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Kono Chem Co.,Ltd

Xi'an Kono Chem Co., Ltd., founded in 2014, is a holding enterprise of Hongkong Pioneer Biotech Group. It is an export-oriented manufacturing enterprise supported by the Ministry of Commerce. Kono Chem is located in Xi'an, Shaanxi Province,

TRIBUTYL(1-ETHOXYVINYL)TIN CAS 97674-02-7

Cas:97674-02-7

Min.Order:100 Kilogram

FOB Price: $600.0 / 625.0

Type:Other

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Hebei yanxi chemical co.,LTD.

hebei yanxi chemical co., LTD who registered capital of 10 million yuan, nearly to $2 million, we have a pharmaceutical raw materials factory production of pharmaceutical raw materials, and a reagent r&d center, and we do research and developm

Tri-n-butyl(1-ethoxyvinyl)tin CAS NO.97674-02-7

Cas:97674-02-7

Min.Order:1 Metric Ton

FOB Price: $1.0 / 3.0

Type:Manufacturers

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Dayang Chem (Hangzhou) Co.,Ltd.

Dayangchem's R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. DayangChem can provide different quantities

Tributyl-(1-ethoxyvinyl)tin

Cas:97674-02-7

Min.Order:1 Kilogram

FOB Price: $3.0

Type:Lab/Research institutions

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Chemwill Asia Co., Ltd.

Our main production base is located in Xuzhou industry park. We are certified both to the ISO 9001 and ISO 14001 Standards, have a safety management system in place.Our R&D team masters core technology for process-design of target building block

Tributyl-(1-ethoxyvinyl)-tin

Cas:97674-02-7

Min.Order:5 Kiloliter

FOB Price: $1.2 / 5.0

Type:Manufacturers

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Henan Tianfu Chemical Co., Ltd.

TRIBUTYL(1-ETHOXYVINYL)TIN Basic information Product Name: TRIBUTYL(1-ETHOXYVINYL)TIN Synonyms: (1-ETHOXYVINYL)TRIBUTYLSTANNANE;1-ETHOXYVINYL-TRI-N-BUTYLTIN;TRIBUTYL(1-ETHOXYVINYL)TIN;(1

TRIBUTYL(1-ETHOXYVINYL)TIN

Cas:97674-02-7

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

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Zhuozhou Wenxi import and Export Co., Ltd

WITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et

Manufacturer supply CAS 97674-02-7 with best quality

Cas:97674-02-7

Min.Order:1 Kilogram

FOB Price: $139.0 / 210.0

Type:Trading Company

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Shanghai Upbio Tech Co.,Ltd

1.No Less 8 years exporting experience. Clients can 100% received goods 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Upbio is Specialized

Stannane,tributyl(1-ethoxyethenyl)- 97674-02-7

Cas:97674-02-7

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

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Shanghai Minstar Chemical Co., Ltd

Product Name: TRIBUTYL(1-ETHOXYVINYL)TIN CAS: 97674-02-7 MF: C16H34OSn MW: 361.15 EINECS: Mol File: 97674-02-7.mol TRIBUTYL(1-ETHOXYVINYL)TIN Structure TRIBUTYL(1-ETHOXYVINYL)TIN Chemical Properties Melting point <0°C

TRIBUTYL(1-ETHOXYVINYL)TIN

Cas:97674-02-7

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

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Baoji Guokang Healthchem co.,ltd

Our company has been in existence for 10 years since its establishment. We have our own unique team. The company integrates independent research and development, production and sales. We have established famous brands at home and abroad. At prese

TRIBUTYL(1-ETHOXYVINYL)TIN

Cas:97674-02-7

Min.Order:1 Gram

FOB Price: $354.0

Type:Trading Company

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Qingdao Beluga Import and Export Co., LTD

TRIBUTYL(1-ETHOXYVINYL)TIN CAS:97674-02-7 Qingdao Belugas Import and Export Co., Ltd. is a scientific and technological company integrating research and development, production and trade of chemical intermediates, specializing in high quality organi

TRIBUTYL(1-ETHOXYVINYL)TIN CAS:97674-02-7

Cas:97674-02-7

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

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Shandong Hanjiang Chemical Co., Ltd.

Hello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by emai

Stannane,tributyl(1-ethoxyethenyl)-

Cas:97674-02-7

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

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Henan Wentao Chemical Product Co., Ltd.

Henan Wentao Chemical Product Co.,Ltd is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds, which are widely used in the fields of prod

CAS NO.:97674-02-7

Cas:97674-02-7

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Hangzhou J&H Chemical Co., Ltd.

J&H CHEM R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. J&H CHEM has some Manufacturing base in Jia

Stannane,tributyl(1-ethoxyethenyl)-

Cas:97674-02-7

Min.Order:0

Negotiable

Type:Lab/Research institutions

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Shanghai Massive Chemical Technology Co., Ltd.

Massive Chemical is certified with ISO9001 and ISO14001 manufacturer for this product. We will offer all documents as requirement for the materials which includes, Certificate of Analysis, Material Safety Data Sheet, and Method of Analysis and

Tributyl(1-ethoxyvinyl)tin/High quality/Best price

Cas:97674-02-7

Min.Order:1 Gram

FOB Price: $1.0

Type:Lab/Research institutions

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Zibo Hangyu Biotechnology Development Co., Ltd

Zibo Hangyu Biotechnology Development Co., Ltd is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemi

Tributyl(1-ethoxyvinyl)stannane

Cas:97674-02-7

Min.Order:10 Gram

FOB Price: $100.0

Type:Lab/Research institutions

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Siwei Development Group Ltd.

Product name: Tributyl(1-Ethoxyvinyl)Tin CAS No.:97674-02-7 Molecule Formula:C16H34OSn Molecule Weight:361.15 Purity: 97% Package: 25kg/drum Description:Colorless transparent liquid Manufacture Standards:Enterprise Standard TESTI

High Quality Tributyl(1-Ethoxyvinyl)Tin in stock

Cas:97674-02-7

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Hangzhou Huarong Pharm Co., Ltd.

Hangzhou Huarong Pharm Co., Ltd.established since 2006 , has been actively developing specialty products for Finished Dosages, APIs, Intermediates, and Fine chemicals markets in North America, Europe, Korea, Japan, Mid-East and all over the World. Hu

TRIBUTYL(1-ETHOXYVINYL)TIN

Cas:97674-02-7

Min.Order:0

Negotiable

Type:Trading Company

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Win-Win chemical Co.Ltd

Stock products, own laboratory Package:Grams, Kilograms Application:For R&D Transportation:According to customer request Port:Shanghai

Tributyl(1-ethoxyvinyl)tin cas no. 97674-02-7 98%

Cas:97674-02-7

Min.Order:0

Negotiable

Type:Lab/Research institutions

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GIHI CHEMICALS CO.,LIMITED

Lower price, sample is available,SDS test documents are available,large stock in warehouseAppearance:White powder Storage:Sealed and preserved Package:200/Kilograms Application:Fine chemical intermediates, used as the main raw material for the synthe

Tributyl-(1-ethoxyvinyl)tin

Cas:97674-02-7

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Hangzhou Dingyan Chem Co., Ltd

Hangzhou Dingyan Chem is a leading manufacturer and supplier of chemicals in China.We develop,produce and distribute high quality pharmaceuticals, intermediates, special chemicals and other fine chemicals. We could give you: 1.Best quality in your re

Tri-n-butyl(1-ethoxyvinyl)tin

Cas:97674-02-7

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Shanghai Acmec Biochemical Technology Co., Ltd.

Acmec is a leading manufacturer and supplier of biochemical reagents and life science products. We have over 40,000 items in stock (real-time inventory) and offer discounted prices to registered members of the online store ( www.acmec.com.cn ) Appea

Acmec Tributyl(1-ethoxyvinyl)tin 1kg

Cas:97674-02-7

Min.Order:1 bottle

Negotiable

Type:Lab/Research institutions

inquiry

Hubei Taiho Chemical Co.,LTD

TAIHO Unique Advantages:1.We're factory2.Free samples available3.Commodity inspection can be done4.ISO9001,Kosher certifications5.10 years experiences Storage:Store in cool &dry place Package:aluminium foil bag/fiber can/plastic drum Application:comp

Tributyl(1-ethoxyvinyl)stannane

Cas:97674-02-7

Min.Order:0

Negotiable

Type:Manufacturers

inquiry

Xian Changyue Biological Technology Co., Ltd.

best seller Application:API

TRIBUTYL(1-ETHOXYVINYL)TIN

Cas:97674-02-7

Min.Order:0

Negotiable

Type:Manufacturers

inquiry

Hunan chemfish Pharmaceutical co.,Ltd

Hunan chemfish Pharmaceutical co.,Ltd.located in Lugu High-tech industral park ,Hunan province . with its own R&D center and more than 10000㎡manufacture plant . Chemfish owns 40 reactors from 1000L to 8000L. With complete auxiliary equipment as

Tributyl(1-ethoxyvinyl)tin

Cas:97674-02-7

Min.Order:0

Negotiable

Type:Manufacturers

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Antimex Chemical Limied

Ansciep Chemical is a professional enterprise manufacturing and distributing fine chemicals and speciality chemicals. We have been dedicated to heterocycle compounds and phenyl rings for tens of years. This is our mature product for export. Our quali

Stannane,tributyl(1-ethoxyethenyl)-

Cas:97674-02-7

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

HANGZHOU TIANYE CHEMICALS CO., LTD.

We product this chemical more than 10 years . We are very experience to export it to many countries, Our superior & stable quality , competitive price gain warm reception from our customers. Application:Chemical intermediate

TRIBUTYL(1-ETHOXYVINYL)TIN

Cas:97674-02-7

Min.Order:0

Negotiable

Type:Trading Company

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Enke Pharma-tech Co.,Ltd. (Cangzhou, China )

high purity Storage:normal temperature Package:DRUM Application:mainly for medical use for R&Dpurpose use only Transportation:AIR,SEA Port:BEIJING,SHANGHAI,TIANJIN,SHENZHEN

Tributyl(1-ethoxyvinyl)stannane

Cas:97674-02-7

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Guangdong Juda Chemical Industrial Co.,Limited

Appearance:solid or liquid Storage:sealed in cool and dry place Package:As customer's requested Application:Pharma Intermediate Transportation:by courier/air/sea Port:Any port in China

TRIBUTYL(1-ETHOXYVINYL)TIN CAS No.97674-02-7

Cas:97674-02-7

Min.Order:0

Negotiable

Type:Trading Company

inquiry

DB BIOTECH CO., LTD

best seller Application:API

TRIBUTYL(1-ETHOXYVINYL)TIN

Cas:97674-02-7

Min.Order:0

Negotiable

Type:Trading Company

inquiry

BOC Sciences

We are committed to providing our customers with the best products and services at the most competitive prices.Appearance:white powder Storage:Room temperature with sealed well Package:according to the clients requirement Application:Use as primary a

TRIBUTYL(1-ETHOXYVINYL)TIN

Cas:97674-02-7

Min.Order:0

Negotiable

Type:Trading Company

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Synthetic route

tributyltin chloride
1461-22-9

tributyltin chloride

ethyl vinyl ether
109-92-2

ethyl vinyl ether

tributyl(1-ethoxyvinyl)stannane
97674-02-7

tributyl(1-ethoxyvinyl)stannane

Conditions
ConditionsYield
Stage #1: ethyl vinyl ether With n-butyllithium; N,N,N,N,-tetramethylethylenediamine; potassium tert-butylate In tetrahydrofuran; hexane at -40 - -30℃; for 1.5h; Inert atmosphere;
Stage #2: tributyltin chloride In tetrahydrofuran; hexane; water at -78℃; for 10h; Stille Carbonyl Synthesis;
81.03%
With tert.-butyl lithium at -78℃;
Stage #1: ethyl vinyl ether With tert.-butyl lithium In tetrahydrofuran; pentane at -78 - 0℃; for 0.25h; Inert atmosphere;
Stage #2: tributyltin chloride In tetrahydrofuran; pentane at -78 - 20℃; for 0.5h; Inert atmosphere;
hydrogen
1333-74-0

hydrogen

ethoxy(tributylstannyl)acetylene
137344-20-8

ethoxy(tributylstannyl)acetylene

tributyl(1-ethoxyvinyl)stannane
97674-02-7

tributyl(1-ethoxyvinyl)stannane

Conditions
ConditionsYield
With tributylphosphine In toluene toluene, 5 mol% Ru-complex, tributylphosphine (30 mol %) under 1 atm. ofH2, 80°C, 6 h;65%
{1-[6-(6-bromo-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-2-ylamino)pyridin-3-yl]pyrrolidin-3-yl}carbamic acid tert-butyl ester
571189-53-2

{1-[6-(6-bromo-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-2-ylamino)pyridin-3-yl]pyrrolidin-3-yl}carbamic acid tert-butyl ester

tributyl(1-ethoxyvinyl)stannane
97674-02-7

tributyl(1-ethoxyvinyl)stannane

(1-{6-[8-cyclopentyl-6-(1-ethoxyvinyl)-5-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-2-ylamino]pyridin-3-yl}pyrrolidin-3-yl)carbamic acid tert-butyl ester
571189-52-1

(1-{6-[8-cyclopentyl-6-(1-ethoxyvinyl)-5-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-2-ylamino]pyridin-3-yl}pyrrolidin-3-yl)carbamic acid tert-butyl ester

Conditions
ConditionsYield
With tetrakis(triphenylphosphine) palladium(0) In toluene at 110℃; for 12h; Stille coupling;100%
2,5-dibromofluorobenzene
1435-52-5

2,5-dibromofluorobenzene

tributyl(1-ethoxyvinyl)stannane
97674-02-7

tributyl(1-ethoxyvinyl)stannane

1-(4-acetyl-2-fluorophenyl)ethan-1-one
380608-27-5

1-(4-acetyl-2-fluorophenyl)ethan-1-one

Conditions
ConditionsYield
bis-triphenylphosphine-palladium(II) chloride In tetrahydrofuran for 18h; Heating / reflux;100%
6-bromo-2-cyclopropyl-7-methoxy-5-methyl-1,3-benzoxazole-4-carbonitrile
927389-54-6

6-bromo-2-cyclopropyl-7-methoxy-5-methyl-1,3-benzoxazole-4-carbonitrile

tributyl(1-ethoxyvinyl)stannane
97674-02-7

tributyl(1-ethoxyvinyl)stannane

2-cyclopropyl-6-[1-(ethoxy)ethenyl]-7-methoxy-5-methyl-1,3-benzoxazole-4-carbonitrile
927389-55-7

2-cyclopropyl-6-[1-(ethoxy)ethenyl]-7-methoxy-5-methyl-1,3-benzoxazole-4-carbonitrile

Conditions
ConditionsYield
bis-triphenylphosphine-palladium(II) chloride; 2,6-di-tert-butyl-4-methyl-phenol In toluene for 22h; Heating / reflux;100%
6-bromo-2-[2-methoxy-1,1-dimethylethyl]-7-fluoro-5-methyl-1,3-benzoxazole-4-carbonitrile
927389-91-1

6-bromo-2-[2-methoxy-1,1-dimethylethyl]-7-fluoro-5-methyl-1,3-benzoxazole-4-carbonitrile

tributyl(1-ethoxyvinyl)stannane
97674-02-7

tributyl(1-ethoxyvinyl)stannane

C18H21FN2O3
927389-93-3

C18H21FN2O3

Conditions
ConditionsYield
bis-triphenylphosphine-palladium(II) chloride; 2,6-di-tert-butyl-4-methyl-phenol In toluene for 6h; Heating / reflux;100%
6-bromo-2-cyclopropyl-7-fluoro-5-methyl-1,3-benzoxazole-4-carbonitrile
927389-32-0

6-bromo-2-cyclopropyl-7-fluoro-5-methyl-1,3-benzoxazole-4-carbonitrile

tributyl(1-ethoxyvinyl)stannane
97674-02-7

tributyl(1-ethoxyvinyl)stannane

2-cyclopropyl-6-[1-(ethoxy)ethenyl]-7-fluoro-5-methyl-1,3-benzoxazole-4-carbonitrile
927389-44-4

2-cyclopropyl-6-[1-(ethoxy)ethenyl]-7-fluoro-5-methyl-1,3-benzoxazole-4-carbonitrile

Conditions
ConditionsYield
bis-triphenylphosphine-palladium(II) chloride; 2,6-di-tert-butyl-4-methyl-phenol In toluene for 17h; Heating / reflux;100%
N-(5-bromo-pyridin-3-yl)-acetamide
15862-46-1

N-(5-bromo-pyridin-3-yl)-acetamide

tributyl(1-ethoxyvinyl)stannane
97674-02-7

tributyl(1-ethoxyvinyl)stannane

N-[5-(1-ethoxyvinyl)pyridin-3-yl]acetamide
1035234-81-1

N-[5-(1-ethoxyvinyl)pyridin-3-yl]acetamide

Conditions
ConditionsYield
Stage #1: N-(5-bromo-pyridin-3-yl)-acetamide; tributyl(1-ethoxyvinyl)stannane With bis-triphenylphosphine-palladium(II) chloride In N,N-dimethyl-formamide at 80℃; for 24h;
Stage #2: With potassium fluoride In water; N,N-dimethyl-formamide at 20℃; for 0.5h;
100%
8-bromo-2-morpholino-4-oxo-4H-chromene-6-carboxylic acid
1296271-35-6

8-bromo-2-morpholino-4-oxo-4H-chromene-6-carboxylic acid

tributyl(1-ethoxyvinyl)stannane
97674-02-7

tributyl(1-ethoxyvinyl)stannane

8-acetyl-2-morpholino-4-oxo-4H-chromene-6-carboxylic acid
1296271-36-7

8-acetyl-2-morpholino-4-oxo-4H-chromene-6-carboxylic acid

Conditions
ConditionsYield
Stage #1: 8-bromo-2-morpholino-4-oxo-4H-chromene-6-carboxylic acid; tributyl(1-ethoxyvinyl)stannane; bis-triphenylphosphine-palladium(II) chloride In 1,4-dioxane at 100℃; for 3h; Inert atmosphere;
Stage #2: With hydrogenchloride; water In 1,4-dioxane at 50℃; for 0.416667h;
100%
Stage #1: 8-bromo-2-morpholino-4-oxo-4H-chromene-6-carboxylic acid; tributyl(1-ethoxyvinyl)stannane; bis-triphenylphosphine-palladium(II) chloride In 1,4-dioxane at 100℃; for 3h; Stille Coupling; Inert atmosphere;
Stage #2: With hydrogenchloride In 1,4-dioxane at 50℃; for 0.416667h;
100%
Stage #1: 8-bromo-2-morpholino-4-oxo-4H-chromene-6-carboxylic acid; tributyl(1-ethoxyvinyl)stannane With bis-triphenylphosphine-palladium(II) chloride In 1,4-dioxane at 100℃; for 3h; Stille Cross Coupling; Inert atmosphere;
Stage #2: With hydrogenchloride In 1,4-dioxane; water at 50℃; for 0.416667h; Stille Cross Coupling; Inert atmosphere;
200 mg
6-bromo-3-chloro-isoquinoline
552331-06-3

6-bromo-3-chloro-isoquinoline

tributyl(1-ethoxyvinyl)stannane
97674-02-7

tributyl(1-ethoxyvinyl)stannane

3-chloro-6-(1-ethoxyvinyl)isoquinoline
1381812-85-6

3-chloro-6-(1-ethoxyvinyl)isoquinoline

Conditions
ConditionsYield
With bis-triphenylphosphine-palladium(II) chloride In toluene at 50℃; for 18h; Stille Cross Coupling; Inert atmosphere;100%
Stage #1: 6-bromo-3-chloro-isoquinoline; tributyl(1-ethoxyvinyl)stannane In toluene for 0.5h; Inert atmosphere;
Stage #2: With bis-triphenylphosphine-palladium(II) chloride In toluene at 60℃; for 20h;
92%
With bis-triphenylphosphine-palladium(II) chloride In toluene at 60℃; for 20h; Inert atmosphere;92%
With bis-triphenylphosphine-palladium(II) chloride In toluene at 60℃; for 20h; Inert atmosphere;92%
bis-triphenylphosphine-palladium(II) chloride In toluene at 50℃; for 18h; Inert atmosphere;
methyl {(2S)-1-[(2S)-2-{5-[4-(6-bromoquinoxalin-2-yl)phenyl]-1H-imidazol-2-yl}pyrrolidin-1-yl]-3-methyl-1-oxobutan-2-yl}carbamate
1261072-54-1

methyl {(2S)-1-[(2S)-2-{5-[4-(6-bromoquinoxalin-2-yl)phenyl]-1H-imidazol-2-yl}pyrrolidin-1-yl]-3-methyl-1-oxobutan-2-yl}carbamate

tributyl(1-ethoxyvinyl)stannane
97674-02-7

tributyl(1-ethoxyvinyl)stannane

methyl (S)-1-((S)-2-(5-(4-(6-(1-ethoxyvinyl)quinoxalin-2-yl)phenyl)-1H-imidazol-2-yl)pyrrolidin-1-yl)-3-methyl-1-oxobutan-2-ylcarbamate
1399845-38-5

methyl (S)-1-((S)-2-(5-(4-(6-(1-ethoxyvinyl)quinoxalin-2-yl)phenyl)-1H-imidazol-2-yl)pyrrolidin-1-yl)-3-methyl-1-oxobutan-2-ylcarbamate

Conditions
ConditionsYield
dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH2Cl2 In 1,4-dioxane at 80℃; for 6h; Inert atmosphere;100%
8-chloro-N-(2-methylallyl)quinoxalin-2-amine
1552315-38-4

8-chloro-N-(2-methylallyl)quinoxalin-2-amine

tributyl(1-ethoxyvinyl)stannane
97674-02-7

tributyl(1-ethoxyvinyl)stannane

8-(1-ethoxyvinyl)-N-(2-methylallyl)quinoxalin-2-amine
1552315-40-8

8-(1-ethoxyvinyl)-N-(2-methylallyl)quinoxalin-2-amine

Conditions
ConditionsYield
With tris-(dibenzylideneacetone)dipalladium(0); copper(l) iodide; cesium fluoride; XPhos at 120℃; Sealed tube; Inert atmosphere;100%
C14H14BrN3O4
1622880-49-2

C14H14BrN3O4

tributyl(1-ethoxyvinyl)stannane
97674-02-7

tributyl(1-ethoxyvinyl)stannane

C16H17N3O5

C16H17N3O5

Conditions
ConditionsYield
Stage #1: C14H14BrN3O4; tributyl(1-ethoxyvinyl)stannane With bis-triphenylphosphine-palladium(II) chloride In 1,4-dioxane at 100℃; for 18h; Stille Cross-Coupling (Migita-Kosugi-Stille Coupling);
Stage #2: With hydrogenchloride In water for 0.166667h;
100%
4-[(4-bromo-3,3,7-trifluoro-2-oxo-2,3-dihydro-1H-indol-1-yl)methyl]pyridine-2-carbonitrile

4-[(4-bromo-3,3,7-trifluoro-2-oxo-2,3-dihydro-1H-indol-1-yl)methyl]pyridine-2-carbonitrile

tributyl(1-ethoxyvinyl)stannane
97674-02-7

tributyl(1-ethoxyvinyl)stannane

4-[(4-acetyl-3,3,7-trifluoro-2-oxo-2,3-dihydro-1H-indol-1-yl)methyl]pyridine-2-carbonitrile

4-[(4-acetyl-3,3,7-trifluoro-2-oxo-2,3-dihydro-1H-indol-1-yl)methyl]pyridine-2-carbonitrile

Conditions
ConditionsYield
Stage #1: 4-[(4-bromo-3,3,7-trifluoro-2-oxo-2,3-dihydro-1H-indol-1-yl)methyl]pyridine-2-carbonitrile; tributyl(1-ethoxyvinyl)stannane With tetrakis(triphenylphosphine) palladium(0) In N,N-dimethyl-formamide at 120℃; for 3h;
Stage #2: With hydrogenchloride In water; N,N-dimethyl-formamide at 20℃; for 1h;
100%
5-bromo-3-fluoro-2-(trifluoromethyl)pyridine
1262412-30-5

5-bromo-3-fluoro-2-(trifluoromethyl)pyridine

tributyl(1-ethoxyvinyl)stannane
97674-02-7

tributyl(1-ethoxyvinyl)stannane

1-[5-fluoro-6-(trifluoromethyl)-3-pyridyl]ethanone

1-[5-fluoro-6-(trifluoromethyl)-3-pyridyl]ethanone

Conditions
ConditionsYield
Stage #1: 5-bromo-3-fluoro-2-(trifluoromethyl)pyridine; tributyl(1-ethoxyvinyl)stannane With tetrakis(triphenylphosphine) palladium(0); trimethylamine In 1,4-dioxane at 100℃; for 4h; Inert atmosphere;
Stage #2: With hydrogenchloride; water In 1,4-dioxane at 20℃;
100%
tributyl(1-ethoxyvinyl)stannane
97674-02-7

tributyl(1-ethoxyvinyl)stannane

2-chloro-5-(trifluoromethyl)pyrimidine
69034-12-4

2-chloro-5-(trifluoromethyl)pyrimidine

2-(1-ethoxyethenyl)-5-(trifluoromethyl)pyrimidine

2-(1-ethoxyethenyl)-5-(trifluoromethyl)pyrimidine

Conditions
ConditionsYield
With bis-triphenylphosphine-palladium(II) chloride In N,N-dimethyl-formamide at 100℃; for 3h; Inert atmosphere;100%
4-[6-(6-bromo-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-2-ylamino)pyridin-3-yl]-2,2-dimethylpiperazine-1-carboxylic acid tert-butyl ester
571189-69-0

4-[6-(6-bromo-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-2-ylamino)pyridin-3-yl]-2,2-dimethylpiperazine-1-carboxylic acid tert-butyl ester

tributyl(1-ethoxyvinyl)stannane
97674-02-7

tributyl(1-ethoxyvinyl)stannane

4-{6-[8-cyclopentyl-6-(1-ethoxyvinyl)-5-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-2-ylamino]pyridin-3-yl}-2,2-dimethylpiperazine-1-carboxylic acid tert-butyl ester
571189-71-4

4-{6-[8-cyclopentyl-6-(1-ethoxyvinyl)-5-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-2-ylamino]pyridin-3-yl}-2,2-dimethylpiperazine-1-carboxylic acid tert-butyl ester

Conditions
ConditionsYield
With tetrakis(triphenylphosphine) palladium(0) In toluene for 1h; Stille coupling; Heating;99%
4-[6-(6-bromo-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-2-ylamino)pyridin-3-yl]-2,2-dimethylpiperazine-1-carboxylic acid tert-butyl ester
571189-69-0

4-[6-(6-bromo-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-2-ylamino)pyridin-3-yl]-2,2-dimethylpiperazine-1-carboxylic acid tert-butyl ester

tributyl(1-ethoxyvinyl)stannane
97674-02-7

tributyl(1-ethoxyvinyl)stannane

A

4-{6-[8-cyclopentyl-6-(1-ethoxyvinyl)-5-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-2-ylamino]pyridin-3-yl}-2,2-dimethylpiperazine-1-carboxylic acid tert-butyl ester
571189-71-4

4-{6-[8-cyclopentyl-6-(1-ethoxyvinyl)-5-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-2-ylamino]pyridin-3-yl}-2,2-dimethylpiperazine-1-carboxylic acid tert-butyl ester

B

4-16-[8-Cyclopentyl-6-(1-ethoxy-vin l)-5-methyl-7-oxo-7,8-dihydro-pyrido[2,3-d]pyrimidin-2-ylamino]-pyridin-3-yl-2,2-dimethyl-piperazine-1-carboxylic Acid Tert-butyl Ester

4-16-[8-Cyclopentyl-6-(1-ethoxy-vin l)-5-methyl-7-oxo-7,8-dihydro-pyrido[2,3-d]pyrimidin-2-ylamino]-pyridin-3-yl-2,2-dimethyl-piperazine-1-carboxylic Acid Tert-butyl Ester

Conditions
ConditionsYield
tetrakis(triphenylphosphine) palladium(0) In dichloromethane; tolueneA n/a
B 99%
benzyl 2-bromobenzoate
67460-09-7

benzyl 2-bromobenzoate

tributyl(1-ethoxyvinyl)stannane
97674-02-7

tributyl(1-ethoxyvinyl)stannane

2-(1-Ethoxyethenyl)benzoic acid phenylmethyl ester
267647-97-2

2-(1-Ethoxyethenyl)benzoic acid phenylmethyl ester

Conditions
ConditionsYield
dichlorobis(triphenylphosphine)palladium[II] In 1,4-dioxane99%
1,1-dimethylethyl [2-chloro-5-fluoro-6-(methyloxy)-3-pyridinyl]carbamate
943025-87-4

1,1-dimethylethyl [2-chloro-5-fluoro-6-(methyloxy)-3-pyridinyl]carbamate

tributyl(1-ethoxyvinyl)stannane
97674-02-7

tributyl(1-ethoxyvinyl)stannane

1,1-dimethylethyl [2-[1-(ethyloxy)ethenyl]-5-fluoro-6-(methyloxy)-3-pyridinyl]carbamate
943025-88-5

1,1-dimethylethyl [2-[1-(ethyloxy)ethenyl]-5-fluoro-6-(methyloxy)-3-pyridinyl]carbamate

Conditions
ConditionsYield
Stage #1: 1,1-dimethylethyl [2-chloro-5-fluoro-6-(methyloxy)-3-pyridinyl]carbamate; tributyl(1-ethoxyvinyl)stannane With cesium fluoride; bis(tri-t-butylphosphine)palladium(0) In 1,4-dioxane at 100℃;
Stage #2: With potassium fluoride In 1,4-dioxane; water for 0.5h;
99%
Stage #1: 1,1-dimethylethyl [2-chloro-5-fluoro-6-(methyloxy)-3-pyridinyl]carbamate; tributyl(1-ethoxyvinyl)stannane With cesium fluoride; bis(tri-t-butylphosphine)palladium(0) In dioxane,1,4 at 100℃;
Stage #2: With potassium fluoride In dioxane,1,4-; water
99%
methyl 1-chloro-N-(methoxymethyl)pyrido[3,4-b]indole-3-carboxylate
757234-77-8

methyl 1-chloro-N-(methoxymethyl)pyrido[3,4-b]indole-3-carboxylate

tributyl(1-ethoxyvinyl)stannane
97674-02-7

tributyl(1-ethoxyvinyl)stannane

methyl 1-acetyl-9H-pyrido[3,4-b]indole-3-carboxylate
66154-37-8

methyl 1-acetyl-9H-pyrido[3,4-b]indole-3-carboxylate

Conditions
ConditionsYield
Stage #1: methyl 1-chloro-N-(methoxymethyl)pyrido[3,4-b]indole-3-carboxylate; tributyl(1-ethoxyvinyl)stannane With bis-triphenylphosphine-palladium(II) chloride; tetraethylammonium chloride In N,N-dimethyl-formamide at 100℃; for 3h; Inert atmosphere;
Stage #2: With hydrogenchloride In methanol; N,N-dimethyl-formamide at 20℃; for 1h; Inert atmosphere;
99%
Stage #1: methyl 1-chloro-N-(methoxymethyl)pyrido[3,4-b]indole-3-carboxylate; tributyl(1-ethoxyvinyl)stannane With bis-triphenylphosphine-palladium(II) chloride; C8H20N(1+)*ClH In N,N-dimethyl-formamide at 100℃; for 2h; Stille Carbonyl Synthesis;
Stage #2: With hydrogenchloride; methanol at 20℃; for 1h; Stille Carbonyl Synthesis;
99%
4-(5-chloro-2-fluoropyridin-3-yl)-6-methyl-1,3,5-triazin-2-amine
1253575-82-4

4-(5-chloro-2-fluoropyridin-3-yl)-6-methyl-1,3,5-triazin-2-amine

tributyl(1-ethoxyvinyl)stannane
97674-02-7

tributyl(1-ethoxyvinyl)stannane

4-(5-(1-ethoxyvinyl)-2-fluoropyridin-3-yl)-6-methyl-1,3,5-triazin-2-amine

4-(5-(1-ethoxyvinyl)-2-fluoropyridin-3-yl)-6-methyl-1,3,5-triazin-2-amine

Conditions
ConditionsYield
With palladium diacetate; cesium fluoride; XPhos In 1,4-dioxane; N,N-dimethyl-formamide at 110℃; for 1.5h; Stille Cross Coupling;99%
2-benzyl-5-bromo-6-phenyl-2,3-dihydropyridazin-3-one

2-benzyl-5-bromo-6-phenyl-2,3-dihydropyridazin-3-one

tributyl(1-ethoxyvinyl)stannane
97674-02-7

tributyl(1-ethoxyvinyl)stannane

2-benzyl-5-(1-ethoxyethenyl)-6-phenyl-2,3-dihydropyridazin-3-one

2-benzyl-5-(1-ethoxyethenyl)-6-phenyl-2,3-dihydropyridazin-3-one

Conditions
ConditionsYield
With bis-triphenylphosphine-palladium(II) chloride In toluene for 2h; Reflux;99%
6-bromo-7-fluoroquinoline
127827-52-5

6-bromo-7-fluoroquinoline

tributyl(1-ethoxyvinyl)stannane
97674-02-7

tributyl(1-ethoxyvinyl)stannane

1-(7-fluoroquinolin-6-yl)ethan-1-one

1-(7-fluoroquinolin-6-yl)ethan-1-one

Conditions
ConditionsYield
Stage #1: 6-bromo-7-fluoroquinoline; tributyl(1-ethoxyvinyl)stannane With bis-triphenylphosphine-palladium(II) chloride In 1,4-dioxane at 90℃; Inert atmosphere;
Stage #2: With potassium fluoride In 1,4-dioxane; water at 20℃; for 2h; Inert atmosphere;
99%
With bis-triphenylphosphine-palladium(II) chloride In 1,4-dioxane at 110℃; for 4h;87%
With bis-triphenylphosphine-palladium(II) chloride In 1,4-dioxane at 110℃; for 4h;
4-chloro-N-(tetrahydro-2H-pyran-4-yl)pyrimidin-2-amine

4-chloro-N-(tetrahydro-2H-pyran-4-yl)pyrimidin-2-amine

tributyl(1-ethoxyvinyl)stannane
97674-02-7

tributyl(1-ethoxyvinyl)stannane

4-(1-ethoxyvinyl)-N-(tetrahydro-2H-pyran-4-yl)pyrimidin-2-amine

4-(1-ethoxyvinyl)-N-(tetrahydro-2H-pyran-4-yl)pyrimidin-2-amine

Conditions
ConditionsYield
Stage #1: 4-chloro-N-(tetrahydro-2H-pyran-4-yl)pyrimidin-2-amine; tributyl(1-ethoxyvinyl)stannane With bis-triphenylphosphine-palladium(II) chloride In N,N-dimethyl-formamide at 25 - 100℃; for 12h; Inert atmosphere;
Stage #2: With potassium fluoride In ethyl acetate; N,N-dimethyl-formamide at 20℃; for 2h;
99%
2-chloro-4-nitropyridine
23056-36-2

2-chloro-4-nitropyridine

tributyl(1-ethoxyvinyl)stannane
97674-02-7

tributyl(1-ethoxyvinyl)stannane

C7H6N2O3

C7H6N2O3

Conditions
ConditionsYield
Stage #1: 2-chloro-4-nitropyridine; tributyl(1-ethoxyvinyl)stannane With bis-triphenylphosphine-palladium(II) chloride In N,N-dimethyl-formamide at 85℃; for 3h; Inert atmosphere;
Stage #2: With hydrogenchloride In water at 20℃; Solvent; Temperature; Reagent/catalyst;
99%
tributyl(1-ethoxyvinyl)stannane
97674-02-7

tributyl(1-ethoxyvinyl)stannane

tert-butyl N-(8-bromoimidazo[1,2-b]pyridazin-7-yl)carbamate

tert-butyl N-(8-bromoimidazo[1,2-b]pyridazin-7-yl)carbamate

tert-butyl N-[8-(1-ethoxyvinyl)imidazo[1,2-b]pyridazin-7-yl]carbamate

tert-butyl N-[8-(1-ethoxyvinyl)imidazo[1,2-b]pyridazin-7-yl]carbamate

Conditions
ConditionsYield
With bis-triphenylphosphine-palladium(II) chloride In N,N-dimethyl-formamide at 100℃; for 3h; Inert atmosphere;99%
4-bromo-3-fluorobenzonitrile
133059-44-6

4-bromo-3-fluorobenzonitrile

tributyl(1-ethoxyvinyl)stannane
97674-02-7

tributyl(1-ethoxyvinyl)stannane

4-acetyl-3-fluorobenzonitrile
1352144-78-5

4-acetyl-3-fluorobenzonitrile

Conditions
ConditionsYield
With bis-triphenylphosphine-palladium(II) chloride; triethylamine In toluene Heating;98.1%
Stage #1: 4-bromo-3-fluorobenzonitrile; tributyl(1-ethoxyvinyl)stannane With bis-triphenylphosphine-palladium(II) chloride In toluene at 20℃; Inert atmosphere; Reflux;
Stage #2: With potassium fluoride In toluene for 0.5h; Inert atmosphere;
Stage #3: With hydrogenchloride In water; toluene at 70℃; for 2h;
88%
With dichlorobis(triphenylphosphine)palladium(II) In toluene at 110℃; for 4h;70.5%
4-chloromethoxybenzene
623-12-1

4-chloromethoxybenzene

tributyl(1-ethoxyvinyl)stannane
97674-02-7

tributyl(1-ethoxyvinyl)stannane

1-(1'-ethoxyvinyl)-4-methoxybenzene
66821-19-0

1-(1'-ethoxyvinyl)-4-methoxybenzene

Conditions
ConditionsYield
With tri-tert-butyl phosphine; cesium fluoride; tris(dibenzylideneacetone)dipalladium (0) In 1,4-dioxane at 100℃; for 48h; Substitution; Stille cross-coupling reaction;98%
With P(i-BuNCH2CH2)3N; cesium fluoride; tris(dibenzylideneacetone)dipalladium (0) In 1,4-dioxane at 100 - 110℃; Stille reaction;97%
With tris(dibenzylideneacetone)dipalladium (0); cesium fluoride; 2,8,9-tris(2-methylpropyl)-2,5,8,9-tetraaza-1-phosphabicyclo[3.3.3]undecane In 1,4-dioxane at 110℃; for 48h; Stille cross-coupling;97%
With tris(dibenzylideneacetone)dipalladium (0); tri-tert-butyl phosphine; cesium fluoride In 1,4-dioxane at 100℃; for 48h; Stille cross-coupling;97%
2-methylphenyl bromide
95-46-5

2-methylphenyl bromide

tributyl(1-ethoxyvinyl)stannane
97674-02-7

tributyl(1-ethoxyvinyl)stannane

1-(1-ethoxyvinyl)-2-methylbenzene
31732-33-9

1-(1-ethoxyvinyl)-2-methylbenzene

Conditions
ConditionsYield
With tris(dibenzylideneacetone)dipalladium (0); tri-tert-butyl phosphine; cesium fluoride In 1-methyl-pyrrolidin-2-one; hexane at 20℃; for 3h; Stille cross-coupling;98%
tributyl(1-ethoxyvinyl)stannane
97674-02-7

tributyl(1-ethoxyvinyl)stannane

5-Bromo-2-methoxymethyl-6-phenylpyridazin-3-one
247158-79-8

5-Bromo-2-methoxymethyl-6-phenylpyridazin-3-one

2-methoxymethyl-6-phenyl-5-[(1'-ethoxy)vinyl]-3-pyridazinone
617693-71-7

2-methoxymethyl-6-phenyl-5-[(1'-ethoxy)vinyl]-3-pyridazinone

Conditions
ConditionsYield
With bis-triphenylphosphine-palladium(II) chloride In toluene for 2h; Stille reaction; Heating;98%
6-bromo-2-methoxy-3-(4-methyl-1H-imidazol-1-yl)pyridine
1123194-98-8

6-bromo-2-methoxy-3-(4-methyl-1H-imidazol-1-yl)pyridine

tributyl(1-ethoxyvinyl)stannane
97674-02-7

tributyl(1-ethoxyvinyl)stannane

6-(1-ethoxyvinyl)-2-methoxy-3-(4-methyl-1H-imidazol-1-yl)pyridine
1241428-42-1

6-(1-ethoxyvinyl)-2-methoxy-3-(4-methyl-1H-imidazol-1-yl)pyridine

Conditions
ConditionsYield
With bis-triphenylphosphine-palladium(II) chloride In 1,4-dioxane at 100℃; for 18h; Inert atmosphere;98%
bis-triphenylphosphine-palladium(II) chloride In 1,4-dioxane at 100℃; for 5.75h;
bis-triphenylphosphine-palladium(II) chloride In 1,4-dioxane at 100℃; for 5.75h;

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