With dihydrogen peroxide; potassium hydroxide In ethanol at 0 - 60℃; for 4h; | 65.3% |
With iodosylbenzene In acetone for 15h; Ambient temperature; | 62% |
[1-(4-isopropoxypyrimidin-2-yl)piperidin-2-yl]-methanol
uracil
Conditions | Yield |
---|---|
With hydrogenchloride In water at 90℃; for 0.333333h; | 100% |
3-Phenyl-5,7a-dihydro-1-oxa-2,3a,5-triaza-inden-4-one
uracil
Conditions | Yield |
---|---|
In methanol for 24h; | 100% |
4-methylsulfanylpyrimidin-2(1H)-one
uracil
Conditions | Yield |
---|---|
With ferrous(II) sulfate heptahydrate In water at 80℃; for 72h; | 100% |
Conditions | Yield |
---|---|
With 18-crown-6 ether In dimethyl sulfoxide at 50℃; for 36h; | 97.3% |
With Lactobacillus animalis ATCC 35046 2’-N-deoxyribosyltransferase immobilized in DEAE-Sepharose; water for 1h; Enzymatic reaction; | 22% |
With potassium phosphate; 5'-amino-5'-deoxyuridine phosphorylase In Tris HCl buffer at 30℃; for 3h; pH=9; Kinetics; Concentration; Time; Enzymatic reaction; |
Conditions | Yield |
---|---|
Stage #1: uridine With magnesium(II) chloride hexahydrate; recombinant E. coli uridine phosphorylase In aq. phosphate buffer at 23℃; pH=7.0; Stage #2: With ammonium hydroxide; barium(II) acetate In aq. phosphate buffer at 4℃; pH=8.0; | A 96% B n/a |
Conditions | Yield |
---|---|
Stage #1: araU With magnesium(II) chloride hexahydrate; recombinant E. coli uridine phosphorylase In aq. phosphate buffer at 40℃; for 72h; pH=7.0; Stage #2: With ammonium hydroxide; barium(II) acetate In aq. phosphate buffer at 4℃; pH=8.0; | A 96% B n/a |
Conditions | Yield |
---|---|
Stage #1: urea With sodium methylate In 5,5-dimethyl-1,3-cyclohexadiene at 60℃; for 4h; Stage #2: methyl 3-methoxyprop-2-enoate In 5,5-dimethyl-1,3-cyclohexadiene at 80 - 110℃; for 6h; Temperature; Time; Solvent; Reagent/catalyst; | 95.2% |
3',5'-di-O-acetyl-2'-deoxy-2'-<(4-methoxyphenyl)sulfonyl>uridine
B
uracil
Conditions | Yield |
---|---|
With N1,N1,N12,N12-tetramethyl-7,8-dihydro-6H-dipyrido[1,2-a:2,1'-c][1,4]diazepine-2,12-diamine In N,N-dimethyl-formamide at 20℃; for 0.25h; Inert atmosphere; | A 95% B n/a |
Conditions | Yield |
---|---|
With N,N-dimethyl acetamide at 180℃; for 7h; | 93.8% |
With isopropyl alcohol Product distribution; Mechanism; Quantum yield; Irradiation; deuterated 2-propanol solvents; | |
In ethanol Product distribution; Quantum yield; Mechanism; Irradiation; further solvent; |
Conditions | Yield |
---|---|
Stage #1: urea With sodium methylate In 5,5-dimethyl-1,3-cyclohexadiene at 60℃; for 4h; Stage #2: ethyl 3-ethoxyacrylate In 5,5-dimethyl-1,3-cyclohexadiene at 80 - 110℃; for 6h; Temperature; Time; Solvent; Reagent/catalyst; | 92.4% |
2'-deoxyuridine
2-amino-6-hydroxypurine
A
uracil
B
2'-deoxyguanosine
Conditions | Yield |
---|---|
With potassium dihydrogenphosphate; multimeric uridine phosphorylase-Sepabeads-PEI-DX; purine nucleoside phosphorylase-glyoxyl-agarose In water at 45℃; for 24h; pH=10; | A n/a B 92% |
Conditions | Yield |
---|---|
Stage #1: urea With sodium methylate In 5,5-dimethyl-1,3-cyclohexadiene at 60℃; for 4h; Stage #2: 3-methoxyacrylic acid ethyl ester In 5,5-dimethyl-1,3-cyclohexadiene at 80 - 110℃; for 6h; Temperature; Time; Solvent; Reagent/catalyst; | 90.6% |
Conditions | Yield |
---|---|
With Oxone In 1,4-dioxane; water | A 10% B 90% |
Conditions | Yield |
---|---|
Stage #1: urea With sodium methylate In 5,5-dimethyl-1,3-cyclohexadiene at 60℃; for 4h; Stage #2: 3-ethoxyacrylic acid methyl ester In 5,5-dimethyl-1,3-cyclohexadiene at 80 - 110℃; for 6h; Temperature; Time; Solvent; Reagent/catalyst; | 89.2% |
Conditions | Yield |
---|---|
With 2,2'-azobis(isobutyronitrile); hypophosphorous acid; sodium hydrogencarbonate In water for 1.5h; Heating; | 89% |
With tris-(trimethylsilyl)silane; 2-hydroxyethanethiol; 1,1'-azobis(1-cyanocyclohexanenitrile) In water at 100℃; for 4h; | 98 % Turnov. |
With indium In water at 20℃; sonication; |
2',3'-dithiouridine
uracil
Conditions | Yield |
---|---|
With triethylamine In methanol for 1h; Ambient temperature; | 88% |
N1-Iodomethyluracil
uracil
Conditions | Yield |
---|---|
With water for 0.5h; Heating; | 87% |
Conditions | Yield |
---|---|
Stage #1: urea With sodium methylate In 5,5-dimethyl-1,3-cyclohexadiene at 80 - 110℃; for 6h; Stage #2: methyl 3-aminoacrylate In 5,5-dimethyl-1,3-cyclohexadiene at 80 - 110℃; for 6h; Temperature; Time; Solvent; Reagent/catalyst; | 85.8% |
2'-azido-2'-deoxyuridine
A
uracil
B
1-(2-amino-2-deoxy-β-D-ribofuranosyl)uracil
Conditions | Yield |
---|---|
With 2,2'-azobis(isobutyronitrile); tri-n-butyl-tin hydride In N,N-dimethyl acetamide; benzene for 0.5h; Heating; | A 13% B 85% |
2-hydroxypyrimidine hydrochloride
uracil
Conditions | Yield |
---|---|
With Agrobacterium sp. DSM 6136 for 15h; | 85% |
Conditions | Yield |
---|---|
With potassium dihydrogenphosphate; multimeric uridine phosphorylase-Sepabeads-PEI-DX; purine nucleoside phosphorylase-glyoxyl-agarose In water at 45℃; for 5h; pH=10; Product distribution; Further Variations:; pH-values; Temperatures; | A 85% B n/a |
uracil
Conditions | Yield |
---|---|
With hydrogenchloride In water at 22 - 98℃; for 5.5h; Temperature; Large scale; | 84.5% |
Conditions | Yield |
---|---|
Stage #1: urea With sodium methylate In 5,5-dimethyl-1,3-cyclohexadiene at 60℃; for 4h; Stage #2: ethyl 3-aminoacrylate In 5,5-dimethyl-1,3-cyclohexadiene at 80 - 110℃; for 6h; Temperature; Time; Solvent; Reagent/catalyst; | 83.4% |
1,3-dibenzyluracil
uracil
Conditions | Yield |
---|---|
With ammonium formate; palladium on activated charcoal In methanol for 48h; Heating; | 82.5% |
With boron tribromide In xylene at 138℃; for 19h; | 80% |
With boron tribromide In xylene for 19h; Mechanism; Product distribution; Heating; various solvents, temperatures and reaction times; |
Conditions | Yield |
---|---|
Stage #1: urea With sodium methylate In 5,5-dimethyl-1,3-cyclohexadiene at 60℃; for 4h; Stage #2: n-butyl 3-n-butoxyacrylate In 5,5-dimethyl-1,3-cyclohexadiene at 80 - 110℃; for 6h; Temperature; Time; Solvent; Reagent/catalyst; | 81.1% |
2,5-diphenylpyrimido<1,2-f>-1,3,4,6-thiatriazepin-7-one
A
diphenyl-[1,3,4]thiadiazole
B
uracil
Conditions | Yield |
---|---|
With hydrogenchloride In methanol for 1h; Product distribution; Heating; various thitriazepines, hydrolysis; | A 64% B 81% |
uracil
Conditions | Yield |
---|---|
With hydrogenchloride In tetrahydrofuran for 2h; Heating; | 81% |
Conditions | Yield |
---|---|
With potassium superoxide; 18-crown-6 ether for 72h; Ambient temperature; | 80% |
With diphenylselenoxide In ethanol |
uracil
Conditions | Yield |
---|---|
With hydrogenchloride for 1h; Heating; | 80% |
Conditions | Yield |
---|---|
With potassium hydroxide In water at 50 - 52℃; for 68h; | 100% |
With potassium hydroxide for 0.05h; microwave irradiation; | 98% |
With potassium hydroxide In water at 0 - 55℃; for 36h; | 98% |
Conditions | Yield |
---|---|
With sodium hydroxide; tetrabutylammomium bromide In dichloromethane at 40℃; for 3h; | 100% |
propynoic acid methyl ester
uracil
(E)-3-[3-((E)-2-Methoxycarbonyl-vinyl)-2,6-dioxo-3,6-dihydro-2H-pyrimidin-1-yl]-acrylic acid methyl ester
Conditions | Yield |
---|---|
With dmap In acetonitrile at 20℃; for 2h; hetero-Michael addition; | 100% |
di-tert-butyl dicarbonate
uracil
tert-butyl 2,4-dioxo-1,2,3,4-tetrahydropyrimidine-1-carboxylate
Conditions | Yield |
---|---|
Stage #1: uracil With pyridine; dmap at 20℃; for 0.5h; Inert atmosphere; Stage #2: di-tert-butyl dicarbonate at 20℃; for 12h; Inert atmosphere; | 100% |
With dmap In acetonitrile at 20℃; for 4h; | 70% |
With pyridine at 0 - 20℃; for 24h; Inert atmosphere; | 63.49% |
With dmap In acetonitrile at 20℃; for 24h; regioselective reaction; |
uracil
5,6-bisdeuteropyrimidin-2,4(1H,3H)-dione
Conditions | Yield |
---|---|
With hydrogen; water-d2; palladium on activated charcoal at 160℃; for 24h; | 100% |
With water-d2; palladium on activated charcoal; hydrogen at 160℃; for 24h; | 100% |
With palladium 10% on activated carbon; hydrogen; water-d2 at 20 - 160℃; for 24.1667h; | 96% |
uracil
1,2,3,5-tetra-O-benzoyl-2-C-methyl-β-D-ribofuranose
Conditions | Yield |
---|---|
Stage #1: uracil With N,O-bis-(trimethylsilyl)-acetamide In acetonitrile at 90℃; for 0.75h; Stage #2: 1,2,3,5-tetra-O-benzoyl-2-C-methyl-β-D-ribofuranose With trimethylsilyl trifluoromethanesulfonate In acetonitrile at 90℃; for 2h; | 100% |
uracil
sodium hydroxide
sodium pyrimidin-1-ide-2,4-dione
Conditions | Yield |
---|---|
In ethanol; water at 20℃; for 0.25h; | 100% |
Conditions | Yield |
---|---|
With 1,3-dibromo-5,5-dimethylimidazolidine-2,4-dione; acetic anhydride; acetic acid at 50℃; for 1.5h; Temperature; Reagent/catalyst; | 99.9% |
With 1,3-dibromo-5,5-dimethylimidazolidine-2,4-dione; acetic anhydride; acetic acid at 50℃; for 1.5h; Temperature; Reagent/catalyst; | 99.9% |
With N-Bromosuccinimide; montmorillonite K-10; tetrabutylammomium bromide for 0.0666667h; microwave irradiation; | 96% |
Conditions | Yield |
---|---|
With tetrabutyl ammonium fluoride for 6h; | 99% |
With 18-crown-6 ether; potassium carbonate In acetonitrile at 40 - 82℃; | 91.5% |
With sodium hydroxide; tetrabutylammomium bromide In benzene at 80℃; for 14h; | 90% |
Conditions | Yield |
---|---|
With 1,1,1,3,3,3-hexamethyl-disilazane Heating; | 99% |
In various solvent(s) Silylation; Heating; | 83% |
With triethylamine In 1,4-dioxane at 25℃; for 16h; | 54% |
uracil
1,1,1,3,3,3-hexamethyl-disilazane
O,O'-bis-(trimethylsilyl)uracil
Conditions | Yield |
---|---|
With chloro-trimethyl-silane for 24h; Reflux; | 99% |
With chloro-trimethyl-silane at 150 - 170℃; for 2h; | |
for 16h; Heating; |
uracil
1,2-di-O-acetyl-3,5-di-O-benzyl-4-C-fluoromethyl-D-ribofuranose
2'-O-acetyl-3',5'-di-O-benzyl-4'-C-fluoromethyluridine
Conditions | Yield |
---|---|
Stage #1: uracil With N,O-bis-(trimethylsilyl)-acetamide In acetonitrile at 80℃; for 0.5h; Inert atmosphere; Stage #2: 1,2-di-O-acetyl-3,5-di-O-benzyl-4-C-fluoromethyl-D-ribofuranose With tin(IV) chloride In acetonitrile at 80℃; for 0.5h; Inert atmosphere; | 99% |
Stage #1: uracil With ammonium sulfate; 1,1,1,3,3,3-hexamethyl-disilazane for 3h; silylation; Heating; Stage #2: 1,2-di-O-acetyl-3,5-di-O-benzyl-4-C-fluoromethyl-D-ribofuranose With trimethylsilyl trifluoromethanesulfonate In 1,2-dichloro-ethane at 0 - 20℃; for 2h; glycosylation; | 91% |
methyl 6-S-acetyl-3,4-anhydro-6-thio-1-O-trifluoromethanesulfonyl-α-D-tagatofuranoside
uracil
thioacetic acid S-[4-(2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-ylmethyl)-4-methoxy-3,6-dioxa-bicyclo[3.1.0]hex-2-ylmethyl] ester
Conditions | Yield |
---|---|
Stage #1: uracil With chloro-trimethyl-silane; 1,1,1,3,3,3-hexamethyl-disilazane for 16h; Heating; Stage #2: methyl 6-S-acetyl-3,4-anhydro-6-thio-1-O-trifluoromethanesulfonyl-α-D-tagatofuranoside In 1,2-dichloro-ethane at 60℃; for 48h; | 99% |
diphenyl diselenide
uracil
5-(phenylselanyl)pyrimidine-2,4(1H,3H)-dione
Conditions | Yield |
---|---|
With dihydrogen peroxide; sodium iodide In dimethyl sulfoxide at 50℃; for 3h; Schlenk technique; | 99% |
With ammonium iodide In N,N-dimethyl-formamide at 50℃; for 2h; Reagent/catalyst; Solvent; Electrochemical reaction; Green chemistry; | 92% |
With potassium iodide In dimethyl sulfoxide at 20℃; for 12h; Electrolysis; Green chemistry; | 92% |
With dihydrogen peroxide; sodium iodide In dimethyl sulfoxide at 50℃; | 91% |
With bis-[(trifluoroacetoxy)iodo]benzene In acetonitrile for 0.2h; Ambient temperature; | 81% |
uracil
<5-2H>uracil
Conditions | Yield |
---|---|
With water-d2; triethylamine at 70℃; for 288h; Inert atmosphere; | 99% |
With water-d2 pH=8; Kinetics; aq. phosphate buffer; |
Conditions | Yield |
---|---|
With dihydrogen peroxide; sodium iodide In dimethyl sulfoxide at 50℃; for 3h; Schlenk technique; | 99% |
With ammonium iodide In N,N-dimethyl-formamide at 50℃; for 2h; Electrochemical reaction; Green chemistry; | 89% |
With dihydrogen peroxide; sodium iodide In dimethyl sulfoxide at 50℃; | 88% |
With potassium iodide In dimethyl sulfoxide at 20℃; for 16h; Electrolysis; Green chemistry; | 82% |
bis(p-chlorophenyl) diselenide
uracil
Conditions | Yield |
---|---|
With dihydrogen peroxide; sodium iodide In dimethyl sulfoxide at 50℃; for 3h; Schlenk technique; | 99% |
With dihydrogen peroxide; sodium iodide In dimethyl sulfoxide at 50℃; | 90% |
With ammonium iodide In N,N-dimethyl-formamide at 50℃; for 2h; Electrochemical reaction; Green chemistry; | 88% |
Conditions | Yield |
---|---|
With trichlorophosphate at 105℃; | 98% |
With phosgene; Triphenylphosphine oxide In nitrobenzene at -5 - 105℃; for 0.666667h; Inert atmosphere; | 90% |
With N-ethyl-N,N-diisopropylamine; trichlorophosphate at 0 - 95℃; for 3h; Sealed tube; | 82% |
Conditions | Yield |
---|---|
With Iodine monochloride In methanol at 50℃; for 4h; | 98% |
With dmap; iodine; potassium carbonate In tetrahydrofuran for 5h; | 97% |
With N6O17Se2(2-)*H3N*2H(1+); iodine In acetonitrile at 20℃; for 72h; | 95% |
Conditions | Yield |
---|---|
Stage #1: uracil With potassium carbonate for 1h; Milling; Stage #2: benzyl bromide In N,N-dimethyl-formamide for 1h; Milling; | 98% |
Stage #1: uracil With potassium carbonate In N,N-dimethyl-formamide at 20℃; for 18h; Inert atmosphere; Stage #2: benzyl bromide In N,N-dimethyl-formamide at 20℃; for 72h; Inert atmosphere; | 93% |
Stage #1: uracil With potassium carbonate In N,N-dimethyl-formamide for 18h; Inert atmosphere; Stage #2: benzyl bromide In N,N-dimethyl-formamide for 72h; Inert atmosphere; | 89% |
With potassium carbonate In N,N-dimethyl-formamide for 48h; Ambient temperature; | |
With potassium hydroxide; tetrabutylammomium bromide 1.) 80 deg C, 2 h, 2.) 1 h; Yield given. Multistep reaction; |
Conditions | Yield |
---|---|
With chloro-trimethyl-silane; trimethylsilyl trifluoromethanesulfonate; 1,1,1,3,3,3-hexamethyl-disilazane In acetonitrile Substitution; | 98% |
2,3,5-tri-O-acetyl-D-ribofuranosyl 1-(N-phenyl)-2,2,2-trifluoroacetimidate
uracil
Tri-O-acetyluridine
Conditions | Yield |
---|---|
Stage #1: uracil With N,O-bis-(trimethylsilyl)-acetamide In acetonitrile at 20℃; for 0.5h; Stage #2: 2,3,5-tri-O-acetyl-D-ribofuranosyl 1-(N-phenyl)-2,2,2-trifluoroacetimidate With trimethylsilyl trifluoromethanesulfonate In 1,2-dichloro-ethane at 20℃; Further stages.; | 98% |
2,3,5-tri-O-benzoyl-D-ribofuranosyl(N-phenyl)trifluoroacetimidate
uracil
tribenzoyl uridine
Conditions | Yield |
---|---|
Stage #1: uracil With N,O-bis-(trimethylsilyl)-acetamide In acetonitrile at 20℃; for 0.5h; Stage #2: 2,3,5-tri-O-benzoyl-D-ribofuranosyl(N-phenyl)trifluoroacetimidate With trimethylsilyl trifluoromethanesulfonate In 1,2-dichloro-ethane at 20℃; Further stages.; | 98% |
Stage #1: 2,3,5-tri-O-benzoyl-D-ribofuranosyl(N-phenyl)trifluoroacetimidate; uracil With N,O-Bis(trimethylsilyl)trifluoroacetamide In acetonitrile at 20℃; for 0.5h; Stage #2: With trimethylsilyl trifluoromethanesulfonate In acetonitrile at 20℃; | 88% |
2,3,4,6-tetra-O-acetyl-D-galactosyl 1-(N-phenyl)-2,2,2-trifluoroacetimidate
uracil
1-(2’,3’,4’,6’-tetra-O-acetyl-β-D-galactopyranosyl)-uracil
Conditions | Yield |
---|---|
Stage #1: 2,3,4,6-tetra-O-acetyl-D-galactosyl 1-(N-phenyl)-2,2,2-trifluoroacetimidate; uracil With N,O-Bis(trimethylsilyl)trifluoroacetamide In nitromethane at 20℃; for 0.5h; Stage #2: With trimethylsilyl trifluoromethanesulfonate In nitromethane at 20℃; | 98% |
Ethyl bromodifluoroacetate
uracil
ethyl 2-(2,4-dioxo-1,2,3,4-tetrahydropyrimidin-5-yl)-2,2-difluoroacetate
Conditions | Yield |
---|---|
With dipotassium hydrogenphosphate; fac-tris[2-phenylpyridinato-C2,N]iridium(III) In dimethyl sulfoxide at 20℃; for 24h; Schlenk technique; Irradiation; Inert atmosphere; | 98% |
With tris[2-phenylpyridinato-C2,N]iridium(III); dipotassium hydrogenphosphate In dimethyl sulfoxide for 12h; Reagent/catalyst; Inert atmosphere; | 96% |
With ferrocene; dihydrogen peroxide; dimethyl sulfoxide In water at 20℃; for 12.0417h; Inert atmosphere; | 58% |
uracil
Conditions | Yield |
---|---|
With potassium hydroxide In water for 0.166667h; | 98% |
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