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Hangzhou Sartort Biopharma Co., Ltd

Appearance:White or almost white crystalline powder Storage:ln stock Package:1kg/Tin Application:Chemical Transportation:Express/Sea/Air Port:Any port of china

API Fluocinolone acetonide cas:67-73-2

Cas:67-73-2

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

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Dayang Chem (Hangzhou) Co.,Ltd.

Dayangchem's R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. DayangChem can provide different quantities

Fluocinolone acetonide Manufacturer/High quality/Best price/In stock

Cas:67-73-2

Min.Order:1 Kilogram

FOB Price: $3.0

Type:Lab/Research institutions

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Wuhan Fortuna Chemical Co.,Ltd

Unique advantages for Fluocinolone acetonide Cas 67-73-2 Guaranteed purity High quality & competitive price Quality control Fast feedback Prompt shipment Appearance:White or almost white crystalline powder Storage:Refrigerator Package

Reliable manufacture supply Fluocinolone acetonide Cas 67-73-2 with high quality and good price

Cas:67-73-2

Min.Order:10 Gram

FOB Price: $9.0 / 10.0

Type:Trading Company

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Hangzhou JINLAN Pharm-Drugs Technology Co., Ltd

We can provide GMP validation service that complies with SFDA, FDA, WHO and EU EMPA.Excellent registration team could help us easlily to register our products in different countries.If you and your customer are interested in some products or need C

Fluocinolone Acetonide manufacturer with low price

Cas:67-73-2

Min.Order:1 Gram

Negotiable

Type:Manufacturers

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Ality Chemical Corporation

The above product is Ality Chemical's strong item with best price, good quality and fast supply. Ality Chemical has been focusing on the research and production of this field for over 14 years. At the same time, we are always committed to providi

Factory Supply Fluocinolone Acetonide

Cas:67-73-2

Min.Order:1

Negotiable

Type:Other

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Xi'an Xszo Chem Co., Ltd.

1. Factory price and high quality must be guaranteed, base on 8 years of production and R&D experience2. Free samples will be provided,ensure specifications and quality are right for customer3. Customers will receive the most professional technical s

High Quality 99% Fluocinolone acetonide 67-73-2 ISO Producer

Cas:67-73-2

Min.Order:1 Gram

FOB Price: $0.1

Type:Manufacturers

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Enke Pharma-tech Co.,Ltd. (Cangzhou, China )

Cangzhou Enke Pharma Tech Co.,ltd. is located in Cangzhou City, Hebei province ,where is a famous petroleum chemical industry city in China. Enke Pharma a high-tech enterprise ,and we are dedicated to developing and manufacturing new api, intermedi

Fluocinolone acetonide

Cas:67-73-2

Min.Order:1 Kilogram

FOB Price: $5.0

Type:Manufacturers

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Chemwill Asia Co., Ltd.

Our main production base is located in Xuzhou industry park. We are certified both to the ISO 9001 and ISO 14001 Standards, have a safety management system in place.Our R&D team masters core technology for process-design of target building block

Fluocinolone acetonide

Cas:67-73-2

Min.Order:5 Kiloliter

FOB Price: $1.2 / 5.0

Type:Manufacturers

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Sinoway Industrial Co., Ltd.

Why is SINOWAY: 1) Specialized in pharmaceutical and healthcare industrial for 34 years. 2) ISO 9001:2015 & SGS audited supplier . 3) Accept various payment terms : T.T 30-60 days. 4) We have warehouse in USA with quickly shipment . 5) We c

Fluocinolone acetonide CAS 67-73-2

Cas:67-73-2

Min.Order:5 Kilogram

FOB Price: $1000.0

Type:Trading Company

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Hubei DiBo chemical co., LTD

Name:Fluocinolone Acetonide CAS NO: 67-73-2 Grade:Medical scientific research and export Molecular formula:C24H30F2O6 Molecular weight:452.4882 Product Quality 12 years of chemical raw materials Mature operation of the industry System stab

Fluocinolone Acetonide/ CAS:67-73-2/Fluocinolone Acetonide raw material/ high-quality

Cas:67-73-2

Min.Order:25 Kilogram

FOB Price: $1.0 / 2.0

Type:Other

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Henan Tianfu Chemical Co., Ltd.

Fluocinolone acetonide Basic information Corticosteroid drug Physical and Chemical Properties Fluocinolone acetonide Application Product Name: Fluocinolon

TIANFU-CHEM Fluocinolone acetonide 67-73-2

Cas:67-73-2

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

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Hebei Nengqian Chemical Import and Export Co., LTD

With our good experience, we offer detailed technical support and advice to assist customers. We communicate closely with customers to establish their quality requirements. Consistent Quality Our plant has strict quality control in each manufacturin

Fluocinolone acetonide

Cas:67-73-2

Min.Order:1 Kilogram

FOB Price: $1.0 / 10.0

Type:Trading Company

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Zhuozhou Wenxi import and Export Co., Ltd

WITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et

BP Standard CAS 67-73-2 with best quality

Cas:67-73-2

Min.Order:10 Gram

FOB Price: $146.0 / 176.0

Type:Trading Company

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Wuhan Han Sheng New Material Technology Co.,Ltd

Our Advantage: high quality with competitive price High quality standard: BP/USP/EP Enterprise standard All purity customized Fast and safe delivery We have reliable forwarder who can help us deliver our goods more fast and safe. We

Fluocinolone acetonide

Cas:67-73-2

Min.Order:1 Gram

Negotiable

Type:Trading Company

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Hebei Sankai Chemical Technology Co., Ltd

1. Product advantages ♦ High purity, all above 98.5%, no impurities after dissolution ♦ We will test each batch to ensure quality ♦ OEM and private brand services designed for free ♦ Various cap colors available ♦ W

Fluocinolone acetonide CAS67-73-2

Cas:67-73-2

Min.Order:1 Kilogram

FOB Price: $7.0 / 9.0

Type:Trading Company

inquiry

Shandong Hanjiang Chemical Co., Ltd.

Hello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by email in time prod

Fluocinolone acetonide Powder USP Standard

Cas:67-73-2

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

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LIDE PHARMACEUTICALS LIMITED

Advantage : LIDE PHARMACEUTICALS LTD. is a mid-small manufacturing-type enterprise, engaged in pharmaceutical intermediates of R&D, custom-made and production, and also involving trading chemicals for export. We have established the R&amp

Fluocinolone acetonide/ LIDE PHARMA- Factory supply / Best price

Cas:67-73-2

Min.Order:0

Negotiable

Type:Lab/Research institutions

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Henan Sinotech Import&Export Corporation

CAS Number:67-73-2 Name:Fluocinolone acetonide Formula:C24H30F2O6 Molecular Weight:452.54 Synonyms:6-alpha,11-beta,16-alpha)-idene)bis(oxy));(6alpha,11beta,16alpha)-idene)bis(oxy));20-dione,6,9-difluoro-11,12-dihydroxy-16,17-((1-methylethy

Fluocinolone acetonide

Cas:67-73-2

Min.Order:1 Kilogram

FOB Price: $1.0

Type:Other

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Hubei Langyou International Trading Co., Ltd

Our Adwantage: 1.We have stock so we can delivery quickly at the very day when receive the payment. 2.Best price, first class service, high successful delivery rate. A discount would be given when you make a large order. 3.High quality gua

Shanghai Upbio Tech Co.,Ltd

1,In No Less five years exporting experience. 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Onchem specialized in APIs, chemical intermediate

Hotsale Fluocinolone Acetonide 99% with lower price

Cas:67-73-2

Min.Order:25 Kilogram

FOB Price: $1.0

Type:Lab/Research institutions

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Baoji Guokang Healthchem co.,ltd

Our company has been in existence for 10 years since its establishment. We have our own unique team. The company integrates independent research and development, production and sales. We have established famous brands at home and abroad. At present

Fluocinolone acetonide

Cas:67-73-2

Min.Order:10 Gram

FOB Price: $8.0 / 9.0

Type:Trading Company

inquiry

Qingdao Beluga Import and Export Co., LTD

Fluocinolone acetonide CAS:67-73-2 Qingdao Belugas Import and Export Co., Ltd. is a scientific and technological company integrating research and development, production and trade of chemical intermediates, specializing in high quality organic inter

Fluocinolone acetonide CAS:67-73-2

Cas:67-73-2

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Shanghai Terui OP New Material Technology Co., Ltd.

We have overseas warehouses in California, New Laredo Mexico, Vancouver Canada, Amsterdam Netherlands, and Melbourne Australia. Overseas warehouses can provide some of the best-selling products. We look forward to the cooperation of local powerful

CAS 67-73-2 Fluocinolone acetonide High quality products at great prices

Cas:67-73-2

Min.Order:0 Metric Ton

Negotiable

Type:Trading Company

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Wuhan Wonda Pharm Limited

1.high quality: quality is life. quality is the most important element for all goods. we have a lab doing research in wuhan china. hplc and nmr is available if needed. 2.reasonable price: we provide high quality products wi

Top quality Fluocinolone acetonide 67-73-2 with reasonable price and fast delivery on hot selling

Cas:67-73-2

Min.Order:10 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Henan Wentao Chemical Product Co., Ltd.

Henan Wentao Chemical Product Co.,Ltd is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds, which are widely used in the fields of prod

CAS NO.:67-73-2

Cas:67-73-2

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Hebei Mojin Biotechnology Co.,Ltd

Product quality: Our company have high quality product , and also the product we have good manufacture . First of all, this product is of fine quality. Every finish should be checked by quality inspection system.And every one should be also tried

Fluocinolone acetonide CAS NO.67-73-2

Cas:67-73-2

Min.Order:1 Kilogram

FOB Price: $20.0 / 30.0

Type:Trading Company

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Changchun Artel lmport and Export trade company

minimum order qty. 10 gram

Fluocinolone Acetonide 67-73-2 CAS NO.67-73-2

Cas:67-73-2

Min.Order:10 Gram

Negotiable

Type:Trading Company

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Triumph International Development Limilted

Lorcaserin(856681-05-5)is an orally administered agent and a selective 5-HT2C receptor agonist for the treatment of obesity. It had been approved for marketing in US by FDA on 27 June in 2012. In clinical studies, lorcaserin h

Fluocinolone Acetonide

Cas:67-73-2

Min.Order:100 Metric Ton

Negotiable

Type:Lab/Research institutions

inquiry

Afine Chemicals Limited

Our Services 1. New Molecules R&D 2. Own test center HPLC NMR GC LC-MS 3. API and Intermediates from China reputed manufacturers 4. Documents support COA MOA MSDS DMF open part Our advantages 1. Government awarded company. Top 100 enter

Fluocinolone acetonide

Cas:67-73-2

Min.Order:1 Kilogram

FOB Price: $1.0 / 100000.0

Type:Lab/Research institutions

inquiry

Hangzhou Keyingchem Co.,Ltd

Hangzhou KeyingChem Co., Ltd. exported this product to many countries and regions at best price. If you are looking for the material’s manufacturer or supplier in China, KeyingChem is your best choice. Pls contact with us freely for getting det

Fluocinolone acetonide

Cas:67-73-2

Min.Order:0 Metric Ton

Negotiable

Type:Lab/Research institutions

inquiry

Synthetic route

fluocinonide
356-12-7

fluocinonide

fluocinolone Acetonide
67-73-2

fluocinolone Acetonide

Conditions
ConditionsYield
With sodium hydroxide In dichloromethane; water at 0 - 5℃; Inert atmosphere;99.4%
With sodium hydroxide; sodium sulfite In dichloromethane; water at 5 - 15℃; for 1.5h; Reagent/catalyst; Temperature; Inert atmosphere;91%
With sodium methylate; sodium hydroxide In dichloromethane Inert atmosphere;83.6%
11β,21-diacetoxy-6α,9α-difluoro-16α,17-[(1-methylethylidene)bis(oxy)]pregna-1,4-diene-3,20-dione

11β,21-diacetoxy-6α,9α-difluoro-16α,17-[(1-methylethylidene)bis(oxy)]pregna-1,4-diene-3,20-dione

fluocinolone Acetonide
67-73-2

fluocinolone Acetonide

Conditions
ConditionsYield
With water; potassium carbonate In methanol80%
With potassium carbonate In methanol; water
ethanol
64-17-5

ethanol

(6α,11β,16α)-6,9-difluoro-11,21-dihydroxy-16,17-[(1-methylethylidene)bis(oxy)]pregna-1,4-diene-3,20-dione-21-(2'-phenoxypropionate)
1217194-25-6

(6α,11β,16α)-6,9-difluoro-11,21-dihydroxy-16,17-[(1-methylethylidene)bis(oxy)]pregna-1,4-diene-3,20-dione-21-(2'-phenoxypropionate)

A

fluocinolone Acetonide
67-73-2

fluocinolone Acetonide

B

ethyl 2-phenoxypropionate
42412-84-0

ethyl 2-phenoxypropionate

Conditions
ConditionsYield
With sodium hydrogencarbonate In water
21-acetoxy-6α,9α-difluoro-11β-hydroxy-16α,17-[(1-methylethylidene)bis(oxy)]pregn-4-ene-3,20-dione
3932-49-8

21-acetoxy-6α,9α-difluoro-11β-hydroxy-16α,17-[(1-methylethylidene)bis(oxy)]pregn-4-ene-3,20-dione

fluocinolone Acetonide
67-73-2

fluocinolone Acetonide

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: pyridine; dmap
2: benzeneseleninic anhydride / toluene / 7 h / Reflux
3: potassium carbonate / methanol; water
View Scheme
11β,21-diacetoxy-6α,9α-difluoro-16α,17-[(1-methylethylidene)bis(oxy)]pregn-4-ene-3,20-dione

11β,21-diacetoxy-6α,9α-difluoro-16α,17-[(1-methylethylidene)bis(oxy)]pregn-4-ene-3,20-dione

fluocinolone Acetonide
67-73-2

fluocinolone Acetonide

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: benzeneseleninic anhydride / toluene / 7 h / Reflux
2: potassium carbonate / methanol; water
View Scheme
(6α,11β,16α)-6,9-difluoro-11,21-dihydroxy-16,17-[(1-methylethylidene)bis(oxy)]pregna-1,4-diene-3,20-dione-21-(2'-phenoxypropionate)
1217194-25-6

(6α,11β,16α)-6,9-difluoro-11,21-dihydroxy-16,17-[(1-methylethylidene)bis(oxy)]pregna-1,4-diene-3,20-dione-21-(2'-phenoxypropionate)

fluocinolone Acetonide
67-73-2

fluocinolone Acetonide

Conditions
ConditionsYield
With ethanol; sodium hydrogencarbonate In water Kinetics;
(6α,11β,16α)-6,9-difluoro-11,21-dihydroxy-16,17-[(1-methylethylidene)bis(oxy)]pregna-1,4-diene-3,20-dione-21-(2'-ethoxypropionate)
1269666-11-6

(6α,11β,16α)-6,9-difluoro-11,21-dihydroxy-16,17-[(1-methylethylidene)bis(oxy)]pregna-1,4-diene-3,20-dione-21-(2'-ethoxypropionate)

fluocinolone Acetonide
67-73-2

fluocinolone Acetonide

Conditions
ConditionsYield
With ethanol; sodium hydrogencarbonate In water Kinetics;
(6α,11β,16α)-6,9-difluoro-11,21-dihydroxy-16,17-[(1-methylethylidene)bis(oxy)]pregna-1,4-diene-3,20-dione-21-(2'-ethoxybutyrate)
1269666-13-8

(6α,11β,16α)-6,9-difluoro-11,21-dihydroxy-16,17-[(1-methylethylidene)bis(oxy)]pregna-1,4-diene-3,20-dione-21-(2'-ethoxybutyrate)

fluocinolone Acetonide
67-73-2

fluocinolone Acetonide

Conditions
ConditionsYield
With ethanol; sodium hydrogencarbonate In water Kinetics;
(6α,11β,16α)-6,9-difluoro-11,21-dihydroxy-16,17-[(1-methylethylidene)bis(oxy)]pregna-1,4-diene-3,20-dione-21-(2'-methoxypropionate)
1269666-10-5

(6α,11β,16α)-6,9-difluoro-11,21-dihydroxy-16,17-[(1-methylethylidene)bis(oxy)]pregna-1,4-diene-3,20-dione-21-(2'-methoxypropionate)

fluocinolone Acetonide
67-73-2

fluocinolone Acetonide

Conditions
ConditionsYield
With ethanol; sodium hydrogencarbonate In water Kinetics;
(6α,11β,16α)-6,9-difluoro-11,21-dihydroxy-16,17-[(1-methylethylidene)bis(oxy)]pregna-1,4-diene-3,20-dione-21-(2'-methoxybutyrate)
1269666-12-7

(6α,11β,16α)-6,9-difluoro-11,21-dihydroxy-16,17-[(1-methylethylidene)bis(oxy)]pregna-1,4-diene-3,20-dione-21-(2'-methoxybutyrate)

fluocinolone Acetonide
67-73-2

fluocinolone Acetonide

Conditions
ConditionsYield
With ethanol; sodium hydrogencarbonate In water Kinetics;
anecortave
7753-60-8

anecortave

fluocinolone Acetonide
67-73-2

fluocinolone Acetonide

Conditions
ConditionsYield
Multi-step reaction with 10 steps
1.1: D-glucose / aq. phosphate buffer
2.1: perchloric acid / acetone; water / 0.17 h / 0 - 5 °C
2.2: 1 h / 0 - 5 °C
2.3: 2 h / 0 - 35 °C
3.1: pyridine; toluene-4-sulfonic acid; Isopropenyl acetate / acetonitrile; methanol / 3 h / 80 °C / Inert atmosphere
4.1: SelectfluorTM / acetonitrile / 8.5 h
5.1: toluene-4-sulfonic acid / 12 h / 70 °C
6.1: hydrogen fluoride; N,N-dimethyl acetamide / water / -15 °C
7.1: potassium acetate / N,N-dimethyl-formamide / 8 h / 90 - 100 °C / Inert atmosphere
8.1: formic acid; potassium permanganate / acetone / 0.33 h / -5 - 0 °C
9.1: perchloric acid / 25 - 30 °C
10.1: sodium hydroxide / water; dichloromethane / 0 - 5 °C / Inert atmosphere
View Scheme
pregna-1,4,9(11)-triene-17α,21-diol-3,20-dione 21-acetate
4380-55-6

pregna-1,4,9(11)-triene-17α,21-diol-3,20-dione 21-acetate

fluocinolone Acetonide
67-73-2

fluocinolone Acetonide

Conditions
ConditionsYield
Multi-step reaction with 9 steps
1.1: perchloric acid / acetone; water / 0.17 h / 0 - 5 °C
1.2: 1 h / 0 - 5 °C
1.3: 2 h / 0 - 35 °C
2.1: pyridine; toluene-4-sulfonic acid; Isopropenyl acetate / acetonitrile; methanol / 3 h / 80 °C / Inert atmosphere
3.1: SelectfluorTM / acetonitrile / 8.5 h
4.1: toluene-4-sulfonic acid / 12 h / 70 °C
5.1: hydrogen fluoride; N,N-dimethyl acetamide / water / -15 °C
6.1: potassium acetate / N,N-dimethyl-formamide / 8 h / 90 - 100 °C / Inert atmosphere
7.1: formic acid; potassium permanganate / acetone / 0.33 h / -5 - 0 °C
8.1: perchloric acid / 25 - 30 °C
9.1: sodium hydroxide / water; dichloromethane / 0 - 5 °C / Inert atmosphere
View Scheme
21-acetyloxy-9β,11β-epoxy-17α-hydroxy-1,4-diene-3,20-dione
38680-83-0

21-acetyloxy-9β,11β-epoxy-17α-hydroxy-1,4-diene-3,20-dione

fluocinolone Acetonide
67-73-2

fluocinolone Acetonide

Conditions
ConditionsYield
Multi-step reaction with 8 steps
1: pyridine; toluene-4-sulfonic acid; Isopropenyl acetate / acetonitrile; methanol / 3 h / 80 °C / Inert atmosphere
2: SelectfluorTM / acetonitrile / 8.5 h
3: toluene-4-sulfonic acid / 12 h / 70 °C
4: hydrogen fluoride; N,N-dimethyl acetamide / water / -15 °C
5: potassium acetate / N,N-dimethyl-formamide / 8 h / 90 - 100 °C / Inert atmosphere
6: formic acid; potassium permanganate / acetone / 0.33 h / -5 - 0 °C
7: perchloric acid / 25 - 30 °C
8: sodium hydroxide / water; dichloromethane / 0 - 5 °C / Inert atmosphere
View Scheme
C30H33NO9

C30H33NO9

fluocinolone Acetonide
67-73-2

fluocinolone Acetonide

Conditions
ConditionsYield
Multi-step reaction with 7 steps
1: SelectfluorTM / acetonitrile / 8.5 h
2: toluene-4-sulfonic acid / 12 h / 70 °C
3: hydrogen fluoride; N,N-dimethyl acetamide / water / -15 °C
4: potassium acetate / N,N-dimethyl-formamide / 8 h / 90 - 100 °C / Inert atmosphere
5: formic acid; potassium permanganate / acetone / 0.33 h / -5 - 0 °C
6: perchloric acid / 25 - 30 °C
7: sodium hydroxide / water; dichloromethane / 0 - 5 °C / Inert atmosphere
View Scheme
21-acetyloxy-9β,11β-epoxy-6α-fluoro-17α-hydroxy-1,4-diene-3,20-dione
3802-45-7

21-acetyloxy-9β,11β-epoxy-6α-fluoro-17α-hydroxy-1,4-diene-3,20-dione

fluocinolone Acetonide
67-73-2

fluocinolone Acetonide

Conditions
ConditionsYield
Multi-step reaction with 6 steps
1: toluene-4-sulfonic acid / 12 h / 70 °C
2: hydrogen fluoride; N,N-dimethyl acetamide / water / -15 °C
3: potassium acetate / N,N-dimethyl-formamide / 8 h / 90 - 100 °C / Inert atmosphere
4: formic acid; potassium permanganate / acetone / 0.33 h / -5 - 0 °C
5: perchloric acid / 25 - 30 °C
6: sodium hydroxide / water; dichloromethane / 0 - 5 °C / Inert atmosphere
View Scheme
17α, 21-diacetyloxy-9β,11β-epoxy-6α-fluoro-1,4-diene-3,20-dione
72498-89-6

17α, 21-diacetyloxy-9β,11β-epoxy-6α-fluoro-1,4-diene-3,20-dione

fluocinolone Acetonide
67-73-2

fluocinolone Acetonide

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1: hydrogen fluoride; N,N-dimethyl acetamide / water / -15 °C
2: potassium acetate / N,N-dimethyl-formamide / 8 h / 90 - 100 °C / Inert atmosphere
3: formic acid; potassium permanganate / acetone / 0.33 h / -5 - 0 °C
4: perchloric acid / 25 - 30 °C
5: sodium hydroxide / water; dichloromethane / 0 - 5 °C / Inert atmosphere
View Scheme
17α,21-diacetyloxy-11β-hydroxy-6α, 9α-difluoro-1,4-diene-3,20-dione

17α,21-diacetyloxy-11β-hydroxy-6α, 9α-difluoro-1,4-diene-3,20-dione

fluocinolone Acetonide
67-73-2

fluocinolone Acetonide

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: potassium acetate / N,N-dimethyl-formamide / 8 h / 90 - 100 °C / Inert atmosphere
2: formic acid; potassium permanganate / acetone / 0.33 h / -5 - 0 °C
3: perchloric acid / 25 - 30 °C
4: sodium hydroxide / water; dichloromethane / 0 - 5 °C / Inert atmosphere
View Scheme
acetic acid 2-((6S,8S,9R,10S,11S,13S,14S)-6,9-difluoro-11-hydroxy-10,13-dimethyl-3-oxo-6,7,8,9,10,11,12,13,14,15-decahydro-3H-cyclopenta[a]phenanthrene-17-yl)-2-oxo-ethyl ester
2326-26-3

acetic acid 2-((6S,8S,9R,10S,11S,13S,14S)-6,9-difluoro-11-hydroxy-10,13-dimethyl-3-oxo-6,7,8,9,10,11,12,13,14,15-decahydro-3H-cyclopenta[a]phenanthrene-17-yl)-2-oxo-ethyl ester

fluocinolone Acetonide
67-73-2

fluocinolone Acetonide

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: formic acid; potassium permanganate / acetone / 0.33 h / -5 - 0 °C
2: perchloric acid / 25 - 30 °C
3: sodium hydroxide / water; dichloromethane / 0 - 5 °C / Inert atmosphere
View Scheme
21-acetyloxy-11β,16α,17α-trihydroxy-6α,9α-difluoro-1,4-diene-3,20-dione
4306-83-6

21-acetyloxy-11β,16α,17α-trihydroxy-6α,9α-difluoro-1,4-diene-3,20-dione

fluocinolone Acetonide
67-73-2

fluocinolone Acetonide

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: perchloric acid / 25 - 30 °C
2: sodium hydroxide / water; dichloromethane / 0 - 5 °C / Inert atmosphere
View Scheme
2-((10S,13S,14S)-10,13-dimethyl-3-oxo-6,7,8,10,12,13,14,15-octahydro-3H-cyclopenta[a]phenanthren-17-yl)-2-oxoethyl acetate
37413-91-5

2-((10S,13S,14S)-10,13-dimethyl-3-oxo-6,7,8,10,12,13,14,15-octahydro-3H-cyclopenta[a]phenanthren-17-yl)-2-oxoethyl acetate

fluocinolone Acetonide
67-73-2

fluocinolone Acetonide

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1.1: 1,3-dibromo-5,5-dimethylimidazolidine-2,4-dione; perchloric acid / acetone; water / 2 h / -10 - -5 °C
1.2: 12 h / -5 - 35 °C
2.1: methanesulfonic acid / 3 h / 85 °C
2.2: 12 h / -10 - -5 °C
2.3: 1 h / -10 - -5 °C
3.1: hydrogen fluoride / 4 h / -30 - -25 °C
3.2: 2 h / -50 - -45 °C
4.1: sodium hydroxide / methanol; dichloromethane / 2 h / -5 - 2 °C / Inert atmosphere
View Scheme
C23H26O5

C23H26O5

fluocinolone Acetonide
67-73-2

fluocinolone Acetonide

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1.1: methanesulfonic acid / 3 h / 85 °C
1.2: 12 h / -10 - -5 °C
1.3: 1 h / -10 - -5 °C
2.1: hydrogen fluoride / 4 h / -30 - -25 °C
2.2: 2 h / -50 - -45 °C
3.1: sodium hydroxide / methanol; dichloromethane / 2 h / -5 - 2 °C / Inert atmosphere
View Scheme
C26H32O7

C26H32O7

fluocinolone Acetonide
67-73-2

fluocinolone Acetonide

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: pyridine; 4-nitro-benzoyl chloride; toluene-4-sulfonic acid / acetonitrile / 60 °C
2: 1-ethyl-3-methylimidazole hydrogen fluoride / 25 °C
3: sodium hydroxide; sodium methylate / dichloromethane / Inert atmosphere
View Scheme
C26H31FO7

C26H31FO7

fluocinolone Acetonide
67-73-2

fluocinolone Acetonide

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 1-ethyl-3-methylimidazole hydrogen fluoride / 25 °C
2: sodium hydroxide; sodium methylate / dichloromethane / Inert atmosphere
View Scheme
fluocinolone Acetonide
67-73-2

fluocinolone Acetonide

acetic anhydride
108-24-7

acetic anhydride

fluocinonide
356-12-7

fluocinonide

Conditions
ConditionsYield
With trimethylsilyl trifluoromethanesulfonate In dichloromethane at 20℃; for 0.0833333h;100%
With trimethylsilyl trifluoromethanesulfonate In dichloromethane at 20℃; for 1.16667h;59%
With trimethylsilyl trifluoromethanesulfonate In dichloromethane
fluocinolone Acetonide
67-73-2

fluocinolone Acetonide

C24H30(3)H2F2O6
106915-70-2

C24H30(3)H2F2O6

Conditions
ConditionsYield
With Wilkinson's catalyst; tritium In tetrahydrofuran; toluene100%
With Wilkinson's catalyst; tritium In tetrahydrofuran; toluene
fluocinolone Acetonide
67-73-2

fluocinolone Acetonide

methanesulfonyl chloride
124-63-0

methanesulfonyl chloride

6α,9α-difluoro-11β-hydroxy-16α,17α-isopropylidenedioxy-21-methanesulfonyloxy-pregna-1,4-diene-3,20-dione
3793-01-9

6α,9α-difluoro-11β-hydroxy-16α,17α-isopropylidenedioxy-21-methanesulfonyloxy-pregna-1,4-diene-3,20-dione

Conditions
ConditionsYield
With pyridine at 0℃; for 0.5h;99%
fluocinolone Acetonide
67-73-2

fluocinolone Acetonide

acetic anhydride
108-24-7

acetic anhydride

11β,21-diacetoxy-6α,9α-difluoro-16α,17-[(1-methylethylidene)bis(oxy)]pregna-1,4-diene-3,20-dione

11β,21-diacetoxy-6α,9α-difluoro-16α,17-[(1-methylethylidene)bis(oxy)]pregna-1,4-diene-3,20-dione

Conditions
ConditionsYield
With trimethylsilyl trifluoromethanesulfonate In dichloromethane at 20℃; for 0.5h;99%
With trimethylsilyl trifluoromethanesulfonate In dichloromethane at 20℃; for 0.5h;99%
With pyridine; dmap at 20℃; for 22h; Inert atmosphere; Heating;86%
fluocinolone Acetonide
67-73-2

fluocinolone Acetonide

6α,9α-difluoro-11β,20,21-trihydroxy-16α,17α-isopropylidenedioxypregnane-1,4-dien-3-one
327185-94-4

6α,9α-difluoro-11β,20,21-trihydroxy-16α,17α-isopropylidenedioxypregnane-1,4-dien-3-one

Conditions
ConditionsYield
With sodium tetrahydroborate In tetrahydrofuran at 20℃; for 18h;99%
fluocinolone Acetonide
67-73-2

fluocinolone Acetonide

2-((2S,6aS,6bR,7S,8aS,8bS,11aR,12aS,12bS)-2,6b-difluoro-7-hydroxy-6a,8a,10,10-tetramethyl-4-oxo-2,4,6a,6b,7,8,8a,8b,11a,12,12a,12b-dodecahydro-1H-naphtho[2',1':4,5]indeno[1,2-d][1,3]dioxol-8b-yl)-2-oxoacetaldehyde
13242-30-3

2-((2S,6aS,6bR,7S,8aS,8bS,11aR,12aS,12bS)-2,6b-difluoro-7-hydroxy-6a,8a,10,10-tetramethyl-4-oxo-2,4,6a,6b,7,8,8a,8b,11a,12,12a,12b-dodecahydro-1H-naphtho[2',1':4,5]indeno[1,2-d][1,3]dioxol-8b-yl)-2-oxoacetaldehyde

Conditions
ConditionsYield
With copper diacetate In methanol at 20℃;98%
With copper diacetate In methanol at 20℃;98%
With copper diacetate; oxygen In methanol
fluocinolone Acetonide
67-73-2

fluocinolone Acetonide

6α,9α-Difluoro-11β-hydroxy-16α,17α-isopropylidenedioxy-21-trifluoro-methanesulfonyloxy-pregna-1,4-diene-3,20-dione

6α,9α-Difluoro-11β-hydroxy-16α,17α-isopropylidenedioxy-21-trifluoro-methanesulfonyloxy-pregna-1,4-diene-3,20-dione

Conditions
ConditionsYield
With pyridine; trifluoromethanesulfonic acid anhydride In diethyl ether; dichloromethane96%
fluocinolone Acetonide
67-73-2

fluocinolone Acetonide

6α,9α-difluoro-11β,16α,17α,21-tetra-hydroxypregna-1,4-diene-3,20-dione
807-38-5, 67438-36-2

6α,9α-difluoro-11β,16α,17α,21-tetra-hydroxypregna-1,4-diene-3,20-dione

Conditions
ConditionsYield
With tetrafluoroboric acid In water at 22℃; for 2h;94.5%
With tetrafluoroboric acid In water at 25℃; for 48h;60.3%
With tetrafluoroboric acid In water at 25℃; for 48h;60.3%
With tetrafluoroboric acid In water at 25℃; for 48h;60.3%
With tetrafluoroboric acid; water at 20℃; for 7h;
fluocinolone Acetonide
67-73-2

fluocinolone Acetonide

11β-hydroxy-16α,17α-isopropylidenedioxy-3-oxo-6α,9α-difluoroandrosta-1,4-diene-17β-carboxylic acid
65751-34-0

11β-hydroxy-16α,17α-isopropylidenedioxy-3-oxo-6α,9α-difluoroandrosta-1,4-diene-17β-carboxylic acid

Conditions
ConditionsYield
With periodic acid In 1,4-dioxane; water at 20℃; for 4.5h; Product distribution / selectivity;92%
With sodium hydroxide; air In methanol; dichloromethane for 3h; Ambient temperature;77.6%
With air; potassium carbonate In methanol at 20℃; for 16h;75%
fluocinolone Acetonide
67-73-2

fluocinolone Acetonide

2-phenoxypropanoic acid chloride
122-35-0

2-phenoxypropanoic acid chloride

(6α,11β,16α)-6,9-difluoro-11,21-dihydroxy-16,17-[(1-methylethylidene)bis(oxy)]pregna-1,4-diene-3,20-dione-21-(2'-phenoxypropionate)
1217194-25-6

(6α,11β,16α)-6,9-difluoro-11,21-dihydroxy-16,17-[(1-methylethylidene)bis(oxy)]pregna-1,4-diene-3,20-dione-21-(2'-phenoxypropionate)

Conditions
ConditionsYield
With triethylamine at 0 - 20℃; for 4.08333h; Inert atmosphere;89%
With triethylamine In dichloromethane at 0 - 20℃; for 4h;
fluocinolone Acetonide
67-73-2

fluocinolone Acetonide

4-Nitrophenyl chloroformate
7693-46-1

4-Nitrophenyl chloroformate

C31H33F2NO10
1308322-37-3

C31H33F2NO10

Conditions
ConditionsYield
With pyridine In dichloromethane at 0℃;83%
fluocinolone Acetonide
67-73-2

fluocinolone Acetonide

(4aS,4bR,5S,6aS,6bR,9aR,10aS,10bS,12S)-4b,12-Difluoro-5,7-dihydroxy-4a,6a-dimethyl-4b,5,6,6a,6b,7,9a,10,10a,10b,11,12-dodecahydro-4aH-9-oxa-pentaleno[2,1-a]phenanthrene-2,8-dione

(4aS,4bR,5S,6aS,6bR,9aR,10aS,10bS,12S)-4b,12-Difluoro-5,7-dihydroxy-4a,6a-dimethyl-4b,5,6,6a,6b,7,9a,10,10a,10b,11,12-dodecahydro-4aH-9-oxa-pentaleno[2,1-a]phenanthrene-2,8-dione

Conditions
ConditionsYield
With sodium hydride Rearrangement;81%
fluocinolone Acetonide
67-73-2

fluocinolone Acetonide

butyraldehyde
123-72-8

butyraldehyde

(1S,2S,4R,8S,9S,11S,12R,13S,19S)-12,19-difluoro-11-hydroxy-8-(2-hydroxyacetyl)-9,13-dimethyl-6-propyl-5,7-dioxapentacyclo[10.8.0.02,9.04,8.013,18]icosa-14,17-dien-16-one

(1S,2S,4R,8S,9S,11S,12R,13S,19S)-12,19-difluoro-11-hydroxy-8-(2-hydroxyacetyl)-9,13-dimethyl-6-propyl-5,7-dioxapentacyclo[10.8.0.02,9.04,8.013,18]icosa-14,17-dien-16-one

Conditions
ConditionsYield
With perchloric acid; silica gel In n-heptane at 0 - 20℃;78%
With perchloric acid; silica gel In n-heptane at 0 - 20℃; for 0.166667h;16%
Stage #1: fluocinolone Acetonide; butyraldehyde With silica gel In n-heptane at 10 - 20℃; for 0.166667h;
Stage #2: With perchloric acid In n-heptane at 10 - 20℃;
16%
Stage #1: fluocinolone Acetonide; butyraldehyde With silica gel In n-heptane at 10 - 20℃; for 0.166667h;
Stage #2: With perchloric acid In n-heptane at 0 - 20℃; for 12h;
16%
fluocinolone Acetonide
67-73-2

fluocinolone Acetonide

9α-fluoro-21-hydroxy-16α,17α-(1,1-dimethylmethylenedioxy)-1β,11β-oxy-pregna-3,5-dien-2,20-dione

9α-fluoro-21-hydroxy-16α,17α-(1,1-dimethylmethylenedioxy)-1β,11β-oxy-pregna-3,5-dien-2,20-dione

Conditions
ConditionsYield
In acetonitrile Irradiation;76%
fluocinolone Acetonide
67-73-2

fluocinolone Acetonide

21-oic acid of Fluocinolone Acetonide
106931-78-6

21-oic acid of Fluocinolone Acetonide

Conditions
ConditionsYield
Stage #1: fluocinolone Acetonide With copper diacetate
Stage #2: With 3-chloro-benzenecarboperoxoic acid for 18h;
70%
Multi-step reaction with 2 steps
1: O2, Cu(OAc)2 / methanol
2: NaClO2, KH2PO4 / tetrahydrofuran; 2-methyl-propan-2-ol; H2O
View Scheme
fluocinolone Acetonide
67-73-2

fluocinolone Acetonide

C22H28F2O6

C22H28F2O6

Conditions
ConditionsYield
With oxygen In methanol Irradiation;60%
fluocinolone Acetonide
67-73-2

fluocinolone Acetonide

6α,9α-difluoro-11β,21-dihydroxy-16α,17α-(1,1-dimethylmethylenedioxy)-1,5-cyclopregna-3-en-2,20-dione

6α,9α-difluoro-11β,21-dihydroxy-16α,17α-(1,1-dimethylmethylenedioxy)-1,5-cyclopregna-3-en-2,20-dione

Conditions
ConditionsYield
In acetonitrile for 2.5h; Irradiation;50%
fluocinolone Acetonide
67-73-2

fluocinolone Acetonide

butyraldehyde
123-72-8

butyraldehyde

(1S,2S,4R,6R,8S,9S,11S,12R,13S,19S)-12,19-difluoro-11-hydroxy-8-(2-hydroxyacetyl)-9,13-dimethyl-6-propyl-5,7-dioxapentacyclo[10.8.0.02'9.04,8.013'18]icosa-14,17-dien-16-one
51547-52-5

(1S,2S,4R,6R,8S,9S,11S,12R,13S,19S)-12,19-difluoro-11-hydroxy-8-(2-hydroxyacetyl)-9,13-dimethyl-6-propyl-5,7-dioxapentacyclo[10.8.0.02'9.04,8.013'18]icosa-14,17-dien-16-one

Conditions
ConditionsYield
With perchloric acid; fine sand In n-heptane
With sand; 70percent HClO4 In n-heptane
fluocinolone Acetonide
67-73-2

fluocinolone Acetonide

A

6α,9α-difluoro-11β-hydroxy-16α,17α-(1-methylethylidenedioxy)androsta-1,4-dien-3-one

6α,9α-difluoro-11β-hydroxy-16α,17α-(1-methylethylidenedioxy)androsta-1,4-dien-3-one

B

6α,9α-difluoro-11β,21-dihydroxy-16α,17α-(1,1-dimethylmethylenedioxy)-1,5-cyclopregna-3-en-2,20-dione

6α,9α-difluoro-11β,21-dihydroxy-16α,17α-(1,1-dimethylmethylenedioxy)-1,5-cyclopregna-3-en-2,20-dione

Conditions
ConditionsYield
In acetonitrile Quantum yield; Further Variations:; irradiation wavelength; UV-irradiation;
In acetonitrile Quantum yield; Further Variations:; irradiation wavelength; Irradiation;
In acetonitrile for 2h; Irradiation;A 80 % Turnov.
B 5 % Turnov.
fluocinolone Acetonide
67-73-2

fluocinolone Acetonide

methylthiomethyl 6α,9-difluoro-11β-hydroxy-3,20-dioxo-16α,17-isopropylidenedioxypregn-1,4-diene-21-carboxylate

methylthiomethyl 6α,9-difluoro-11β-hydroxy-3,20-dioxo-16α,17-isopropylidenedioxypregn-1,4-diene-21-carboxylate

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1.1: cupric acetate monohydrate
1.2: 70 percent / m-chloroperbenzoic acid / 18 h
2.1: triethylamine
View Scheme
fluocinolone Acetonide
67-73-2

fluocinolone Acetonide

16α,17α-[(R)-butylidenedioxy]-6α,9α-difluoro-11β-hydroxy-21-methylsulfonyloxypregna-1,4-diene-3,20-dione
193408-59-2

16α,17α-[(R)-butylidenedioxy]-6α,9α-difluoro-11β-hydroxy-21-methylsulfonyloxypregna-1,4-diene-3,20-dione

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: sand; 70percent HClO4 / heptane
2: 97 percent / pyridine / 2 h
View Scheme
fluocinolone Acetonide
67-73-2

fluocinolone Acetonide

16α,17α-[(R)-butylidenedioxy]-6α,9α-difluoro-11β-hydroxy-21-[(3R)-2-oxotetrahydrofuran-3-ylsulfanyl]pregna-1,4-diene-3,20-dione

16α,17α-[(R)-butylidenedioxy]-6α,9α-difluoro-11β-hydroxy-21-[(3R)-2-oxotetrahydrofuran-3-ylsulfanyl]pregna-1,4-diene-3,20-dione

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1.1: sand; 70percent HClO4 / heptane
2.1: 97 percent / pyridine / 2 h
3.1: NaH / tetrahydrofuran / 0.5 h / 0 °C
3.2: 16 percent / tetrahydrofuran / 19 h / 0 - 21 °C
View Scheme
fluocinolone Acetonide
67-73-2

fluocinolone Acetonide

16α,17α-[(R)-butylidenedioxy]-6α,9α-difluoro-11β-hydroxy-21-[(3S)-2-oxotetrahydrofuran-3-ylsulfanyl]pregna-1,4-diene-3,20-dione

16α,17α-[(R)-butylidenedioxy]-6α,9α-difluoro-11β-hydroxy-21-[(3S)-2-oxotetrahydrofuran-3-ylsulfanyl]pregna-1,4-diene-3,20-dione

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1.1: sand; 70percent HClO4 / heptane
2.1: 97 percent / pyridine / 2 h
3.1: NaH / tetrahydrofuran / 0.5 h / 0 °C
3.2: 26 percent / tetrahydrofuran / 19 h / 0 - 21 °C
View Scheme
fluocinolone Acetonide
67-73-2

fluocinolone Acetonide

6α,9α-difluoro-17β-formyl-11β-hydroxy-16α,17α-isopropylidenedioxyandrosta-1,4-dien-3-one
327185-95-5

6α,9α-difluoro-17β-formyl-11β-hydroxy-16α,17α-isopropylidenedioxyandrosta-1,4-dien-3-one

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 99 percent / NaBH4 / tetrahydrofuran / 18 h / 20 °C
2: 100 percent / aq. NaIO4 / ethanol / 4 h / 20 °C
View Scheme
fluocinolone Acetonide
67-73-2

fluocinolone Acetonide

6α,9α-difluoro-11β-hydroxy-17β-hydroxymethyl-16α,17α-isopropylidenedioxyandrosta-1,4-dien-3-one
327185-96-6

6α,9α-difluoro-11β-hydroxy-17β-hydroxymethyl-16α,17α-isopropylidenedioxyandrosta-1,4-dien-3-one

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: 99 percent / NaBH4 / tetrahydrofuran / 18 h / 20 °C
2: 100 percent / aq. NaIO4 / ethanol / 4 h / 20 °C
3: 45 percent / NaBH4 / ethanol / 0.5 h / 0 °C
View Scheme
fluocinolone Acetonide
67-73-2

fluocinolone Acetonide

6α,9α-difluoro-11β-hydroxy-16α,17α-isopropylidenedioxy-17β-[(2-oxotetrahydrofuran-4-ylsulfanyl)methyl]androsta-1,4-dien-3-one

6α,9α-difluoro-11β-hydroxy-16α,17α-isopropylidenedioxy-17β-[(2-oxotetrahydrofuran-4-ylsulfanyl)methyl]androsta-1,4-dien-3-one

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1.1: 99 percent / NaBH4 / tetrahydrofuran / 18 h / 20 °C
2.1: 100 percent / aq. NaIO4 / ethanol / 4 h / 20 °C
3.1: 45 percent / NaBH4 / ethanol / 0.5 h / 0 °C
4.1: 93 percent / pyridine / CH2Cl2 / 1.5 h / 0 °C
5.1: NaH / tetrahydrofuran / 0.08 h
5.2: 21 percent / tetrahydrofuran / 18 h / 20 °C
View Scheme
fluocinolone Acetonide
67-73-2

fluocinolone Acetonide

6α,9α-difluoro-11β-hydroxy-16α,17α-isopropylidenedioxy-17β-[(2-oxotetrahydrofuran-3-ylsulfanyl)methyl]androsta-1,4-dien-3-one

6α,9α-difluoro-11β-hydroxy-16α,17α-isopropylidenedioxy-17β-[(2-oxotetrahydrofuran-3-ylsulfanyl)methyl]androsta-1,4-dien-3-one

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1.1: 99 percent / NaBH4 / tetrahydrofuran / 18 h / 20 °C
2.1: 100 percent / aq. NaIO4 / ethanol / 4 h / 20 °C
3.1: 45 percent / NaBH4 / ethanol / 0.5 h / 0 °C
4.1: 93 percent / pyridine / CH2Cl2 / 1.5 h / 0 °C
5.1: NaH / tetrahydrofuran / 0.08 h
5.2: 43 percent / tetrahydrofuran / 16 h / 20 °C
View Scheme

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