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Dayang Chem (Hangzhou) Co.,Ltd.

As a leading manufacturer and supplier of chemicals in China, DayangChem not only supply popular chemicals, but also DayangChem's R&D center offer custom synthesis services. DayangChem can provide different quantities of custom synthesis ch

2,4-Dichloropyrimidine Manufacturer/High quality/Best price/In stock

Cas:3934-20-1

Min.Order:1 Kilogram

FOB Price: $3.0

Type:Lab/Research institutions

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Yangzhou Qinyuan Pharmatech Co.,Ltd

2,4-Dichloropyrimidine Cas no. 3934-20-1 API or Intermediates Our products are high quality, good price, quick delivery time and we supply all customers best service in the long-term cooperation as below: 1.Established manufacturer. 2.Professiona

2,4-Dichloropyrimidine

Cas:3934-20-1

Min.Order:100 Gram

Negotiable

Type:Trading Company

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AstaTech ( Chengdu) BioPharmaceutical Corp.

Quality assurance, stable process and affordable priceAppearance:detailed see specifications Storage:enquiry Package:according to the clients requirement Application:Pharmaceutical intermediates Transportation:Normal Port:chengdu

2,4-Dichloropyrimidine

Cas:3934-20-1

Min.Order:0

Negotiable

Type:Trading Company

inquiry

Sinoway Industrial Co., Ltd.

Why is SINOWAY: 1) Specialized in pharmaceutical and healthcare industrial for 34 years. 2) ISO 9001:2015 & SGS audited supplier . 3) Accept various payment terms : T.T 30-60 days. 4) We have warehouse in USA with quickly shipment . 5) We c

99% up by HPLC 2,4-Dichloropyrimidine / Osimertinib Intermediate 3934-20-1

Cas:3934-20-1

Min.Order:1 Kilogram

Negotiable

Type:Trading Company

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Hangzhou Dingyan Chem Co., Ltd

Items Standard Result Appearance Pale yellow or offwhite crystalline Complies Assay ≥98%

High purity 2,4-Dichloropyrimidine with high quality and best price cas:3934-20-1

Cas:3934-20-1

Min.Order:1 Kilogram

FOB Price: $125.0 / 150.0

Type:Manufacturers

inquiry

Simagchem Corporation

Welcome to Simagchem, your partner in China as a premier supply of bulk specialty chemicals for industry and life science. We introduce experienced quality product and exceptional JIT service with instant market intelligence in China to benefit our

High quality 2,4-Dichloropyrimidine supplier in China

Cas:3934-20-1

Min.Order:0 Metric Ton

Negotiable

Type:Manufacturers

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Jinan Finer Chemical Co., Ltd

Our Services 1. Certificate Of Analysis (COA) 2. Material Safety Data Sheet (MSDS) 3. Route of synthesis (ROS) 4. Method of Aanlysis (MOA) 5. Nuclear Magnetic Resonance (NMR) 6. Packing pictures and loading video before loading 7. Free S

2,4-Dichloropyrimidine

Cas:3934-20-1

Min.Order:1 Gram

FOB Price: $8.0

Type:Lab/Research institutions

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Wuhan Fortuna Chemical Co.,Ltd

Hot selling 2,4-Dichloropyrimidine CAS 3934-20-1 with competitive price Company profile Wuhan Fortuna Chemical Co.,Ltd established in 2006, is a big integrative chemical enterprise being engaged in Pharmaceutical & its intermediates, Food/Fe

Hot selling 2,4-Dichloropyrimidine CAS 3934-20-1 with competitive price

Cas:3934-20-1

Min.Order:1 Gram

FOB Price: $10.0

Type:Trading Company

inquiry

Hefei TNJ chemical industry co.,ltd

Specifications Name:2,4-Dichloropyrimidine CAS:3934-20-1 MF:C4H2Cl2N2 MW:148.98 Assay:98%min Name:2,4-Dichloropyrimidine CAS:3934-20-1 MF:C4H2Cl2N2 MW:148.98 Assay:98%min Molecular formula:

Good quality 2,4-Dichloropyrimidine//3934-20-1

Cas:3934-20-1

Min.Order:1 Kilogram

Negotiable

Type:Trading Company

inquiry

Hangzhou Think Chemical Co. Ltd

2,4-Dichloropyrimidine CAS No.:3934-20-1 Name: 2,4-Dichloropyrimidine Molecular Structure: Molecular Formula: C4H2Cl2N2 Molec

High purity 2,4-Dichloropyrimidine CAS No.:3934-20-1

Cas:3934-20-1

Min.Order:1 Kilogram

FOB Price: $2.0

Type:Other

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Ality Chemical Corporation

The above product is Ality Chemical's strong item with best price, good quality and fast supply. Ality Chemical has been focusing on the research and production of this field for over 14 years. At the same time, we are always committed to providi

Factory Supply 2,4-dichloropyrimidine

Cas:3934-20-1

Min.Order:1

Negotiable

Type:Other

inquiry

Xi'an Xszo Chem Co., Ltd.

1. Factory price and high quality must be guaranteed, base on 8 years of production and R&D experience2. Free samples will be provided,ensure specifications and quality are right for customer3. Customers will receive the most professional technical s

Factory Price OLED 99% 3934-20-1 2,4-dichloropyrimidine Manufacturer

Cas:3934-20-1

Min.Order:1 Gram

FOB Price: $0.1

Type:Manufacturers

inquiry

ANQING CHICO PHARMACEUTICAL CO.,LTD.

High quality. Factory supply. In stock. Best price. 1.Quick response within 24 hours. 2.Best quality in your requirement. 3.We pay more attention on delivery time, and usually ship on time. 4.Free samples will be provided. 5.Ensure specifications an

2,4-Dichloropyrimidine

Cas:3934-20-1

Min.Order:1 Kilogram

Negotiable

Type:Trading Company

inquiry

COLORCOM LTD.

Colorcom is a global leader in industrial chemical manufacturing and is continuously innovating and transforming to exceed client expectations and industry standards. Colorcom prides itself on superior customer and technical focus, while focusing on

2,4-Dichloropyrimidine

Cas:3934-20-1

Min.Order:1 Metric Ton

Negotiable

Type:Manufacturers

inquiry

Chemwill Asia Co., Ltd.

Our main production base is located in Xuzhou industry park. We are certified both to the ISO 9001 and ISO 14001 Standards, have a safety management system in place.Our R&D team masters core technology for process-design of target building block

2,4-Dichloropyrimidine

Cas:3934-20-1

Min.Order:5 Kiloliter

FOB Price: $1.2 / 5.0

Type:Manufacturers

inquiry

Henan Tianfu Chemical Co., Ltd.

TIANFUCHEM--3934-20-1 -- 2,4-Dichloropyrimidine factory price Our company was built in 2009 with an ISO certificate.In the past 10 years, we have grown up as a famous fine chemicals supplier in China And we had established stable business

TIANFUCHEM--3934-20-1 -- 2,4-Dichloropyrimidine factory price

Cas:3934-20-1

Min.Order:1 Metric Ton

FOB Price: $2000.0

Type:Lab/Research institutions

inquiry

Zhuozhou Wenxi import and Export Co., Ltd

WITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et

HPLC 98% CAS 3934-20-1 with high-quality service

Cas:3934-20-1

Min.Order:10 Gram

FOB Price: $146.0 / 176.0

Type:Trading Company

inquiry

Wuhan Han Sheng New Material Technology Co.,Ltd

Our Advantage: high quality with competitive price High quality standard: BP/USP/EP Enterprise standard All purity customized Fast and safe delivery We have reliable forwarder who can help us deliver our goods more fast and safe. We

High purity 2,4-Dichloropyrimidine with high quality and best price cas:3934-20-1

Cas:3934-20-1

Min.Order:10 Kilogram

Negotiable

Type:Trading Company

inquiry

Shandong Hanjiang Chemical Co., Ltd.

Hello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by email in time prod

2,4-Dichloropyrimidine

Cas:3934-20-1

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

LIDE PHARMACEUTICALS LIMITED

Advantage : LIDE PHARMACEUTICALS LTD. is a mid-small manufacturing-type enterprise, engaged in pharmaceutical intermediates of R&D, custom-made and production, and also involving trading chemicals for export. We have established the R&amp

2,4-Dichloropyrimidine/ LIDE PHARMA- Factory supply / Best price

Cas:3934-20-1

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Henan Sinotech Import&Export Corporation

Product Name: 2,4-Dichloropyrimidine Synonyms: 2,4-dichloro-pyrimidin;2,4-Dichlorpyrimidin;Pyrimidine,2,4-dichloro-;AKOS 91058;2,4DCPY;2,4-DICHLOROPYRIMIDINE;2,6-DICHLOROPYRIMIDINE;2-4-DICHLOROPYRIMIDIN

2,4-Dichloropyrimidine CAS: 3934-20-1

Cas:3934-20-1

Min.Order:5 Metric Ton

FOB Price: $1.0 / 2.0

Type:Other

inquiry

Hebei yanxi chemical co.,LTD.

chengdu and import and export trade co., LTD., who registered capital of 10 million yuan, nearly to $2 million, we have a pharmaceutical raw materials factory production of pharmaceutical raw materials, and a reagent r&d center, and we

Lowest price and high quality Pazopanib intermediate

Cas:3934-20-1

Min.Order:1 Gram

FOB Price: $1.0

Type:Manufacturers

inquiry

Hubei Langyou International Trading Co., Ltd

High purity 2,4-Dichloropyrimidine with high quality and best price cas:3934-20-1 1. Guaranteed purity; 2. Large quantity in stock; 3. Largest manufacturer; 4. Best service after shipment with email; 5. High quality & competitive

Shanghai Upbio Tech Co.,Ltd

1.No Less 8 years exporting experience. Clients can 100% received goods 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Upbio is Specialized

2,4-Dichloropyrimidine 3934-20-1

Cas:3934-20-1

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Hebei Nengqian Chemical Import and Export Co., LTD

With our good experience, we offer detailed technical support and advice to assist customers. We communicate closely with customers to establish their quality requirements. Consistent Quality Our plant has strict quality control in each manufactu

2, 4-Dichloropyrimidine:3934-20-1

Cas:3934-20-1

Min.Order:1 Kilogram

FOB Price: $1.0 / 10.0

Type:Trading Company

inquiry

Baoji Guokang Healthchem co.,ltd

Our company has been in existence for 10 years since its establishment. We have our own unique team. The company integrates independent research and development, production and sales. We have established famous brands at home and abroad. At prese

2,4-Dichloropyrimidine

Cas:3934-20-1

Min.Order:1 Kilogram

FOB Price: $85.0 / 100.0

Type:Trading Company

inquiry

Qingdao Beluga Import and Export Co., LTD

2,4-Dichloropyrimidine CAS:3934-20-1 Qingdao Belugas Import and Export Co., Ltd. is a scientific and technological company integrating research and development, production and trade of chemical intermediates, specializing in high quality organic int

2,4-Dichloropyrimidine CAS:3934-20-1

Cas:3934-20-1

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Changchun Artel lmport and Export trade company

Minimum Order Qty. 10 Gram Supply Ability 500 Kilograms/Month Storage store in cool, dry, ventilated place 20℃ Delivery Time 3 business days after payment Payment Term TT,western union,Paypal,MoneyGram Package 10g,20g,50g,100g,500g,1KGS,

2,4-Dichloropyrimidine CAS NO.3934-20-1

Cas:3934-20-1

Min.Order:10 Gram

Negotiable

Type:Trading Company

inquiry

Henan Wentao Chemical Product Co., Ltd.

Henan Wentao Chemical Product Co.,Ltd is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds, which are widely used in the fields of prod

CAS NO.:3934-20-1

Cas:3934-20-1

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Leader Biochemical Group

PRODUCT DETAILS

China Original Largest Manufacturer sales 2,4-Dichloropyrimidine CAS 3934-20-1

Cas:3934-20-1

Min.Order:500 Kilogram

FOB Price: $1.0 / 2.0

Type:Lab/Research institutions

inquiry

Synthetic route

uracil
66-22-8

uracil

2,6-Dichloropyrimidine
3934-20-1

2,6-Dichloropyrimidine

Conditions
ConditionsYield
With trichlorophosphate at 105℃;98%
With phosgene; Triphenylphosphine oxide In nitrobenzene at -5 - 105℃; for 0.666667h; Inert atmosphere;90%
With N-ethyl-N,N-diisopropylamine; trichlorophosphate at 0 - 95℃; for 3h; Sealed tube;82%
2,4-dihydroxypyrimidine
66-22-8

2,4-dihydroxypyrimidine

2,6-Dichloropyrimidine
3934-20-1

2,6-Dichloropyrimidine

Conditions
ConditionsYield
With dmap; thionyl chloride; bis(trichloromethyl) carbonate at 65 - 70℃;95%
With dmap; thionyl chloride; bis(trichloromethyl) carbonate for 9.5h; Reflux; Green chemistry;95%
With pyridine; trichlorophosphate at 180℃; under 150.015 - 900.09 Torr; for 2h; Neat (no solvent);91%
With trichlorophosphate
With thionyl chloride at 20℃;
4-Chloro-2-methylthiopyrimidine
49844-90-8

4-Chloro-2-methylthiopyrimidine

2,6-Dichloropyrimidine
3934-20-1

2,6-Dichloropyrimidine

Conditions
ConditionsYield
With sulfuryl dichloride In dichloromethane; acetonitrile at 0℃; for 24h;60%
4-hydroxy-2-mercaptopyrimidine
141-90-2

4-hydroxy-2-mercaptopyrimidine

2,6-Dichloropyrimidine
3934-20-1

2,6-Dichloropyrimidine

Conditions
ConditionsYield
With phosphorus pentachloride
dichlorotriphenoxyphosphorane
15493-07-9

dichlorotriphenoxyphosphorane

uracil
66-22-8

uracil

2,6-Dichloropyrimidine
3934-20-1

2,6-Dichloropyrimidine

Conditions
ConditionsYield
at 200℃;
2,4,6-trichloropyrimidine
3764-01-0

2,4,6-trichloropyrimidine

2,6-Dichloropyrimidine
3934-20-1

2,6-Dichloropyrimidine

Conditions
ConditionsYield
With ammonium chloride; zinc In water; acetone
2-thiouracil
141-90-2

2-thiouracil

phosphorus pentachloride
10026-13-8, 874483-75-7

phosphorus pentachloride

2,6-Dichloropyrimidine
3934-20-1

2,6-Dichloropyrimidine

uracil
66-22-8

uracil

phosphorus oxychloride

phosphorus oxychloride

2,6-Dichloropyrimidine
3934-20-1

2,6-Dichloropyrimidine

Conditions
ConditionsYield
at 140℃;
ammonium hydroxide
1336-21-6

ammonium hydroxide

4,6-dichloro-5-methoxy-2-(2-naphthylmethylthio)-pyrimidine
166752-02-9

4,6-dichloro-5-methoxy-2-(2-naphthylmethylthio)-pyrimidine

A

2,6-Dichloropyrimidine
3934-20-1

2,6-Dichloropyrimidine

B

4-amino-5-methoxy-6-chloro-2-(2-naphthylmethylthio)-pyrimidine

4-amino-5-methoxy-6-chloro-2-(2-naphthylmethylthio)-pyrimidine

Conditions
ConditionsYield
In acetonitrile
In acetonitrile
4,6-dihydroxy-5-benzylthiopyrimidine
138918-23-7

4,6-dihydroxy-5-benzylthiopyrimidine

A

2,6-Dichloropyrimidine
3934-20-1

2,6-Dichloropyrimidine

B

4,6-dichloro-5-benzylthiopyrimidine
138918-24-8

4,6-dichloro-5-benzylthiopyrimidine

Conditions
ConditionsYield
With trichlorophosphate In chloroform
With trichlorophosphate In chloroform
Vilsmeier reagent
3724-43-4, 149409-22-3

Vilsmeier reagent

malononitrile
109-77-3

malononitrile

A

2,6-Dichloropyrimidine
3934-20-1

2,6-Dichloropyrimidine

B

1-(dimethylamine)-2,2-dicyanoethylene
16849-88-0

1-(dimethylamine)-2,2-dicyanoethylene

Conditions
ConditionsYield
Stage #1: Vilsmeier reagent; malononitrile at -10℃;
Stage #2: With sodium hydroxide In water pH=3; Cooling with ice;
N,N-dimethyl-formamide
68-12-2, 33513-42-7

N,N-dimethyl-formamide

uracil
66-22-8

uracil

A

2,6-Dichloropyrimidine
3934-20-1

2,6-Dichloropyrimidine

B

2,4-dichloro-5-pyrimidinecarboxaldehyde
871254-61-4

2,4-dichloro-5-pyrimidinecarboxaldehyde

Conditions
ConditionsYield
Stage #1: N,N-dimethyl-formamide With trichlorophosphate at -5 - 5℃; for 0.5h;
Stage #2: uracil at 5℃; for 2h; Temperature;
2,6-Dichloropyrimidine
3934-20-1

2,6-Dichloropyrimidine

1-(2-hydroxy-3-methyl-5-fluorobenzyl)-3-(3-t-butyl-1-p-tolyl-1H-pyrazol-5-yl)urea
940875-66-1

1-(2-hydroxy-3-methyl-5-fluorobenzyl)-3-(3-t-butyl-1-p-tolyl-1H-pyrazol-5-yl)urea

1-(2-(2-chloropyrimidin-4-yloxy)-3-methyl-5-fluorobenzyl)-3-(3-t-butyl-1-p-tolyl-1H-pyrazol-5-yl)urea
940871-30-7

1-(2-(2-chloropyrimidin-4-yloxy)-3-methyl-5-fluorobenzyl)-3-(3-t-butyl-1-p-tolyl-1H-pyrazol-5-yl)urea

Conditions
ConditionsYield
With sodium hydroxide In water; acetone at 0 - 20℃; for 24h;100%
With sodium hydroxide In water; acetone at 20℃;
2,6-Dichloropyrimidine
3934-20-1

2,6-Dichloropyrimidine

sodium thiomethoxide
5188-07-8

sodium thiomethoxide

2,4-Bis(methylthio)pyrimidine
5909-26-2

2,4-Bis(methylthio)pyrimidine

Conditions
ConditionsYield
In tetrahydrofuran at 80℃; for 4h;100%
2,6-Dichloropyrimidine
3934-20-1

2,6-Dichloropyrimidine

1-isopropyl-2-methoxy-6-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2- yl)-1H-benzo[d]imidazole

1-isopropyl-2-methoxy-6-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2- yl)-1H-benzo[d]imidazole

6-(2-chloropyrimidin-4-yl)-1-isopropyl-2-methoxy-1H-benzo[d]imidazole

6-(2-chloropyrimidin-4-yl)-1-isopropyl-2-methoxy-1H-benzo[d]imidazole

Conditions
ConditionsYield
With bis-triphenylphosphine-palladium(II) chloride; sodium carbonate In water; acetonitrile at 80℃; for 2.5h; Inert atmosphere;100%
2,6-Dichloropyrimidine
3934-20-1

2,6-Dichloropyrimidine

1-isopropyl-2-methyl-6-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-benzo[d]imidazole

1-isopropyl-2-methyl-6-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-benzo[d]imidazole

6-(2-chloropyrimidin-4-yl)-1-isopropyl-2-methyl-1H-benzo[d]imidazole

6-(2-chloropyrimidin-4-yl)-1-isopropyl-2-methyl-1H-benzo[d]imidazole

Conditions
ConditionsYield
With bis-triphenylphosphine-palladium(II) chloride; sodium carbonate In water; acetonitrile at 80℃; for 2.5h; Inert atmosphere;100%
2,6-Dichloropyrimidine
3934-20-1

2,6-Dichloropyrimidine

4-tert-butoxy-1-isopropyl-2-methyl-6-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-benzo[d]imidazole

4-tert-butoxy-1-isopropyl-2-methyl-6-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-benzo[d]imidazole

6-(2-chloropyrimidin-4-yl)-4-tert-butoxy-1-isopropyl-2-methyl-1H-benzo[d]imidazole

6-(2-chloropyrimidin-4-yl)-4-tert-butoxy-1-isopropyl-2-methyl-1H-benzo[d]imidazole

Conditions
ConditionsYield
With bis-triphenylphosphine-palladium(II) chloride; sodium carbonate In water; acetonitrile at 80℃; for 2h; Inert atmosphere;100%
2,6-Dichloropyrimidine
3934-20-1

2,6-Dichloropyrimidine

1-isopropyl-2-(methyl-d3)-6-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-benzo[d]imidazole

1-isopropyl-2-(methyl-d3)-6-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-benzo[d]imidazole

6-(2-chloropyrimidin-4-yl)-1-isopropyl-2-(methyl-d3)-1H-benzo[d]imidazole

6-(2-chloropyrimidin-4-yl)-1-isopropyl-2-(methyl-d3)-1H-benzo[d]imidazole

Conditions
ConditionsYield
With bis-triphenylphosphine-palladium(II) chloride; sodium carbonate In water; acetonitrile at 80℃; for 2.5h; Inert atmosphere;100%
2,6-Dichloropyrimidine
3934-20-1

2,6-Dichloropyrimidine

2-methyl-1-(propyl-2-yl-1,1,1,3,3,3-d6)-6-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-benzo[d]imidazole

2-methyl-1-(propyl-2-yl-1,1,1,3,3,3-d6)-6-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-benzo[d]imidazole

6-(2-chloropyrimidin-4-yl)-2-methyl-1-(propyl-2-yl-1,1,1,3,3,3-d6)-1H-benzo[d]imidazole

6-(2-chloropyrimidin-4-yl)-2-methyl-1-(propyl-2-yl-1,1,1,3,3,3-d6)-1H-benzo[d]imidazole

Conditions
ConditionsYield
With bis-triphenylphosphine-palladium(II) chloride; sodium carbonate In water; acetonitrile at 80℃; for 2.5h; Inert atmosphere;100%
2,6-Dichloropyrimidine
3934-20-1

2,6-Dichloropyrimidine

6-bromo-2-(difluoromethyl)-4-fluoro-1-(propan-2-yl)-1H-benzimidazole

6-bromo-2-(difluoromethyl)-4-fluoro-1-(propan-2-yl)-1H-benzimidazole

6-(2-chloropyrimidin-4-yl)-2-(difluoromethyl)-4-fluoro-1-isopropyl-1H-benzo[d]imidazole

6-(2-chloropyrimidin-4-yl)-2-(difluoromethyl)-4-fluoro-1-isopropyl-1H-benzo[d]imidazole

Conditions
ConditionsYield
Stage #1: 6-bromo-2-(difluoromethyl)-4-fluoro-1-isopropyl-1H-benzo[d]imidazole With dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH2Cl2; potassium acetate; bis(pinacol)diborane In 1,4-dioxane at 100℃; Inert atmosphere;
Stage #2: 2,6-Dichloropyrimidine With potassium carbonate In 1,4-dioxane; water at 80℃; for 2h; Inert atmosphere;
99.5%
2,6-Dichloropyrimidine
3934-20-1

2,6-Dichloropyrimidine

(5-fluoro-2-methoxypyridin-4-yl)boronic acid
1043869-98-2

(5-fluoro-2-methoxypyridin-4-yl)boronic acid

2-chloro-4-(5-fluoro-2-methoxypyridin-4-yl)pyrimidine
1453853-02-5

2-chloro-4-(5-fluoro-2-methoxypyridin-4-yl)pyrimidine

Conditions
ConditionsYield
With dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH2Cl2; sodium carbonate In 1,4-dioxane; water at 80℃; Suzuki Coupling; Inert atmosphere;99%
With dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH2Cl2; sodium carbonate In 1,4-dioxane; water at 80℃; Inert atmosphere;99%
2,6-Dichloropyrimidine
3934-20-1

2,6-Dichloropyrimidine

tert-butyl 3,5-dimethyl-2-oxoindoline-1-carboxylate
1262759-24-9

tert-butyl 3,5-dimethyl-2-oxoindoline-1-carboxylate

tert-butyl 3-(2-chloropyrimidin-4-yl)-3,5-dimethyl-2-oxoindoline-1-carboxylate

tert-butyl 3-(2-chloropyrimidin-4-yl)-3,5-dimethyl-2-oxoindoline-1-carboxylate

Conditions
ConditionsYield
With tetrabutylammomium bromide; potassium carbonate In tetrahydrofuran at 50℃; for 18h; Schlenk technique; Inert atmosphere; regioselective reaction;99%
2,6-Dichloropyrimidine
3934-20-1

2,6-Dichloropyrimidine

sodium methylate
124-41-4

sodium methylate

2-chloro-4-methoxypyrimidine
22536-63-6

2-chloro-4-methoxypyrimidine

Conditions
ConditionsYield
In methanol at 0 - 20℃;98%
In methanol at 20℃;97%
In methanol at 0℃; for 2h;82%
morpholine
110-91-8

morpholine

2,6-Dichloropyrimidine
3934-20-1

2,6-Dichloropyrimidine

4-(2-chloro-pyrimidin-4-yl)-morpholine
62968-37-0

4-(2-chloro-pyrimidin-4-yl)-morpholine

Conditions
ConditionsYield
With N-ethyl-N,N-diisopropylamine In acetonitrile at 55℃; for 2h;98%
With triethylamine In ethanol at 0℃; for 3h;90%
at 50℃; for 12h;88%
2,6-Dichloropyrimidine
3934-20-1

2,6-Dichloropyrimidine

1-t-Butoxycarbonylpiperazine
57260-71-6

1-t-Butoxycarbonylpiperazine

4-(2-chloropyrimidin-4-yl)piperazine-1-carboxylic acid tert-butyl ester
221050-88-0

4-(2-chloropyrimidin-4-yl)piperazine-1-carboxylic acid tert-butyl ester

Conditions
ConditionsYield
With triethylamine In N,N-dimethyl-formamide at 0 - 20℃; for 19h;98%
With triethylamine In N,N-dimethyl-formamide at 20℃;95%
With triethylamine In N,N-dimethyl-formamide at 20℃; for 4h; Product distribution / selectivity;90%
2,6-Dichloropyrimidine
3934-20-1

2,6-Dichloropyrimidine

5-amino-2-methylbenzimidazole
29043-48-9

5-amino-2-methylbenzimidazole

N-(2-chloropyrimidin-4-yl)-2-methyl-1H-benzo[d]imidazol-5-amine
191728-95-7

N-(2-chloropyrimidin-4-yl)-2-methyl-1H-benzo[d]imidazol-5-amine

Conditions
ConditionsYield
With sodium hydrogencarbonate In tetrahydrofuran; ethanol Reflux; Inert atmosphere;98%
morpholine
110-91-8

morpholine

2,6-Dichloropyrimidine
3934-20-1

2,6-Dichloropyrimidine

4-(4-chloro-pyrimidine-2-yl)-morpholine
24192-96-9

4-(4-chloro-pyrimidine-2-yl)-morpholine

Conditions
ConditionsYield
With potassium carbonate In tetrahydrofuran at 25℃; for 48h;98%
With triethylamine In dichloromethane at 0 - 20℃; for 4h;53%
With triethylamine In ethanol at 0 - 20℃;
2,6-Dichloropyrimidine
3934-20-1

2,6-Dichloropyrimidine

2-((tetrahydro-2H-pyran-4-yl)oxy)-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzonitrile
1292317-54-4

2-((tetrahydro-2H-pyran-4-yl)oxy)-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzonitrile

5-(2-chloropyrimidin-4-yl)-2-(tetrahydro-2H-pyran-4-yloxy)benzonitrile
1292317-55-5

5-(2-chloropyrimidin-4-yl)-2-(tetrahydro-2H-pyran-4-yloxy)benzonitrile

Conditions
ConditionsYield
With potassium carbonate; tetrakis(triphenylphosphine) palladium(0) In 1,4-dioxane; water at 90℃; for 16h;98%
With tetrakis(triphenylphosphine) palladium(0); potassium carbonate In 1,4-dioxane; water at 90℃; for 16h;44%
With potassium carbonate; tetrakis(triphenylphosphine) palladium(0) In water; acetonitrile for 20h; Reflux;41%
With potassium carbonate; tetrakis(triphenylphosphine) palladium(0) In water; acetonitrile at 90℃; for 16h; Product distribution / selectivity;41%
2,6-Dichloropyrimidine
3934-20-1

2,6-Dichloropyrimidine

((3-(dibenzo[b,d]thiophen-4-yl)phenyl)boronic acid)
1307859-67-1

((3-(dibenzo[b,d]thiophen-4-yl)phenyl)boronic acid)

C22H13ClN2S
1383628-98-5

C22H13ClN2S

Conditions
ConditionsYield
With tetrakis(triphenylphosphine) palladium(0); sodium carbonate In ethanol; water; toluene at 80℃; for 12h;98%
2,6-Dichloropyrimidine
3934-20-1

2,6-Dichloropyrimidine

4-chloro-1-methyl-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-indole

4-chloro-1-methyl-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-indole

2-chloro-4-(4-chloro-1N-methylindol-3-yl)pyrimidine

2-chloro-4-(4-chloro-1N-methylindol-3-yl)pyrimidine

Conditions
ConditionsYield
With dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH2Cl2; potassium carbonate In 1,4-dioxane; water at 80℃; for 4h; Inert atmosphere;98%
2,6-Dichloropyrimidine
3934-20-1

2,6-Dichloropyrimidine

2-(1,N-(methoxymethyl)-5-methyl-2-oxopyrid-3-yl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane

2-(1,N-(methoxymethyl)-5-methyl-2-oxopyrid-3-yl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane

2-chloro-4-(1,N-(methoxymethyl)-5-methyl-2-oxopyrid-3-yl)pyrimidine

2-chloro-4-(1,N-(methoxymethyl)-5-methyl-2-oxopyrid-3-yl)pyrimidine

Conditions
ConditionsYield
With dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH2Cl2; sodium carbonate In 1,4-dioxane; water at 100℃; for 3h; Inert atmosphere;98%
2,6-Dichloropyrimidine
3934-20-1

2,6-Dichloropyrimidine

tert-butyl 5-chloro-3-methyl-2-oxoindoline-1-carboxylate

tert-butyl 5-chloro-3-methyl-2-oxoindoline-1-carboxylate

tert-butyl 5-chloro-3-(2-chloropyrimidin-4-yl)-3-methyl-2-oxoindoline-1-carboxylate

tert-butyl 5-chloro-3-(2-chloropyrimidin-4-yl)-3-methyl-2-oxoindoline-1-carboxylate

Conditions
ConditionsYield
With tetrabutylammomium bromide; potassium carbonate In tetrahydrofuran at 50℃; for 18h; Schlenk technique; Inert atmosphere; regioselective reaction;98%
2,6-Dichloropyrimidine
3934-20-1

2,6-Dichloropyrimidine

4-methoxyphenylboronic acid
5720-07-0

4-methoxyphenylboronic acid

2-chloro-4-(4-methoxyphenyl)pyrimidine
75634-04-7

2-chloro-4-(4-methoxyphenyl)pyrimidine

Conditions
ConditionsYield
With sodium carbonate; tetrakis(triphenylphosphine) palladium(0) In water; acetonitrile at 90℃; for 16h;97%
With bis-triphenylphosphine-palladium(II) chloride; sodium carbonate In 1,4-dioxane; water; N,N-dimethyl-formamide at 80℃; for 10h; Inert atmosphere;87%
Stage #1: 2,6-Dichloropyrimidine; 4-methoxyphenylboronic acid With sodium carbonate In water for 0.25h; Suzuki-Miyaura Coupling; Inert atmosphere;
Stage #2: With tetrakis(triphenylphosphine) palladium(0) In water Suzuki-Miyaura Coupling; Inert atmosphere;
80%
With tetrakis(triphenylphosphine) palladium(0); potassium carbonate In ethanol; water; toluene at 55℃; for 12h; Suzuki coupling; Inert atmosphere; regioselective reaction;
2,6-Dichloropyrimidine
3934-20-1

2,6-Dichloropyrimidine

1H-indazol-5-ylamine
19335-11-6

1H-indazol-5-ylamine

N-(2-chloropyrimidin-4-yl)-1H-indazol-5-amine
1071105-22-0

N-(2-chloropyrimidin-4-yl)-1H-indazol-5-amine

Conditions
ConditionsYield
With triethylamine In ethanol Reflux;97%
With triethylamine In ethanol Temperature; Reflux;97%
With triethylamine In ethanol for 5h; Heating / reflux;80%
2,6-Dichloropyrimidine
3934-20-1

2,6-Dichloropyrimidine

methyl 4-mercaptobenzoate
6302-65-4

methyl 4-mercaptobenzoate

methyl 4-(2-chloropyrimidin-4-ylthio)benzoate
1042129-33-8

methyl 4-(2-chloropyrimidin-4-ylthio)benzoate

Conditions
ConditionsYield
Stage #1: methyl 4-mercaptobenzoate With sodium hydroxide In methanol; water at 20℃; for 1h;
Stage #2: 2,6-Dichloropyrimidine In methanol; water at 20℃; for 16.0833h;
97%
2-(benzo[d]oxazol-2-yl)acetonitrile
15344-56-6

2-(benzo[d]oxazol-2-yl)acetonitrile

2,6-Dichloropyrimidine
3934-20-1

2,6-Dichloropyrimidine

1,3-benzoxazol-2(3H)-ylidene(2-chloro-pyrimidin-4-yl)acetonitrile

1,3-benzoxazol-2(3H)-ylidene(2-chloro-pyrimidin-4-yl)acetonitrile

Conditions
ConditionsYield
Stage #1: 2-(benzo[d]oxazol-2-yl)acetonitrile With sodium hydride In tetrahydrofuran at 0℃; for 1h;
Stage #2: 2,6-Dichloropyrimidine In tetrahydrofuran at 20℃;
Stage #3: With hydrogenchloride In tetrahydrofuran; water at 4℃; for 3h;
97%
2,6-Dichloropyrimidine
3934-20-1

2,6-Dichloropyrimidine

tributyl(1-ethoxyvinyl)stannane
97674-02-7

tributyl(1-ethoxyvinyl)stannane

2-chloro-4-(1-ethoxyvinyl)pyrimidine
932738-81-3

2-chloro-4-(1-ethoxyvinyl)pyrimidine

Conditions
ConditionsYield
Stage #1: 2,6-Dichloropyrimidine; tributyl(1-ethoxyvinyl)stannane With bis-triphenylphosphine-palladium(II) chloride In N,N-dimethyl-formamide at 25 - 80℃; for 2h; Inert atmosphere;
Stage #2: With potassium fluoride In ethyl acetate; N,N-dimethyl-formamide at 20℃; for 2h;
97%
With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium fluoride In N,N-dimethyl-formamide at 85℃; for 4h; Inert atmosphere;80%
With bis-triphenylphosphine-palladium(II) chloride In N,N-dimethyl-formamide at 80℃; Stille coupling;79%
With bis-triphenylphosphine-palladium(II) chloride In N,N-dimethyl-formamide at 80℃; for 8h;
With potassium fluoride; tetrakis(triphenylphosphine) palladium(0) In N,N-dimethyl-formamide at 20 - 100℃; for 2h; Inert atmosphere;
2,6-Dichloropyrimidine
3934-20-1

2,6-Dichloropyrimidine

N-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)acetamide
214360-60-8

N-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)acetamide

N-(4-(2-chloropyrimidin-4-yl)phenyl)acetamide
945756-13-8

N-(4-(2-chloropyrimidin-4-yl)phenyl)acetamide

Conditions
ConditionsYield
With tetrakis(triphenylphosphine) palladium(0); sodium carbonate In water; acetonitrile Reflux; Inert atmosphere;97%
With tetrakis(triphenylphosphine) palladium(0); sodium carbonate In water; acetonitrile at 90℃;
2,6-Dichloropyrimidine
3934-20-1

2,6-Dichloropyrimidine

3-[(7-chloroquinolin-4-yl)amino]propan-1-ol
60548-22-3

3-[(7-chloroquinolin-4-yl)amino]propan-1-ol

4-chloro-2-[(7-chloroquinolin-4-ylamino)propoxy]pyrimidine
1526936-66-2

4-chloro-2-[(7-chloroquinolin-4-ylamino)propoxy]pyrimidine

Conditions
ConditionsYield
With potassium carbonate In tetrahydrofuran at 25℃; for 48h;97%
2,6-Dichloropyrimidine
3934-20-1

2,6-Dichloropyrimidine

Cyclopropylmethanol
2516-33-8

Cyclopropylmethanol

2-chloro-4-(cyclopropylmethoxy)pyrimidine

2-chloro-4-(cyclopropylmethoxy)pyrimidine

Conditions
ConditionsYield
Stage #1: Cyclopropylmethanol With sodium hydride In tetrahydrofuran; mineral oil at 20℃; for 0.0833333h;
Stage #2: 2,6-Dichloropyrimidine In tetrahydrofuran; mineral oil at 20℃;
97%
1-methyl-1H-pyrazol-4-ol
78242-20-3

1-methyl-1H-pyrazol-4-ol

2,6-Dichloropyrimidine
3934-20-1

2,6-Dichloropyrimidine

2-chloro-4-((1-methyl-1H-pyrazol-4-yl)oxy)pyrimidine

2-chloro-4-((1-methyl-1H-pyrazol-4-yl)oxy)pyrimidine

Conditions
ConditionsYield
With potassium carbonate In N,N-dimethyl-formamide at 20 - 40℃;97%

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