3319-99-1Relevant articles and documents
Palladium-catalyzed cross-coupling reactions of organomercurials with organic halides
Bumagin, N. A.,More, P. G.,Beletskaya, I. P.
, p. 231 - 234 (1989)
Organomercurials, (A)2Hg (A = 5-methyl-2-furyl, thienyl) react with organic halides, ArI, in the presence of a palladium catalyst and iodide ion under argon to give cross-coupled products AAr, in high yields.
Dual effect of halides in the stille reaction: In situ halide metathesis and catalyst stabilization
Verbeeck, Stefan,Meyers, Caroline,Franck, Philippe,Jutand, Anny,Maes, Bert U. W.
, p. 12831 - 12837 (2010)
Halide anions can increase or decrease the transmetallation rate of the Stille reaction through in situ halide metathesis. Although the influence of the halogen present in oxidative addition complexes on the transmetallation rate with organostannanes was already known, the application of in situ halide metathesis to accelerate cross-coupling reactions with organometallic reagents is not described in the literature yet. In addition a second unprecedented role of halides was discovered. Halide anions stabilize the [Pd0(L) 2] catalyst in Stille reactions, by means of [Pd0X(L) 2]? formation (X=Cl, I), hereby preventing its leaching from the catalytic cycle. Both arene (iodobenzene) and azaheteroarene (2-halopyridine, halopyrazine, 2-halopyrimidine) substrates were used.
N- Heterocyclic carbene palladium complex with butterfly structure and application thereof (by machine translation)
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Paragraph 0088-0098, (2020/05/30)
N - Heterocyclic carbene palladium complex, with a butterfly structure prevents aromatic amine from encircling carbon-nitrogen bond upset, and in a steric hindrance C11 framework structure to inhibit C12 coupling reaction, between nitrogen-containing heterocyclic chlorine and low-activity nitrogen-containing heterocyclic boronic acid and reaction can be carried out β - under mild conditions of air and water at the same time to ensure higher reaction yield, The present invention also greatly improves the reaction activity, Suzuki - Miyaura of the catalyst. (by machine translation)
Accessing Heterobiaryls through Transition-Metal-Free C-H Functionalization
Banik, Ananya,Paira, Rupankar,Shaw, Bikash Kumar,Vijaykumar, Gonela,Mandal, Swadhin K.
, p. 3236 - 3244 (2018/03/23)
Herein we report a transition-metal-free synthetic protocol for heterobiaryls, one of the most important pharmacophores in the modern drug industry, employing a new multidonor phenalenyl (PLY)-based ligand. The current procedure offers a wide substrate scope (24 examples) with a low catalyst loading resulting in an excellent product yield (up to 95%). The reaction mechanism involves a single electron transfer (SET) from a phenalenyl-based radical to generate a reactive heteroaryl radical. To establish the mechanism, we have isolated the catalytically active SET initiator, characterizing by a magnetic study.
