356-12-7Relevant articles and documents
Preparation of high specific activity tritium labeled 6α,9,-difluoro- 11 β,21-dihydroxy- 16α,17-[(1-methylethylidene)bis(oxy)]pregna- 1,4-diene-3,20-one, fluocinolone acetonide
Zhong,Lewin, Anita H.
, p. 103 - 109 (2009)
Fluocinolone acetonide was tritiated by selective reduction of the 1,2-double bond of the O-protected analog under tritium, followed by re-establishment of the 1,2-double bond and deprotection. Protection of both hydroxyl functionalities was required. The product was obtained with specific activity 36.8Ci/mmol. Copyright
Synthesis method and application of 9-fluorosteroid compound
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Paragraph 0089-0096, (2021/01/15)
The invention provides a synthesis method and application of a 9-fluorosteroid compound, and relates to the technical field of chemical synthesis. The synthesis method of the 9-fluorosteroid compoundcomprises the following step: reacting a compound II in an ionic liquid containing hydrogen fluoride salt to obtain a 9-fluorosteroid compound III. According to the synthesis method of the 9-fluorosteroid compound, the ionic liquid containing the hydrogen fluoride salt is used as a fluorinating agent to replace a traditional hydrogen fluoride aqueous solution, volatilization of hydrogen fluoride gas is avoided, corrosivity is small, toxicity is greatly reduced, reaction conditions are mild, reaction can be completed at the room temperature, operability is high, the safety coefficient is high,and production applicability is improved. The synthesis method of the 9-fluorosteroid compound is used for preparing corticosteroid drugs, highly toxic chemical reagents are not used in the synthesisroute, the operability is high, the safety coefficient is high, and the production applicability is improved.
Preparation method of fluocinonide
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Paragraph 0008; 0140-0146, (2018/09/21)
The invention relates to a preparation method of fluocinonide, in particular to preparation of fluocinonide. The preparation method of the fluocinonide comprises the following steps: taking chloride as an initiator; and successively carrying out 9,11-epoxy, 1,2-dehydrogenation, 17-dehydration, 6-fluorination, 9,11-ring-opening, 16,17-position double-bond dihydroxy oxidation, 21-position esterification and 16,17-position condensation to obtain the fluocinonide. The novel process has high industrial value, side effects can be controlled effectively, and reaction yield and quality are improved; high-risk reaction is not involved in technological design, and industrialization is easy to implement; and high-pollution reaction does not exist, and environmental protection treatment pressure is relieved.