Appearance:White or almost white crystalline powder Storage:ln stock Package:1kg/Tin Application:Chemical Transportation:Express/Sea/Air Port:Any port of china
Cas:67-73-2
Min.Order:1 Kilogram
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inquiryDayangchem's R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. DayangChem can provide different quantities
Cas:67-73-2
Min.Order:1 Kilogram
FOB Price: $3.0
Type:Lab/Research institutions
inquiryUnique advantages for Fluocinolone acetonide Cas 67-73-2 Guaranteed purity High quality & competitive price Quality control Fast feedback Prompt shipment Appearance:White or almost white crystalline powder Storage:Refrigerator Package
Cas:67-73-2
Min.Order:10 Gram
FOB Price: $9.0 / 10.0
Type:Trading Company
inquiryWe can provide GMP validation service that complies with SFDA, FDA, WHO and EU EMPA.Excellent registration team could help us easlily to register our products in different countries.If you and your customer are interested in some products or need C
Cas:67-73-2
Min.Order:1 Gram
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Type:Manufacturers
inquiryThe above product is Ality Chemical's strong item with best price, good quality and fast supply. Ality Chemical has been focusing on the research and production of this field for over 14 years. At the same time, we are always committed to providi
1. Factory price and high quality must be guaranteed, base on 8 years of production and R&D experience2. Free samples will be provided,ensure specifications and quality are right for customer3. Customers will receive the most professional technical s
Cas:67-73-2
Min.Order:1 Gram
FOB Price: $0.1
Type:Manufacturers
inquiryCangzhou Enke Pharma Tech Co.,ltd. is located in Cangzhou City, Hebei province ,where is a famous petroleum chemical industry city in China. Enke Pharma a high-tech enterprise ,and we are dedicated to developing and manufacturing new api, intermedi
Our main production base is located in Xuzhou industry park. We are certified both to the ISO 9001 and ISO 14001 Standards, have a safety management system in place.Our R&D team masters core technology for process-design of target building block
Cas:67-73-2
Min.Order:5 Kiloliter
FOB Price: $1.2 / 5.0
Type:Manufacturers
inquiryWhy is SINOWAY: 1) Specialized in pharmaceutical and healthcare industrial for 34 years. 2) ISO 9001:2015 & SGS audited supplier . 3) Accept various payment terms : T.T 30-60 days. 4) We have warehouse in USA with quickly shipment . 5) We c
Cas:67-73-2
Min.Order:5 Kilogram
FOB Price: $1000.0
Type:Trading Company
inquiryName:Fluocinolone Acetonide CAS NO: 67-73-2 Grade:Medical scientific research and export Molecular formula:C24H30F2O6 Molecular weight:452.4882 Product Quality 12 years of chemical raw materials Mature operation of the industry System stab
Cas:67-73-2
Min.Order:25 Kilogram
FOB Price: $1.0 / 2.0
Type:Other
inquiryFluocinolone acetonide Basic information Corticosteroid drug Physical and Chemical Properties Fluocinolone acetonide Application Product Name: Fluocinolon
Cas:67-73-2
Min.Order:1 Kilogram
Negotiable
Type:Lab/Research institutions
inquiryWith our good experience, we offer detailed technical support and advice to assist customers. We communicate closely with customers to establish their quality requirements. Consistent Quality Our plant has strict quality control in each manufacturin
Cas:67-73-2
Min.Order:1 Kilogram
FOB Price: $1.0 / 10.0
Type:Trading Company
inquiryWITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et
Cas:67-73-2
Min.Order:10 Gram
FOB Price: $146.0 / 176.0
Type:Trading Company
inquiryOur Advantage: high quality with competitive price High quality standard: BP/USP/EP Enterprise standard All purity customized Fast and safe delivery We have reliable forwarder who can help us deliver our goods more fast and safe. We
1. Product advantages ♦ High purity, all above 98.5%, no impurities after dissolution ♦ We will test each batch to ensure quality ♦ OEM and private brand services designed for free ♦ Various cap colors available ♦ W
Cas:67-73-2
Min.Order:1 Kilogram
FOB Price: $7.0 / 9.0
Type:Trading Company
inquiryHello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by email in time prod
Cas:67-73-2
Min.Order:1 Kilogram
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Type:Lab/Research institutions
inquiryAdvantage : LIDE PHARMACEUTICALS LTD. is a mid-small manufacturing-type enterprise, engaged in pharmaceutical intermediates of R&D, custom-made and production, and also involving trading chemicals for export. We have established the R&
Cas:67-73-2
Min.Order:0
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Type:Lab/Research institutions
inquiryCAS Number:67-73-2 Name:Fluocinolone acetonide Formula:C24H30F2O6 Molecular Weight:452.54 Synonyms:6-alpha,11-beta,16-alpha)-idene)bis(oxy));(6alpha,11beta,16alpha)-idene)bis(oxy));20-dione,6,9-difluoro-11,12-dihydroxy-16,17-((1-methylethy
Our Adwantage: 1.We have stock so we can delivery quickly at the very day when receive the payment. 2.Best price, first class service, high successful delivery rate. A discount would be given when you make a large order. 3.High quality gua
Cas:67-73-2
Min.Order:10 Gram
Negotiable
Type:Other
inquiry1,In No Less five years exporting experience. 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Onchem specialized in APIs, chemical intermediate
Cas:67-73-2
Min.Order:25 Kilogram
FOB Price: $1.0
Type:Lab/Research institutions
inquiryOur company has been in existence for 10 years since its establishment. We have our own unique team. The company integrates independent research and development, production and sales. We have established famous brands at home and abroad. At present
Cas:67-73-2
Min.Order:10 Gram
FOB Price: $8.0 / 9.0
Type:Trading Company
inquiryFluocinolone acetonide CAS:67-73-2 Qingdao Belugas Import and Export Co., Ltd. is a scientific and technological company integrating research and development, production and trade of chemical intermediates, specializing in high quality organic inter
Cas:67-73-2
Min.Order:1 Gram
Negotiable
Type:Lab/Research institutions
inquiryWe have overseas warehouses in California, New Laredo Mexico, Vancouver Canada, Amsterdam Netherlands, and Melbourne Australia. Overseas warehouses can provide some of the best-selling products. We look forward to the cooperation of local powerful
Cas:67-73-2
Min.Order:0 Metric Ton
Negotiable
Type:Trading Company
inquiry1.high quality: quality is life. quality is the most important element for all goods. we have a lab doing research in wuhan china. hplc and nmr is available if needed. 2.reasonable price: we provide high quality products wi
Cas:67-73-2
Min.Order:10 Gram
Negotiable
Type:Lab/Research institutions
inquiryHenan Wentao Chemical Product Co.,Ltd is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds, which are widely used in the fields of prod
Product quality: Our company have high quality product , and also the product we have good manufacture . First of all, this product is of fine quality. Every finish should be checked by quality inspection system.And every one should be also tried
Cas:67-73-2
Min.Order:1 Kilogram
FOB Price: $20.0 / 30.0
Type:Trading Company
inquiryminimum order qty. 10 gram
Cas:67-73-2
Min.Order:10 Gram
Negotiable
Type:Trading Company
inquiryLorcaserin(856681-05-5)is an orally administered agent and a selective 5-HT2C receptor agonist for the treatment of obesity. It had been approved for marketing in US by FDA on 27 June in 2012. In clinical studies, lorcaserin h
Cas:67-73-2
Min.Order:100 Metric Ton
Negotiable
Type:Lab/Research institutions
inquiryOur Services 1. New Molecules R&D 2. Own test center HPLC NMR GC LC-MS 3. API and Intermediates from China reputed manufacturers 4. Documents support COA MOA MSDS DMF open part Our advantages 1. Government awarded company. Top 100 enter
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Min.Order:1 Kilogram
FOB Price: $1.0 / 100000.0
Type:Lab/Research institutions
inquiryHangzhou KeyingChem Co., Ltd. exported this product to many countries and regions at best price. If you are looking for the material’s manufacturer or supplier in China, KeyingChem is your best choice. Pls contact with us freely for getting det
Cas:67-73-2
Min.Order:0 Metric Ton
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Type:Lab/Research institutions
inquiryConditions | Yield |
---|---|
With sodium hydroxide In dichloromethane; water at 0 - 5℃; Inert atmosphere; | 99.4% |
With sodium hydroxide; sodium sulfite In dichloromethane; water at 5 - 15℃; for 1.5h; Reagent/catalyst; Temperature; Inert atmosphere; | 91% |
With sodium methylate; sodium hydroxide In dichloromethane Inert atmosphere; | 83.6% |
fluocinolone Acetonide
Conditions | Yield |
---|---|
With water; potassium carbonate In methanol | 80% |
With potassium carbonate In methanol; water |
ethanol
(6α,11β,16α)-6,9-difluoro-11,21-dihydroxy-16,17-[(1-methylethylidene)bis(oxy)]pregna-1,4-diene-3,20-dione-21-(2'-phenoxypropionate)
A
fluocinolone Acetonide
B
ethyl 2-phenoxypropionate
Conditions | Yield |
---|---|
With sodium hydrogencarbonate In water |
21-acetoxy-6α,9α-difluoro-11β-hydroxy-16α,17-[(1-methylethylidene)bis(oxy)]pregn-4-ene-3,20-dione
fluocinolone Acetonide
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: pyridine; dmap 2: benzeneseleninic anhydride / toluene / 7 h / Reflux 3: potassium carbonate / methanol; water View Scheme |
fluocinolone Acetonide
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: benzeneseleninic anhydride / toluene / 7 h / Reflux 2: potassium carbonate / methanol; water View Scheme |
(6α,11β,16α)-6,9-difluoro-11,21-dihydroxy-16,17-[(1-methylethylidene)bis(oxy)]pregna-1,4-diene-3,20-dione-21-(2'-phenoxypropionate)
fluocinolone Acetonide
Conditions | Yield |
---|---|
With ethanol; sodium hydrogencarbonate In water Kinetics; |
(6α,11β,16α)-6,9-difluoro-11,21-dihydroxy-16,17-[(1-methylethylidene)bis(oxy)]pregna-1,4-diene-3,20-dione-21-(2'-ethoxypropionate)
fluocinolone Acetonide
Conditions | Yield |
---|---|
With ethanol; sodium hydrogencarbonate In water Kinetics; |
(6α,11β,16α)-6,9-difluoro-11,21-dihydroxy-16,17-[(1-methylethylidene)bis(oxy)]pregna-1,4-diene-3,20-dione-21-(2'-ethoxybutyrate)
fluocinolone Acetonide
Conditions | Yield |
---|---|
With ethanol; sodium hydrogencarbonate In water Kinetics; |
(6α,11β,16α)-6,9-difluoro-11,21-dihydroxy-16,17-[(1-methylethylidene)bis(oxy)]pregna-1,4-diene-3,20-dione-21-(2'-methoxypropionate)
fluocinolone Acetonide
Conditions | Yield |
---|---|
With ethanol; sodium hydrogencarbonate In water Kinetics; |
(6α,11β,16α)-6,9-difluoro-11,21-dihydroxy-16,17-[(1-methylethylidene)bis(oxy)]pregna-1,4-diene-3,20-dione-21-(2'-methoxybutyrate)
fluocinolone Acetonide
Conditions | Yield |
---|---|
With ethanol; sodium hydrogencarbonate In water Kinetics; |
Conditions | Yield |
---|---|
Multi-step reaction with 10 steps 1.1: D-glucose / aq. phosphate buffer 2.1: perchloric acid / acetone; water / 0.17 h / 0 - 5 °C 2.2: 1 h / 0 - 5 °C 2.3: 2 h / 0 - 35 °C 3.1: pyridine; toluene-4-sulfonic acid; Isopropenyl acetate / acetonitrile; methanol / 3 h / 80 °C / Inert atmosphere 4.1: SelectfluorTM / acetonitrile / 8.5 h 5.1: toluene-4-sulfonic acid / 12 h / 70 °C 6.1: hydrogen fluoride; N,N-dimethyl acetamide / water / -15 °C 7.1: potassium acetate / N,N-dimethyl-formamide / 8 h / 90 - 100 °C / Inert atmosphere 8.1: formic acid; potassium permanganate / acetone / 0.33 h / -5 - 0 °C 9.1: perchloric acid / 25 - 30 °C 10.1: sodium hydroxide / water; dichloromethane / 0 - 5 °C / Inert atmosphere View Scheme |
Conditions | Yield |
---|---|
Multi-step reaction with 9 steps 1.1: perchloric acid / acetone; water / 0.17 h / 0 - 5 °C 1.2: 1 h / 0 - 5 °C 1.3: 2 h / 0 - 35 °C 2.1: pyridine; toluene-4-sulfonic acid; Isopropenyl acetate / acetonitrile; methanol / 3 h / 80 °C / Inert atmosphere 3.1: SelectfluorTM / acetonitrile / 8.5 h 4.1: toluene-4-sulfonic acid / 12 h / 70 °C 5.1: hydrogen fluoride; N,N-dimethyl acetamide / water / -15 °C 6.1: potassium acetate / N,N-dimethyl-formamide / 8 h / 90 - 100 °C / Inert atmosphere 7.1: formic acid; potassium permanganate / acetone / 0.33 h / -5 - 0 °C 8.1: perchloric acid / 25 - 30 °C 9.1: sodium hydroxide / water; dichloromethane / 0 - 5 °C / Inert atmosphere View Scheme |
21-acetyloxy-9β,11β-epoxy-17α-hydroxy-1,4-diene-3,20-dione
fluocinolone Acetonide
Conditions | Yield |
---|---|
Multi-step reaction with 8 steps 1: pyridine; toluene-4-sulfonic acid; Isopropenyl acetate / acetonitrile; methanol / 3 h / 80 °C / Inert atmosphere 2: SelectfluorTM / acetonitrile / 8.5 h 3: toluene-4-sulfonic acid / 12 h / 70 °C 4: hydrogen fluoride; N,N-dimethyl acetamide / water / -15 °C 5: potassium acetate / N,N-dimethyl-formamide / 8 h / 90 - 100 °C / Inert atmosphere 6: formic acid; potassium permanganate / acetone / 0.33 h / -5 - 0 °C 7: perchloric acid / 25 - 30 °C 8: sodium hydroxide / water; dichloromethane / 0 - 5 °C / Inert atmosphere View Scheme |
fluocinolone Acetonide
Conditions | Yield |
---|---|
Multi-step reaction with 7 steps 1: SelectfluorTM / acetonitrile / 8.5 h 2: toluene-4-sulfonic acid / 12 h / 70 °C 3: hydrogen fluoride; N,N-dimethyl acetamide / water / -15 °C 4: potassium acetate / N,N-dimethyl-formamide / 8 h / 90 - 100 °C / Inert atmosphere 5: formic acid; potassium permanganate / acetone / 0.33 h / -5 - 0 °C 6: perchloric acid / 25 - 30 °C 7: sodium hydroxide / water; dichloromethane / 0 - 5 °C / Inert atmosphere View Scheme |
21-acetyloxy-9β,11β-epoxy-6α-fluoro-17α-hydroxy-1,4-diene-3,20-dione
fluocinolone Acetonide
Conditions | Yield |
---|---|
Multi-step reaction with 6 steps 1: toluene-4-sulfonic acid / 12 h / 70 °C 2: hydrogen fluoride; N,N-dimethyl acetamide / water / -15 °C 3: potassium acetate / N,N-dimethyl-formamide / 8 h / 90 - 100 °C / Inert atmosphere 4: formic acid; potassium permanganate / acetone / 0.33 h / -5 - 0 °C 5: perchloric acid / 25 - 30 °C 6: sodium hydroxide / water; dichloromethane / 0 - 5 °C / Inert atmosphere View Scheme |
17α, 21-diacetyloxy-9β,11β-epoxy-6α-fluoro-1,4-diene-3,20-dione
fluocinolone Acetonide
Conditions | Yield |
---|---|
Multi-step reaction with 5 steps 1: hydrogen fluoride; N,N-dimethyl acetamide / water / -15 °C 2: potassium acetate / N,N-dimethyl-formamide / 8 h / 90 - 100 °C / Inert atmosphere 3: formic acid; potassium permanganate / acetone / 0.33 h / -5 - 0 °C 4: perchloric acid / 25 - 30 °C 5: sodium hydroxide / water; dichloromethane / 0 - 5 °C / Inert atmosphere View Scheme |
fluocinolone Acetonide
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1: potassium acetate / N,N-dimethyl-formamide / 8 h / 90 - 100 °C / Inert atmosphere 2: formic acid; potassium permanganate / acetone / 0.33 h / -5 - 0 °C 3: perchloric acid / 25 - 30 °C 4: sodium hydroxide / water; dichloromethane / 0 - 5 °C / Inert atmosphere View Scheme |
acetic acid 2-((6S,8S,9R,10S,11S,13S,14S)-6,9-difluoro-11-hydroxy-10,13-dimethyl-3-oxo-6,7,8,9,10,11,12,13,14,15-decahydro-3H-cyclopenta[a]phenanthrene-17-yl)-2-oxo-ethyl ester
fluocinolone Acetonide
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: formic acid; potassium permanganate / acetone / 0.33 h / -5 - 0 °C 2: perchloric acid / 25 - 30 °C 3: sodium hydroxide / water; dichloromethane / 0 - 5 °C / Inert atmosphere View Scheme |
21-acetyloxy-11β,16α,17α-trihydroxy-6α,9α-difluoro-1,4-diene-3,20-dione
fluocinolone Acetonide
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: perchloric acid / 25 - 30 °C 2: sodium hydroxide / water; dichloromethane / 0 - 5 °C / Inert atmosphere View Scheme |
2-((10S,13S,14S)-10,13-dimethyl-3-oxo-6,7,8,10,12,13,14,15-octahydro-3H-cyclopenta[a]phenanthren-17-yl)-2-oxoethyl acetate
fluocinolone Acetonide
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1.1: 1,3-dibromo-5,5-dimethylimidazolidine-2,4-dione; perchloric acid / acetone; water / 2 h / -10 - -5 °C 1.2: 12 h / -5 - 35 °C 2.1: methanesulfonic acid / 3 h / 85 °C 2.2: 12 h / -10 - -5 °C 2.3: 1 h / -10 - -5 °C 3.1: hydrogen fluoride / 4 h / -30 - -25 °C 3.2: 2 h / -50 - -45 °C 4.1: sodium hydroxide / methanol; dichloromethane / 2 h / -5 - 2 °C / Inert atmosphere View Scheme |
fluocinolone Acetonide
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1.1: methanesulfonic acid / 3 h / 85 °C 1.2: 12 h / -10 - -5 °C 1.3: 1 h / -10 - -5 °C 2.1: hydrogen fluoride / 4 h / -30 - -25 °C 2.2: 2 h / -50 - -45 °C 3.1: sodium hydroxide / methanol; dichloromethane / 2 h / -5 - 2 °C / Inert atmosphere View Scheme |
fluocinolone Acetonide
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: pyridine; 4-nitro-benzoyl chloride; toluene-4-sulfonic acid / acetonitrile / 60 °C 2: 1-ethyl-3-methylimidazole hydrogen fluoride / 25 °C 3: sodium hydroxide; sodium methylate / dichloromethane / Inert atmosphere View Scheme |
fluocinolone Acetonide
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: 1-ethyl-3-methylimidazole hydrogen fluoride / 25 °C 2: sodium hydroxide; sodium methylate / dichloromethane / Inert atmosphere View Scheme |
Conditions | Yield |
---|---|
With trimethylsilyl trifluoromethanesulfonate In dichloromethane at 20℃; for 0.0833333h; | 100% |
With trimethylsilyl trifluoromethanesulfonate In dichloromethane at 20℃; for 1.16667h; | 59% |
With trimethylsilyl trifluoromethanesulfonate In dichloromethane |
fluocinolone Acetonide
C24H30(3)H2F2O6
Conditions | Yield |
---|---|
With Wilkinson's catalyst; tritium In tetrahydrofuran; toluene | 100% |
With Wilkinson's catalyst; tritium In tetrahydrofuran; toluene |
fluocinolone Acetonide
methanesulfonyl chloride
6α,9α-difluoro-11β-hydroxy-16α,17α-isopropylidenedioxy-21-methanesulfonyloxy-pregna-1,4-diene-3,20-dione
Conditions | Yield |
---|---|
With pyridine at 0℃; for 0.5h; | 99% |
Conditions | Yield |
---|---|
With trimethylsilyl trifluoromethanesulfonate In dichloromethane at 20℃; for 0.5h; | 99% |
With trimethylsilyl trifluoromethanesulfonate In dichloromethane at 20℃; for 0.5h; | 99% |
With pyridine; dmap at 20℃; for 22h; Inert atmosphere; Heating; | 86% |
fluocinolone Acetonide
6α,9α-difluoro-11β,20,21-trihydroxy-16α,17α-isopropylidenedioxypregnane-1,4-dien-3-one
Conditions | Yield |
---|---|
With sodium tetrahydroborate In tetrahydrofuran at 20℃; for 18h; | 99% |
fluocinolone Acetonide
2-((2S,6aS,6bR,7S,8aS,8bS,11aR,12aS,12bS)-2,6b-difluoro-7-hydroxy-6a,8a,10,10-tetramethyl-4-oxo-2,4,6a,6b,7,8,8a,8b,11a,12,12a,12b-dodecahydro-1H-naphtho[2',1':4,5]indeno[1,2-d][1,3]dioxol-8b-yl)-2-oxoacetaldehyde
Conditions | Yield |
---|---|
With copper diacetate In methanol at 20℃; | 98% |
With copper diacetate In methanol at 20℃; | 98% |
With copper diacetate; oxygen In methanol |
fluocinolone Acetonide
Conditions | Yield |
---|---|
With pyridine; trifluoromethanesulfonic acid anhydride In diethyl ether; dichloromethane | 96% |
fluocinolone Acetonide
6α,9α-difluoro-11β,16α,17α,21-tetra-hydroxypregna-1,4-diene-3,20-dione
Conditions | Yield |
---|---|
With tetrafluoroboric acid In water at 22℃; for 2h; | 94.5% |
With tetrafluoroboric acid In water at 25℃; for 48h; | 60.3% |
With tetrafluoroboric acid In water at 25℃; for 48h; | 60.3% |
With tetrafluoroboric acid In water at 25℃; for 48h; | 60.3% |
With tetrafluoroboric acid; water at 20℃; for 7h; |
fluocinolone Acetonide
11β-hydroxy-16α,17α-isopropylidenedioxy-3-oxo-6α,9α-difluoroandrosta-1,4-diene-17β-carboxylic acid
Conditions | Yield |
---|---|
With periodic acid In 1,4-dioxane; water at 20℃; for 4.5h; Product distribution / selectivity; | 92% |
With sodium hydroxide; air In methanol; dichloromethane for 3h; Ambient temperature; | 77.6% |
With air; potassium carbonate In methanol at 20℃; for 16h; | 75% |
fluocinolone Acetonide
2-phenoxypropanoic acid chloride
(6α,11β,16α)-6,9-difluoro-11,21-dihydroxy-16,17-[(1-methylethylidene)bis(oxy)]pregna-1,4-diene-3,20-dione-21-(2'-phenoxypropionate)
Conditions | Yield |
---|---|
With triethylamine at 0 - 20℃; for 4.08333h; Inert atmosphere; | 89% |
With triethylamine In dichloromethane at 0 - 20℃; for 4h; |
Conditions | Yield |
---|---|
With pyridine In dichloromethane at 0℃; | 83% |
fluocinolone Acetonide
Conditions | Yield |
---|---|
With sodium hydride Rearrangement; | 81% |
Conditions | Yield |
---|---|
With perchloric acid; silica gel In n-heptane at 0 - 20℃; | 78% |
With perchloric acid; silica gel In n-heptane at 0 - 20℃; for 0.166667h; | 16% |
Stage #1: fluocinolone Acetonide; butyraldehyde With silica gel In n-heptane at 10 - 20℃; for 0.166667h; Stage #2: With perchloric acid In n-heptane at 10 - 20℃; | 16% |
Stage #1: fluocinolone Acetonide; butyraldehyde With silica gel In n-heptane at 10 - 20℃; for 0.166667h; Stage #2: With perchloric acid In n-heptane at 0 - 20℃; for 12h; | 16% |
fluocinolone Acetonide
Conditions | Yield |
---|---|
In acetonitrile Irradiation; | 76% |
fluocinolone Acetonide
21-oic acid of Fluocinolone Acetonide
Conditions | Yield |
---|---|
Stage #1: fluocinolone Acetonide With copper diacetate Stage #2: With 3-chloro-benzenecarboperoxoic acid for 18h; | 70% |
Multi-step reaction with 2 steps 1: O2, Cu(OAc)2 / methanol 2: NaClO2, KH2PO4 / tetrahydrofuran; 2-methyl-propan-2-ol; H2O View Scheme |
fluocinolone Acetonide
Conditions | Yield |
---|---|
With oxygen In methanol Irradiation; | 60% |
fluocinolone Acetonide
Conditions | Yield |
---|---|
In acetonitrile for 2.5h; Irradiation; | 50% |
fluocinolone Acetonide
butyraldehyde
(1S,2S,4R,6R,8S,9S,11S,12R,13S,19S)-12,19-difluoro-11-hydroxy-8-(2-hydroxyacetyl)-9,13-dimethyl-6-propyl-5,7-dioxapentacyclo[10.8.0.02'9.04,8.013'18]icosa-14,17-dien-16-one
Conditions | Yield |
---|---|
With perchloric acid; fine sand In n-heptane | |
With sand; 70percent HClO4 In n-heptane |
fluocinolone Acetonide
Conditions | Yield |
---|---|
In acetonitrile Quantum yield; Further Variations:; irradiation wavelength; UV-irradiation; | |
In acetonitrile Quantum yield; Further Variations:; irradiation wavelength; Irradiation; | |
In acetonitrile for 2h; Irradiation; | A 80 % Turnov. B 5 % Turnov. |
fluocinolone Acetonide
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1.1: cupric acetate monohydrate 1.2: 70 percent / m-chloroperbenzoic acid / 18 h 2.1: triethylamine View Scheme |
fluocinolone Acetonide
16α,17α-[(R)-butylidenedioxy]-6α,9α-difluoro-11β-hydroxy-21-methylsulfonyloxypregna-1,4-diene-3,20-dione
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: sand; 70percent HClO4 / heptane 2: 97 percent / pyridine / 2 h View Scheme |
fluocinolone Acetonide
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1.1: sand; 70percent HClO4 / heptane 2.1: 97 percent / pyridine / 2 h 3.1: NaH / tetrahydrofuran / 0.5 h / 0 °C 3.2: 16 percent / tetrahydrofuran / 19 h / 0 - 21 °C View Scheme |
fluocinolone Acetonide
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1.1: sand; 70percent HClO4 / heptane 2.1: 97 percent / pyridine / 2 h 3.1: NaH / tetrahydrofuran / 0.5 h / 0 °C 3.2: 26 percent / tetrahydrofuran / 19 h / 0 - 21 °C View Scheme |
fluocinolone Acetonide
6α,9α-difluoro-17β-formyl-11β-hydroxy-16α,17α-isopropylidenedioxyandrosta-1,4-dien-3-one
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: 99 percent / NaBH4 / tetrahydrofuran / 18 h / 20 °C 2: 100 percent / aq. NaIO4 / ethanol / 4 h / 20 °C View Scheme |
fluocinolone Acetonide
6α,9α-difluoro-11β-hydroxy-17β-hydroxymethyl-16α,17α-isopropylidenedioxyandrosta-1,4-dien-3-one
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: 99 percent / NaBH4 / tetrahydrofuran / 18 h / 20 °C 2: 100 percent / aq. NaIO4 / ethanol / 4 h / 20 °C 3: 45 percent / NaBH4 / ethanol / 0.5 h / 0 °C View Scheme |
fluocinolone Acetonide
Conditions | Yield |
---|---|
Multi-step reaction with 5 steps 1.1: 99 percent / NaBH4 / tetrahydrofuran / 18 h / 20 °C 2.1: 100 percent / aq. NaIO4 / ethanol / 4 h / 20 °C 3.1: 45 percent / NaBH4 / ethanol / 0.5 h / 0 °C 4.1: 93 percent / pyridine / CH2Cl2 / 1.5 h / 0 °C 5.1: NaH / tetrahydrofuran / 0.08 h 5.2: 21 percent / tetrahydrofuran / 18 h / 20 °C View Scheme |
fluocinolone Acetonide
Conditions | Yield |
---|---|
Multi-step reaction with 5 steps 1.1: 99 percent / NaBH4 / tetrahydrofuran / 18 h / 20 °C 2.1: 100 percent / aq. NaIO4 / ethanol / 4 h / 20 °C 3.1: 45 percent / NaBH4 / ethanol / 0.5 h / 0 °C 4.1: 93 percent / pyridine / CH2Cl2 / 1.5 h / 0 °C 5.1: NaH / tetrahydrofuran / 0.08 h 5.2: 43 percent / tetrahydrofuran / 16 h / 20 °C View Scheme |
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