1001315-13-4

Basic information

• Product Name: (S)-[4-(2-nitro-6,7-dihydro-5H-imidazo[2,1-b][1,3]oxazin-6-yloxymethyl)-phenoxy]-acetic acid tert-butyl ester
• Synonyms: (S)-[4-(2-nitro-6,7-dihydro-5H-imidazo[2,1-b][1,3]oxazin-6-yloxymethyl)-phenoxy]-acetic acid tert-butyl ester
• CAS NO: 1001315-13-4
• Molecular Weight: 405.408
• Mol File: 1001315-13-4.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (S)-[4-(2-nitro-6,7-dihydro-5H-imidazo[2,1-b][1,3]oxazin-6-yloxymethyl)-phenoxy]-acetic acid tert-butyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: (S)-[4-(2-nitro-6,7-dihydro-5H-imidazo[2,1-b][1,3]oxazin-6-yloxymethyl)-phenoxy]-acetic acid tert-butyl ester(1001315-13-4)
• EPA Substance Registry System: (S)-[4-(2-nitro-6,7-dihydro-5H-imidazo[2,1-b][1,3]oxazin-6-yloxymethyl)-phenoxy]-acetic acid tert-butyl ester(1001315-13-4)

Safety Data

• Hazardous Substances Data: 1001315-13-4(Hazardous Substances Data)

Upstream product

• 187235-08-1 (S)‐2‐nitro‐6,7‐dihydro‐5H‐imidazo[2,1‐b][1,3]oxazin‐6‐ol 
• 1001315-10-1 (4-chloromethyl-phenoxy)-acetic acid tert-butyl ester 
• 208661-59-0 (4-hydroxymethyl-phenoxy)-acetic acid tert-butyl ester 
• 623-05-2 (4-hydroxyphenyl)methanol 

Downstream Products

• 1188917-61-4 (S,S)-N-{3-[3-fluoro-4-(4-{2-[4-(2-nitro-6,7-dihydro-5H-imidazo[2,1-b][1,3]oxazin-6-yloxymethyl)-phenoxy]-acetyl}-piperazin-1-yl)-phenyl]-2-oxo-oxazolidin-5-ylmethyl}-acetamide 

Relevant articles and documents

BICYCLIC NITROIMIDAZOLES COVALENTLY LINKED TO SUBSTITUTED PHENYL OXAZOLIDINONES

The current invention provides a series of bicyclic nitroimidazole- substituted phenyl oxazolidinones in which a bicyclic nitroimidazole pharmacophore is covalently bonded to a phenyl oxazolidinone, their pharmaceutical compositions, and the method of use of the compositions for prevention and treatment of bacterial infections. The bicyclic nitroimidazole-substituted phenyl oxazolidinones possess surprising antibacterial activity against wild- type and resistant strains of pathogens, and are therefore useful for the prevention, control and treatment of a number of human and veterinary bacterial infections caused by these pathogens, such as Mycobacterium tuberculosis.