299-39-8 Usage
Description
SPARTEINE SULFATE is a chemical compound that serves as a class 1a antiarrhythmic agent and a sodium channel blocker. It is characterized by its off-white to pale yellow solid appearance.
Uses
Used in Pharmaceutical Industry:
SPARTEINE SULFATE is used as an antiarrhythmic agent for the treatment of cardiac arrhythmias. It functions by blocking sodium channels, which helps to regulate the electrical activity of the heart and maintain a normal heart rhythm.
Used in Cardiology:
SPARTEINE SULFATE is used as a sodium channel blocker for the management of certain heart conditions. By inhibiting the sodium channels, it can prevent the rapid and irregular electrical impulses that cause arrhythmias, thus promoting a more stable and regular heartbeat.
Check Digit Verification of cas no
The CAS Registry Mumber 299-39-8 includes 6 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 3 digits, 2,9 and 9 respectively; the second part has 2 digits, 3 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 299-39:
(5*2)+(4*9)+(3*9)+(2*3)+(1*9)=88
88 % 10 = 8
So 299-39-8 is a valid CAS Registry Number.
InChI:InChI=1/C15H26N2.H2O4S/c1-3-7-16-11-13-9-12(14(16)5-1)10-17-8-4-2-6-15(13)17;1-5(2,3)4/h12-15H,1-11H2;(H2,1,2,3,4)/t12-,13?,14-,15+;/m1./s1
299-39-8Relevant articles and documents
Gram-Scale Synthesis of the (?)-Sparteine Surrogate and (?)-Sparteine
Firth, James D.,Canipa, Steven J.,Ferris, Leigh,O'Brien, Peter
, p. 223 - 226 (2017/12/29)
An 8-step, gram-scale synthesis of the (?)-sparteine surrogate (22 % yield, with just 3 chromatographic purifications) and a 10-step, gram-scale synthesis of (?)-sparteine (31 % yield) are reported. Both syntheses proceed with complete diastereocontrol and allow access to either antipode. Since the syntheses do not rely on natural product extraction, our work addresses long-term supply issues relating to these widely used chiral ligands.