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Dayang Chem (Hangzhou) Co.,Ltd.

DayangChem exported this product to many countries and regions at best price. If you are looking for the material's manufacturer or supplier in China, DayangChem is your best choice. Pls contact with us freely for getting detailed product spe

Flurbiprofen Manufacturer/High quality/Best price/In stock

Cas:5104-49-4

Min.Order:1 Kilogram

FOB Price: $3.0

Type:Lab/Research institutions

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Hangzhou Dingyan Chem Co., Ltd

flurbiprofen 5104-49-4 Items Standard Result Description White or almost white crystalline powder Conforms

flurbiprofen 5104-49-4

Cas:5104-49-4

Min.Order:1 Gram

Negotiable

Type:Manufacturers

inquiry

Kono Chem Co.,Ltd

Flurbiprofen Introduction Flurbiprofen is a propionic acid non-steroidal anti-inflammatory medicine. It mainly acts by inhibiting prostaglandin synthase, and has analgesic, anti-inflammatory and antipyretic effects. Flurbiprofen'

Flurbiprofen CAS 5104-49-4

Cas:5104-49-4

Min.Order:1 Kilogram

FOB Price: $800.0 / 1050.0

Type:Other

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Wuhan Fortuna Chemical Co.,Ltd

Flurbiprofen CAS 5104-49-4 Company profile Wuhan Fortuna Chemical Co.,Ltd established in 2006, is a big integrative chemical enterprise being engaged in Pharmaceutical & its intermediates, Food/Feed additives, Fine chemicals in distributing

Flurbiprofen CAS 5104-49-4

Cas:5104-49-4

Min.Order:10 Kilogram

FOB Price: $10.0

Type:Trading Company

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Xi'an Quanao Biotech Co., Ltd.

Xi’an Quanao Biotech Co., Ltd. with 18 years experience in plant extract filed. Product grade: Medicine, Health care product, Cosmetics, Food, Beverage, Feed. Hot selling market: Europe, North America, South America, Middle East, Asia Pacifi

High quality 99% Flurbiprofen powder CAS:5104-49-4

Cas:5104-49-4

Min.Order:50 Gram

FOB Price: $0.7 / 0.9

Type:Manufacturers

inquiry

Hefei TNJ chemical industry co.,ltd

APIs Appearance:White Crystalline Powder Storage:Store at RT Package:25kg/drum or acc to customers' request Application:(R)-2-Flurbiprofen is the R-isomer of Flurbiprofen (F598700), an anti-inflammatory used as an analgesic. Transportation:acc to c

Good quality Flurbiprofen

Cas:5104-49-4

Min.Order:1 Kilogram

Negotiable

Type:Trading Company

inquiry

Henan Allgreen Chemical Co.,Ltd

The company has a professional R & D team, mature technology, very competitive prices and stable high quality products for customers to order high quality and low price product efforts! Appearance:White or off-white Solid Storage:Sealed, dry, m

Flurbiprofen(Ansaid)

Cas:5104-49-4

Min.Order:1 Kilogram

Negotiable

Type:Manufacturers

inquiry

Ality Chemical Corporation

The above product is Ality Chemical's strong item with best price, good quality and fast supply. Ality Chemical has been focusing on the research and production of this field for over 14 years. At the same time, we are always committed to providi

Factory Supply Flurbiprofen

Cas:5104-49-4

Min.Order:1

Negotiable

Type:Other

inquiry

Xi'an Xszo Chem Co., Ltd.

1. Factory price and high quality must be guaranteed, base on 8 years of production and R&D experience2. Free samples will be provided,ensure specifications and quality are right for customer3. Customers will receive the most professional technical s

Factory Price API 99% Flurbiprofen 5104-49-4 GMP Manufacturer

Cas:5104-49-4

Min.Order:1 Gram

FOB Price: $0.1

Type:Manufacturers

inquiry

Xi`an Eastling Biotech Co., Ltd.

5104-49-4 - Physico-chemical Properties Molecular Formula C15H13FO2 Molar Mass 244.26 Density 1.199±0.06 g/cm3(Predicted) Melting Point 110-113°C(lit.) Boling Point 376.2±

Factory high quality Flurbiprofen

Cas:5104-49-4

Min.Order:1 Gram

FOB Price: $159.0 / 170.0

Type:Lab/Research institutions

inquiry

Shanghai Seasonsgreen Chemical Co.,Ltd

Shanghai Seasonsgreen Chemical is a high-tech research and development, production, sale and custom synthesis set in one high-tech chemical products enterprises. Our sales and marketing division is located in Shanghai, serving international pharmaceu

lower price High quality Flurbiprofen

Cas:5104-49-4

Min.Order:1 Kilogram

FOB Price: $1.0

Type:Manufacturers

inquiry

LIDE PHARMACEUTICALS LIMITED

LIDE PHARMACEUTICALS LIMITED is a professional chemicals and APIs leading manufacturer in China. Our core business line covers APIs, Intermediates, Herb extract, etc.

Flurbiprofen

Cas:5104-49-4

Min.Order:1 Kilogram

FOB Price: $0.9 / 1.0

Type:Lab/Research institutions

inquiry

Henan Tianfu Chemical Co., Ltd.

Our company was built in 2009 with an ISO certificate.In the past 5 years, we have grown up as a famous fine chemicals supplier in China and we had established stable business relationships with Samsung,LG,Merck,Thermo Fisher Scientific and so on.O

Flurbiprofen,5104-49-4

Cas:5104-49-4

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Hebei Nengqian Chemical Import and Export Co., LTD

With our good experience, we offer detailed technical support and advice to assist customers. We communicate closely with customers to establish their quality requirements. Consistent Quality Our plant has strict quality control in each manufacturin

Antipyretic Analgesics CAS 5104-49-4 Flurbiprofen

Cas:5104-49-4

Min.Order:1 Gram

FOB Price: $6.0 / 9.0

Type:Trading Company

inquiry

Zhuozhou Wenxi import and Export Co., Ltd

WITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et

New production CAS 5104-49-4 with best quality

Cas:5104-49-4

Min.Order:1 Kilogram

FOB Price: $139.0 / 210.0

Type:Trading Company

inquiry

Wuhan Han Sheng New Material Technology Co.,Ltd

Our Advantage: high quality with competitive price High quality standard: BP/USP/EP Enterprise standard All purity customized Fast and safe delivery We have reliable forwarder who can help us deliver our goods more fast and safe. We

High quality Flurbiprofen

Cas:5104-49-4

Min.Order:10 Kilogram

Negotiable

Type:Trading Company

inquiry

Henan Sinotech Import&Export Corporation

Name Flurbiprofen CAS No. 5104-49-4 EINECS 225-827-6 MF C15H13FO2 MW 244.26 Storage temp. Store at RT MP

Flurbiprofen

Cas:5104-49-4

Min.Order:1 Kilogram

FOB Price: $1.0

Type:Other

inquiry

Henan Wentao Chemical Product Co., Ltd.

We are leading fine chemicals supplier in China with ISO certificate, Our main business covers the fields below: 1.Noble Metal Catalysts (Pt.Pd...) 2.Organic Phosphine Ligands (Tert-butyl-phosphine.Cyclohexyl-phosphine...) 3.OLED

[1,1'-Biphenyl]-4-aceticacid, 2-fluoro-a-methyl-CAS NO.: 5104-49-4

Cas:5104-49-4

Min.Order:1 Gram

FOB Price: $2.0

Type:Lab/Research institutions

inquiry

Shanghai Upbio Tech Co.,Ltd

1,In No Less five years exporting experience. 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Onchem (China) Co.,Ltd is Specia

High quality Flurbiprofen

Cas:5104-49-4

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Xi'an Faithful Biotech Co., Ltd.

We are the manufacturers and suppliers of API in China, and warehouse in Germany and USA of California, which can quickly and safely deliver to your address 1.High quality and competitive price. 2.Free sample for your evaluation. 3.Promptly delivery

Baoji Guokang Healthchem co.,ltd

Our company has been in existence for 10 years since its establishment. We have our own unique team. The company integrates independent research and development, production and sales. We have established famous brands at home and abroad. At present

Flurbiprofen Non-steroidal anti-inflammatory drugs

Cas:5104-49-4

Min.Order:1 Kilogram

FOB Price: $105.0 / 120.0

Type:Trading Company

inquiry

Qingdao Beluga Import and Export Co., LTD

Flurbiprofen CAS:5104-49-4 Qingdao Belugas Import and Export Co., Ltd. is a scientific and technological company integrating research and development, production and trade of chemical intermediates, specializing in high quality organic intermediates

Flurbiprofen CAS:5104-49-4

Cas:5104-49-4

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Shandong Hanjiang Chemical Co., Ltd.

Hello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by emai

Flurbiprofen Powder USP Standard

Cas:5104-49-4

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Wuhan Wonda Pharm Limited

1.high quality: quality is life. quality is the most important element for all goods. we have a lab doing research in wuhan china. hplc and nmr is available if needed. 2.reasonable price: we provide high quality products with competi

Factory Sell 99% Purity Flurbiprofen Powder

Cas:5104-49-4

Min.Order:10 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Hebei Mojin Biotechnology Co.,Ltd

Product quality: Our company have high quality product , and also the product we have good manufacture . First of all, this product is of fine quality. Every finish should be checked by quality inspection system.And every one should be also tried

CAS 5104-49-4 Flurbiprofen

Cas:5104-49-4

Min.Order:1 Metric Ton

FOB Price: $11000.0 / 12000.0

Type:Trading Company

inquiry

Hebei Quanhe Biotechnology Co. LTD

1. Timely and efficient service to ensure communication with customers 2. Produce products of different specifications and sizes according to your requirements. 3. Quality procedures and standards recognized by SGS. Advanced plant equipment ensures s

Flurbiprofen

Cas:5104-49-4

Min.Order:1 Kilogram

FOB Price: $40.0 / 60.0

Type:Lab/Research institutions

inquiry

Triumph International Development Limilted

Triumph has the complete production of G- KG - MT service chain,we can make the new technology into productivity quickly in the research and development of new products. Main Service 1.Own made fine chemical products 2.Out sourcing and quality c

(2R)-2-(3-fluoro-4-phenyl-phenyl)propanoic acid

Cas:5104-49-4

Min.Order:100 Metric Ton

Negotiable

Type:Lab/Research institutions

inquiry

Afine Chemicals Limited

Our Services 1. New Molecules R&D 2. Own test center HPLC NMR GC LC-MS 3. API and Intermediates from China reputed manufacturers 4. Documents support COA MOA MSDS DMF open part Our advantages 1. Government awarded company. Top 100 enter

Flurbiprofen

Cas:5104-49-4

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Zhengzhou Yuanli Biological Technology Co., Ltd.

ProName: 5104-49-4 flurbiprofen 99% YL CasNo: 5104-49-4 Molecular Formula: C15H13FO2 Appearance: White fine crystalline powder. Application: Intermediates. DeliveryTime:Have stock. Processing period:1 kg/12 weeks. PackAge: 25 kg/barrel.

5104-49-4 flurbiprofen 99% YL

Cas:5104-49-4

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Hubei Yuanmeng Biological Technology Co., Ltd.

Hubei Yuanmeng Biological Technology Co., Ltd., which is located in Wuhan, China. We are specializing in the exportation of APIs, and plant extracts ect. Our products has been exported to America, Australia, Brazil, the Europe, Middle East and other

High Purity Flurbiprofen CAS 5104-49-4

Cas:5104-49-4

Min.Order:1 Kilogram

FOB Price: $3.0 / 5.0

Type:Trading Company

inquiry

Synthetic route

methyl 2-(2-fluoro-4-biphenylyl)propionate
113544-38-0, 113544-39-1, 114376-61-3, 66202-86-6

methyl 2-(2-fluoro-4-biphenylyl)propionate

fluorobiprofen
5104-49-4

fluorobiprofen

Conditions
ConditionsYield
With sulfuric acid; water In 1,4-dioxane at 120℃; for 4h; Inert atmosphere;99%
With potassium hydroxide In ethanol75%
With sodium hydroxide
C12H16FNO5S
1201594-47-9

C12H16FNO5S

phenylboronic acid
98-80-6

phenylboronic acid

fluorobiprofen
5104-49-4

fluorobiprofen

Conditions
ConditionsYield
Stage #1: C12H16FNO5S; phenylboronic acid With potassium phosphate; bis(tricyclohexylphosphine)nickel(II) dichloride In toluene at 130℃; for 24h; Suzuki-Miyaura coupling reaction; Inert atmosphere;
Stage #2: With sulfuric acid In 1,4-dioxane; water at 100℃; for 6h;
99%
α-methyl-(2-fluoro-4-biphenylyl)acetonitrile
74648-00-3

α-methyl-(2-fluoro-4-biphenylyl)acetonitrile

fluorobiprofen
5104-49-4

fluorobiprofen

Conditions
ConditionsYield
With sodium hydroxide In ethanol; water at 110℃; for 5h;99%
With sodium hydroxide In ethanol; water at 110℃; for 7h; Inert atmosphere;84%
Stage #1: α-methyl-(2-fluoro-4-biphenylyl)acetonitrile With sodium hydroxide In ethanol; water for 5h; Inert atmosphere; Reflux;
Stage #2: With sulfuric acid In ethanol; water at 20℃; Inert atmosphere;
82%
With sulfuric acid In water at 100℃; for 3h;
3-(2-fluorobiphenyl-4-yl)butan-2-one
72625-13-9

3-(2-fluorobiphenyl-4-yl)butan-2-one

fluorobiprofen
5104-49-4

fluorobiprofen

Conditions
ConditionsYield
With sodium hypochlorite at 70℃; for 0.25h;95%
4-bromo-3-fluoro α-methylphenylacetic acid

4-bromo-3-fluoro α-methylphenylacetic acid

phenylboronic acid
98-80-6

phenylboronic acid

fluorobiprofen
5104-49-4

fluorobiprofen

Conditions
ConditionsYield
With palladium on activated charcoal; sodium carbonate In water for 6h; Reflux;94.98%
With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium carbonate In ethanol; water; toluene for 6h; Concentration; Reagent/catalyst; Suzuki Coupling; Inert atmosphere; Reflux;81.7 g
2-(2-fluoro-[1,1'-biphenyl]-4-yl)acetic acid
5001-96-7

2-(2-fluoro-[1,1'-biphenyl]-4-yl)acetic acid

methyl iodide
74-88-4

methyl iodide

fluorobiprofen
5104-49-4

fluorobiprofen

Conditions
ConditionsYield
Stage #1: 2-(2-fluoro-[1,1'-biphenyl]-4-yl)acetic acid With lithium hexamethyldisilazane In tetrahydrofuran at 20℃; for 0.333333h; Inert atmosphere;
Stage #2: methyl iodide In tetrahydrofuran at 20℃; for 0.333333h; Inert atmosphere;
77%
With potassium tert-butylate; lithium diisopropyl amide 1.) THF, hexane, -25 deg C, 2 h; Yield given; Multistep reaction;
Stage #1: 2-(2-fluoro-[1,1'-biphenyl]-4-yl)acetic acid With n-butyllithium In tetrahydrofuran; hexanes at 0℃; for 0.166667h; Inert atmosphere;
Stage #2: methyl iodide In tetrahydrofuran; hexanes Inert atmosphere;
carbon dioxide
124-38-9

carbon dioxide

1-ethyl-3-fluoro-4-phenylbenzene
55258-76-9

1-ethyl-3-fluoro-4-phenylbenzene

fluorobiprofen
5104-49-4

fluorobiprofen

Conditions
ConditionsYield
With (4s,6s)-2,4,5,6-tetra(9H-carbazol-9-yl)isophthalonitrile; triisopropylsilanethiol In N,N-dimethyl-formamide at 0℃; under 3040.2 Torr; for 24h; Irradiation; Sealed tube;76%
2-Fluoro-4-((E)-1-methyl-but-2-enyl)-biphenyl

2-Fluoro-4-((E)-1-methyl-but-2-enyl)-biphenyl

fluorobiprofen
5104-49-4

fluorobiprofen

Conditions
ConditionsYield
With ozone In acetone at -78℃;75%
ethyl 2-(2-fluoro-4-biphenylyl)-propionate
64858-90-8

ethyl 2-(2-fluoro-4-biphenylyl)-propionate

fluorobiprofen
5104-49-4

fluorobiprofen

Conditions
ConditionsYield
Stage #1: ethyl 2-(2-fluoro-4-biphenylyl)-propionate With water; sodium hydroxide at 95℃; for 3h;
Stage #2: In ethyl acetate; Petroleum ether at 65℃;
72.2%
With sodium hydroxide Reflux;
With lithium hydroxide In tetrahydrofuran; water at 20℃;93.9 mg
trimethylborane
593-90-8

trimethylborane

1-bromo-3-fluoro-4-phenylbenzene
41604-19-7

1-bromo-3-fluoro-4-phenylbenzene

Ethyl oxalyl chloride
4755-77-5

Ethyl oxalyl chloride

fluorobiprofen
5104-49-4

fluorobiprofen

Conditions
ConditionsYield
Stage #1: 1-bromo-3-fluoro-4-phenylbenzene With magnesium
Stage #2: Ethyl oxalyl chloride
Stage #3: trimethylborane Further stages;
67%
C12H16FNO5S
1201594-47-9

C12H16FNO5S

phenylboronic acid
98-80-6

phenylboronic acid

A

fluorobiprofen
5104-49-4

fluorobiprofen

B

methyl 2-(2-fluoro-4-biphenylyl)propionate
113544-38-0, 113544-39-1, 114376-61-3, 66202-86-6

methyl 2-(2-fluoro-4-biphenylyl)propionate

Conditions
ConditionsYield
With potassium phosphate; bis(tricyclohexylphosphine)nickel(II) dichloride In toluene at 130℃; for 24h; Suzuki-Miyaura coupling reaction; Inert atmosphere;A 29%
B 56%
carbon dioxide
124-38-9

carbon dioxide

4-ethenyl-2-fluorobiphenyl
63444-55-3

4-ethenyl-2-fluorobiphenyl

fluorobiprofen
5104-49-4

fluorobiprofen

Conditions
ConditionsYield
Stage #1: carbon dioxide; 4-ethenyl-2-fluorobiphenyl With diethylzinc In N,N-dimethyl acetamide; toluene at 20 - 80℃; for 24h; Inert atmosphere; Sealed tube;
Stage #2: diazomethane
55%
carbon dioxide
124-38-9

carbon dioxide

C20H24BFO2

C20H24BFO2

fluorobiprofen
5104-49-4

fluorobiprofen

Conditions
ConditionsYield
With copper(l) iodide; cesium fluoride; sodium t-butanolate; 1,3-bis[2,6-diisopropylphenyl]imidazolium chloride In 2-methyltetrahydrofuran at 120℃; for 24h; Sealed tube;53%
Stage #1: carbon dioxide; C20H24BFO2 With potassium tert-butylate In tetrahydrofuran; toluene at -78 - 20℃; under 760.051 Torr; for 3h;
Stage #2: With hydrogenchloride In tetrahydrofuran; water; toluene
diester of flurbiprofen

diester of flurbiprofen

pentaethylene glycol
2615-15-8

pentaethylene glycol

fluorobiprofen
5104-49-4

fluorobiprofen

Conditions
ConditionsYield
In acetone; benzene38.5%
diethyl 2-(2-fluorobiphenyl-4-yl)-2-methylmalonate
42771-81-3

diethyl 2-(2-fluorobiphenyl-4-yl)-2-methylmalonate

fluorobiprofen
5104-49-4

fluorobiprofen

Conditions
ConditionsYield
With sodium hydroxide In ethanol; water for 6h; Reflux;34%
Multi-step reaction with 2 steps
1.1: sodium hydroxide / ethanol / 6 h / 20 °C / Inert atmosphere; Schlenk technique
1.2: Inert atmosphere; Schlenk technique
2.1: Escherichia coli arylmalonate decarboxylase; tris hydrochloride / 1 h / 30 °C / pH 8.5 / Inert atmosphere; Schlenk technique
View Scheme
diphenyl N-<2-(2-fluoro-4-biphenylyl)-1-pyrrolidinopropylidene>phosphoramidate
71574-83-9

diphenyl N-<2-(2-fluoro-4-biphenylyl)-1-pyrrolidinopropylidene>phosphoramidate

fluorobiprofen
5104-49-4

fluorobiprofen

Conditions
ConditionsYield
With potassium hydroxide In ethylene glycol for 8h; Heating;30%
diester of flurbiprofen

diester of flurbiprofen

Tetraethylene glycol
112-60-7

Tetraethylene glycol

fluorobiprofen
5104-49-4

fluorobiprofen

Conditions
ConditionsYield
In acetone; benzene30%
Sodium; 2-(2-fluoro-biphenyl-4-yl)-1-oxo-propane-1-sulfonate

Sodium; 2-(2-fluoro-biphenyl-4-yl)-1-oxo-propane-1-sulfonate

fluorobiprofen
5104-49-4

fluorobiprofen

Conditions
ConditionsYield
With potassium carbonate In water Yield given;
complex of flurbiprofen with β-cyclodextrin (1:1)

complex of flurbiprofen with β-cyclodextrin (1:1)

A

fluorobiprofen
5104-49-4

fluorobiprofen

B

β‐cyclodextrin
7585-39-9

β‐cyclodextrin

Conditions
ConditionsYield
at 15℃; Thermodynamic data; Equilibrium constant; ΔG298, ΔH, ΔS298; stability constant; dissolution rate; other temperatures;
Conditions
ConditionsYield
Stage #1: fluorobiprofen With (S)-1-phenyl-ethylamine In methanol; toluene at 20 - 60℃; for 0.166667h;
Stage #2: In methanol; toluene at 0 - 5℃; for 1h;
85.2%
Stage #1: fluorobiprofen With (S)-1-phenyl-ethylamine In toluene at 60℃; for 0.5h;
Stage #2: With ammonium hydroxide In ethyl acetate for 0.166667h;
66%
Multi-step reaction with 4 steps
1.1: 99 percent / H2SO4 / 3 h / Heating
2.1: diisopropylamine; n-BuLi / tetrahydrofuran; hexane / 0.83 h / -78 °C
2.2: 90 percent / hexane; tetrahydrofuran / 2 h / 0 °C
3.1: 85 percent / KOH / H2O; ethanol / 1 h / 0 °C
4.1: Tris-HCl buffer; arylmalonate decarboxylaze EC 4.1.1.76 / H2O; ethanol / 0.67 h / 30 °C / pH 8.0
View Scheme
fluorobiprofen
5104-49-4

fluorobiprofen

2-(2-fluoro-biphenyl-4-yl)-propan-1-ol
64858-91-9

2-(2-fluoro-biphenyl-4-yl)-propan-1-ol

Conditions
ConditionsYield
Stage #1: fluorobiprofen With triethanolamine; isobutyl chloroformate In tetrahydrofuran for 1h;
Stage #2: With sodium tetrahydroborate In tetrahydrofuran; water at -20 - 0℃; for 2.25h;
95%
Multi-step reaction with 2 steps
1: 94 percent / SOCl2 / 6 h / Heating
2: 78 percent / LAH / diethyl ether / 8 h / Heating
View Scheme
With dimethylsulfide borane complex
fluorobiprofen
5104-49-4

fluorobiprofen

α-Methyl-3-fluoro-4-phenylbenzeneacetyl chloride
137361-33-2, 56430-63-8

α-Methyl-3-fluoro-4-phenylbenzeneacetyl chloride

Conditions
ConditionsYield
With thionyl chloride In DMF (N,N-dimethyl-formamide); 1,2-dichloro-ethane Heating / reflux;100%
With oxalyl dichloride In benzene for 3h; Heating;
With phosphorus pentachloride In tetrachloromethane at 40℃; for 0.5h;
fluorobiprofen
5104-49-4

fluorobiprofen

2-(2-fluoro-[1,1′-biphenyl]-4-yl)propanehydrazide
190124-72-2

2-(2-fluoro-[1,1′-biphenyl]-4-yl)propanehydrazide

Conditions
ConditionsYield
Stage #1: fluorobiprofen With hydrazine hydrate; 1,1'-carbonyldiimidazole In tetrahydrofuran for 0.166667h;
Stage #2: With hydrazine hydrate In tetrahydrofuran for 4h; Reflux;
89%
Multi-step reaction with 2 steps
1: sulfuric acid / 3 h / Reflux
2: hydrazine hydrate / ethanol / 2 h / Reflux
View Scheme
Multi-step reaction with 2 steps
1: sulfuric acid / 0.25 h / Reflux; Microwave irradiation
2: hydrazine hydrate / ethanol / Reflux; Microwave irradiation
View Scheme
Multi-step reaction with 2 steps
1: sulfuric acid / 6 h / Reflux
2: hydrazine hydrate / ethanol / 8 h / Reflux
View Scheme
Multi-step reaction with 2 steps
1: sulfuric acid / 3 h / Reflux
2: hydrazine hydrate / 2 h / Reflux
View Scheme
methanol
67-56-1

methanol

fluorobiprofen
5104-49-4

fluorobiprofen

methyl 2-(2-fluoro-4-biphenylyl)propionate
113544-38-0, 113544-39-1, 114376-61-3, 66202-86-6

methyl 2-(2-fluoro-4-biphenylyl)propionate

Conditions
ConditionsYield
With sulfuric acid for 3h; Heating;99%
With sulfuric acid for 0.25h; Reflux; Microwave irradiation;98.8%
With sulfuric acid for 3h; Reflux;95%
fluorobiprofen
5104-49-4

fluorobiprofen

1,2:3,4-di-O-isopropylidene-α-D-galactopyranose
4064-06-6

1,2:3,4-di-O-isopropylidene-α-D-galactopyranose

diacetone 6'-O-flurbiprofen-D-galactopyranoside
1207167-00-7

diacetone 6'-O-flurbiprofen-D-galactopyranoside

Conditions
ConditionsYield
With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; dmap In dichloromethane at 20℃; for 12h;61%
fluorobiprofen
5104-49-4

fluorobiprofen

2-selenocyanatopropanamine hydrobromide

2-selenocyanatopropanamine hydrobromide

2-(2-fluorobiphenyl-4-yl)-N-(3-selenocyanatopropyl)propanamide

2-(2-fluorobiphenyl-4-yl)-N-(3-selenocyanatopropyl)propanamide

Conditions
ConditionsYield
Stage #1: fluorobiprofen With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine In dichloromethane; N,N-dimethyl-formamide at 25℃; for 0.5h;
Stage #2: 2-selenocyanatopropanamine hydrobromide In dichloromethane; N,N-dimethyl-formamide at 25℃; for 16h;
65%
Stage #1: fluorobiprofen With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine In dichloromethane; N,N-dimethyl-formamide at 25℃; for 0.5h; Inert atmosphere;
Stage #2: 2-selenocyanatopropanamine hydrobromide In dichloromethane; N,N-dimethyl-formamide at 25℃; for 16h; Inert atmosphere;
62%
Stage #1: fluorobiprofen With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine In dichloromethane; N,N-dimethyl-formamide at 25℃; for 0.5h;
Stage #2: 2-selenocyanatopropanamine hydrobromide In dichloromethane; N,N-dimethyl-formamide at 25℃; for 16h;
fluorobiprofen
5104-49-4

fluorobiprofen

sodium 2-(2-fluoro-4-biphenylyl)propionate dihydrate

sodium 2-(2-fluoro-4-biphenylyl)propionate dihydrate

Conditions
ConditionsYield
Stage #1: fluorobiprofen With ascorbic acid In ethanol; water at 70 - 75℃; Large scale;
Stage #2: With sodium hydroxide In ethanol; water for 1.5h; Large scale;
95.7%
fluorobiprofen
5104-49-4

fluorobiprofen

flurbiprofen sodium

flurbiprofen sodium

Conditions
ConditionsYield
With sodium methylate In methanol at 65℃; for 1.5h; Large scale;94.8%
3-methylpyridin-2-ylamine
1603-40-3

3-methylpyridin-2-ylamine

fluorobiprofen
5104-49-4

fluorobiprofen

2-(2-fluoro-(1,1'-biphenyl)-4-yl)-N-(3-methylpyridin-2-yl)propanamide

2-(2-fluoro-(1,1'-biphenyl)-4-yl)-N-(3-methylpyridin-2-yl)propanamide

Conditions
ConditionsYield
With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In acetonitrile at 20℃; for 24h;91%
fluorobiprofen
5104-49-4

fluorobiprofen

tert-butyl (2,2-difluoro-3-hydroxypropyl)carbamate

tert-butyl (2,2-difluoro-3-hydroxypropyl)carbamate

C23H26F3NO4

C23H26F3NO4

Conditions
ConditionsYield
With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In dichloromethane at 0 - 20℃; for 5h;100%
Phenylselenyl chloride
5707-04-0

Phenylselenyl chloride

fluorobiprofen
5104-49-4

fluorobiprofen

C21H17FOSe

C21H17FOSe

Conditions
ConditionsYield
With tributylphosphine In dichloromethane at -15℃; for 3h; Inert atmosphere;73%
With tributylphosphine In dichloromethane at -15℃; for 3h; Inert atmosphere;73%
fluorobiprofen

fluorobiprofen

(S)-4-(3-aminoazepan-1-yl)coumarin

(S)-4-(3-aminoazepan-1-yl)coumarin

C30H29FN2O3

C30H29FN2O3

fluorobiprofen
5104-49-4

fluorobiprofen

dichlorodihydroxydiamineplatinum

dichlorodihydroxydiamineplatinum

cisplatin flurbiprofen

cisplatin flurbiprofen

Conditions
ConditionsYield
Stage #1: fluorobiprofen With oxalyl dichloride at 70℃; for 1h; Inert atmosphere;
Stage #2: dichlorodihydroxydiamineplatinum In tetrahydrofuran at 70℃; for 2h; Temperature; Darkness;
92.3%
N-tert-butoxycarbonyl-3-aminopropanol
58885-58-8

N-tert-butoxycarbonyl-3-aminopropanol

fluorobiprofen
5104-49-4

fluorobiprofen

Boc-aminopropanol-flurbiprofen

Boc-aminopropanol-flurbiprofen

Conditions
ConditionsYield
With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In dichloromethane at 20℃; Cooling with ice;94%
fluorobiprofen
5104-49-4

fluorobiprofen

acetyl chloride
75-36-5

acetyl chloride

2-(4′-acetyl-2-fluoro-[1,1′-biphenyl]-4-yl)propanoic acid

2-(4′-acetyl-2-fluoro-[1,1′-biphenyl]-4-yl)propanoic acid

Conditions
ConditionsYield
Stage #1: acetyl chloride With aluminum (III) chloride In dichloromethane at 0℃; for 0.5h; Friedel-Crafts Acylation;
Stage #2: fluorobiprofen In dichloromethane at 20℃; for 3h; Friedel-Crafts Acylation;
64.1%
Conditions
ConditionsYield
With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In dichloromethane at 20℃;55%
fluorobiprofen
5104-49-4

fluorobiprofen

methyl 2-(4-(3-aminophenyl)-1H-1,2,3-triazol-1-yl)acetate

methyl 2-(4-(3-aminophenyl)-1H-1,2,3-triazol-1-yl)acetate

methyl 2-(4-(3-(2-(2-fluoro-[1,1'-biphenyl]-4-yl)propanamido)phenyl)-1H-1,2,3-triazol-1-yl)acetate

methyl 2-(4-(3-(2-(2-fluoro-[1,1'-biphenyl]-4-yl)propanamido)phenyl)-1H-1,2,3-triazol-1-yl)acetate

Conditions
ConditionsYield
With N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate In N,N-dimethyl-formamide at 40℃; Inert atmosphere; Sealed tube;84%
4-hydroxybenzenesulphonamide
1576-43-8

4-hydroxybenzenesulphonamide

fluorobiprofen
5104-49-4

fluorobiprofen

2-(2-fluorobiphen-4-yl)-N-(4-hydroxyphenylsulfonyl)propionamide

2-(2-fluorobiphen-4-yl)-N-(4-hydroxyphenylsulfonyl)propionamide

Conditions
ConditionsYield
Stage #1: fluorobiprofen With 1,1'-carbonyldiimidazole In dichloromethane at 0 - 5℃; for 2h;
Stage #2: 4-hydroxybenzenesulphonamide With 1,8-diazabicyclo[5.4.0]undec-7-ene In dichloromethane at 20℃; for 6h;
79%
2-Methanesulfonyl-ethylamine
49773-20-8

2-Methanesulfonyl-ethylamine

fluorobiprofen
5104-49-4

fluorobiprofen

2-(2-fluorobiphen-4-yl)-N-(2-methylsulfonylethyl)propanamide

2-(2-fluorobiphen-4-yl)-N-(2-methylsulfonylethyl)propanamide

Conditions
ConditionsYield
Stage #1: fluorobiprofen With 1,1'-carbonyldiimidazole In dichloromethane at 0 - 5℃; for 2h;
Stage #2: 2-Methanesulfonyl-ethylamine In dichloromethane
77%
benzenesulfonamide
98-10-2

benzenesulfonamide

fluorobiprofen
5104-49-4

fluorobiprofen

2-(2-fluorobiphen-4-yl)-N-(phenylsulfonyl)propionamide

2-(2-fluorobiphen-4-yl)-N-(phenylsulfonyl)propionamide

Conditions
ConditionsYield
Stage #1: fluorobiprofen With 1,1'-carbonyldiimidazole In dichloromethane at 0 - 5℃; for 2h;
Stage #2: benzenesulfonamide With 1,8-diazabicyclo[5.4.0]undec-7-ene In dichloromethane at 20℃; for 6h;
79%
fluorobiprofen
5104-49-4

fluorobiprofen

(S)-4-(3-aminopyrrolidin-1-yl)coumarin

(S)-4-(3-aminopyrrolidin-1-yl)coumarin

C28H25FN2O3

C28H25FN2O3

Conditions
ConditionsYield
With dmap; dicyclohexyl-carbodiimide In dichloromethane at 20℃; for 0.5h;83%
fluorobiprofen
5104-49-4

fluorobiprofen

2-(3-(4-hydroxy-3-methoxyphenyl)acryloyl)-3H-benzocoumarin-3-one

2-(3-(4-hydroxy-3-methoxyphenyl)acryloyl)-3H-benzocoumarin-3-one

2-methoxy-4-(3-oxo-3-(3-oxo-3H-benzocoumarin-2-yl)prop-1-en-1-yl)phenyl 2-(2-fluoro[1,1′-biphenyl]-4-yl)propanoate

2-methoxy-4-(3-oxo-3-(3-oxo-3H-benzocoumarin-2-yl)prop-1-en-1-yl)phenyl 2-(2-fluoro[1,1′-biphenyl]-4-yl)propanoate

Conditions
ConditionsYield
With dmap; triethylamine; trichlorophosphate In dichloromethane at 20℃;80%
fluorobiprofen
5104-49-4

fluorobiprofen

(S)-4-(3-minopiperidin-1-yl)coumarin

(S)-4-(3-minopiperidin-1-yl)coumarin

C29H27FN2O3

C29H27FN2O3

Conditions
ConditionsYield
With dicyclohexyl-carbodiimide In dichloromethane at 20℃; for 0.5h;72%
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