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Dayang Chem (Hangzhou) Co.,Ltd.

Dayangchem's R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. DayangChem can provide different quantities

Fluocinonide Manufacturer/High quality/Best price/In stock

Cas:356-12-7

Min.Order:1 Kilogram

FOB Price: $3.0

Type:Lab/Research institutions

inquiry

Wuhan Fortuna Chemical Co.,Ltd

Unique advantages for USP/EP/BP Fluocinonide Cas 356-12-7 Guaranteed the purity High quality & competitive price Quality control Fast feedback Prompt shipment Appearance:Powder Storage:Refrigerator Package:5g/bag, 1kg/foil bag or as you r

High quality USP/EP/BP Fluocinonide Cas 356-12-7 with factory favorable price

Cas:356-12-7

Min.Order:5 Gram

FOB Price: $60.0

Type:Trading Company

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Xi'an Quanao Biotech Co., Ltd.

Xi’an Quanao Biotech Co., Ltd. with 18 years experience in plant extract filed. Product grade: Medicine, Health care product, Cosmetics, Food, Beverage, Feed. Hot selling market: Europe, North America, South America, Middle East, Asia Pacifi

Lab supply USP 99% Fluocinonide Powder price cas:356-12-7

Cas:356-12-7

Min.Order:50 Gram

FOB Price: $0.8 / 0.95

Type:Manufacturers

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Hangzhou Dingyan Chem Co., Ltd

Items Standard Result Assay (Ursolic acid) 98%min 98.22% ----------------------------------------------------------------

High purity 356-12-7 Fluocinonide

Cas:356-12-7

Min.Order:1 Gram

FOB Price: $100.0 / 500.0

Type:Trading Company

inquiry

Xi'an Xszo Chem Co., Ltd.

1. Factory price and high quality must be guaranteed, base on 8 years of production and R&D experience2. Free samples will be provided,ensure specifications and quality are right for customer3. Customers will receive the most professional technical s

Xi`an Eastling Biotech Co., Ltd.

fluocinolone acetonide 21-acetate CAS: 356-12-7 Molecular Formula: C26H32F2O7 Home Product Category other other 356-12-7 356-12-7 - Names and Identifiers Name fluocinolone acetonide 21-acetate Synonyms Vanos Gel

factory supply Fluocinonide Powder

Cas:356-12-7

Min.Order:1 Kilogram

FOB Price: $135.0 / 140.0

Type:Trading Company

inquiry

Chemwill Asia Co., Ltd.

Our main production base is located in Xuzhou industry park. We are certified both to the ISO 9001 and ISO 14001 Standards, have a safety management system in place.Our R&D team masters core technology for process-design of target building block

Fluocinonide

Cas:356-12-7

Min.Order:5 Kiloliter

FOB Price: $1.2 / 5.0

Type:Manufacturers

inquiry

Henan Tianfu Chemical Co., Ltd.

Our company was built in 2009 with an ISO certificate.In the past 5 years, we have grown up as a famous fine chemicals supplier in China and we had established stable business relationships with Samsung,LG,Merck,Thermo Fisher Scientific and so on.O

TIANFU-CHEM 356-12-7 Fluocinonide

Cas:356-12-7

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Hebei Nengqian Chemical Import and Export Co., LTD

With our good experience, we offer detailed technical support and advice to assist customers. We communicate closely with customers to establish their quality requirements. Consistent Quality Our plant has strict quality control in each manufacturin

Fluocinonide

Cas:356-12-7

Min.Order:1 Kilogram

FOB Price: $1.0 / 10.0

Type:Trading Company

inquiry

Zhuozhou Wenxi import and Export Co., Ltd

WITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et

Top Pure CAS 356-12-7 with high-quality service

Cas:356-12-7

Min.Order:10 Gram

FOB Price: $146.0 / 176.0

Type:Trading Company

inquiry

Wuhan Han Sheng New Material Technology Co.,Ltd

Our Advantage: high quality with competitive price High quality standard: BP/USP/EP Enterprise standard All purity customized Fast and safe delivery We have reliable forwarder who can help us deliver our goods more fast and safe. We

Fluocinonide

Cas:356-12-7

Min.Order:1 Gram

Negotiable

Type:Trading Company

inquiry

Shandong Hanjiang Chemical Co., Ltd.

Hello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by email in time prod

LIDE PHARMACEUTICALS LIMITED

Advantage : LIDE PHARMACEUTICALS LTD. is a mid-small manufacturing-type enterprise, engaged in pharmaceutical intermediates of R&D, custom-made and production, and also involving trading chemicals for export. We have established the R&amp

Fluocinonide/ LIDE PHARMA- Factory supply / Best price

Cas:356-12-7

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Hangzhou Sartort Biopharma Co., Ltd

Appearance:White or almost white, crystalline powder Storage:ln stock Package:1kg/Tin Application:Chemicals Transportation:Express/Sea/Air Port:Any port in china

Fluocinonide API with USP grade

Cas:356-12-7

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Hubei Langyou International Trading Co., Ltd

Our Adwantage: 1.We have stock so we can delivery quickly at the very day when receive the payment. 2.Best price, first class service, high successful delivery rate. A discount would be given when you make a large order. 3.High quality gua

Shanghai Upbio Tech Co.,Ltd

1,In No Less ten years exporting experience. 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Onchem specialized in APIs, chemical intermedi

High quality Fluocinonide 99%

Cas:356-12-7

Min.Order:100 Gram

FOB Price: $100.0

Type:Lab/Research institutions

inquiry

Baoji Guokang Healthchem co.,ltd

Our company has been in existence for 10 years since its establishment. We have our own unique team. The company integrates independent research and development, production and sales. We have established famous brands at home and abroad. At present

Fluocinonide

Cas:356-12-7

Min.Order:10 Gram

FOB Price: $17.0 / 20.0

Type:Trading Company

inquiry

Qingdao Beluga Import and Export Co., LTD

Fluocinonide CAS:356-12-7 Qingdao Belugas Import and Export Co., Ltd. is a scientific and technological company integrating research and development, production and trade of chemical intermediates, specializing in high quality organic intermediates,

Fluocinonide CAS:356-12-7

Cas:356-12-7

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Afine Chemicals Limited

Our Services 1. New Molecules R&D 2. Own test center HPLC NMR GC LC-MS 3. API and Intermediates from China reputed manufacturers 4. Documents support COA MOA MSDS DMF open part Our advantages 1. Government awarded company. Top 100 enter

Fluocinonide

Cas:356-12-7

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

HANGZHOU YUNUO CHEMICAL CO.,LTD

superior quality Appearance:White Solid Storage:Stored in cool, dry and ventilation place; Away from fire and heat Package:1kg/bag, 1kg/drum or 25kg/drum or as per your request. Application:antiinflammatory, glucocorticoid Glucocorticoid; anti-inf

kern enterprises

ProName: Topical Anti-inflammatory Glucocortico... CasNo: 356-12-7 Molecular Formula: C26H32F2O7 Appearance: White Powder Application: Pharmaceutical; Health and Medical; DeliveryTime: within 24 hours after your payment P

High quality Fluocinonide CAS NO.356-12-7

Cas:356-12-7

Min.Order:100 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Hangzhou Keyingchem Co.,Ltd

Hangzhou KeyingChem Co., Ltd. exported this product to many countries and regions at best price. If you are looking for the material’s manufacturer or supplier in China, KeyingChem is your best choice. Pls contact with us freely for getting det

Fluocinonide

Cas:356-12-7

Min.Order:0 Metric Ton

Negotiable

Type:Lab/Research institutions

inquiry

Hangzhou J&H Chemical Co., Ltd.

J&H CHEM R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. J&H CHEM has some Manufacturing base in Jia

Zibo Hangyu Biotechnology Development Co., Ltd

Zibo Hangyu Biotechnology Development Co., Ltd is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemi

High quality Fluocinonide

Cas:356-12-7

Min.Order:10 Gram

FOB Price: $100.0

Type:Lab/Research institutions

inquiry

SHANGHAI SYSTEAM BIOCHEM CO., LTD

We are one of a few suppliers that can offer custom synthesis service of this product We are specialized in custom synthesis, chemical/pharmaceutical/ pesticides outsourcing and contract research. We are committed to prov

Fluocinonide 99%

Cas:356-12-7

Min.Order:100 Gram

FOB Price: $100.0 / 2000.0

Type:Lab/Research institutions

inquiry

TaiChem Taizhou Limited

Established in May 2015, TaiChem Ltd. is initially invested by a British research and development company and started by PhDs back from aboard. The company is registered in China Medical City (CMC), Taizhou, Jiangsu Province, and the production site

Fluocinonide

Cas:356-12-7

Min.Order:10 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Lyander (Xiamen) Medical Technology Co., LTD

Lyander’s R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. Lyander can provide different quantities of cu

Fluocinonide

Cas:356-12-7

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Siwei Development Group Ltd.

Product name: Fluocinonide CAS No.: 356-12-7 Molecule Formula:C26H32F2O7 Molecule Weight:594.52 Purity: 99.0% Package: 25kg/drum Description:White crystalline powder Manufacture Standards:Enterprise Standard TESTING ITEMS

Lower Price Fluocinonide on stock

Cas:356-12-7

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Zibo Dorne chemical technology co. LTD

Product Details Grade: pharmaceutical grade Purity:99%+ ProductionCapacity: 1000 Kilogram/Month Scope of use: For scientific research only(The product must be used legally) Our Advantage 1. Best quality with competitive price. 2. Quick shipping,

High purity Fluocinonide

Cas:356-12-7

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Henan Sinotech Import&Export Corporation

The Fluocinolide with CAS registry number of 356-12-7 is also known as Topsymin. The systematic name is 2-[(4aS,4bR,5S,6aS,6bS,9aR,10aS,10bS,12S)-4b,12-Difluoro-5-hydroxy-4a,6a,8,8-tetramethyl-2-oxo-2,4a,4b,5,6,6a,9a,10,10a,10b,11,12-dodecahydro-6b

Fluocinonide 356-12-7

Cas:356-12-7

Min.Order:100 Pound

FOB Price: $1.0

Type:Other

inquiry

Synthetic route

fluocinolone Acetonide
67-73-2

fluocinolone Acetonide

acetic anhydride
108-24-7

acetic anhydride

fluocinonide
356-12-7

fluocinonide

Conditions
ConditionsYield
With trimethylsilyl trifluoromethanesulfonate In dichloromethane at 20℃; for 0.0833333h;100%
With trimethylsilyl trifluoromethanesulfonate In dichloromethane at 20℃; for 1.16667h;59%
With trimethylsilyl trifluoromethanesulfonate In dichloromethane
C26H31FO7

C26H31FO7

fluocinonide
356-12-7

fluocinonide

Conditions
ConditionsYield
With 1-ethyl-3-methylimidazole hydrogen fluoride at 25℃; Reagent/catalyst; Temperature;98.2%
21-acetyloxy-11β,16α,17α-trihydroxy-6α,9α-difluoro-1,4-diene-3,20-dione
4306-83-6

21-acetyloxy-11β,16α,17α-trihydroxy-6α,9α-difluoro-1,4-diene-3,20-dione

acetone
67-64-1

acetone

fluocinonide
356-12-7

fluocinonide

Conditions
ConditionsYield
With perchloric acid at 25 - 30℃;87.3%
With toluene-4-sulfonic acid at 35℃; Reagent/catalyst; Temperature; Inert atmosphere;6.9 g
With methanesulfonic acid at 50℃; for 1.5h; Temperature;
21-acetoxy-6α,9α-difluoro-11β-hydroxy-16α,17-[(1-methylethylidene)bis(oxy)]pregn-4-ene-3,20-dione
3932-49-8

21-acetoxy-6α,9α-difluoro-11β-hydroxy-16α,17-[(1-methylethylidene)bis(oxy)]pregn-4-ene-3,20-dione

fluocinonide
356-12-7

fluocinonide

Conditions
ConditionsYield
With pyridine; selenium(IV) oxide In tert-butyl alcohol Reflux;
With selenium(IV) oxide In pyridine; tert-butyl alcohol at 95℃;
fluocinolone Acetonide
67-73-2

fluocinolone Acetonide

acetic anhydride
108-24-7

acetic anhydride

A

fluocinonide
356-12-7

fluocinonide

B

11β,21-diacetoxy-6α,9α-difluoro-16α,17-[(1-methylethylidene)bis(oxy)]pregna-1,4-diene-3,20-dione

11β,21-diacetoxy-6α,9α-difluoro-16α,17-[(1-methylethylidene)bis(oxy)]pregna-1,4-diene-3,20-dione

Conditions
ConditionsYield
With pyridine; dmap at 20℃; for 4h; Inert atmosphere; Heating;
anecortave
7753-60-8

anecortave

fluocinonide
356-12-7

fluocinonide

Conditions
ConditionsYield
Multi-step reaction with 9 steps
1.1: D-glucose / aq. phosphate buffer
2.1: perchloric acid / acetone; water / 0.17 h / 0 - 5 °C
2.2: 1 h / 0 - 5 °C
2.3: 2 h / 0 - 35 °C
3.1: pyridine; toluene-4-sulfonic acid; Isopropenyl acetate / acetonitrile; methanol / 3 h / 80 °C / Inert atmosphere
4.1: SelectfluorTM / acetonitrile / 8.5 h
5.1: toluene-4-sulfonic acid / 12 h / 70 °C
6.1: hydrogen fluoride; N,N-dimethyl acetamide / water / -15 °C
7.1: potassium acetate / N,N-dimethyl-formamide / 8 h / 90 - 100 °C / Inert atmosphere
8.1: formic acid; potassium permanganate / acetone / 0.33 h / -5 - 0 °C
9.1: perchloric acid / 25 - 30 °C
View Scheme
pregna-1,4,9(11)-triene-17α,21-diol-3,20-dione 21-acetate
4380-55-6

pregna-1,4,9(11)-triene-17α,21-diol-3,20-dione 21-acetate

fluocinonide
356-12-7

fluocinonide

Conditions
ConditionsYield
Multi-step reaction with 8 steps
1.1: perchloric acid / acetone; water / 0.17 h / 0 - 5 °C
1.2: 1 h / 0 - 5 °C
1.3: 2 h / 0 - 35 °C
2.1: pyridine; toluene-4-sulfonic acid; Isopropenyl acetate / acetonitrile; methanol / 3 h / 80 °C / Inert atmosphere
3.1: SelectfluorTM / acetonitrile / 8.5 h
4.1: toluene-4-sulfonic acid / 12 h / 70 °C
5.1: hydrogen fluoride; N,N-dimethyl acetamide / water / -15 °C
6.1: potassium acetate / N,N-dimethyl-formamide / 8 h / 90 - 100 °C / Inert atmosphere
7.1: formic acid; potassium permanganate / acetone / 0.33 h / -5 - 0 °C
8.1: perchloric acid / 25 - 30 °C
View Scheme
21-acetyloxy-9β,11β-epoxy-17α-hydroxy-1,4-diene-3,20-dione
38680-83-0

21-acetyloxy-9β,11β-epoxy-17α-hydroxy-1,4-diene-3,20-dione

fluocinonide
356-12-7

fluocinonide

Conditions
ConditionsYield
Multi-step reaction with 7 steps
1: pyridine; toluene-4-sulfonic acid; Isopropenyl acetate / acetonitrile; methanol / 3 h / 80 °C / Inert atmosphere
2: SelectfluorTM / acetonitrile / 8.5 h
3: toluene-4-sulfonic acid / 12 h / 70 °C
4: hydrogen fluoride; N,N-dimethyl acetamide / water / -15 °C
5: potassium acetate / N,N-dimethyl-formamide / 8 h / 90 - 100 °C / Inert atmosphere
6: formic acid; potassium permanganate / acetone / 0.33 h / -5 - 0 °C
7: perchloric acid / 25 - 30 °C
View Scheme
C30H33NO9

C30H33NO9

fluocinonide
356-12-7

fluocinonide

Conditions
ConditionsYield
Multi-step reaction with 6 steps
1: SelectfluorTM / acetonitrile / 8.5 h
2: toluene-4-sulfonic acid / 12 h / 70 °C
3: hydrogen fluoride; N,N-dimethyl acetamide / water / -15 °C
4: potassium acetate / N,N-dimethyl-formamide / 8 h / 90 - 100 °C / Inert atmosphere
5: formic acid; potassium permanganate / acetone / 0.33 h / -5 - 0 °C
6: perchloric acid / 25 - 30 °C
View Scheme
21-acetyloxy-9β,11β-epoxy-6α-fluoro-17α-hydroxy-1,4-diene-3,20-dione
3802-45-7

21-acetyloxy-9β,11β-epoxy-6α-fluoro-17α-hydroxy-1,4-diene-3,20-dione

fluocinonide
356-12-7

fluocinonide

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1: toluene-4-sulfonic acid / 12 h / 70 °C
2: hydrogen fluoride; N,N-dimethyl acetamide / water / -15 °C
3: potassium acetate / N,N-dimethyl-formamide / 8 h / 90 - 100 °C / Inert atmosphere
4: formic acid; potassium permanganate / acetone / 0.33 h / -5 - 0 °C
5: perchloric acid / 25 - 30 °C
View Scheme
17α, 21-diacetyloxy-9β,11β-epoxy-6α-fluoro-1,4-diene-3,20-dione
72498-89-6

17α, 21-diacetyloxy-9β,11β-epoxy-6α-fluoro-1,4-diene-3,20-dione

fluocinonide
356-12-7

fluocinonide

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: hydrogen fluoride; N,N-dimethyl acetamide / water / -15 °C
2: potassium acetate / N,N-dimethyl-formamide / 8 h / 90 - 100 °C / Inert atmosphere
3: formic acid; potassium permanganate / acetone / 0.33 h / -5 - 0 °C
4: perchloric acid / 25 - 30 °C
View Scheme
17α,21-diacetyloxy-11β-hydroxy-6α, 9α-difluoro-1,4-diene-3,20-dione

17α,21-diacetyloxy-11β-hydroxy-6α, 9α-difluoro-1,4-diene-3,20-dione

fluocinonide
356-12-7

fluocinonide

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: potassium acetate / N,N-dimethyl-formamide / 8 h / 90 - 100 °C / Inert atmosphere
2: formic acid; potassium permanganate / acetone / 0.33 h / -5 - 0 °C
3: perchloric acid / 25 - 30 °C
View Scheme
acetic acid 2-((6S,8S,9R,10S,11S,13S,14S)-6,9-difluoro-11-hydroxy-10,13-dimethyl-3-oxo-6,7,8,9,10,11,12,13,14,15-decahydro-3H-cyclopenta[a]phenanthrene-17-yl)-2-oxo-ethyl ester
2326-26-3

acetic acid 2-((6S,8S,9R,10S,11S,13S,14S)-6,9-difluoro-11-hydroxy-10,13-dimethyl-3-oxo-6,7,8,9,10,11,12,13,14,15-decahydro-3H-cyclopenta[a]phenanthrene-17-yl)-2-oxo-ethyl ester

fluocinonide
356-12-7

fluocinonide

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: formic acid; potassium permanganate / acetone / 0.33 h / -5 - 0 °C
2: perchloric acid / 25 - 30 °C
View Scheme
C23H27FO7

C23H27FO7

acetone
67-64-1

acetone

fluocinonide
356-12-7

fluocinonide

Conditions
ConditionsYield
Stage #1: C23H27FO7 With hydrogen fluoride at -30 - -25℃; for 4h;
Stage #2: acetone at -50 - -45℃; for 2h;
1.5 g
2-((10S,13S,14S)-10,13-dimethyl-3-oxo-6,7,8,10,12,13,14,15-octahydro-3H-cyclopenta[a]phenanthren-17-yl)-2-oxoethyl acetate
37413-91-5

2-((10S,13S,14S)-10,13-dimethyl-3-oxo-6,7,8,10,12,13,14,15-octahydro-3H-cyclopenta[a]phenanthren-17-yl)-2-oxoethyl acetate

fluocinonide
356-12-7

fluocinonide

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1.1: 1,3-dibromo-5,5-dimethylimidazolidine-2,4-dione; perchloric acid / acetone; water / 2 h / -10 - -5 °C
1.2: 12 h / -5 - 35 °C
2.1: methanesulfonic acid / 3 h / 85 °C
2.2: 12 h / -10 - -5 °C
2.3: 1 h / -10 - -5 °C
3.1: hydrogen fluoride / 4 h / -30 - -25 °C
3.2: 2 h / -50 - -45 °C
View Scheme
C23H26O5

C23H26O5

fluocinonide
356-12-7

fluocinonide

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1.1: methanesulfonic acid / 3 h / 85 °C
1.2: 12 h / -10 - -5 °C
1.3: 1 h / -10 - -5 °C
2.1: hydrogen fluoride / 4 h / -30 - -25 °C
2.2: 2 h / -50 - -45 °C
View Scheme
21-chloro-17-hydroxy-pregna-4,9(11)-diene-3,20-dione
75868-48-3

21-chloro-17-hydroxy-pregna-4,9(11)-diene-3,20-dione

fluocinonide
356-12-7

fluocinonide

Conditions
ConditionsYield
Multi-step reaction with 8 steps
1.1: perchloric acid; 2,2-dibromo-3-nitrilopropionamide / tetrahydrofuran / 0.5 h / 0 °C
2.1: methanol / 32 h / 30 - 70 °C
3.1: p-toluenesulfonyl chloride / triethylamine; pyridine / 70 °C
4.1: benzoyl chloride / pyridine; N,N-dimethyl acetamide / 80 - 95 °C / Inert atmosphere
4.2: -5 °C / Inert atmosphere
5.1: hydrogen fluoride / tetrahydrofuran; water / -5 - 0 °C
6.1: potassium permanganate / water; acetone; formic acid / -8 - 10 °C
7.1: N,N-dimethyl-formamide / 80 °C
8.1: toluene-4-sulfonic acid / 35 °C / Inert atmosphere
View Scheme
C21H27ClO4

C21H27ClO4

fluocinonide
356-12-7

fluocinonide

Conditions
ConditionsYield
Multi-step reaction with 7 steps
1.1: methanol / 32 h / 30 - 70 °C
2.1: p-toluenesulfonyl chloride / triethylamine; pyridine / 70 °C
3.1: benzoyl chloride / pyridine; N,N-dimethyl acetamide / 80 - 95 °C / Inert atmosphere
3.2: -5 °C / Inert atmosphere
4.1: hydrogen fluoride / tetrahydrofuran; water / -5 - 0 °C
5.1: potassium permanganate / water; acetone; formic acid / -8 - 10 °C
6.1: N,N-dimethyl-formamide / 80 °C
7.1: toluene-4-sulfonic acid / 35 °C / Inert atmosphere
View Scheme
C21H25ClO4

C21H25ClO4

fluocinonide
356-12-7

fluocinonide

Conditions
ConditionsYield
Multi-step reaction with 6 steps
1.1: p-toluenesulfonyl chloride / triethylamine; pyridine / 70 °C
2.1: benzoyl chloride / pyridine; N,N-dimethyl acetamide / 80 - 95 °C / Inert atmosphere
2.2: -5 °C / Inert atmosphere
3.1: hydrogen fluoride / tetrahydrofuran; water / -5 - 0 °C
4.1: potassium permanganate / water; acetone; formic acid / -8 - 10 °C
5.1: N,N-dimethyl-formamide / 80 °C
6.1: toluene-4-sulfonic acid / 35 °C / Inert atmosphere
View Scheme
C21H23ClO3

C21H23ClO3

fluocinonide
356-12-7

fluocinonide

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1.1: benzoyl chloride / pyridine; N,N-dimethyl acetamide / 80 - 95 °C / Inert atmosphere
1.2: -5 °C / Inert atmosphere
2.1: hydrogen fluoride / tetrahydrofuran; water / -5 - 0 °C
3.1: potassium permanganate / water; acetone; formic acid / -8 - 10 °C
4.1: N,N-dimethyl-formamide / 80 °C
5.1: toluene-4-sulfonic acid / 35 °C / Inert atmosphere
View Scheme
C21H22ClFO3

C21H22ClFO3

fluocinonide
356-12-7

fluocinonide

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: hydrogen fluoride / tetrahydrofuran; water / -5 - 0 °C
2: potassium permanganate / water; acetone; formic acid / -8 - 10 °C
3: N,N-dimethyl-formamide / 80 °C
4: toluene-4-sulfonic acid / 35 °C / Inert atmosphere
View Scheme
C21H23ClF2O3

C21H23ClF2O3

fluocinonide
356-12-7

fluocinonide

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: potassium permanganate / water; acetone; formic acid / -8 - 10 °C
2: N,N-dimethyl-formamide / 80 °C
3: toluene-4-sulfonic acid / 35 °C / Inert atmosphere
View Scheme
fluocinonide
356-12-7

fluocinonide

fluocinolone Acetonide
67-73-2

fluocinolone Acetonide

Conditions
ConditionsYield
With sodium hydroxide In dichloromethane; water at 0 - 5℃; Inert atmosphere;99.4%
With sodium hydroxide; sodium sulfite In dichloromethane; water at 5 - 15℃; for 1.5h; Reagent/catalyst; Temperature; Inert atmosphere;91%
With sodium methylate; sodium hydroxide In dichloromethane Inert atmosphere;83.6%
trifluoromethylsulfonic anhydride
358-23-6

trifluoromethylsulfonic anhydride

fluocinonide
356-12-7

fluocinonide

A

21-acetyloxy-11β,16α,17α-trihydroxy-6α,9α-difluoro-1,4-diene-3,20-dione
4306-83-6

21-acetyloxy-11β,16α,17α-trihydroxy-6α,9α-difluoro-1,4-diene-3,20-dione

B

Acetic acid 2-oxo-2-[(5aS,5bS,8aR,9aR)-5a,7,7-trimethyl-2-(2-methyl-5-trifluoromethanesulfonyloxy-phenyl)-4,5,5a,8a,9,9a-hexahydro-3,6,8-trioxa-cyclopenta[b]-as-indacen-5b-yl]-ethyl ester

Acetic acid 2-oxo-2-[(5aS,5bS,8aR,9aR)-5a,7,7-trimethyl-2-(2-methyl-5-trifluoromethanesulfonyloxy-phenyl)-4,5,5a,8a,9,9a-hexahydro-3,6,8-trioxa-cyclopenta[b]-as-indacen-5b-yl]-ethyl ester

C

Acetic acid 2-{(3aS,3bS,5S,7S,7aS,8aR)-7-[(S)-2-fluoro-2-(2-methyl-5-trifluoromethanesulfonyloxy-phenyl)-ethyl]-2,2,3b-trimethyl-6-oxo-5-trifluoromethanesulfonyloxy-octahydro-indeno[1,2-d][1,3]dioxol-3a-yl}-2-oxo-ethyl ester

Acetic acid 2-{(3aS,3bS,5S,7S,7aS,8aR)-7-[(S)-2-fluoro-2-(2-methyl-5-trifluoromethanesulfonyloxy-phenyl)-ethyl]-2,2,3b-trimethyl-6-oxo-5-trifluoromethanesulfonyloxy-octahydro-indeno[1,2-d][1,3]dioxol-3a-yl}-2-oxo-ethyl ester

Conditions
ConditionsYield
With trimethylsilyl trifluoromethanesulfonate In dichloromethane at 20℃; for 3h; Product distribution; various amounts of reagents;A 1%
B 5%
C 12%
fluocinonide
356-12-7

fluocinonide

21-acetoxy-6α,9α-difluoro-11β-hydroxy-16α,17-[(1-methylethylidene)bis(oxy)]pregn-4-ene-3,20-dione
3932-49-8

21-acetoxy-6α,9α-difluoro-11β-hydroxy-16α,17-[(1-methylethylidene)bis(oxy)]pregn-4-ene-3,20-dione

Conditions
ConditionsYield
With Wilkinson's catalyst; hydrogen In tetrahydrofuran; toluene
With Wilkinson's catalyst; hydrogen In tetrahydrofuran; toluene
fluocinonide
356-12-7

fluocinonide

[1,2-(3)H]-21-acetoxy-6α,9α-difluoro-11β-hydroxy-16α,17-[(1-methylethylidene)bis(oxy)]pregn-4-ene-3,20-dione
1190404-62-6

[1,2-(3)H]-21-acetoxy-6α,9α-difluoro-11β-hydroxy-16α,17-[(1-methylethylidene)bis(oxy)]pregn-4-ene-3,20-dione

Conditions
ConditionsYield
With Wilkinson's catalyst; tritium In tetrahydrofuran; toluene under 658 Torr; for 48h;
With Wilkinson's catalyst; tritium In tetrahydrofuran; toluene
fluocinonide
356-12-7

fluocinonide

[1,2-(3)H]-11β,21-diacetoxy-6α,9α-difluoro-16α,17-[(1-methylethylidene)bis(oxy)]pregn-4-ene-3,20-dione
1190404-63-7

[1,2-(3)H]-11β,21-diacetoxy-6α,9α-difluoro-16α,17-[(1-methylethylidene)bis(oxy)]pregn-4-ene-3,20-dione

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: Wilkinson's catalyst; tritium / tetrahydrofuran; toluene
2: pyridine; dmap
View Scheme
fluocinonide
356-12-7

fluocinonide

[1,2-(3)H]-11β,21-diacetoxy-6α,9α-difluoro-16α,17-[(1-methylethylidene)bis(oxy)]pregna-1,4-diene-3,20-dione
1190404-64-8

[1,2-(3)H]-11β,21-diacetoxy-6α,9α-difluoro-16α,17-[(1-methylethylidene)bis(oxy)]pregna-1,4-diene-3,20-dione

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: Wilkinson's catalyst; tritium / tetrahydrofuran; toluene
2: pyridine; dmap
3: benzeneseleninic anhydride / toluene / 37 h / Reflux
View Scheme
fluocinonide
356-12-7

fluocinonide

11β,21-diacetoxy-6α,9α-difluoro-16α,17-[(1-methylethylidene)bis(oxy)]pregn-4-ene-3,20-dione

11β,21-diacetoxy-6α,9α-difluoro-16α,17-[(1-methylethylidene)bis(oxy)]pregn-4-ene-3,20-dione

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: Wilkinson's catalyst; hydrogen / tetrahydrofuran; toluene
2: pyridine; dmap
View Scheme
fluocinonide
356-12-7

fluocinonide

C24H26(3)H2F2O6

C24H26(3)H2F2O6

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: Wilkinson's catalyst; tritium / tetrahydrofuran; toluene
2: benzeneseleninic anhydride / toluene / Reflux
3: potassium carbonate / methanol; water
View Scheme
fluocinonide
356-12-7

fluocinonide

11β,21-diacetoxy-6α,9α-difluoro-16α,17-[(1-methylethylidene)bis(oxy)]pregna-1,4-diene-3,20-dione

11β,21-diacetoxy-6α,9α-difluoro-16α,17-[(1-methylethylidene)bis(oxy)]pregna-1,4-diene-3,20-dione

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: Wilkinson's catalyst; hydrogen / tetrahydrofuran; toluene
2: pyridine; dmap
3: benzeneseleninic anhydride / toluene / 7 h / Reflux
View Scheme
fluocinonide
356-12-7

fluocinonide

6α,9α-difluoro-11β,21-dihydroxy-16α,17α-isopropylidenedioxypregn-4-ene-3,20-dione
1178-54-7

6α,9α-difluoro-11β,21-dihydroxy-16α,17α-isopropylidenedioxypregn-4-ene-3,20-dione

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: sodium hydrogencarbonate / methanol; water
2: Wilkinson's catalyst; hydrogen
View Scheme
Multi-step reaction with 5 steps
1: Wilkinson's catalyst; hydrogen / tetrahydrofuran; toluene
2: pyridine; dmap
3: benzeneseleninic anhydride / toluene / 7 h / Reflux
4: potassium carbonate / methanol; water
5: Wilkinson's catalyst; hydrogen
View Scheme

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