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HANGZHOU YUNUO CHEMICAL CO.,LTD

Hangzhou Yunuo Chemical Co., Ltd is located in Hangzhou city China. As a global supplier in the chemical industry, Yunuochem is to create added value for customers around the world. Sticking to such business idea of "Good faith wins the bu

4-Bromo-2-fluorobiphenyl

Cas:41604-19-7

Min.Order:1 Kilogram

Negotiable

Type:Trading Company

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Dayang Chem (Hangzhou) Co.,Ltd.

DayangChem exported this product to many countries and regions at best price. If you are looking for the material's manufacturer or supplier in China, DayangChem is your best choice. Pls contact with us freely for getting detailed product spe

4-Bromo-2-fluorobiphenyl Manufacturer/High quality/Best price/In stock

Cas:41604-19-7

Min.Order:1 Kilogram

FOB Price: $3.0

Type:Lab/Research institutions

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Simagchem Corporation

Welcome to Simagchem, your partner in China as a premier supply of bulk specialty chemicals for industry and life science. We introduce experienced quality product and exceptional JIT service with instant market intelligence in China to benefit our

High quality 4-Bromo-2-Fluorobiphenyl supplier in China

Cas:41604-19-7

Min.Order:1 Metric Ton

Negotiable

Type:Manufacturers

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Henan Allgreen Chemical Co.,Ltd

high quality Appearance:Solid Storage:Sealed, dry, microtherm , avoid light and smell. Package:According to the demand of customer Application:Intermediates Transportation:by air or by sea Port:Shanghai, Qingdao

4-Bromo-2-fluorobiphenyl

Cas:41604-19-7

Min.Order:1 Kilogram

Negotiable

Type:Manufacturers

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Ality Chemical Corporation

The above product is Ality Chemical's strong item with best price, good quality and fast supply. Ality Chemical has been focusing on the research and production of this field for over 14 years. At the same time, we are always committed to providi

Factory Supply 4-bromo-2-fluoro-1,1'-biphenyl

Cas:41604-19-7

Min.Order:1

Negotiable

Type:Other

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Xi'an Xszo Chem Co., Ltd.

1. Factory price and high quality must be guaranteed, base on 8 years of production and R&D experience2. Free samples will be provided,ensure specifications and quality are right for customer3. Customers will receive the most professional technical s

High Quality Oled CAS 41604-19-7 4-Bromo-2-fluorobiphenyl

Cas:41604-19-7

Min.Order:1 Gram

FOB Price: $0.1

Type:Manufacturers

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Chemwill Asia Co., Ltd.

Our main production base is located in Xuzhou industry park. We are certified both to the ISO 9001 and ISO 14001 Standards, have a safety management system in place.Our R&D team masters core technology for process-design of target building block

4-Bromo-2-fluorobiphenyl

Cas:41604-19-7

Min.Order:5 Kiloliter

FOB Price: $1.2 / 5.0

Type:Manufacturers

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Hebei yanxi chemical co.,LTD.

1 Factory price 2 High quality 3 Good service 4 Prompt service Appearance:The crystallization Storage:Kept in dry and cool place and from sunlight; Kept the packing intact. Package: 25kg plastic woven bag with inner linning. Application: Food

4-Bromo-2-fluorobiphenyl

Cas:41604-19-7

Min.Order:100 Kilogram

FOB Price: $1000.0

Type:Trading Company

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Henan Tianfu Chemical Co., Ltd.

4-Bromo-2-fluorobiphenyl Basic information Product Name: 4-Bromo-2-fluorobiphenyl Synonyms: 4-BROMO-2-FLUOROBIPHENYL;4-BROMO-2-FLUORO-1,1'-BIPHENYL;2-FLUORO-4-B

best offer 4-Bromo-2-fluorobiphenyl

Cas:41604-19-7

Min.Order:1 Metric Ton

Negotiable

Type:Lab/Research institutions

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Hebei Nengqian Chemical Import and Export Co., LTD

With our good experience, we offer detailed technical support and advice to assist customers. We communicate closely with customers to establish their quality requirements. Consistent Quality Our plant has strict quality control in each manufacturin

4-Bromo-2-Fluorobiphenyl CAS 41604-19-7

Cas:41604-19-7

Min.Order:1 Kilogram

FOB Price: $3.0 / 10.0

Type:Trading Company

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Zhuozhou Wenxi import and Export Co., Ltd

WITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et

Top Purity CAS 41604-19-7 with fast shipping

Cas:41604-19-7

Min.Order:1 Kilogram

FOB Price: $139.0 / 210.0

Type:Trading Company

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Henan Sinotech Import&Export Corporation

Name: 4-Bromo-2-fluorobiphenyl Synonyms: 1-chloro-4-methylsulfonyl-2-(trifluoromethyl)benzene CAS:41604-19-7 MF: C8H6ClF3O2S Appearance: white powder Storage:Store in cool and dry place, away from sun light. Package: 25kgs/drum Application:Ph

4-Bromo-2-fluorobiphenyl CAS:41604-19-7

Cas:41604-19-7

Min.Order:1 Kilogram

FOB Price: $1.0

Type:Other

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Shanghai Upbio Tech Co.,Ltd

1.No Less 8 years exporting experience. Clients can 100% received goods 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Upbio is Specialized

4-Bromo-2-fluorobiphenyl 41604-19-7

Cas:41604-19-7

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

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Baoji Guokang Healthchem co.,ltd

Our company has been in existence for 10 years since its establishment. We have our own unique team. The company integrates independent research and development, production and sales. We have established famous brands at home and abroad. At prese

Antipyretic analgesia, 4-Bromo-2-fluorobiphenyl CAS:41604-19-7

Cas:41604-19-7

Min.Order:1 Kilogram

FOB Price: $25.4 / 29.3

Type:Trading Company

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Qingdao Beluga Import and Export Co., LTD

4-Bromo-2-fluorobiphenyl CAS:41604-19-7 Qingdao Belugas Import and Export Co., Ltd. is a scientific and technological company integrating research and development, production and trade of chemical intermediates, specializing in high quality organic

4-Bromo-2-fluorobiphenyl CAS:41604-19-7

Cas:41604-19-7

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

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Shandong Hanjiang Chemical Co., Ltd.

Hello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by emai

4-Bromo-2-fluorobiphenyl

Cas:41604-19-7

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

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Henan Wentao Chemical Product Co., Ltd.

Henan Wentao Chemical Product Co.,Ltd is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds, which are widely used in the fields of prod

CAS NO.:41604-19-7

Cas:41604-19-7

Min.Order:0

Negotiable

Type:Lab/Research institutions

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Hebei Quanhe Biotechnology Co. LTD

1. Timely and efficient service to ensure communication with customers 2. Produce products of different specifications and sizes according to your requirements. 3. Quality procedures and standards recognized by SGS. Advanced plant equipment ensures s

4-Bromo-2-fluorobiphenyl

Cas:41604-19-7

Min.Order:1 Kilogram

FOB Price: $80.0 / 100.0

Type:Lab/Research institutions

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Hangzhou Keyingchem Co.,Ltd

Hangzhou KeyingChem Co., Ltd. exported this product to many countries and regions at best price. If you are looking for the material’s manufacturer or supplier in China, KeyingChem is your best choice. Pls contact with us freely for getting det

4-Bromo-2-fluorobiphenyl

Cas:41604-19-7

Min.Order:0 Metric Ton

Negotiable

Type:Lab/Research institutions

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Wuhan Han Sheng New Material Technology Co.,Ltd

Our Advantage: high quality with competitive price High quality standard: BP/USP/EP Enterprise standard All purity customized Fast and safe delivery We have reliable forwarder who can help us deliver our goods more fast and safe. We

99% chemical product, 4-Bromo-2-fluorobiphenyl , CAS: 41604-19-7

Cas:41604-19-7

Min.Order:10 Kilogram

Negotiable

Type:Trading Company

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Hangzhou J&H Chemical Co., Ltd.

J&H CHEM R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. J&H CHEM has some Manufacturing base in Jia

Bromo-2-fluorobiphenyl

Cas:41604-19-7

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Afine Chemicals Limited

Our Services 1. New Molecules R&D 2. Own test center HPLC NMR GC LC-MS 3. API and Intermediates from China reputed manufacturers 4. Documents support COA MOA MSDS DMF open part Our advantages 1. Government awarded company. Top 100 enter

4-Bromo-2-fluorobiphenyl

Cas:41604-19-7

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

SHANGHAI T&W PHARMACEUTICAL CO., LTD.

A substitute for perfluorooctanoic acid, mainly used as a surfactant, dispersant, additive, etc Appearance:White solid or Colorless liquid Purity:99.3 % We will ship the goods in a timely manner as required We can provide relevant documents acc

4-Bromo-2-fluorobiphenyl

Cas:41604-19-7

Min.Order:4 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Shanghai Hope Chem Co., Ltd

1. Product advantages: exquisite appearance and unique functions. 2. Product Advantages: Our products are the best,fast speed ,in large stock 3. High-quality products and thoughtful service are your greatest satisfaction. 4. The product

4-Bromo-2-fluoro-1,1'-biphenyl

Cas:41604-19-7

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Zibo Hangyu Biotechnology Development Co., Ltd

Zibo Hangyu Biotechnology Development Co., Ltd is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemi

High quality 4-Bromo-2-Fluorobiphenyl

Cas:41604-19-7

Min.Order:10 Gram

FOB Price: $100.0

Type:Lab/Research institutions

inquiry

Shanghai Massive Chemical Technology Co., Ltd.

Massive Chemical is certified with ISO9001 and ISO14001 manufacturer for this product. We will offer all documents as requirement for the materials which includes, Certificate of Analysis, Material Safety Data Sheet, and Method of Analysis and als

4-Bromo-2-fluorobiphenyl

Cas:41604-19-7

Min.Order:1 Gram

FOB Price: $1.0

Type:Lab/Research institutions

inquiry

Siwei Development Group Ltd.

Product name: 4-Bromo-2-Fluorobiphenyl CAS No.:41604-19-7 Molecule Formula:C8H6ClF3O2S Molecule Weight:258.65 Purity: 98.0% Package: 25kg/drum Description:White powder Manufacture Standards:Enterprise Standard TEST

High Quality 4-Bromo-2-Fluorobiphenyl on stock

Cas:41604-19-7

Min.Order:1 Kilogram

Negotiable

Type:Trading Company

inquiry

Xiamen Jenny Chemical Technology Co., Ltd.

GMP standard, high purity, competitive price, in stock 1. Quick Response: within 6 hours after receiving your email. 2. Quality Guarantee: All products are strictly tested by our QC, confirmed by QA, and approved by a third-party lab in China, USA,

4-Bromo-2-fluorobiphenyl

Cas:41604-19-7

Min.Order:1 Milligram

Negotiable

Type:Trading Company

inquiry

EAST CHEMSOURCES LIMITED

factory?direct?saleAppearance:White Powder Storage:Store In Dry, Cool And Ventilated Place Package:25kg/drum, also according to the clients requirement Application:It is widely used as a thickener, emulsifier and stabilizer Transportation:By Sea Or B

4-Bromo-2-fluorobiphenyl

Cas:41604-19-7

Min.Order:1 Kilogram

FOB Price: $18.0 / 20.0

Type:Trading Company

inquiry

TAIZHOU ZHENYU BIOTECHNOLOGY CO., LTD

Zhenyu biotech exported this product to many countries and regions at best price. if you are looking for the material's manufacturer or supplier in china, zhenyu biotech is your best choice. pls contact with us freely for getting detailed

4-Bromo-2-fluorobiphenyl

Cas:41604-19-7

Min.Order:1 Kilogram

FOB Price: $2.0

Type:Lab/Research institutions

inquiry

Synthetic route

sodium carbonate
497-19-8

sodium carbonate

1-bromo-3-fluoro-4-iodobenzene
105931-73-5

1-bromo-3-fluoro-4-iodobenzene

phenylboronic acid
98-80-6

phenylboronic acid

1-bromo-3-fluoro-4-phenylbenzene
41604-19-7

1-bromo-3-fluoro-4-phenylbenzene

Conditions
ConditionsYield
palladium In fluorobenzene; nitrogen87%
Pd on carbon; palladium dichloride In fluorobenzene; concentrated ethanol55%
4-bromo-2-fluoroaniline
367-24-8

4-bromo-2-fluoroaniline

1-bromo-3-fluoro-4-phenylbenzene
41604-19-7

1-bromo-3-fluoro-4-phenylbenzene

Conditions
ConditionsYield
83%
4-bromo-2-fluoroaniline
367-24-8

4-bromo-2-fluoroaniline

benzene
71-43-2

benzene

1-bromo-3-fluoro-4-phenylbenzene
41604-19-7

1-bromo-3-fluoro-4-phenylbenzene

Conditions
ConditionsYield
With i-propyl nitrite; copper(l) chloride at 20℃; for 3h;76%
With methyl nitrite; copper(l) chloride at 43 - 50℃; for 1.83333h;75%
C12H8BF4(1-)*K(1+)

C12H8BF4(1-)*K(1+)

1-bromo-3-fluoro-4-phenylbenzene
41604-19-7

1-bromo-3-fluoro-4-phenylbenzene

Conditions
ConditionsYield
With pyridinium hydrobromide perbromide In tetrahydrofuran; water at 20℃; for 0.666667h; chemoselective reaction;74%
1-bromo-3-fluoro-4-iodobenzene
105931-73-5

1-bromo-3-fluoro-4-iodobenzene

phenylboronic acid
98-80-6

phenylboronic acid

1-bromo-3-fluoro-4-phenylbenzene
41604-19-7

1-bromo-3-fluoro-4-phenylbenzene

Conditions
ConditionsYield
With tetrakis(triphenylphosphine) palladium(0); potassium carbonate In ethanol; toluene for 5h; Reflux;70%
C6H3BrFN2(1+)*C7H7O3S(1-)

C6H3BrFN2(1+)*C7H7O3S(1-)

phenylboronic acid
98-80-6

phenylboronic acid

1-bromo-3-fluoro-4-phenylbenzene
41604-19-7

1-bromo-3-fluoro-4-phenylbenzene

Conditions
ConditionsYield
With palladium diacetate In water at 20℃; for 72h; Suzuki-Miyaura Coupling; Inert atmosphere;30%
4-bromo-2-fluoroaniline
367-24-8

4-bromo-2-fluoroaniline

1-bromo-3-fluoro-4-phenylbenzene
41604-19-7

1-bromo-3-fluoro-4-phenylbenzene

Conditions
ConditionsYield
With hydrogenchloride; sodium nitrite In methanol; water; acetic acid; benzene64.6 grams (51.5%)
With hydrogenchloride; sodium nitrite In methanol; water; acetic acid; benzene64.6 grams (51.5%)
fluoroboric acid

fluoroboric acid

4-bromo-2-amino-1,1'-biphenyl
41604-22-2

4-bromo-2-amino-1,1'-biphenyl

1-bromo-3-fluoro-4-phenylbenzene
41604-19-7

1-bromo-3-fluoro-4-phenylbenzene

2-phenylpropionic acid methyl ester
31508-44-8

2-phenylpropionic acid methyl ester

1-bromo-3-fluoro-4-phenylbenzene
41604-19-7

1-bromo-3-fluoro-4-phenylbenzene

methyl α-(3-fluoro-4-phenylphenyl)-α-phenylpropionate

methyl α-(3-fluoro-4-phenylphenyl)-α-phenylpropionate

Conditions
ConditionsYield
With tri-tert-butyl phosphine; lithium dicyclohexylamide; P(dba)2 In toluene at 20℃; for 15h;97%
1-bromo-3-fluoro-4-phenylbenzene
41604-19-7

1-bromo-3-fluoro-4-phenylbenzene

zinc(II) chloride
7646-85-7

zinc(II) chloride

(2-fluoro-[1,1'-biphenyl]-4-yl)zinc chloride

(2-fluoro-[1,1'-biphenyl]-4-yl)zinc chloride

Conditions
ConditionsYield
Stage #1: 1-bromo-3-fluoro-4-phenylbenzene With magnesium; lithium chloride In tetrahydrofuran at 25℃; Schlenk technique; Inert atmosphere;
Stage #2: zinc(II) chloride In tetrahydrofuran at 0 - 25℃; for 0.25h; Schlenk technique; Inert atmosphere;
96%
With magnesium; lithium chloride In tetrahydrofuran at 0℃; Inert atmosphere;
Stage #1: 1-bromo-3-fluoro-4-phenylbenzene With magnesium; lithium chloride In tetrahydrofuran at 20℃; Inert atmosphere; Schlenk technique; Heating;
Stage #2: zinc(II) chloride In tetrahydrofuran at 0 - 20℃; Inert atmosphere; Schlenk technique;
1-bromo-3-fluoro-4-phenylbenzene
41604-19-7

1-bromo-3-fluoro-4-phenylbenzene

phenylacetylene
536-74-3

phenylacetylene

(4-phenyl-3-fluoro-phenyl)phenylacetylene

(4-phenyl-3-fluoro-phenyl)phenylacetylene

Conditions
ConditionsYield
With potassium carbonate; palladium dichloride; catacxium A In N,N-dimethyl-formamide at 60℃; for 16h; Sonogashira Cross-Coupling; Inert atmosphere; Sealed tube;96%
potassium 2-cyanopropanoate
1266802-94-1

potassium 2-cyanopropanoate

1-bromo-3-fluoro-4-phenylbenzene
41604-19-7

1-bromo-3-fluoro-4-phenylbenzene

α-methyl-(2-fluoro-4-biphenylyl)acetonitrile
74648-00-3

α-methyl-(2-fluoro-4-biphenylyl)acetonitrile

Conditions
ConditionsYield
With bis(η3-allyl-μ-chloropalladium(II)); 4,5-bis(diphenylphos4,5-bis(diphenylphosphino)-9,9-dimethylxanthenephino)-9,9-dimethylxanthene In 1,3,5-trimethyl-benzene at 20 - 140℃; for 3.16667h; Inert atmosphere; Sealed tube; chemoselective reaction;95%
9,9-dimethyl-N-(4-(9-phenyl-9H-carbazol-3-yl)phenyl)-9H-fluoren-2-amine

9,9-dimethyl-N-(4-(9-phenyl-9H-carbazol-3-yl)phenyl)-9H-fluoren-2-amine

1-bromo-3-fluoro-4-phenylbenzene
41604-19-7

1-bromo-3-fluoro-4-phenylbenzene

N-(2-fluoro-[1,1'-biphenyl]-4-yl)-9,9-dimethyl-N-(4-(9-phenyl-9H-carbazol-3-yl)phenyl)-9H-fluoren-2-amine

N-(2-fluoro-[1,1'-biphenyl]-4-yl)-9,9-dimethyl-N-(4-(9-phenyl-9H-carbazol-3-yl)phenyl)-9H-fluoren-2-amine

Conditions
ConditionsYield
With 1,1'-bis(diisopropylphosphino)ferrocene; Pd(dippf)maleimide; sodium t-butanolate In toluene at 120℃; for 24h; Inert atmosphere;94%
acetic acid tert-butyl ester
540-88-5

acetic acid tert-butyl ester

1-bromo-3-fluoro-4-phenylbenzene
41604-19-7

1-bromo-3-fluoro-4-phenylbenzene

tert-butyl α-(3-fluoro-4-phenylphenyl)acetate

tert-butyl α-(3-fluoro-4-phenylphenyl)acetate

Conditions
ConditionsYield
With tri-tert-butyl phosphine; lithium dicyclohexylamide; bis(dibenzylideneacetone)-palladium(0) In toluene at 20℃; for 15h;93%
1-bromo-3-fluoro-4-phenylbenzene
41604-19-7

1-bromo-3-fluoro-4-phenylbenzene

2-fluorobiphenyl
321-60-8

2-fluorobiphenyl

Conditions
ConditionsYield
With hydrogen; triethylamine In methanol; water at 120℃; under 22502.3 Torr; for 46h; Autoclave;93%
With hydrogen; triethylamine In methanol; water at 120℃; under 22502.3 Torr;93%
With lithium aluminium tetrahydride; niobium pentachloride In 1,2-dimethoxyethane for 0.5h; Heating;40%
With iron(III)-acetylacetonate; tert-butylmagnesium chloride In tetrahydrofuran at 0℃; for 1.5h; Inert atmosphere;86 %Chromat.
1-bromo-3-fluoro-4-phenylbenzene
41604-19-7

1-bromo-3-fluoro-4-phenylbenzene

trimethylsilylacetylene
1066-54-2

trimethylsilylacetylene

3-fluoro-4-phenyl-1-ethynylbenzene

3-fluoro-4-phenyl-1-ethynylbenzene

Conditions
ConditionsYield
Stage #1: 1-bromo-3-fluoro-4-phenylbenzene; trimethylsilylacetylene With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; triethylamine In tetrahydrofuran at 55℃; for 24h; Sonogashira Cross-Coupling; Inert atmosphere; Schlenk technique; Sealed tube;
Stage #2: With potassium carbonate In tetrahydrofuran; methanol at 20℃; for 2h; Inert atmosphere; Schlenk technique; Sealed tube;
93%
1-bromo-3-fluoro-4-phenylbenzene
41604-19-7

1-bromo-3-fluoro-4-phenylbenzene

diethyl malonate
105-53-3

diethyl malonate

diethyl 2-(2-fluorobiphenyl-4-yl)malonate

diethyl 2-(2-fluorobiphenyl-4-yl)malonate

Conditions
ConditionsYield
With potassium phosphate; tri-tert-butyl phosphine; bis(dibenzylideneacetone)-palladium(0) In toluene at 70℃; for 12h;91%
With sodium hydride; copper(I) bromide 1.) dioxane, 17-20 deg C, 2.) dioxane, reflux, 6 h; Yield given. Multistep reaction;
Methyl isobutyrate
547-63-7

Methyl isobutyrate

1-bromo-3-fluoro-4-phenylbenzene
41604-19-7

1-bromo-3-fluoro-4-phenylbenzene

methyl 2-­(2-­fluoro-­[1,1'-­biphenyl]-­4-­yl)-­2-­methylpropanoate

methyl 2-­(2-­fluoro-­[1,1'-­biphenyl]-­4-­yl)-­2-­methylpropanoate

Conditions
ConditionsYield
With tri-tert-butyl phosphine; lithium dicyclohexylamide; bis(dibenzylideneacetone)-palladium(0) In toluene at 20℃; for 14h;91%
ethene
74-85-1

ethene

1-bromo-3-fluoro-4-phenylbenzene
41604-19-7

1-bromo-3-fluoro-4-phenylbenzene

4-ethenyl-2-fluorobiphenyl
63444-55-3

4-ethenyl-2-fluorobiphenyl

Conditions
ConditionsYield
With 10H-phenothiazine; bis(μ-chloro)bis{(2-(1-(hydroxyimino)methyl)phenyl-C1,N)palladium(II)}; potassium acetate In N,N-dimethyl acetamide at 105℃; under 760.051 Torr; for 18h; Heck-Mizoroki reaction; Inert atmosphere;91%
1-bromo-3-fluoro-4-phenylbenzene
41604-19-7

1-bromo-3-fluoro-4-phenylbenzene

pinacol vinylboronate
75927-49-0

pinacol vinylboronate

4-ethenyl-2-fluorobiphenyl
63444-55-3

4-ethenyl-2-fluorobiphenyl

Conditions
ConditionsYield
With tetrakis(triphenylphosphine) palladium(0); potassium carbonate In 1,4-dioxane; water Inert atmosphere; Reflux;91%
With PdCl2((S)-Xyl-phanephos); potassium carbonate In 1,4-dioxane; water at 101℃; for 17h; Inert atmosphere;59%
Suzuki Coupling;
1,1-bis(trimethylsilyloxy)prop-1-ene
31469-22-4

1,1-bis(trimethylsilyloxy)prop-1-ene

1-bromo-3-fluoro-4-phenylbenzene
41604-19-7

1-bromo-3-fluoro-4-phenylbenzene

fluorobiprofen
5104-49-4

fluorobiprofen

Conditions
ConditionsYield
Stage #1: 1-bromo-3-fluoro-4-phenylbenzene With zinc(II) fluoride; tri-tert-butyl phosphine; bis(dibenzylideneacetone)-palladium(0) In toluene for 0.666667h; Inert atmosphere;
Stage #2: 1,1-bis(trimethylsilyloxy)prop-1-ene In tetrahydrofuran; N,N-dimethyl-formamide; toluene at 80℃; for 12h; Sealed tube; Inert atmosphere;
91%
tert-butyl propionate
20487-40-5

tert-butyl propionate

1-bromo-3-fluoro-4-phenylbenzene
41604-19-7

1-bromo-3-fluoro-4-phenylbenzene

tert-butyl α-(3-fluoro-4-phenylphenyl)propionate

tert-butyl α-(3-fluoro-4-phenylphenyl)propionate

Conditions
ConditionsYield
Stage #1: tert-butyl propionate With palladium diacetate; lithium hexamethyldisilazane; DavePhos In hexanes; toluene at -10℃; Inert atmosphere;
Stage #2: 1-bromo-3-fluoro-4-phenylbenzene In hexanes; toluene at -10 - 80℃; Inert atmosphere;
90%
With palladium diacetate; lithium hexamethyldisilazane; DavePhos In toluene at 80℃; for 0.333333h;86%
With 1,3-bis(2,6-diisopropylphenyl)-4,5-dihydro-1H-imidazolium tetrafluoroborate; sodium hexamethyldisilazane; bis(dibenzylideneacetone)-palladium(0) In toluene at 20℃; for 12h;66%
methyl cyclohexylcarboxylate
4630-82-4

methyl cyclohexylcarboxylate

1-bromo-3-fluoro-4-phenylbenzene
41604-19-7

1-bromo-3-fluoro-4-phenylbenzene

methyl α-(3-fluoro-4-phenylphenyl)cyclohexanecarboxylate

methyl α-(3-fluoro-4-phenylphenyl)cyclohexanecarboxylate

Conditions
ConditionsYield
With tri-tert-butyl phosphine; lithium dicyclohexylamide; bis(dibenzylideneacetone)-palladium(0) In toluene at 20℃; for 18h;90%
benzyl 2-methylpropanoate
103-28-6

benzyl 2-methylpropanoate

1-bromo-3-fluoro-4-phenylbenzene
41604-19-7

1-bromo-3-fluoro-4-phenylbenzene

benzyl α-(3-fluoro-4-phenylphenyl)isobutyrate

benzyl α-(3-fluoro-4-phenylphenyl)isobutyrate

Conditions
ConditionsYield
With tri-tert-butyl phosphine; lithium dicyclohexylamide; bis(dibenzylideneacetone)-palladium(0) In toluene at 20℃; for 12h;90%
1-bromo-3-fluoro-4-phenylbenzene
41604-19-7

1-bromo-3-fluoro-4-phenylbenzene

4,4,5,5-tetramethyl-2-phenethyl-1,3,2-dioxaborolane
165904-22-3

4,4,5,5-tetramethyl-2-phenethyl-1,3,2-dioxaborolane

2-fluoro-4-phenethylbiphenyl
1361022-83-4

2-fluoro-4-phenethylbiphenyl

Conditions
ConditionsYield
With tris-(dibenzylideneacetone)dipalladium(0); sodium t-butanolate; ruphos In water; toluene at 80℃; for 24h; Suzuki coupling; Inert atmosphere;90%
1-bromo-3-fluoro-4-phenylbenzene
41604-19-7

1-bromo-3-fluoro-4-phenylbenzene

acetyl chloride
75-36-5

acetyl chloride

4-acetyl-4'-bromo-2'-fluorobiphenyl
53591-96-1

4-acetyl-4'-bromo-2'-fluorobiphenyl

Conditions
ConditionsYield
With aluminium trichloride In various solvent(s) for 16h; Ambient temperature;88%
With aluminium trichloride In various solvent(s)
With sodium bicarbonate; aluminium trichloride In dichloromethane; water96 g (82.2%)
1-bromo-3-fluoro-4-phenylbenzene
41604-19-7

1-bromo-3-fluoro-4-phenylbenzene

N-tosyl-1,2-oxazetidine

N-tosyl-1,2-oxazetidine

C21H20FNO3S

C21H20FNO3S

Conditions
ConditionsYield
Stage #1: 1-bromo-3-fluoro-4-phenylbenzene With tert.-butyl lithium In tetrahydrofuran; pentane at -78 - -40℃; for 0.75h; Inert atmosphere;
Stage #2: N-tosyl-1,2-oxazetidine With N,N,N,N,-tetramethylethylenediamine In tetrahydrofuran; pentane at -55℃; for 1h; Inert atmosphere;
88%
1-bromo-3-fluoro-4-phenylbenzene
41604-19-7

1-bromo-3-fluoro-4-phenylbenzene

tetramethylammonium trifluoromethylselenate(0)
75264-92-5

tetramethylammonium trifluoromethylselenate(0)

(2-fluoro-[1,1'-biphenyl]-4-yl)(trifluoromethyl)selane

(2-fluoro-[1,1'-biphenyl]-4-yl)(trifluoromethyl)selane

Conditions
ConditionsYield
With [2,2]bipyridinyl; bis(1,5-cyclooctadiene)nickel (0) In tetrahydrofuran at 20℃; for 12h; Inert atmosphere;86%
1-bromo-3-fluoro-4-phenylbenzene
41604-19-7

1-bromo-3-fluoro-4-phenylbenzene

propionyl chloride
79-03-8

propionyl chloride

2-fluoro-4-bromo-4'-propionylbiphenyl
116831-22-2

2-fluoro-4-bromo-4'-propionylbiphenyl

Conditions
ConditionsYield
With aluminium trichloride In various solvent(s) for 16h; Ambient temperature;85%
With aluminium trichloride In various solvent(s)
methanethiosulfonic acid S-methyl ester
2949-92-0

methanethiosulfonic acid S-methyl ester

1-bromo-3-fluoro-4-phenylbenzene
41604-19-7

1-bromo-3-fluoro-4-phenylbenzene

2-fluoro-4-(methylthio)biphenyl
1187442-21-2

2-fluoro-4-(methylthio)biphenyl

Conditions
ConditionsYield
Stage #1: 1-bromo-3-fluoro-4-phenylbenzene With magnesium; lithium chloride In tetrahydrofuran at 25℃; for 0.5h; Inert atmosphere;
Stage #2: methanethiosulfonic acid S-methyl ester In tetrahydrofuran at 0 - 25℃; Inert atmosphere;
Stage #3: In tetrahydrofuran
84%
1-bromo-3-fluoro-4-phenylbenzene
41604-19-7

1-bromo-3-fluoro-4-phenylbenzene

cyclohexanone
108-94-1

cyclohexanone

C18H19FO

C18H19FO

Conditions
ConditionsYield
Stage #1: 1-bromo-3-fluoro-4-phenylbenzene With n-butyllithium In tetrahydrofuran; hexane at -78℃; for 0.5h; Inert atmosphere;
Stage #2: cyclohexanone In tetrahydrofuran; hexane at -78 - 20℃; for 1.83333h; Inert atmosphere;
84%
1-bromo-3-fluoro-4-phenylbenzene
41604-19-7

1-bromo-3-fluoro-4-phenylbenzene

butyryl chloride
141-75-3

butyryl chloride

1-(4'-Bromo-2'-fluoro-biphenyl-4-yl)-butan-1-one
116831-23-3

1-(4'-Bromo-2'-fluoro-biphenyl-4-yl)-butan-1-one

Conditions
ConditionsYield
With aluminium trichloride In various solvent(s) for 16h; Ambient temperature;83%
methyl 2-methylbutanoate
868-57-5

methyl 2-methylbutanoate

1-bromo-3-fluoro-4-phenylbenzene
41604-19-7

1-bromo-3-fluoro-4-phenylbenzene

methyl α-(3-fluoro-4-phenylphenyl)-α-methyl-butyrate

methyl α-(3-fluoro-4-phenylphenyl)-α-methyl-butyrate

Conditions
ConditionsYield
With tri-tert-butyl phosphine; lithium dicyclohexylamide; bis(dibenzylideneacetone)-palladium(0) In toluene at 20℃; for 10h;83%
1-bromo-3-fluoro-4-phenylbenzene
41604-19-7

1-bromo-3-fluoro-4-phenylbenzene

tert-butyl (3R)-3-({[(1S)-2,2-dimethyl-1-({[(1R)-1-phenylethyl]amino}carbonyl)propyl]amino}carbonyl)hex-5-enoate
230961-69-0

tert-butyl (3R)-3-({[(1S)-2,2-dimethyl-1-({[(1R)-1-phenylethyl]amino}carbonyl)propyl]amino}carbonyl)hex-5-enoate

A

tert-butyl (3R,5Z)-3-({[(1S)-2,2-dimethyl-1-({[(1R)-1-phenylethyl]amino}carbonyl)propyl]amino}carbonyl)-6-[3-fluoro-(4-phenyl)phenyl]hex-5-enoate

tert-butyl (3R,5Z)-3-({[(1S)-2,2-dimethyl-1-({[(1R)-1-phenylethyl]amino}carbonyl)propyl]amino}carbonyl)-6-[3-fluoro-(4-phenyl)phenyl]hex-5-enoate

B

C37H45FN2O4

C37H45FN2O4

C

tert-butyl (3R,5E)-3-({[(1S)-2,2-dimethyl-1-({[(1R)-1-phenylethyl]amino}carbonyl)propyl]amino}carbonyl)-6-[3-fluoro-(4-phenyl)phenyl]hex-5-enoate
230962-25-1

tert-butyl (3R,5E)-3-({[(1S)-2,2-dimethyl-1-({[(1R)-1-phenylethyl]amino}carbonyl)propyl]amino}carbonyl)-6-[3-fluoro-(4-phenyl)phenyl]hex-5-enoate

Conditions
ConditionsYield
A n/a
B n/a
C 83%
1-bromo-3-fluoro-4-phenylbenzene
41604-19-7

1-bromo-3-fluoro-4-phenylbenzene

phenylboronic acid
98-80-6

phenylboronic acid

2'-fluoro-1,1':4',1''-terphenyl
113770-42-6

2'-fluoro-1,1':4',1''-terphenyl

Conditions
ConditionsYield
With potassium carbonate In ethanol; water at 75℃; for 12h; Suzuki-Miyaura Coupling;83%
With potassium carbonate In ethanol; water for 0.333333h; Catalytic behavior; Suzuki-Miyaura Coupling; Heating; Green chemistry;60%
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