Details:

Product  Description：

Molecular Formula	C15H13FO2
Molar Mass	244.26
Density	1.199±0.06 g/cm3(Predicted)
Melting Point	110-113°C(lit.)
Boling Point	376.2±30.0 °C(Predicted)
Flash Point	57.7°C
Solubility	Soluble in DMSO (50 mg/ml), methanol (50 mg/ml), ethanol (~100 mg/ml), DMF (~100 mg/ml)
Vapor Presure	2.84mmHg at 25°C
Appearance	White crystal
Color	White to off-white
pKa	4.14±0.10(Predicted)
Storage Condition	Room Temprature
Refractive Index	1.34
MDL	MFCD00079303
In vitro study	Tarenflurbil ((R)-Flurbiprofen) can significantly reduce Aβ secretion, but at the same time, increases the level of intracellular Aβ. The binding between [ 3 H]9-cis-RA and RXRα is competitively inhibited by both unlabeled (R)-Flurbiprofen and 9-cis-RA. (R)-Flurbiprofen can interfere with the interaction between RXRα and 9-cis-retinoid acid (9-cis-RA), and that 9-cis-RA decreases Tarenflurbil ((R)-Flurbiprofen)’s reduction of Aβ secretion. Tarenflurbil ((R)-Flurbiprofen) treatment significantly increases the levels of intracellular Aβ species. The well characterized, nonsteroidal anti-inflammatory drug (nonsteroidal anti-inflammatory drug), Tarenflurbil ((R)-Flurbiprofen) affects only Aβ and not Notch β formation, indicating that second generation GSMs and nonsteroidal anti-inflammatory drug-based GSMs have different modes of action regarding Notch processing.
In vivo study	Effects of the early and late onset of treatment with Tarenflurbil ((R)-Flurbiprofen) are assessed in C57BL6/J mice that develop a non-remitting form of the disease, and in SJL mice that develop a relapsing-remitting (RR)-EAE. Tarenflurbil ((R)-Flurbiprofen) completely prevents the development of clinical EAE scores in C57BL6/J mice when the treatment is started within 3 days after immunization. This regimen is referred to as preventive treatment. The effect is dose-dependent, and the minimum daily dose for complete prevention is 5 mg/kg/day. Effects of Tarenflurbil ((R)-Flurbiprofen) are comparable to those of Fingolimod (FTY720, 0.5 mg/kg/day), which is used as the positive control. Tarenflurbil ((R)-Flurbiprofen) also significantly reduces clinical EAE scores in C57BL6/J mice when treatment is started shortly before onset of clinical manifestations, referred to as semi-therapeutic (10 mg/kg/day) and reduces clinical scores when the treatment is initiated after full development of the disease on day 13 (5 mg/g/day).

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Company Profile：

 

Wuhan Han Sheng New Material Technology Co. Ltd is a professional company which specialized in manufacturing and selling chemical raw materials, chemical products, pharmaceutical intermediates, veterinary medicine intermediates, dye intermediates, pigments, cosmetics raw materials and chemical reagents.

We have long term cooperation pharmaceutical raw material production plant and a reagent research and development center, with a rich professional background and strong competitive advantage. We have a professional and experienced team and we promise clients to provide the best quality, price and service. During the business cooperation with clients, we always adhere principle of Honesty, Trustworthiness and win-win policy. We guarantee 100% qualification of our products pass through the standard of USA, Mexico, UK, Australia, Canada, Brazil, France, Germany, Spain, Belgium, Sweden, the Netherlands and so on.

 

 

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Exhibitions:

 

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Products & Packaging：

 

Our products are used for pharmaceuticals, pesticides, synthetic dyes, organic chemicals, inorganic chemicals, coatings, spices and essence, cosmetics and toilet products, soaps and synthetic detergents, surfactants, printing inks and their auxiliaries, adhesives, photosensitive materials, magnetic materials, catalysts, reagents, water treatment agents and polymer flocculants, papermaking auxiliaries, leather auxiliaries, synthetic materials auxiliaries, textile printing and dyeing agents and finishing agents, food additives Feed additives, animal drugs, etc.

 

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About  Us 

 

 

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Shipment & Payment：

 

*small quantity: By Fedex, DHL, HKPOST, UPS, TNT or As customers’ requirement

*Bulk order: By air or sea

*Delivery: within 3 days for samples and 10 days for bulk order

 

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Our Markets: 

 

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FAQ

 

1. Are you a trade company or factory

We are a factory with our own trading company.

 

2. How do you control the quality

Our factory is equipped with professional technicians to inspect the quality around production lines. The inspection test would be made every 2 hours to ensure the production conform to quality standard. We also accept BV, SGS, or any third pary inspection.

3. How long is lead time

We deliver goods within 3 days for small order, 7-10 days for bulk order.

 

4. Where is your factory located How can I visit the factory

Our factory located in Hebei, China

 

5. Can I get some samples

Yes, we can supply sample with free, but the shipping cost be paid by our customers.

 

6. How to start orders or make payments

Proforma Invoice will be issued first after confirmation of order, enclosed our bank information. Payment could be done by T/T or .

 

7. How to confirm the product quality before placing order

You can get free samples for some products. You only need to pay the shipping cost or arrange a courier to us and take the samples.

 

8. How do you treat quality complaint

First of all, our quality control will reduce the quality problem to near zero. If there is a real quality problem caused by us, we will send you free goods for replacement or refund your loss.