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HANWAYS CHEMPHARM CO.,LIMITED

Product Description Tacrolimus Brief Description CAS NO. 104987-11-3 M.F: C44H69NO12 M.W: 804.02 Competitive price with high quality Conforms to BP/USP/EP/FCC Specification ITEM

Tacrolimus/Sirolimus/Everolimus/Pimecrolimus CAS 104987-11-3 pharmaceutical API supply

Cas:104987-11-3

Min.Order:1 Kilogram

Negotiable

Type:Trading Company

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CHANGZHOU HANGYU PHARMACEUTICAL TECHNOLOGY CO., LTD

CHANGZHOU HANGYU PHARMACEUTICAL TECHNOLOGY CO., LTD. founded in 1984, engages in pharmaceutical research, development, production, process design and technical consultation of synthetic pharmaceutical products. The organizational

Tacrolimus FK-506 99% manufacturer in China

Cas:104987-11-3

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

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Henan Tianfu Chemical Co., Ltd.

Tacrolimus Basic information Product Name: Tacrolimus Synonyms: (2-propenyl)-,(3s-(3r*(e(1s*,3s*,4s*)),4s*,5r*,8s*,9e,12r*,14r*,15s*,16r*,18s*;,19s*,26ar*))-;16-dimethoxy-4,10,12,18-tetr

TIANFU-CHEM CAS:104987-11-3 Tacrolimus

Cas:104987-11-3

Min.Order:1 Gram

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Type:Lab/Research institutions

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GUANGZHOU MEDCAN PHARMATECH LTD

Tacrolimus is an immunosuppressive drug that is used mainly after allogeneic organ transplant to reduce the activity of the patient's immune system and so lower the risk of organ rejection. It is also used in a topical preparation in the

Tacrolimus

Cas:104987-11-3

Min.Order:1 Gram

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Type:Lab/Research institutions

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Hangzhou Dawn Ray Pharmaceutical Co.,Ltd

Assay:98%-102% Appearance:White or almost white crystalline powder Storage:2-8℃ Package:in bags or customer requirements Application:Immunological suppression pharmaceutical raw material Molecular Formula C44H69NO12 Molecular Weight 804.0182

Tacrolimus

Cas:104987-11-3

Min.Order:1 Gram

Negotiable

Type:Trading Company

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Dayang Chem (Hangzhou) Co.,Ltd.

Dayangchem's R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. DayangChem can provide different quantities

Tacrolimus Manufacturer/High quality/Best price/In stock

Cas:104987-11-3

Min.Order:1 Kilogram

FOB Price: $3.0

Type:Lab/Research institutions

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Sinoway Industrial Co., Ltd.

We are very compeitive on Tacrolimus.Our mfr is GMP certified for this item with CEP document. Product Name: Tacrolimus CAS: 104987-11-3 MF: C44 H69 N O12 MW: 804.02 EINECS: 1308068-626-2

factory supply GMP,DMF,CEP Tacrolimus

Cas:104987-11-3

Min.Order:1 Kilogram

Negotiable

Type:Trading Company

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GIHI CHEMICALS CO.,LIMITED

GIHI CHEMICALS exported this product to many countries and regions at best price. if you are looking for the material's manufacturer or supplier in china, GIHI CHEMICALS is your best choice. pls contact with us freely for getting detailed prod

104987-11-3 Tacrolimus global trader

Cas:104987-11-3

Min.Order:1 Metric Ton

FOB Price: $2.0

Type:Lab/Research institutions

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Hangzhou Dingyan Chem Co., Ltd

Items Standard Result Assay 98%min ----------------------------------------------------------------------------------------------

High purity Various Specifications Tacrolimus CAS:104987-11-3

Cas:104987-11-3

Min.Order:1 Gram

FOB Price: $100.0 / 500.0

Type:Manufacturers

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Hangzhou JINLAN Pharm-Drugs Technology Co., Ltd

Jinlan Pharm-Drugs Technology Co.,Limited (with its export company Hangzhou Royall Import & Export Co.,Ltd.)is located in Hangzhou, Zhejiang Province. Neighboring Ningbo port, Shanghai port, Hangzhou Xiaoshan Int’l Airport and Shanghai Pu

Tacrolimus 104987-11-3 API

Cas:104987-11-3

Min.Order:1 Gram

Negotiable

Type:Manufacturers

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Wuhan Fortuna Chemical Co.,Ltd

Unique advantages of Tacrolimus Cas 104987-11-3 Guaranteed purity High quality & competitive price Quality control Fast feedback Prompt shipment Appearance:White to off-white crystalline powder Storage:Cool dry place Package:1g/fo

High quality Tacrolimus Cas 104987-11-3 with favorable price

Cas:104987-11-3

Min.Order:1 Gram

Negotiable

Type:Trading Company

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Hebei yanxi chemical co.,LTD.

Hebei yanxi chemical co., LTD is a professional research, development and production . enterprise backbone members by local well-known entrepreneurs and professional senior engineers in the party's "low carbon environmental protection

Hot sales, 99% Tacrolimus

Cas:104987-11-3

Min.Order:1 Kilogram

FOB Price: $11.0 / 16.0

Type:Manufacturers

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Hangzhou Think Chemical Co. Ltd

Tacrolimus CAS:104987-11-3 Test Items Standards Test Results Character Off-white to white powder conform M

Good supply Tacrolimus Manufacture

Cas:104987-11-3

Min.Order:10 Gram

Negotiable

Type:Other

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Henan Allgreen Chemical Co.,Ltd

T he company has advanced technology, as well as a large number of excellent R & D team, to provide customers from the grams to one hundred kilograms and tons of high-quality products, competitive prices and quality service Appearance:white

Tacrolimus

Cas:104987-11-3

Min.Order:1 Kilogram

Negotiable

Type:Manufacturers

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Ality Chemical Corporation

The above product is Ality Chemical's strong item with best price, good quality and fast supply. Ality Chemical has been focusing on the research and production of this field for over 14 years. At the same time, we are always committed to providi

Factory Supply Tacrolimus

Cas:104987-11-3

Min.Order:1

Negotiable

Type:Other

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Xi'an Xszo Chem Co., Ltd.

1. Factory price and high quality must be guaranteed, base on 8 years of production and R&D experience2. Free samples will be provided,ensure specifications and quality are right for customer3. Customers will receive the most professional technical s

Factory Price API 99% Tacrolimus 104987-11-3 GMP Manufacturer

Cas:104987-11-3

Min.Order:1 Gram

FOB Price: $0.1

Type:Manufacturers

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Enke Pharma-tech Co.,Ltd. (Cangzhou, China )

Cangzhou Enke Pharma Tech Co.,ltd. is located in Cangzhou City, Hebei province ,where is a famous petroleum chemical industry city in China. Enke Pharma a high-tech enterprise ,and we are dedicated to developing and manufacturing new api, intermedi

Tacrolimus

Cas:104987-11-3

Min.Order:1 Kilogram

FOB Price: $5.0

Type:Manufacturers

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Hubei DiBo chemical co., LTD

Name:Tacrolimus CAS:104987-11-3 Grade:For chemical industry, scientific research and export Product Quality 12 years of chemical raw materials Mature operation of the industry System stability Data storage Security without vulnerability P

Tacrolimus FK-506 99% manufacturer in China

Cas:104987-11-3

Min.Order:25 Kilogram

FOB Price: $1.0 / 2.0

Type:Other

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LIDE PHARMACEUTICALS LIMITED

Advantage : LIDE PHARMACEUTICALS LTD. is a mid-small manufacturing-type enterprise, engaged in pharmaceutical intermediates of R&D, custom-made and production, and also involving trading chemicals for export. We have established the R&amp

Tacrolimus

Cas:104987-11-3

Min.Order:1 Gram

FOB Price: $1.0

Type:Lab/Research institutions

inquiry

Hebei Nengqian Chemical Import and Export Co., LTD

Our advantages: 1. All inquiries will be replied within 12 hours. 2. Dedication to quality, supply & service. 3. Strictly on selecting raw materials. 4. Reasonable & competitive price, fast lead time. 5. Sample is available for your eva

Tacrolimus In stock

Cas:104987-11-3

Min.Order:1 Gram

FOB Price: $1000.0 / 1300.0

Type:Trading Company

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Zhuozhou Wenxi import and Export Co., Ltd

WITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et

Pharmaceutical Grade CAS 104987-11-3 with competitive price

Cas:104987-11-3

Min.Order:1 Kilogram

FOB Price: $139.0 / 210.0

Type:Trading Company

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Henan Sinotech Import&Export Corporation

Name: Tacrolimus CAS:104987-11-3 MF: C44H69NO12 Appearance:White Powder Storage:Store in cool and dry place, away from sun light. Package:25kg Application:APIS Transportation:By sea or by air Port:Qingdao Port

Tacrolimus CAS:104987-11-3

Cas:104987-11-3

Min.Order:1 Kilogram

FOB Price: $1.0

Type:Other

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Hubei Langyou International Trading Co., Ltd

Our Adwantage: 1.We have stock so we can delivery quickly at the very day when receive the payment. 2.Best price, first class service, high successful delivery rate. A discount would be given when you make a large order. 3.High quality gua

Hangzhou Sartort Biopharma Co., Ltd

Appearance:White powder Storage:Room temperature Package:10g/bag,1kg/bag Application:API Transportation:Express/Sea/Air Port:Any port in china

API Tacrolimus FK-506 99% Manufacturer in China

Cas:104987-11-3

Min.Order:10 Gram

Negotiable

Type:Lab/Research institutions

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Hefei TNJ chemical industry co.,ltd

1. We are one of the domestic largest manufacturers of API; 2. We are always the supplier of products with higher quality and at more competitive price; 3. We are supplier of safe and ecofriendly products ; 4. We provide stable supply and

Manufacturer of Tacrolimus at Factory Price

Cas:104987-11-3

Min.Order:25 Kilogram

Negotiable

Type:Trading Company

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Shanghai Upbio Tech Co.,Ltd

1,In No Less five years exporting experience. 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Onchem specialized in APIs, chemical intermediate

Tacrolimus FK-506 with lower price

Cas:104987-11-3

Min.Order:1 Kilogram

FOB Price: $1.0

Type:Lab/Research institutions

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Xi'an Faithful Biotech Co., Ltd.

We are the manufacturers and suppliers of API in China, and warehouse in Germany and USA of California, which can quickly and safely deliver to your address 1.High quality and competitive price. 2.Free sample for your evaluation. 3.Promptly delivery

Baoji Guokang Healthchem co.,ltd

Our company has been in existence for 10 years since its establishment. We have our own unique team. The company integrates independent research and development, production and sales. We have established famous brands at home and abroad. At present

Tacrolimus

Cas:104987-11-3

Min.Order:1 Kilogram

FOB Price: $80.0 / 100.0

Type:Trading Company

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Qingdao Beluga Import and Export Co., LTD

Beluga chemical professional supply High qualityTacrolimus CAS 104987-11-3 1. Beluga Chemical has a professional RESEARCH and development team and strong technical force to ensure technical support and research capabilities. 2. Made in China and

High qualityTacrolimus CAS 104987-11-3

Cas:104987-11-3

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

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Shanghai Terui OP New Material Technology Co., Ltd.

We have overseas warehouses in California, New Laredo Mexico, Vancouver Canada, Amsterdam Netherlands, and Melbourne Australia. Overseas warehouses can provide some of the best-selling products. We look forward to the cooperation of local powerful

CAS 104987-11-3 Tacrolimus

Cas:104987-11-3

Min.Order:0 Metric Ton

Negotiable

Type:Trading Company

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Synthetic route

C56H97NO12Si2
118977-96-1

C56H97NO12Si2

Tacrolimus
104987-11-3

Tacrolimus

Conditions
ConditionsYield
With hydrogen fluoride In acetonitrile at 20℃; for 0.05h;100%
With hydrogen fluoride; acetonitrile In dichloromethane at 0℃; for 0.0833333h;81%
With hydrogen fluoride In acetonitrile at 20℃;81%
24,33-Bis-(t.butyl-dimethylsilyl)-FK 506
133941-75-0

24,33-Bis-(t.butyl-dimethylsilyl)-FK 506

Tacrolimus
104987-11-3

Tacrolimus

Conditions
ConditionsYield
With hydrogen fluoride In acetonitrile at 50℃; for 0.2h;100%
With hydrogen fluoride In acetonitrile at 20℃; for 2.5h;
14-<(tert-butyldimethylsilyl)oxy>-24,32-bis<(triisopropylsilyl)oxy>-FK506
128685-18-7

14-<(tert-butyldimethylsilyl)oxy>-24,32-bis<(triisopropylsilyl)oxy>-FK506

Tacrolimus
104987-11-3

Tacrolimus

Conditions
ConditionsYield
With hydrogen fluoride In acetonitrile for 18h; Ambient temperature;73%
C66H101NO11Si2
176656-40-9

C66H101NO11Si2

Tacrolimus
104987-11-3

Tacrolimus

Conditions
ConditionsYield
With hydrogen fluoride; 3,3-dimethyldioxirane 1) acetone, CH2Cl2, -45 deg C -> -25 deg C, 1 h; -25 deg C -> 0 deg C, 1 h, 2) MeCN, 6 h; Yield given. Multistep reaction;
C66H101NO12Si2
197250-11-6

C66H101NO12Si2

Tacrolimus
104987-11-3

Tacrolimus

Conditions
ConditionsYield
With hydrogen fluoride In acetonitrile at 20℃; for 10h; Cyclization; desilylation;10.5 mg
C55H95NO13Si2

C55H95NO13Si2

Tacrolimus
104987-11-3

Tacrolimus

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 46 percent / epichlorohydrin / 1,2-dichloro-benzene / 0.05 h / 140 °C
2: 100 percent / aq. HF / acetonitrile / 0.2 h / 50 °C
View Scheme
{1-hydroxy-23,25-dimethoxy-12-[2-(3-methoxy-4-triethylsilanyloxy-cyclohexyl)-1-methyl-vinyl]-13,19,21,27-tetramethyl-2,3,10,16-tetraoxo-14-triethylsilanyloxy-11,28-dioxa-4-aza-tricyclo[22.3.1.04,9]octacos-18-en-17-yl}-acetaldehyde

{1-hydroxy-23,25-dimethoxy-12-[2-(3-methoxy-4-triethylsilanyloxy-cyclohexyl)-1-methyl-vinyl]-13,19,21,27-tetramethyl-2,3,10,16-tetraoxo-14-triethylsilanyloxy-11,28-dioxa-4-aza-tricyclo[22.3.1.04,9]octacos-18-en-17-yl}-acetaldehyde

Tacrolimus
104987-11-3

Tacrolimus

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 43 percent / epichlorohydrin / 1,2-dichloro-benzene / 0.05 h / 140 °C
2: 100 percent / aq. HF / acetonitrile / 0.05 h / 20 °C
View Scheme
C69H107NO12Si2
197250-10-5

C69H107NO12Si2

Tacrolimus
104987-11-3

Tacrolimus

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 100 percent / dimethyl dioxirane / acetone / 2.17 h / -50 - -26 °C
2: 10.5 mg / aq. HF / acetonitrile / 10 h / 20 °C
View Scheme
C72H112INO13Si2

C72H112INO13Si2

Tacrolimus
104987-11-3

Tacrolimus

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: 110 percent / C8K-ZnCl2-AgOAc / tetrahydrofuran / 1 h / 0 °C
2: 100 percent / dimethyl dioxirane / acetone / 2.17 h / -50 - -26 °C
3: 10.5 mg / aq. HF / acetonitrile / 10 h / 20 °C
View Scheme
C72H113NO14Si2

C72H113NO14Si2

Tacrolimus
104987-11-3

Tacrolimus

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: 88 percent / triphenylphosphine; imidazole; iodine / toluene / 0.5 h / 70 °C
2: 110 percent / C8K-ZnCl2-AgOAc / tetrahydrofuran / 1 h / 0 °C
3: 100 percent / dimethyl dioxirane / acetone / 2.17 h / -50 - -26 °C
4: 10.5 mg / aq. HF / acetonitrile / 10 h / 20 °C
View Scheme
C80H121NO15Si2

C80H121NO15Si2

Tacrolimus
104987-11-3

Tacrolimus

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1: 92 percent / DDQ / CH2Cl2; H2O / 0.83 h / 20 °C
2: 88 percent / triphenylphosphine; imidazole; iodine / toluene / 0.5 h / 70 °C
3: 110 percent / C8K-ZnCl2-AgOAc / tetrahydrofuran / 1 h / 0 °C
4: 100 percent / dimethyl dioxirane / acetone / 2.17 h / -50 - -26 °C
5: 10.5 mg / aq. HF / acetonitrile / 10 h / 20 °C
View Scheme
C80H123NO16Si2

C80H123NO16Si2

Tacrolimus
104987-11-3

Tacrolimus

Conditions
ConditionsYield
Multi-step reaction with 6 steps
1: 21.0 mg / Et3N; methyl-2-chloropyridinium iodide / CH2Cl2 / 14 h / 20 °C
2: 92 percent / DDQ / CH2Cl2; H2O / 0.83 h / 20 °C
3: 88 percent / triphenylphosphine; imidazole; iodine / toluene / 0.5 h / 70 °C
4: 110 percent / C8K-ZnCl2-AgOAc / tetrahydrofuran / 1 h / 0 °C
5: 100 percent / dimethyl dioxirane / acetone / 2.17 h / -50 - -26 °C
6: 10.5 mg / aq. HF / acetonitrile / 10 h / 20 °C
View Scheme
C63H93NO13Si

C63H93NO13Si

Tacrolimus
104987-11-3

Tacrolimus

Conditions
ConditionsYield
Multi-step reaction with 6 steps
1: 81 percent / Dess-Martin periodinane / CH2Cl2 / 3 h / Ambient temperature
2: 84 percent / L-Selectride / tetrahydrofuran / 0.5 h / -78 °C
3: 83 percent / I2, PPh3, imidazole / toluene / 0.5 h / 75 °C
4: 74 percent / 1) KHMDS / tetrahydrofuran; toluene / 1) -78 deg C, 30 min, 2) 30 min
5: 67 percent / graphite, potassium, ZnCl2, AgOAc / tetrahydrofuran / 1.5 h / Ambient temperature
6: 1) dimethyldioxirane, 2) 40percent HF / 1) acetone, CH2Cl2, -45 deg C -> -25 deg C, 1 h; -25 deg C -> 0 deg C, 1 h, 2) MeCN, 6 h
View Scheme
C63H92INO12Si

C63H92INO12Si

Tacrolimus
104987-11-3

Tacrolimus

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: 74 percent / 1) KHMDS / tetrahydrofuran; toluene / 1) -78 deg C, 30 min, 2) 30 min
2: 67 percent / graphite, potassium, ZnCl2, AgOAc / tetrahydrofuran / 1.5 h / Ambient temperature
3: 1) dimethyldioxirane, 2) 40percent HF / 1) acetone, CH2Cl2, -45 deg C -> -25 deg C, 1 h; -25 deg C -> 0 deg C, 1 h, 2) MeCN, 6 h
View Scheme
C63H93NO13Si

C63H93NO13Si

Tacrolimus
104987-11-3

Tacrolimus

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: 83 percent / I2, PPh3, imidazole / toluene / 0.5 h / 75 °C
2: 74 percent / 1) KHMDS / tetrahydrofuran; toluene / 1) -78 deg C, 30 min, 2) 30 min
3: 67 percent / graphite, potassium, ZnCl2, AgOAc / tetrahydrofuran / 1.5 h / Ambient temperature
4: 1) dimethyldioxirane, 2) 40percent HF / 1) acetone, CH2Cl2, -45 deg C -> -25 deg C, 1 h; -25 deg C -> 0 deg C, 1 h, 2) MeCN, 6 h
View Scheme
C63H93NO14Si

C63H93NO14Si

Tacrolimus
104987-11-3

Tacrolimus

Conditions
ConditionsYield
Multi-step reaction with 6 steps
1: 47.3 mg / 2-chloro-1-methylpyridinium iodide, NET3 / CH2Cl2 / 6 h / Heating
2: 84 percent / L-Selectride / tetrahydrofuran / 0.5 h / -78 °C
3: 83 percent / I2, PPh3, imidazole / toluene / 0.5 h / 75 °C
4: 74 percent / 1) KHMDS / tetrahydrofuran; toluene / 1) -78 deg C, 30 min, 2) 30 min
5: 67 percent / graphite, potassium, ZnCl2, AgOAc / tetrahydrofuran / 1.5 h / Ambient temperature
6: 1) dimethyldioxirane, 2) 40percent HF / 1) acetone, CH2Cl2, -45 deg C -> -25 deg C, 1 h; -25 deg C -> 0 deg C, 1 h, 2) MeCN, 6 h
View Scheme
C63H95NO14Si

C63H95NO14Si

Tacrolimus
104987-11-3

Tacrolimus

Conditions
ConditionsYield
Multi-step reaction with 7 steps
1: 1) 2-chloro-1-methylpyridinium iodide, NEt3, 2) NEt3 / 1) CH2Cl2, reflux, 17 h, 2) EtOH, 5 h
2: 81 percent / Dess-Martin periodinane / CH2Cl2 / 3 h / Ambient temperature
3: 84 percent / L-Selectride / tetrahydrofuran / 0.5 h / -78 °C
4: 83 percent / I2, PPh3, imidazole / toluene / 0.5 h / 75 °C
5: 74 percent / 1) KHMDS / tetrahydrofuran; toluene / 1) -78 deg C, 30 min, 2) 30 min
6: 67 percent / graphite, potassium, ZnCl2, AgOAc / tetrahydrofuran / 1.5 h / Ambient temperature
7: 1) dimethyldioxirane, 2) 40percent HF / 1) acetone, CH2Cl2, -45 deg C -> -25 deg C, 1 h; -25 deg C -> 0 deg C, 1 h, 2) MeCN, 6 h
View Scheme
C63H91NO13Si

C63H91NO13Si

Tacrolimus
104987-11-3

Tacrolimus

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1: 84 percent / L-Selectride / tetrahydrofuran / 0.5 h / -78 °C
2: 83 percent / I2, PPh3, imidazole / toluene / 0.5 h / 75 °C
3: 74 percent / 1) KHMDS / tetrahydrofuran; toluene / 1) -78 deg C, 30 min, 2) 30 min
4: 67 percent / graphite, potassium, ZnCl2, AgOAc / tetrahydrofuran / 1.5 h / Ambient temperature
5: 1) dimethyldioxirane, 2) 40percent HF / 1) acetone, CH2Cl2, -45 deg C -> -25 deg C, 1 h; -25 deg C -> 0 deg C, 1 h, 2) MeCN, 6 h
View Scheme
C68H105NO15Si

C68H105NO15Si

Tacrolimus
104987-11-3

Tacrolimus

Conditions
ConditionsYield
Multi-step reaction with 12 steps
1: NaHCO3, KBr, 4-methoxy-2,2,6,6-tetramethylpiperidinyloxy free radical, NaOCl / CH2Cl2 / 1.33 h / 0 °C
2: NaH2PO4, NaClO2 / 2-methyl-propan-2-ol; H2O; various solvent(s) / 2 h
3: 495 mg / diethyl ether
4: Dess-Martin periodinane / CH2Cl2 / 1 h
5: LiOH*H2O / tetrahydrofuran / 0.5 h
6: 1) TESOTf, 2,6-lutidine, 2) TBAF, AcOH / 1) CH2Cl2, 0 deg C, 1h, 2) THF, 0 deg C, 1 h
7: 47.3 mg / 2-chloro-1-methylpyridinium iodide, NET3 / CH2Cl2 / 6 h / Heating
8: 84 percent / L-Selectride / tetrahydrofuran / 0.5 h / -78 °C
9: 83 percent / I2, PPh3, imidazole / toluene / 0.5 h / 75 °C
10: 74 percent / 1) KHMDS / tetrahydrofuran; toluene / 1) -78 deg C, 30 min, 2) 30 min
11: 67 percent / graphite, potassium, ZnCl2, AgOAc / tetrahydrofuran / 1.5 h / Ambient temperature
12: 1) dimethyldioxirane, 2) 40percent HF / 1) acetone, CH2Cl2, -45 deg C -> -25 deg C, 1 h; -25 deg C -> 0 deg C, 1 h, 2) MeCN, 6 h
View Scheme
Multi-step reaction with 10 steps
1: NaHCO3, KBr, 4-methoxy-2,2,6,6-tetramethylpiperidinyloxy free radical, NaOCl / CH2Cl2 / 1.33 h / 0 °C
2: NaH2PO4, NaClO2 / 2-methyl-propan-2-ol; H2O; various solvent(s) / 2 h
3: 1) TESOTf, 2,6-lutidine, 2) TBAF, AcOH / 1) CH2Cl2, 0 deg C, 1 h, 2) THF, 0 deg C, 1 h
4: 1) 2-chloro-1-methylpyridinium iodide, NEt3, 2) NEt3 / 1) CH2Cl2, reflux, 17 h, 2) EtOH, 5 h
5: 81 percent / Dess-Martin periodinane / CH2Cl2 / 3 h / Ambient temperature
6: 84 percent / L-Selectride / tetrahydrofuran / 0.5 h / -78 °C
7: 83 percent / I2, PPh3, imidazole / toluene / 0.5 h / 75 °C
8: 74 percent / 1) KHMDS / tetrahydrofuran; toluene / 1) -78 deg C, 30 min, 2) 30 min
9: 67 percent / graphite, potassium, ZnCl2, AgOAc / tetrahydrofuran / 1.5 h / Ambient temperature
10: 1) dimethyldioxirane, 2) 40percent HF / 1) acetone, CH2Cl2, -45 deg C -> -25 deg C, 1 h; -25 deg C -> 0 deg C, 1 h, 2) MeCN, 6 h
View Scheme
C69H106INO12Si2

C69H106INO12Si2

Tacrolimus
104987-11-3

Tacrolimus

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 67 percent / graphite, potassium, ZnCl2, AgOAc / tetrahydrofuran / 1.5 h / Ambient temperature
2: 1) dimethyldioxirane, 2) 40percent HF / 1) acetone, CH2Cl2, -45 deg C -> -25 deg C, 1 h; -25 deg C -> 0 deg C, 1 h, 2) MeCN, 6 h
View Scheme
C68H103NO15Si

C68H103NO15Si

Tacrolimus
104987-11-3

Tacrolimus

Conditions
ConditionsYield
Multi-step reaction with 11 steps
1: NaH2PO4, NaClO2 / 2-methyl-propan-2-ol; H2O; various solvent(s) / 2 h
2: 495 mg / diethyl ether
3: Dess-Martin periodinane / CH2Cl2 / 1 h
4: LiOH*H2O / tetrahydrofuran / 0.5 h
5: 1) TESOTf, 2,6-lutidine, 2) TBAF, AcOH / 1) CH2Cl2, 0 deg C, 1h, 2) THF, 0 deg C, 1 h
6: 47.3 mg / 2-chloro-1-methylpyridinium iodide, NET3 / CH2Cl2 / 6 h / Heating
7: 84 percent / L-Selectride / tetrahydrofuran / 0.5 h / -78 °C
8: 83 percent / I2, PPh3, imidazole / toluene / 0.5 h / 75 °C
9: 74 percent / 1) KHMDS / tetrahydrofuran; toluene / 1) -78 deg C, 30 min, 2) 30 min
10: 67 percent / graphite, potassium, ZnCl2, AgOAc / tetrahydrofuran / 1.5 h / Ambient temperature
11: 1) dimethyldioxirane, 2) 40percent HF / 1) acetone, CH2Cl2, -45 deg C -> -25 deg C, 1 h; -25 deg C -> 0 deg C, 1 h, 2) MeCN, 6 h
View Scheme
Multi-step reaction with 9 steps
1: NaH2PO4, NaClO2 / 2-methyl-propan-2-ol; H2O; various solvent(s) / 2 h
2: 1) TESOTf, 2,6-lutidine, 2) TBAF, AcOH / 1) CH2Cl2, 0 deg C, 1 h, 2) THF, 0 deg C, 1 h
3: 1) 2-chloro-1-methylpyridinium iodide, NEt3, 2) NEt3 / 1) CH2Cl2, reflux, 17 h, 2) EtOH, 5 h
4: 81 percent / Dess-Martin periodinane / CH2Cl2 / 3 h / Ambient temperature
5: 84 percent / L-Selectride / tetrahydrofuran / 0.5 h / -78 °C
6: 83 percent / I2, PPh3, imidazole / toluene / 0.5 h / 75 °C
7: 74 percent / 1) KHMDS / tetrahydrofuran; toluene / 1) -78 deg C, 30 min, 2) 30 min
8: 67 percent / graphite, potassium, ZnCl2, AgOAc / tetrahydrofuran / 1.5 h / Ambient temperature
9: 1) dimethyldioxirane, 2) 40percent HF / 1) acetone, CH2Cl2, -45 deg C -> -25 deg C, 1 h; -25 deg C -> 0 deg C, 1 h, 2) MeCN, 6 h
View Scheme
C68H101NO16Si

C68H101NO16Si

Tacrolimus
104987-11-3

Tacrolimus

Conditions
ConditionsYield
Multi-step reaction with 7 steps
1: 1) TESOTf, 2,6-lutidine, 2) TBAF, AcOH / 1) CH2Cl2, 0 deg C, 1h, 2) THF, 0 deg C, 1 h
2: 47.3 mg / 2-chloro-1-methylpyridinium iodide, NET3 / CH2Cl2 / 6 h / Heating
3: 84 percent / L-Selectride / tetrahydrofuran / 0.5 h / -78 °C
4: 83 percent / I2, PPh3, imidazole / toluene / 0.5 h / 75 °C
5: 74 percent / 1) KHMDS / tetrahydrofuran; toluene / 1) -78 deg C, 30 min, 2) 30 min
6: 67 percent / graphite, potassium, ZnCl2, AgOAc / tetrahydrofuran / 1.5 h / Ambient temperature
7: 1) dimethyldioxirane, 2) 40percent HF / 1) acetone, CH2Cl2, -45 deg C -> -25 deg C, 1 h; -25 deg C -> 0 deg C, 1 h, 2) MeCN, 6 h
View Scheme
C68H103NO16Si

C68H103NO16Si

Tacrolimus
104987-11-3

Tacrolimus

Conditions
ConditionsYield
Multi-step reaction with 10 steps
1: 495 mg / diethyl ether
2: Dess-Martin periodinane / CH2Cl2 / 1 h
3: LiOH*H2O / tetrahydrofuran / 0.5 h
4: 1) TESOTf, 2,6-lutidine, 2) TBAF, AcOH / 1) CH2Cl2, 0 deg C, 1h, 2) THF, 0 deg C, 1 h
5: 47.3 mg / 2-chloro-1-methylpyridinium iodide, NET3 / CH2Cl2 / 6 h / Heating
6: 84 percent / L-Selectride / tetrahydrofuran / 0.5 h / -78 °C
7: 83 percent / I2, PPh3, imidazole / toluene / 0.5 h / 75 °C
8: 74 percent / 1) KHMDS / tetrahydrofuran; toluene / 1) -78 deg C, 30 min, 2) 30 min
9: 67 percent / graphite, potassium, ZnCl2, AgOAc / tetrahydrofuran / 1.5 h / Ambient temperature
10: 1) dimethyldioxirane, 2) 40percent HF / 1) acetone, CH2Cl2, -45 deg C -> -25 deg C, 1 h; -25 deg C -> 0 deg C, 1 h, 2) MeCN, 6 h
View Scheme
Multi-step reaction with 8 steps
1: 1) TESOTf, 2,6-lutidine, 2) TBAF, AcOH / 1) CH2Cl2, 0 deg C, 1 h, 2) THF, 0 deg C, 1 h
2: 1) 2-chloro-1-methylpyridinium iodide, NEt3, 2) NEt3 / 1) CH2Cl2, reflux, 17 h, 2) EtOH, 5 h
3: 81 percent / Dess-Martin periodinane / CH2Cl2 / 3 h / Ambient temperature
4: 84 percent / L-Selectride / tetrahydrofuran / 0.5 h / -78 °C
5: 83 percent / I2, PPh3, imidazole / toluene / 0.5 h / 75 °C
6: 74 percent / 1) KHMDS / tetrahydrofuran; toluene / 1) -78 deg C, 30 min, 2) 30 min
7: 67 percent / graphite, potassium, ZnCl2, AgOAc / tetrahydrofuran / 1.5 h / Ambient temperature
8: 1) dimethyldioxirane, 2) 40percent HF / 1) acetone, CH2Cl2, -45 deg C -> -25 deg C, 1 h; -25 deg C -> 0 deg C, 1 h, 2) MeCN, 6 h
View Scheme
C69H105NO16Si

C69H105NO16Si

Tacrolimus
104987-11-3

Tacrolimus

Conditions
ConditionsYield
Multi-step reaction with 9 steps
1: LiOH*H2O / tetrahydrofuran; H2O / 5 h / Ambient temperature
2: 1) TESOTf, 2,6-lutidine, 2) TBAF, AcOH / 1) CH2Cl2, 0 deg C, 1 h, 2) THF, 0 deg C, 1 h
3: 1) 2-chloro-1-methylpyridinium iodide, NEt3, 2) NEt3 / 1) CH2Cl2, reflux, 17 h, 2) EtOH, 5 h
4: 81 percent / Dess-Martin periodinane / CH2Cl2 / 3 h / Ambient temperature
5: 84 percent / L-Selectride / tetrahydrofuran / 0.5 h / -78 °C
6: 83 percent / I2, PPh3, imidazole / toluene / 0.5 h / 75 °C
7: 74 percent / 1) KHMDS / tetrahydrofuran; toluene / 1) -78 deg C, 30 min, 2) 30 min
8: 67 percent / graphite, potassium, ZnCl2, AgOAc / tetrahydrofuran / 1.5 h / Ambient temperature
9: 1) dimethyldioxirane, 2) 40percent HF / 1) acetone, CH2Cl2, -45 deg C -> -25 deg C, 1 h; -25 deg C -> 0 deg C, 1 h, 2) MeCN, 6 h
View Scheme
Multi-step reaction with 9 steps
1: Dess-Martin periodinane / CH2Cl2 / 1 h
2: LiOH*H2O / tetrahydrofuran / 0.5 h
3: 1) TESOTf, 2,6-lutidine, 2) TBAF, AcOH / 1) CH2Cl2, 0 deg C, 1h, 2) THF, 0 deg C, 1 h
4: 47.3 mg / 2-chloro-1-methylpyridinium iodide, NET3 / CH2Cl2 / 6 h / Heating
5: 84 percent / L-Selectride / tetrahydrofuran / 0.5 h / -78 °C
6: 83 percent / I2, PPh3, imidazole / toluene / 0.5 h / 75 °C
7: 74 percent / 1) KHMDS / tetrahydrofuran; toluene / 1) -78 deg C, 30 min, 2) 30 min
8: 67 percent / graphite, potassium, ZnCl2, AgOAc / tetrahydrofuran / 1.5 h / Ambient temperature
9: 1) dimethyldioxirane, 2) 40percent HF / 1) acetone, CH2Cl2, -45 deg C -> -25 deg C, 1 h; -25 deg C -> 0 deg C, 1 h, 2) MeCN, 6 h
View Scheme
C69H103NO16Si

C69H103NO16Si

Tacrolimus
104987-11-3

Tacrolimus

Conditions
ConditionsYield
Multi-step reaction with 8 steps
1: LiOH*H2O / tetrahydrofuran / 0.5 h
2: 1) TESOTf, 2,6-lutidine, 2) TBAF, AcOH / 1) CH2Cl2, 0 deg C, 1h, 2) THF, 0 deg C, 1 h
3: 47.3 mg / 2-chloro-1-methylpyridinium iodide, NET3 / CH2Cl2 / 6 h / Heating
4: 84 percent / L-Selectride / tetrahydrofuran / 0.5 h / -78 °C
5: 83 percent / I2, PPh3, imidazole / toluene / 0.5 h / 75 °C
6: 74 percent / 1) KHMDS / tetrahydrofuran; toluene / 1) -78 deg C, 30 min, 2) 30 min
7: 67 percent / graphite, potassium, ZnCl2, AgOAc / tetrahydrofuran / 1.5 h / Ambient temperature
8: 1) dimethyldioxirane, 2) 40percent HF / 1) acetone, CH2Cl2, -45 deg C -> -25 deg C, 1 h; -25 deg C -> 0 deg C, 1 h, 2) MeCN, 6 h
View Scheme
C80H133NO15Si3

C80H133NO15Si3

Tacrolimus
104987-11-3

Tacrolimus

Conditions
ConditionsYield
Multi-step reaction with 13 steps
1: 71 percent / TBAF / tetrahydrofuran / 2 h
2: NaHCO3, KBr, 4-methoxy-2,2,6,6-tetramethylpiperidinyloxy free radical, NaOCl / CH2Cl2 / 1.33 h / 0 °C
3: NaH2PO4, NaClO2 / 2-methyl-propan-2-ol; H2O; various solvent(s) / 2 h
4: 495 mg / diethyl ether
5: Dess-Martin periodinane / CH2Cl2 / 1 h
6: LiOH*H2O / tetrahydrofuran / 0.5 h
7: 1) TESOTf, 2,6-lutidine, 2) TBAF, AcOH / 1) CH2Cl2, 0 deg C, 1h, 2) THF, 0 deg C, 1 h
8: 47.3 mg / 2-chloro-1-methylpyridinium iodide, NET3 / CH2Cl2 / 6 h / Heating
9: 84 percent / L-Selectride / tetrahydrofuran / 0.5 h / -78 °C
10: 83 percent / I2, PPh3, imidazole / toluene / 0.5 h / 75 °C
11: 74 percent / 1) KHMDS / tetrahydrofuran; toluene / 1) -78 deg C, 30 min, 2) 30 min
12: 67 percent / graphite, potassium, ZnCl2, AgOAc / tetrahydrofuran / 1.5 h / Ambient temperature
13: 1) dimethyldioxirane, 2) 40percent HF / 1) acetone, CH2Cl2, -45 deg C -> -25 deg C, 1 h; -25 deg C -> 0 deg C, 1 h, 2) MeCN, 6 h
View Scheme
Multi-step reaction with 11 steps
1: 71 percent / TBAF / tetrahydrofuran / 2 h
2: NaHCO3, KBr, 4-methoxy-2,2,6,6-tetramethylpiperidinyloxy free radical, NaOCl / CH2Cl2 / 1.33 h / 0 °C
3: NaH2PO4, NaClO2 / 2-methyl-propan-2-ol; H2O; various solvent(s) / 2 h
4: 1) TESOTf, 2,6-lutidine, 2) TBAF, AcOH / 1) CH2Cl2, 0 deg C, 1 h, 2) THF, 0 deg C, 1 h
5: 1) 2-chloro-1-methylpyridinium iodide, NEt3, 2) NEt3 / 1) CH2Cl2, reflux, 17 h, 2) EtOH, 5 h
6: 81 percent / Dess-Martin periodinane / CH2Cl2 / 3 h / Ambient temperature
7: 84 percent / L-Selectride / tetrahydrofuran / 0.5 h / -78 °C
8: 83 percent / I2, PPh3, imidazole / toluene / 0.5 h / 75 °C
9: 74 percent / 1) KHMDS / tetrahydrofuran; toluene / 1) -78 deg C, 30 min, 2) 30 min
10: 67 percent / graphite, potassium, ZnCl2, AgOAc / tetrahydrofuran / 1.5 h / Ambient temperature
11: 1) dimethyldioxirane, 2) 40percent HF / 1) acetone, CH2Cl2, -45 deg C -> -25 deg C, 1 h; -25 deg C -> 0 deg C, 1 h, 2) MeCN, 6 h
View Scheme
(9RS,22S)-14-<(tert-butyldimethylsilyl)oxy>-9,22-tetrahydro-24,32-bis<(triisopropylsilyl)oxy>-FK506
128685-16-5, 128777-66-2

(9RS,22S)-14-<(tert-butyldimethylsilyl)oxy>-9,22-tetrahydro-24,32-bis<(triisopropylsilyl)oxy>-FK506

Tacrolimus
104987-11-3

Tacrolimus

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 82 percent / Dess-Martin periodinane / CH2Cl2 / 15 h / Ambient temperature
2: 73 percent / aq. HF / acetonitrile / 18 h / Ambient temperature
View Scheme
tacrolimus

tacrolimus

Tacrolimus
104987-11-3

Tacrolimus

Conditions
ConditionsYield
With polymer resin accoring to the invention In methanol; acetone`; water Purification / work up;
triisopropylsilyl trifluoromethanesulfonate
80522-42-5

triisopropylsilyl trifluoromethanesulfonate

Tacrolimus
104987-11-3

Tacrolimus

C62H109NO12Si2
123747-39-7

C62H109NO12Si2

Conditions
ConditionsYield
With 2,6-dimethylpyridine In dichloromethane 1) 0 deg C, 1,5 h, 2) 25 deg C, 16 h;99%
Tacrolimus
104987-11-3

Tacrolimus

2-propenamide
79-06-1

2-propenamide

C45H70N2O13
1190108-68-9

C45H70N2O13

Conditions
ConditionsYield
With tricyclohexylphosphine[1,3-bis(2,4,6-trimethylphenyl)-4,5-dihydroimidazol-2-ylidine][benzylidene]ruthenium(II) dichloride In 1,2-dichloro-benzene at 150℃; for 0.0833333h; olefin cross-metathesis reaction; Microwave irradiation; Inert atmosphere;99%
Tacrolimus
104987-11-3

Tacrolimus

acrylic acid
79-10-7

acrylic acid

C45H69NO14
1190108-69-0

C45H69NO14

Conditions
ConditionsYield
With tricyclohexylphosphine[1,3-bis(2,4,6-trimethylphenyl)-4,5-dihydroimidazol-2-ylidine][benzylidene]ruthenium(II) dichloride In 1,2-dichloro-benzene at 150℃; for 0.0833333h; olefin cross-metathesis reaction; Microwave irradiation; Inert atmosphere;99%
With Hoveyda-Grubbs catalyst second generation In 1,2-dichloro-ethane at 85℃; for 1h; Inert atmosphere; Sealed tube; Microwave irradiation;96%
With Hoveyda-Grubbs catalyst second generation In 1,2-dichloro-ethane at 85℃; for 1h; Inert atmosphere; Sealed tube;96%
Conditions
ConditionsYield
With 2,2-dimethoxy-2-phenylacetophenone In dichloromethane for 0.25h; UV-irradiation;99%
2-[(tert-butoxycarbonyl)amino]-1-ethanethiol
67385-09-5

2-[(tert-butoxycarbonyl)amino]-1-ethanethiol

Tacrolimus
104987-11-3

Tacrolimus

C51H84N2O14S

C51H84N2O14S

Conditions
ConditionsYield
With 2,2-dimethoxy-2-phenylacetophenone In dichloromethane at 20℃; for 0.25h; Solvent; Reagent/catalyst; UV-irradiation;98%
With 2,2-dimethoxy-2-phenylacetophenone In dichloromethane at 23℃; for 0.25h; Inert atmosphere; Irradiation;96%
With 2,2-dimethoxy-2-phenylacetophenone In dichloromethane at 23℃; for 0.25h; UV-irradiation; Inert atmosphere;96%
Tacrolimus
104987-11-3

Tacrolimus

3-mercaptopropionic acid
107-96-0

3-mercaptopropionic acid

C47H75NO14S

C47H75NO14S

Conditions
ConditionsYield
With 2,2-dimethoxy-2-phenylacetophenone In dichloromethane for 0.25h; Reagent/catalyst; UV-irradiation;98%
methanol
67-56-1

methanol

Tacrolimus
104987-11-3

Tacrolimus

C45H73NO13
133523-40-7

C45H73NO13

Conditions
ConditionsYield
With zinc(II) chloride for 3h; Ambient temperature;97%
for 3h; Heating;82%
Tacrolimus
104987-11-3

Tacrolimus

acrylic acid methyl ester
292638-85-8

acrylic acid methyl ester

C46H71NO14

C46H71NO14

Conditions
ConditionsYield
With tricyclohexylphosphine[1,3-bis(2,4,6-trimethylphenyl)-4,5-dihydroimidazol-2-ylidine][benzylidene]ruthenium(II) dichloride In 1,2-dichloro-benzene at 150℃; for 0.0833333h; olefin cross-metathesis reaction; Microwave irradiation; Inert atmosphere;97%
Tacrolimus
104987-11-3

Tacrolimus

tert-butyldimethylsilyl chloride
18162-48-6

tert-butyldimethylsilyl chloride

24,33-Bis-(t.butyl-dimethylsilyl)-FK 506
133941-75-0

24,33-Bis-(t.butyl-dimethylsilyl)-FK 506

Conditions
ConditionsYield
With 1H-imidazole In N,N-dimethyl-formamide96.7%
With 1H-imidazole In N,N-dimethyl-formamide Ambient temperature;
Tacrolimus
104987-11-3

Tacrolimus

Cysteamine
60-23-1

Cysteamine

C46H76N2O12S

C46H76N2O12S

Conditions
ConditionsYield
With 2,2-dimethoxy-2-phenylacetophenone In methanol for 0.25h; UV-irradiation;96%
Tacrolimus
104987-11-3

Tacrolimus

acrylic acid
79-10-7

acrylic acid

C45H69NO14

C45H69NO14

Conditions
ConditionsYield
With Hoveyda-Grubbs catalyst second generation In 1,2-dichloro-ethane at 85℃; for 1h; Inert atmosphere; Microwave irradiation;96%
t-butyldimethylsiyl triflate
69739-34-0

t-butyldimethylsiyl triflate

Tacrolimus
104987-11-3

Tacrolimus

24,33-Bis-(t.butyl-dimethylsilyl)-FK 506
133941-75-0

24,33-Bis-(t.butyl-dimethylsilyl)-FK 506

Conditions
ConditionsYield
With 2,6-dimethylpyridine In dichloromethane at 0℃; for 1h; Inert atmosphere;95%
C6H12N4OS
1277177-82-8

C6H12N4OS

Tacrolimus
104987-11-3

Tacrolimus

C50H81N5O13S

C50H81N5O13S

Conditions
ConditionsYield
With 2,2-dimethoxy-2-phenylacetophenone In dichloromethane for 0.25h; UV-irradiation;95%
L-Cysteine
52-90-4

L-Cysteine

Tacrolimus
104987-11-3

Tacrolimus

C47H76N2O14S

C47H76N2O14S

Conditions
ConditionsYield
With 2,2-dimethoxy-2-phenylacetophenone In methanol; water for 0.25h; UV-irradiation;95%
With 2,2-dimethoxy-2-phenylacetophenone In methanol; water at 23℃; for 0.25h; Inert atmosphere; UV-irradiation;92%
succinic acid anhydride
108-30-5

succinic acid anhydride

Tacrolimus
104987-11-3

Tacrolimus

C48H73NO15

C48H73NO15

Conditions
ConditionsYield
With Novozym SP435 In toluene at 45℃; for 80h; Inert atmosphere; Schlenk technique;95%
Conditions
ConditionsYield
With L-Selectride In tetrahydrofuran at -78℃; for 1.5h;90%
With tetramethylammonium triacetoxyborohydride In acetic acid; acetonitrile at -5 - 0℃; for 5h;25%
Multi-step reaction with 3 steps
1: imidazole / dimethylformamide
2: 66 percent / tetramethylammonium triacetoxyborohydride / acetonitrile; acetic acid / 5 h / -5 - 0 °C
3: 87 percent / 40percent aq. HF / acetonitrile / 2 h / 10 °C
View Scheme
Tacrolimus
104987-11-3

Tacrolimus

acryloyl chloride
814-68-6

acryloyl chloride

C45H68ClNO13
1190108-71-4

C45H68ClNO13

Conditions
ConditionsYield
With tricyclohexylphosphine[1,3-bis(2,4,6-trimethylphenyl)-4,5-dihydroimidazol-2-ylidine][benzylidene]ruthenium(II) dichloride In isopropyl alcohol at 150℃; for 0.0833333h; olefin cross-metathesis reaction; Microwave irradiation; Inert atmosphere;88%
Tacrolimus
104987-11-3

Tacrolimus

C45H71NO12
133941-69-2

C45H71NO12

Conditions
ConditionsYield
palladium diacetate In dichloromethane Ambient temperature;87%
4-bromo-N-methylaniline
6911-87-1

4-bromo-N-methylaniline

Tacrolimus
104987-11-3

Tacrolimus

C51H76N2O12

C51H76N2O12

Conditions
ConditionsYield
With palladium diacetate; potassium carbonate; triethylamine; tris-(o-tolyl)phosphine In N,N-dimethyl-formamide at 100℃; for 20h; Inert atmosphere; Schlenk technique;82%
With palladium diacetate; triethylamine; tris-(o-tolyl)phosphine In N,N-dimethyl-formamide at 100℃; for 20h; Heck Reaction; Inert atmosphere; Schlenk technique;62%
methanol
67-56-1

methanol

Tacrolimus
104987-11-3

Tacrolimus

C45H71NO13
124125-40-2

C45H71NO13

Conditions
ConditionsYield
With lead(IV) acetate81%
Tacrolimus
104987-11-3

Tacrolimus

(E)-(1R,9S,12S,13R,14S,17R,21S,23S,24R,25S,27R)-17-Allyl-12-[(E)-2-((1R,3R,4R)-3,4-dimethoxy-cyclohexyl)-1-methyl-vinyl]-1-hydroxy-14,23,25-trimethoxy-13,19,21,27-tetramethyl-11,28-dioxa-4-aza-tricyclo[22.3.1.04,9]octacos-18-ene-2,3,10,16-tetraone
124554-15-0

(E)-(1R,9S,12S,13R,14S,17R,21S,23S,24R,25S,27R)-17-Allyl-12-[(E)-2-((1R,3R,4R)-3,4-dimethoxy-cyclohexyl)-1-methyl-vinyl]-1-hydroxy-14,23,25-trimethoxy-13,19,21,27-tetramethyl-11,28-dioxa-4-aza-tricyclo[22.3.1.04,9]octacos-18-ene-2,3,10,16-tetraone

Conditions
ConditionsYield
With boron trifluoride diethyl etherate In dichloromethane at 0 - 5℃;80%
Tacrolimus
104987-11-3

Tacrolimus

(E)-(8S,11S,12R,13S,16R,20S,22S,23R,24S,26R)-16-Allyl-1,13-dihydroxy-11-[(E)-2-((1R,3R,4R)-4-hydroxy-3-methoxy-cyclohexyl)-1-methyl-vinyl]-22,24-dimethoxy-12,18,20,26-tetramethyl-10,28-dioxa-3-aza-tricyclo[21.4.1.03,8]octacos-17-ene-2,9,15,27-tetraone

(E)-(8S,11S,12R,13S,16R,20S,22S,23R,24S,26R)-16-Allyl-1,13-dihydroxy-11-[(E)-2-((1R,3R,4R)-4-hydroxy-3-methoxy-cyclohexyl)-1-methyl-vinyl]-22,24-dimethoxy-12,18,20,26-tetramethyl-10,28-dioxa-3-aza-tricyclo[21.4.1.03,8]octacos-17-ene-2,9,15,27-tetraone

Conditions
ConditionsYield
With zinc(II) chloride In dichloromethane for 15h; Ambient temperature;80%
4-ethenylbenzoic acid
1075-49-6

4-ethenylbenzoic acid

Tacrolimus
104987-11-3

Tacrolimus

C51H73NO14
1190108-85-0

C51H73NO14

Conditions
ConditionsYield
With tricyclohexylphosphine[1,3-bis(2,4,6-trimethylphenyl)-4,5-dihydroimidazol-2-ylidine][benzylidene]ruthenium(II) dichloride In 1,2-dichloro-benzene at 150℃; for 0.0833333h; olefin cross-metathesis reaction; Microwave irradiation; Inert atmosphere;79%
4-vinyl benzylamine
1520-21-4

4-vinyl benzylamine

Tacrolimus
104987-11-3

Tacrolimus

C50H74N2O12
1190108-83-8

C50H74N2O12

Conditions
ConditionsYield
With tricyclohexylphosphine[1,3-bis(2,4,6-trimethylphenyl)-4,5-dihydroimidazol-2-ylidine][benzylidene]ruthenium(II) dichloride In 1,2-dichloro-benzene at 150℃; for 0.0833333h; olefin cross-metathesis reaction; Microwave irradiation; Inert atmosphere;79%
Tacrolimus
104987-11-3

Tacrolimus

3-fluoro-4-iodopyridine
22282-75-3

3-fluoro-4-iodopyridine

C49H71FN2O12

C49H71FN2O12

Conditions
ConditionsYield
With palladium diacetate; triethylamine; tris-(o-tolyl)phosphine In N,N-dimethyl-formamide at 100℃; for 24h; Heck Reaction; Inert atmosphere; Schlenk technique;78%
trimethylsilyl cyanide
7677-24-9

trimethylsilyl cyanide

Tacrolimus
104987-11-3

Tacrolimus

C45H70N2O12
133523-41-8

C45H70N2O12

Conditions
ConditionsYield
With potassium cyanide; 18-crown-6 ether In benzene at 23℃; for 20h;76%
Tacrolimus
104987-11-3

Tacrolimus

(3R,5S,6R)-6-[(5E,13E)-(1S,3S,7R,10S,11R,12S)-7-Allyl-10,12-dihydroxy-14-((1R,3R,4R)-4-hydroxy-3-methoxy-cyclohexyl)-1-methoxy-3,5,11,13-tetramethyl-8-oxo-tetradeca-5,13-dienyl]-5-methoxy-3-methyl-tetrahydro-pyran-2-one

(3R,5S,6R)-6-[(5E,13E)-(1S,3S,7R,10S,11R,12S)-7-Allyl-10,12-dihydroxy-14-((1R,3R,4R)-4-hydroxy-3-methoxy-cyclohexyl)-1-methoxy-3,5,11,13-tetramethyl-8-oxo-tetradeca-5,13-dienyl]-5-methoxy-3-methyl-tetrahydro-pyran-2-one

Conditions
ConditionsYield
With tetra-n-butylammonium cyanide In tetrahydrofuran; water at 5℃; for 2h;76%

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