1000851-40-0

Basic information

• Product Name: 2-(3-p-tolyl-thiophen-2-yl)-pyridine
• Synonyms: 2-(3-p-tolyl-thiophen-2-yl)-pyridine
• CAS NO: 1000851-40-0
• Molecular Weight: 251.352
• Mol File: 1000851-40-0.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 2-(3-p-tolyl-thiophen-2-yl)-pyridine(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(3-p-tolyl-thiophen-2-yl)-pyridine(1000851-40-0)
• EPA Substance Registry System: 2-(3-p-tolyl-thiophen-2-yl)-pyridine(1000851-40-0)

Safety Data

• Hazardous Substances Data: 1000851-40-0(Hazardous Substances Data)

Upstream product

• 5720-05-8 4-methylphenylboronic acid 
• 3319-99-1 2'-(2-thienyl)pyridine 
• 624-31-7 4-tolyl iodide 

Relevant articles and documents

Copper-Catalyzed Direct Arylation of Indoles and Related (Hetero)arenes: A Ligandless and Solvent-free Approach

A ligandless and solvent-free copper-catalyzed method for the regioselective C?H bond arylation of indoles and related heteroarenes is reported. The use of CuCl efficiently catalyzes the direct coupling of diverse heteroarenes with aryl iodides via chelation-assistance. This reaction could tolerate sensitive and structurally diverse functionalities, including halides, ethers, thioethers, amines, indolyl, pyrrolyl and carbazolyl groups. The directing group, 2-pyridinyl can be smoothly removed to generate C-2 arylated free-NH indoles, and the arylated indoles can further be functionalized into Tryptamine derivatives. Preliminary mechanistic study revealed a radical pathway for the arylation reaction. (Figure presented.).

Directed palladium-catalyzed oxidative C-H arylation of (hetero)arenes with arylboronic acids by using TEMPO

Oxidative coupling of three different arenes and a thiophene derivative with various arylboronic acids with Pd(OAc)2 and the commercially available 2,2,6,6-tetramethylpiperidine-N-oxyl radical (TEMPO) as an oxidant are reported. A 2-pyridyl gro