Flurbiprofen,5104-49-4

Details:

Product Name: Flurbiprofen
Synonyms: 1’-biphenyl)-4-aceticacid,2-fluoro-alpha-methyl-(;1’-biphenyl]-4-aceticacid,2-fluoro-alpha-methyl-[;2-(2-Fluoro-4-biphenyl)propionicacid;2-(2-fluoro-4-biphenylyl)propionicacid;2-fluoro-alpha-methyl-4-biphenylaceticaci;2-Fluoro-a-methyl-(1,1’-biphenyl)-4-aceticacid;bts18322;fp70
CAS: 5104-49-4
MF: C15H13FO2
MW: 244.26
EINECS: 225-827-6
Product Categories: Intermediates & Fine Chemicals;Pharmaceuticals;API's;Aromatics;API;ANSAID;Other APIs
Mol File: 5104-49-4.mol
Flurbiprofen Structure
Flurbiprofen Chemical Properties
mp  110-112 °C(lit.)
storage temp.  Store at RT
Merck  4199
CAS DataBase Reference 5104-49-4(CAS DataBase Reference)
Safety Information
Hazard Codes  T,C
Risk Statements  25-23/24/25
Safety Statements  36/37/39-45
RIDADR  UN 2811 6.1/PG 2
WGK Germany  3
RTECS  DU8341000
HazardClass  6.1(b)
PackingGroup  III
MSDS Information
Provider Language
Flurbiprofen English
SigmaAldrich English
ALFA English
Flurbiprofen Usage And Synthesis
Anti-inflammatory analgesics Flibanserin , also known as flurbiprofen, flurbiprofen, is a potent Phenylalanine anti-inflammatory and antipyretic analgesics,it can inhibit prostaglandin synthesizing cyclooxygenase to have analgesic, anti-inflammatory and antipyretic effects. Its anti-inflammatory and analgesic effects are 250 times and 50 times of aspirin (also known as acetylsalicylic acid) . The oral absorption is rapid , peak plasma concentration achieves after 1.5 hours , half-life is 3.5 hours, it has wide tissue distribution, PPB is 99.4%, it can compete with drugs having a high plasma protein binding rate to bind plasma protein .it Metabolizes in the liver and becomes flurbiprofen hydroxy and its aldehyde acid conjugates. T1 / 2 is 3.5 h. Urine and fecal excretion,account for approximately 60% and 40% respectively . Age has no effect on drug metabolism. It is Mainly used for rheumatoid arthritis, rheumatoid arthritis, ankylosing spondylitis, osteoarthritis. It is also used in preventing aphakic cystoid patchy edema After surgical removal of the lens, inhibiting pupillary constrictionsurgery, treatment of inflammation after cataract and trabeculoplasty argon laser eye surgery. It Also applies to pain caused by some other reasons such as trauma, sprains, surgery.
Chemical Properties White to Off-White Crystalline Solid
Usage An anti-inflammatory used as an analgesic.
Usage antiinflammatory, analgesic
Biological Activity Potent inhibitor of cyclooxygenase (IC 50 values are 0.1 and 0.4 μ M for inhibition of human COX-1 and COX-2 respectively). Analgesic, anti-inflammatory and antipyretic in vivo . Inhibits tumor cell growth in vitro and in vivo . Also inhibits fibroblast proliferation in vitro .
Flurbiprofen Preparation Products And Raw materials
Preparation Products FLURBIPROFEN AXETIL
Raw materials 2-Fluorobiphenyl