The Nobel Prize in Chemistry 1972 was divided, one half awarded to Christian B. Anfinsen "for his work on ribonuclease, especially concerning the connection between the amino acid sequence and the biologically active conformation",the other half jointly to Stanford Moore and William H. Stein "for their contribution to the understanding of the connection between chemical structure and catalytic activity of the active centre of the ribonuclease molecule".
 

They have worked with the same enzyme, ribonuclease. Anfinsen's investigations have provided the answer to an important question concerning the way in which the active enzyme is formed in living cells. Moore and Stein have elucidated important principles related to the biological activity of the enzyme.