1000291-89-3

Basic information

• Product Name: (R)-tert-butyl 2-(2-ethoxy-2-oxoethyl)piperidine-1-carboxylate
• Synonyms: (R)-tert-butyl 2-(2-ethoxy-2-oxoethyl)piperidine-1-carboxylate
• CAS NO: 1000291-89-3
• Molecular Weight: 271.357
• Mol File: 1000291-89-3.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: (R)-tert-butyl 2-(2-ethoxy-2-oxoethyl)piperidine-1-carboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: (R)-tert-butyl 2-(2-ethoxy-2-oxoethyl)piperidine-1-carboxylate(1000291-89-3)
• EPA Substance Registry System: (R)-tert-butyl 2-(2-ethoxy-2-oxoethyl)piperidine-1-carboxylate(1000291-89-3)

Safety Data

• Hazardous Substances Data: 1000291-89-3(Hazardous Substances Data)

Upstream product

• 118667-62-2 tert-butyl 2-(2-ethoxy-2-oxoethyl)piperidine-1-carboxylate 
• 24424-99-5 di-tert-butyl dicarbonate 
• 2739-98-2 ethyl 2-(pyridinyl-2)acetate 

Downstream Products

• 475301-86-1 (-)-sparteine 
• 489-54-3 (1R,2R,9S,10S)-7,15-diazatetracyclo[7.7.1.0^2,7.0^10,15]heptadecane-8,16-dione 
• 299-39-8 (-)-sparteine; bis-hydrogen sulfate 

Relevant articles and documents

Synthesis of Azocanes from Piperidines via an Azetidinium Intermediate

α-Trifluoromethyl azocanes are accessible from 2-(trifluoropropan-2-ol) piperidines by metal-free ring-expansion involving a bicyclic azetidinium intermediate. The opening of the azetidinium intermediate was achieved by various nucleophiles (amines, alcoholates, carboxylates, phosphonates, halides and pseudo-halides) with an excellent regio- diastereo- and enantioselectivity and in good yields. The relative configuration of the piperidines and azocanes were assigned and the deprotected azocanes offer opportunities for further derivatization.