Fluocinonide supplier | CasNO.356-12-7

Name
Fluocinonide
EINECS 206-597-6
CAS No. 356-12-7
Article Data12
CAS DataBase
Density 1.34 g/cm³
Solubility 0.53mg/L(25 oC)
Melting Point 309 °C
Formula C₂₆H₃₂F₂O₇
Boiling Point 591.1 °C at 760 mmHg
Molecular Weight 494.533
Flash Point 311.3 °C
Transport Information UN 2811 6.1/PG 2
Appearance white crystalline powder
Safety 22-25-28-36/37/39-45
Risk Codes 28-63
Molecular Structure
Hazard Symbols T+
Synonyms Pregna-1,4-diene-3,20-dione,6a,9-difluoro-11b,16a,17,21-tetrahydroxy-, cyclic 16,17-acetal withacetone, 21-acetate (7CI,8CI);Biscosal;Dermaplus;Flucinar;Fluocinolide acetate;Fluocinolone acetonide 21-acetate;Fluocinolone acetonide acetate;Lidex;Lidex E;Metosyn;NSC101791;Straderm;Topsym;Topsymin;Topsyn;Vanos;
PSA 99.13000
LogP 2.93760

Synthetic route

: 67-73-2
fluocinolone Acetonide

: 108-24-7
acetic anhydride

: 356-12-7
fluocinonide

Conditions

Conditions	Yield
With trimethylsilyl trifluoromethanesulfonate In dichloromethane at 20℃; for 0.0833333h;	100%
With trimethylsilyl trifluoromethanesulfonate In dichloromethane at 20℃; for 1.16667h;	59%
With trimethylsilyl trifluoromethanesulfonate In dichloromethane

: C26H31FO7

: 356-12-7
fluocinonide

Conditions

Conditions	Yield
With 1-ethyl-3-methylimidazole hydrogen fluoride at 25℃; Reagent/catalyst; Temperature;	98.2%

: 4306-83-6
21-acetyloxy-11β,16α,17α-trihydroxy-6α,9α-difluoro-1,4-diene-3,20-dione

: 67-64-1
acetone

: 356-12-7
fluocinonide

Conditions

Conditions	Yield
With perchloric acid at 25 - 30℃;	87.3%
With toluene-4-sulfonic acid at 35℃; Reagent/catalyst; Temperature; Inert atmosphere;	6.9 g
With methanesulfonic acid at 50℃; for 1.5h; Temperature;

: 3932-49-8
21-acetoxy-6α,9α-difluoro-11β-hydroxy-16α,17-[(1-methylethylidene)bis(oxy)]pregn-4-ene-3,20-dione

: 356-12-7
fluocinonide

Conditions

Conditions	Yield
With pyridine; selenium(IV) oxide In tert-butyl alcohol Reflux;
With selenium(IV) oxide In pyridine; tert-butyl alcohol at 95℃;

: 67-73-2
fluocinolone Acetonide

: 108-24-7
acetic anhydride

A: 356-12-7
fluocinonide

B: 11β,21-diacetoxy-6α,9α-difluoro-16α,17-[(1-methylethylidene)bis(oxy)]pregna-1,4-diene-3,20-dione

Conditions

Conditions	Yield
With pyridine; dmap at 20℃; for 4h; Inert atmosphere; Heating;

...Expand

: 7753-60-8
anecortave

: 356-12-7
fluocinonide

Conditions

Conditions	Yield
Multi-step reaction with 9 steps 1.1: D-glucose / aq. phosphate buffer 2.1: perchloric acid / acetone; water / 0.17 h / 0 - 5 °C 2.2: 1 h / 0 - 5 °C 2.3: 2 h / 0 - 35 °C 3.1: pyridine; toluene-4-sulfonic acid; Isopropenyl acetate / acetonitrile; methanol / 3 h / 80 °C / Inert atmosphere 4.1: SelectfluorTM / acetonitrile / 8.5 h 5.1: toluene-4-sulfonic acid / 12 h / 70 °C 6.1: hydrogen fluoride; N,N-dimethyl acetamide / water / -15 °C 7.1: potassium acetate / N,N-dimethyl-formamide / 8 h / 90 - 100 °C / Inert atmosphere 8.1: formic acid; potassium permanganate / acetone / 0.33 h / -5 - 0 °C 9.1: perchloric acid / 25 - 30 °C View Scheme

Yield

Multi-step reaction with 9 steps
1.1: D-glucose / aq. phosphate buffer
2.1: perchloric acid / acetone; water / 0.17 h / 0 - 5 °C
2.2: 1 h / 0 - 5 °C
2.3: 2 h / 0 - 35 °C
3.1: pyridine; toluene-4-sulfonic acid; Isopropenyl acetate / acetonitrile; methanol / 3 h / 80 °C / Inert atmosphere
4.1: SelectfluorTM / acetonitrile / 8.5 h
5.1: toluene-4-sulfonic acid / 12 h / 70 °C
6.1: hydrogen fluoride; N,N-dimethyl acetamide / water / -15 °C
7.1: potassium acetate / N,N-dimethyl-formamide / 8 h / 90 - 100 °C / Inert atmosphere
8.1: formic acid; potassium permanganate / acetone / 0.33 h / -5 - 0 °C
9.1: perchloric acid / 25 - 30 °C
View Scheme

: 4380-55-6
pregna-1,4,9(11)-triene-17α,21-diol-3,20-dione 21-acetate

: 356-12-7
fluocinonide

Conditions

Conditions	Yield
Multi-step reaction with 8 steps 1.1: perchloric acid / acetone; water / 0.17 h / 0 - 5 °C 1.2: 1 h / 0 - 5 °C 1.3: 2 h / 0 - 35 °C 2.1: pyridine; toluene-4-sulfonic acid; Isopropenyl acetate / acetonitrile; methanol / 3 h / 80 °C / Inert atmosphere 3.1: SelectfluorTM / acetonitrile / 8.5 h 4.1: toluene-4-sulfonic acid / 12 h / 70 °C 5.1: hydrogen fluoride; N,N-dimethyl acetamide / water / -15 °C 6.1: potassium acetate / N,N-dimethyl-formamide / 8 h / 90 - 100 °C / Inert atmosphere 7.1: formic acid; potassium permanganate / acetone / 0.33 h / -5 - 0 °C 8.1: perchloric acid / 25 - 30 °C View Scheme

Yield

Multi-step reaction with 8 steps
1.1: perchloric acid / acetone; water / 0.17 h / 0 - 5 °C
1.2: 1 h / 0 - 5 °C
1.3: 2 h / 0 - 35 °C
2.1: pyridine; toluene-4-sulfonic acid; Isopropenyl acetate / acetonitrile; methanol / 3 h / 80 °C / Inert atmosphere
3.1: SelectfluorTM / acetonitrile / 8.5 h
4.1: toluene-4-sulfonic acid / 12 h / 70 °C
5.1: hydrogen fluoride; N,N-dimethyl acetamide / water / -15 °C
6.1: potassium acetate / N,N-dimethyl-formamide / 8 h / 90 - 100 °C / Inert atmosphere
7.1: formic acid; potassium permanganate / acetone / 0.33 h / -5 - 0 °C
8.1: perchloric acid / 25 - 30 °C
View Scheme

: 38680-83-0
21-acetyloxy-9β,11β-epoxy-17α-hydroxy-1,4-diene-3,20-dione

: 356-12-7
fluocinonide

Conditions

Conditions	Yield
Multi-step reaction with 7 steps 1: pyridine; toluene-4-sulfonic acid; Isopropenyl acetate / acetonitrile; methanol / 3 h / 80 °C / Inert atmosphere 2: SelectfluorTM / acetonitrile / 8.5 h 3: toluene-4-sulfonic acid / 12 h / 70 °C 4: hydrogen fluoride; N,N-dimethyl acetamide / water / -15 °C 5: potassium acetate / N,N-dimethyl-formamide / 8 h / 90 - 100 °C / Inert atmosphere 6: formic acid; potassium permanganate / acetone / 0.33 h / -5 - 0 °C 7: perchloric acid / 25 - 30 °C View Scheme

Yield

Multi-step reaction with 7 steps
1: pyridine; toluene-4-sulfonic acid; Isopropenyl acetate / acetonitrile; methanol / 3 h / 80 °C / Inert atmosphere
2: SelectfluorTM / acetonitrile / 8.5 h
3: toluene-4-sulfonic acid / 12 h / 70 °C
4: hydrogen fluoride; N,N-dimethyl acetamide / water / -15 °C
5: potassium acetate / N,N-dimethyl-formamide / 8 h / 90 - 100 °C / Inert atmosphere
6: formic acid; potassium permanganate / acetone / 0.33 h / -5 - 0 °C
7: perchloric acid / 25 - 30 °C
View Scheme

: C30H33NO9

: 356-12-7
fluocinonide

Conditions

Conditions	Yield
Multi-step reaction with 6 steps 1: SelectfluorTM / acetonitrile / 8.5 h 2: toluene-4-sulfonic acid / 12 h / 70 °C 3: hydrogen fluoride; N,N-dimethyl acetamide / water / -15 °C 4: potassium acetate / N,N-dimethyl-formamide / 8 h / 90 - 100 °C / Inert atmosphere 5: formic acid; potassium permanganate / acetone / 0.33 h / -5 - 0 °C 6: perchloric acid / 25 - 30 °C View Scheme

: 3802-45-7
21-acetyloxy-9β,11β-epoxy-6α-fluoro-17α-hydroxy-1,4-diene-3,20-dione

: 356-12-7
fluocinonide

Conditions

Conditions	Yield
Multi-step reaction with 5 steps 1: toluene-4-sulfonic acid / 12 h / 70 °C 2: hydrogen fluoride; N,N-dimethyl acetamide / water / -15 °C 3: potassium acetate / N,N-dimethyl-formamide / 8 h / 90 - 100 °C / Inert atmosphere 4: formic acid; potassium permanganate / acetone / 0.33 h / -5 - 0 °C 5: perchloric acid / 25 - 30 °C View Scheme

: 72498-89-6
17α, 21-diacetyloxy-9β,11β-epoxy-6α-fluoro-1,4-diene-3,20-dione

: 356-12-7
fluocinonide

Conditions

Conditions	Yield
Multi-step reaction with 4 steps 1: hydrogen fluoride; N,N-dimethyl acetamide / water / -15 °C 2: potassium acetate / N,N-dimethyl-formamide / 8 h / 90 - 100 °C / Inert atmosphere 3: formic acid; potassium permanganate / acetone / 0.33 h / -5 - 0 °C 4: perchloric acid / 25 - 30 °C View Scheme

: 17α,21-diacetyloxy-11β-hydroxy-6α, 9α-difluoro-1,4-diene-3,20-dione

: 356-12-7
fluocinonide

Conditions

Conditions	Yield
Multi-step reaction with 3 steps 1: potassium acetate / N,N-dimethyl-formamide / 8 h / 90 - 100 °C / Inert atmosphere 2: formic acid; potassium permanganate / acetone / 0.33 h / -5 - 0 °C 3: perchloric acid / 25 - 30 °C View Scheme

: 2326-26-3
acetic acid 2-((6S,8S,9R,10S,11S,13S,14S)-6,9-difluoro-11-hydroxy-10,13-dimethyl-3-oxo-6,7,8,9,10,11,12,13,14,15-decahydro-3H-cyclopenta[a]phenanthrene-17-yl)-2-oxo-ethyl ester

: 356-12-7
fluocinonide

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: formic acid; potassium permanganate / acetone / 0.33 h / -5 - 0 °C 2: perchloric acid / 25 - 30 °C View Scheme

: C23H27FO7

: 67-64-1
acetone

: 356-12-7
fluocinonide

Conditions

Conditions	Yield
Stage #1: C23H27FO7 With hydrogen fluoride at -30 - -25℃; for 4h; Stage #2: acetone at -50 - -45℃; for 2h;	1.5 g

: 37413-91-5
2-((10S,13S,14S)-10,13-dimethyl-3-oxo-6,7,8,10,12,13,14,15-octahydro-3H-cyclopenta[a]phenanthren-17-yl)-2-oxoethyl acetate

: 356-12-7
fluocinonide

Conditions

Conditions	Yield
Multi-step reaction with 3 steps 1.1: 1,3-dibromo-5,5-dimethylimidazolidine-2,4-dione; perchloric acid / acetone; water / 2 h / -10 - -5 °C 1.2: 12 h / -5 - 35 °C 2.1: methanesulfonic acid / 3 h / 85 °C 2.2: 12 h / -10 - -5 °C 2.3: 1 h / -10 - -5 °C 3.1: hydrogen fluoride / 4 h / -30 - -25 °C 3.2: 2 h / -50 - -45 °C View Scheme

: C23H26O5

: 356-12-7
fluocinonide

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1.1: methanesulfonic acid / 3 h / 85 °C 1.2: 12 h / -10 - -5 °C 1.3: 1 h / -10 - -5 °C 2.1: hydrogen fluoride / 4 h / -30 - -25 °C 2.2: 2 h / -50 - -45 °C View Scheme

: 75868-48-3
21-chloro-17-hydroxy-pregna-4,9(11)-diene-3,20-dione

: 356-12-7
fluocinonide

Conditions

Conditions	Yield
Multi-step reaction with 8 steps 1.1: perchloric acid; 2,2-dibromo-3-nitrilopropionamide / tetrahydrofuran / 0.5 h / 0 °C 2.1: methanol / 32 h / 30 - 70 °C 3.1: p-toluenesulfonyl chloride / triethylamine; pyridine / 70 °C 4.1: benzoyl chloride / pyridine; N,N-dimethyl acetamide / 80 - 95 °C / Inert atmosphere 4.2: -5 °C / Inert atmosphere 5.1: hydrogen fluoride / tetrahydrofuran; water / -5 - 0 °C 6.1: potassium permanganate / water; acetone; formic acid / -8 - 10 °C 7.1: N,N-dimethyl-formamide / 80 °C 8.1: toluene-4-sulfonic acid / 35 °C / Inert atmosphere View Scheme

Yield

Multi-step reaction with 8 steps
1.1: perchloric acid; 2,2-dibromo-3-nitrilopropionamide / tetrahydrofuran / 0.5 h / 0 °C
2.1: methanol / 32 h / 30 - 70 °C
3.1: p-toluenesulfonyl chloride / triethylamine; pyridine / 70 °C
4.1: benzoyl chloride / pyridine; N,N-dimethyl acetamide / 80 - 95 °C / Inert atmosphere
4.2: -5 °C / Inert atmosphere
5.1: hydrogen fluoride / tetrahydrofuran; water / -5 - 0 °C
6.1: potassium permanganate / water; acetone; formic acid / -8 - 10 °C
7.1: N,N-dimethyl-formamide / 80 °C
8.1: toluene-4-sulfonic acid / 35 °C / Inert atmosphere
View Scheme

: C21H27ClO4

: 356-12-7
fluocinonide

Conditions

Conditions	Yield
Multi-step reaction with 7 steps 1.1: methanol / 32 h / 30 - 70 °C 2.1: p-toluenesulfonyl chloride / triethylamine; pyridine / 70 °C 3.1: benzoyl chloride / pyridine; N,N-dimethyl acetamide / 80 - 95 °C / Inert atmosphere 3.2: -5 °C / Inert atmosphere 4.1: hydrogen fluoride / tetrahydrofuran; water / -5 - 0 °C 5.1: potassium permanganate / water; acetone; formic acid / -8 - 10 °C 6.1: N,N-dimethyl-formamide / 80 °C 7.1: toluene-4-sulfonic acid / 35 °C / Inert atmosphere View Scheme

Yield

Multi-step reaction with 7 steps
1.1: methanol / 32 h / 30 - 70 °C
2.1: p-toluenesulfonyl chloride / triethylamine; pyridine / 70 °C
3.1: benzoyl chloride / pyridine; N,N-dimethyl acetamide / 80 - 95 °C / Inert atmosphere
3.2: -5 °C / Inert atmosphere
4.1: hydrogen fluoride / tetrahydrofuran; water / -5 - 0 °C
5.1: potassium permanganate / water; acetone; formic acid / -8 - 10 °C
6.1: N,N-dimethyl-formamide / 80 °C
7.1: toluene-4-sulfonic acid / 35 °C / Inert atmosphere
View Scheme

: C21H25ClO4

: 356-12-7
fluocinonide

Conditions

Conditions	Yield
Multi-step reaction with 6 steps 1.1: p-toluenesulfonyl chloride / triethylamine; pyridine / 70 °C 2.1: benzoyl chloride / pyridine; N,N-dimethyl acetamide / 80 - 95 °C / Inert atmosphere 2.2: -5 °C / Inert atmosphere 3.1: hydrogen fluoride / tetrahydrofuran; water / -5 - 0 °C 4.1: potassium permanganate / water; acetone; formic acid / -8 - 10 °C 5.1: N,N-dimethyl-formamide / 80 °C 6.1: toluene-4-sulfonic acid / 35 °C / Inert atmosphere View Scheme

Yield

Multi-step reaction with 6 steps
1.1: p-toluenesulfonyl chloride / triethylamine; pyridine / 70 °C
2.1: benzoyl chloride / pyridine; N,N-dimethyl acetamide / 80 - 95 °C / Inert atmosphere
2.2: -5 °C / Inert atmosphere
3.1: hydrogen fluoride / tetrahydrofuran; water / -5 - 0 °C
4.1: potassium permanganate / water; acetone; formic acid / -8 - 10 °C
5.1: N,N-dimethyl-formamide / 80 °C
6.1: toluene-4-sulfonic acid / 35 °C / Inert atmosphere
View Scheme

: C21H23ClO3

: 356-12-7
fluocinonide

Conditions

Conditions	Yield
Multi-step reaction with 5 steps 1.1: benzoyl chloride / pyridine; N,N-dimethyl acetamide / 80 - 95 °C / Inert atmosphere 1.2: -5 °C / Inert atmosphere 2.1: hydrogen fluoride / tetrahydrofuran; water / -5 - 0 °C 3.1: potassium permanganate / water; acetone; formic acid / -8 - 10 °C 4.1: N,N-dimethyl-formamide / 80 °C 5.1: toluene-4-sulfonic acid / 35 °C / Inert atmosphere View Scheme

: C21H22ClFO3

: 356-12-7
fluocinonide

Conditions

Conditions	Yield
Multi-step reaction with 4 steps 1: hydrogen fluoride / tetrahydrofuran; water / -5 - 0 °C 2: potassium permanganate / water; acetone; formic acid / -8 - 10 °C 3: N,N-dimethyl-formamide / 80 °C 4: toluene-4-sulfonic acid / 35 °C / Inert atmosphere View Scheme

: C21H23ClF2O3

: 356-12-7
fluocinonide

Conditions

Conditions	Yield
Multi-step reaction with 3 steps 1: potassium permanganate / water; acetone; formic acid / -8 - 10 °C 2: N,N-dimethyl-formamide / 80 °C 3: toluene-4-sulfonic acid / 35 °C / Inert atmosphere View Scheme

: 356-12-7
fluocinonide

: 67-73-2
fluocinolone Acetonide

Conditions

Conditions	Yield
With sodium hydroxide In dichloromethane; water at 0 - 5℃; Inert atmosphere;	99.4%
With sodium hydroxide; sodium sulfite In dichloromethane; water at 5 - 15℃; for 1.5h; Reagent/catalyst; Temperature; Inert atmosphere;	91%
With sodium methylate; sodium hydroxide In dichloromethane Inert atmosphere;	83.6%

: 358-23-6
trifluoromethylsulfonic anhydride

: 356-12-7
fluocinonide

A: 4306-83-6
21-acetyloxy-11β,16α,17α-trihydroxy-6α,9α-difluoro-1,4-diene-3,20-dione

B: Acetic acid 2-oxo-2-[(5aS,5bS,8aR,9aR)-5a,7,7-trimethyl-2-(2-methyl-5-trifluoromethanesulfonyloxy-phenyl)-4,5,5a,8a,9,9a-hexahydro-3,6,8-trioxa-cyclopenta[b]-as-indacen-5b-yl]-ethyl ester

C: Acetic acid 2-{(3aS,3bS,5S,7S,7aS,8aR)-7-[(S)-2-fluoro-2-(2-methyl-5-trifluoromethanesulfonyloxy-phenyl)-ethyl]-2,2,3b-trimethyl-6-oxo-5-trifluoromethanesulfonyloxy-octahydro-indeno[1,2-d][1,3]dioxol-3a-yl}-2-oxo-ethyl ester

Conditions

Conditions	Yield
With trimethylsilyl trifluoromethanesulfonate In dichloromethane at 20℃; for 3h; Product distribution; various amounts of reagents;	A 1% B 5% C 12%

...Expand

: 356-12-7
fluocinonide

: 3932-49-8
21-acetoxy-6α,9α-difluoro-11β-hydroxy-16α,17-[(1-methylethylidene)bis(oxy)]pregn-4-ene-3,20-dione

Conditions

Conditions	Yield
With Wilkinson's catalyst; hydrogen In tetrahydrofuran; toluene
With Wilkinson's catalyst; hydrogen In tetrahydrofuran; toluene

: 356-12-7
fluocinonide

: 1190404-62-6
[1,2-(3)H]-21-acetoxy-6α,9α-difluoro-11β-hydroxy-16α,17-[(1-methylethylidene)bis(oxy)]pregn-4-ene-3,20-dione

Conditions

Conditions	Yield
With Wilkinson's catalyst; tritium In tetrahydrofuran; toluene under 658 Torr; for 48h;
With Wilkinson's catalyst; tritium In tetrahydrofuran; toluene

: 356-12-7
fluocinonide

: 1190404-63-7
[1,2-(3)H]-11β,21-diacetoxy-6α,9α-difluoro-16α,17-[(1-methylethylidene)bis(oxy)]pregn-4-ene-3,20-dione

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: Wilkinson's catalyst; tritium / tetrahydrofuran; toluene 2: pyridine; dmap View Scheme

: 356-12-7
fluocinonide

: 1190404-64-8
[1,2-(3)H]-11β,21-diacetoxy-6α,9α-difluoro-16α,17-[(1-methylethylidene)bis(oxy)]pregna-1,4-diene-3,20-dione

Conditions

Conditions	Yield
Multi-step reaction with 3 steps 1: Wilkinson's catalyst; tritium / tetrahydrofuran; toluene 2: pyridine; dmap 3: benzeneseleninic anhydride / toluene / 37 h / Reflux View Scheme

: 356-12-7
fluocinonide

: 11β,21-diacetoxy-6α,9α-difluoro-16α,17-[(1-methylethylidene)bis(oxy)]pregn-4-ene-3,20-dione

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: Wilkinson's catalyst; hydrogen / tetrahydrofuran; toluene 2: pyridine; dmap View Scheme

: 356-12-7
fluocinonide

: C24H26(3)H2F2O6

Conditions

Conditions	Yield
Multi-step reaction with 3 steps 1: Wilkinson's catalyst; tritium / tetrahydrofuran; toluene 2: benzeneseleninic anhydride / toluene / Reflux 3: potassium carbonate / methanol; water View Scheme

: 356-12-7
fluocinonide

: 11β,21-diacetoxy-6α,9α-difluoro-16α,17-[(1-methylethylidene)bis(oxy)]pregna-1,4-diene-3,20-dione

Conditions

Conditions	Yield
Multi-step reaction with 3 steps 1: Wilkinson's catalyst; hydrogen / tetrahydrofuran; toluene 2: pyridine; dmap 3: benzeneseleninic anhydride / toluene / 7 h / Reflux View Scheme

: 356-12-7
fluocinonide

: 1178-54-7
6α,9α-difluoro-11β,21-dihydroxy-16α,17α-isopropylidenedioxypregn-4-ene-3,20-dione

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: sodium hydrogencarbonate / methanol; water 2: Wilkinson's catalyst; hydrogen View Scheme
Multi-step reaction with 5 steps 1: Wilkinson's catalyst; hydrogen / tetrahydrofuran; toluene 2: pyridine; dmap 3: benzeneseleninic anhydride / toluene / 7 h / Reflux 4: potassium carbonate / methanol; water 5: Wilkinson's catalyst; hydrogen View Scheme

Fluocinonide Specification

The Fluocinolide with CAS registry number of 356-12-7 is also known as Topsymin. The systematic name is 2-[(4aS,4bR,5S,6aS,6bS,9aR,10aS,10bS,12S)-4b,12-Difluoro-5-hydroxy-4a,6a,8,8-tetramethyl-2-oxo-2,4a,4b,5,6,6a,9a,10,10a,10b,11,12-dodecahydro-6bH-naphtho[2',1':4,5]indeno[1,2-d][1,3]dioxol-6b-yl]-2-ox oethyl acetate. It belongs to product categories of Steroids. Its EINECS registry number is 206-597-6 . In addition, the formula is C₂₆H₃₂F₂O₇ and the molecular weight is 494.52. This chemical is a white crystalline powder and used for atopic dermatitis, eczema and so on.

Physical properties about Fluocinolide are: (1)ACD/LogP: 3.36; (2)# of Rule of 5 Violations: 0; (3)ACD/LogD (pH 5.5): 3.36; (4)ACD/LogD (pH 7.4): 3.36; (5)ACD/BCF (pH 5.5): 209.69; (6)ACD/BCF (pH 7.4): 209.69; (7)ACD/KOC (pH 5.5): 1597.31; (8)ACD/KOC (pH 7.4): 1597.3; (9)#H bond acceptors: 7; (10)#H bond donors: 1; (11)#Freely Rotating Bonds: 5; (12)Index of Refraction: 1.56; (13)Molar Refractivity: 119.09 cm³; (14)Molar Volume: 368 cm³; (15)Surface Tension: 49.9 dyne/cm; (16)Density: 1.34 g/cm³; (17)Flash Point: 311.3 °C; (18)Enthalpy of Vaporization: 101.2 kJ/mol; (19)Boiling Point: 591.1 °C at 760 mmHg; (20)Vapour Pressure: 1.97E-16 mmHg at 25 °C.

Preparation of Fluocinolide: it is prepared by reaction of acetic acid anhydride with fluocinolon-acetonid. The reaction needs reagent trimethylsilyl trifluoromethanesulfonate and solvent CH₂Cl₂ at the temperature of 20 °C for 5 minutes. The yield is about 100%.

Fluocinolide is prepared by reaction of acetic acid anhydride with fluocinolon-acetonid.

When you are using this chemical, please be cautious about it. As a chemical, it is very toxic if swallowed and has possible risk of harm to the unborn child. During using it, wear suitable protective clothing, gloves and eye/face protection. Besides, do not breathe dust and avoid contact with eyes. In case of accident or if you feel unwell seek medical advice immediately.

You can still convert the following datas into molecular structure:
1. Canonical SMILES: CC(=O)OCC(=O)C12C(CC3C1(CC(C4(C3CC(C5=CC(=O)C=CC54C)F)F)O)C)OC(O2)(C)C
2. Isomeric SMILES: CC(=O)OCC(=O)[C@@]12[C@@H](C[C@@H]3[C@@]1(C[C@@H]([C@]4([C@H]3C[C@@H](C5=CC(=O)C=C[C@@]54C)F)F)O)C)OC(O2)(C)C
3. InChI: InChI=1S/C26H32F2O7/c1-13(29)33-12-20(32)26-21(34-22(2,3)35-26)10-15-16-9-18(27)17-8-14(30)6-7-23(17,4)25(16,28)19(31)11-24(15,
26)5/h6-8,15-16,18-19,21,31H,9-12H2,1-5H3/t15-,16-,18-,19-,21+,23-,24-,25-,26+/m0/s1
4. InChIKey: WJOHZNCJWYWUJD-IUGZLZTKSA-N

The toxicity data is as follows:

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Source
guinea pig	LD50	subcutaneous	> 3170mg/kg (3170mg/kg)	Drugs in Japan Vol. 6, Pg. 694, 1982.
mouse	LD50	intraperitoneal	160mg/kg (160mg/kg)	Gekkan Yakuji. Pharmaceuticals Monthly. Vol. 17, Pg. 849, 1975.
mouse	LD50	oral	> 6gm/kg (6000mg/kg)	Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 6, Pg. 386, 1975.
mouse	LD50	subcutaneous	165mg/kg (165mg/kg)	Yakkyoku. Pharmacy. Vol. 26, Pg. 741, 1975.
rat	LD50	intraperitoneal	300ug/kg (0.3mg/kg)	Drugs in Japan Vol. 6, Pg. 694, 1982.
rat	LD50	oral	14mg/kg (14mg/kg)	Drugs in Japan Vol. 6, Pg. 694, 1982.
rat	LD50	subcutaneous	720ug/kg (0.72mg/kg)	Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 6, Pg. 386, 1975.

Product Name

Fluocinonide

Synthetic route

Fluocinonide Specification

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