Fluocinonide 356-12-7

Superiority:

The Fluocinolide with CAS registry number of 356-12-7 is also known as Topsymin. The systematic name is 2-[(4aS,4bR,5S,6aS,6bS,9aR,10aS,10bS,12S)-4b,12-Difluoro-5-hydroxy-4a,6a,8,8-tetramethyl-2-oxo-2,4a,4b,5,6,6a,9a,10,10a,10b,11,12-dodecahydro-6bH-naphtho[2',1':4,5]indeno[1,2-d][1,3]dioxol-6b-yl]-2-ox oethyl acetate. It belongs to product categories of Steroids. Its EINECS registry number is 206-597-6 . In addition, the formula is C26H32F2O7 and the molecular weight is 494.52. This chemical is a white crystalline powder and used for atopic dermatitis, eczema and so on.

Physical properties about Fluocinolide are:

 (1)ACD/LogP: 3.36;

 (2)# of Rule of 5 Violations: 0;

(3)ACD/LogD (pH 5.5): 3.36;

(4)ACD/LogD (pH 7.4): 3.36;

(5)ACD/BCF (pH 5.5): 209.69;

(6)ACD/BCF (pH 7.4): 209.69;

(7)ACD/KOC (pH 5.5): 1597.31;

(8)ACD/KOC (pH 7.4): 1597.3;

(9)#H bond acceptors: 7;

 (10)#H bond donors: 1;

(11)#Freely Rotating Bonds: 5;

(12)Index of Refraction: 1.56;

 (13)Molar Refractivity: 119.09 cm3;

(14)Molar Volume: 368 cm3;

 (15)Surface Tension: 49.9 dyne/cm;

 (16)Density: 1.34 g/cm3;

(17)Flash Point: 311.3 °C;

(18)Enthalpy of Vaporization: 101.2 kJ/mol;

 (19)Boiling Point: 591.1 °C at 760 mmHg;

(20)Vapour Pressure: 1.97E-16 mmHg at 25 °C.

Preparation of Fluocinolide: it is prepared by reaction of acetic acid anhydride with fluocinolon-acetonid. The reaction needs reagent trimethylsilyl trifluoromethanesulfonate and solvent CH2Cl2 at the temperature of 20 °C for 5 minutes. The yield is about 100%.