187235-08-1 Usage
Description
(S)-2-NITRO-6,7-DIHYDRO-5H-IMIDAZO[2,1-B][1,3]OXAZIN-6-OL, also known as (S)-(-)-2-Nitro-6,7-dihydro-5H-imidazo[2,1-b][1,3]oxazin-6-ol, is an organic compound with a unique chemical structure. It is characterized by its imidazo-oxazine ring system and nitro functional group. (S)-2-NITRO-6,7-DIHYDRO-5H-IMIDAZO[2,1-B][1,3]OXAZIN-6-OL is of significant interest due to its role as a key intermediate in the synthesis of various pharmaceutical compounds.
Uses
Used in Pharmaceutical Industry:
(S)-2-NITRO-6,7-DIHYDRO-5H-IMIDAZO[2,1-B][1,3]OXAZIN-6-OL is used as an intermediate in the synthesis of (S)-PA 824 (P122500), a novel anti-tuberculosis drug. (S)-2-NITRO-6,7-DIHYDRO-5H-IMIDAZO[2,1-B][1,3]OXAZIN-6-OL plays a crucial role in the development of new and effective treatments for tuberculosis, a disease that continues to be a major global health concern. The compound's unique structure and properties make it a valuable building block in the creation of innovative pharmaceuticals targeting tuberculosis.
Check Digit Verification of cas no
The CAS Registry Mumber 187235-08-1 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,8,7,2,3 and 5 respectively; the second part has 2 digits, 0 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 187235-08:
(8*1)+(7*8)+(6*7)+(5*2)+(4*3)+(3*5)+(2*0)+(1*8)=151
151 % 10 = 1
So 187235-08-1 is a valid CAS Registry Number.
InChI:InChI=1/C6H7N3O4/c10-4-1-8-2-5(9(11)12)7-6(8)13-3-4/h2,4,10H,1,3H2/t4-/m0/s1
187235-08-1Relevant articles and documents
Synthesis method of PA-824
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, (2018/04/28)
The invention relates to a synthesis method of PA-824, which belongs to the technical field of pharmaceutical chemical engineering. According to the synthesis method of PA-824 disclosed by the invention, LiOH is utilized to carry out deprotection on aliphatic silyl ether protecting groups under the condition of heating. The synthesis method of PA-824 disclosed by the invention avoids the use of tetraalkyl ammonium fluoride and acidic substances, is easy and convenient to operate, increases reaction yield and the purity of the target product, and is favorable for industrial production.
Integration of solventless reaction in a multi-step process: Application to an efficient synthesis of PA-824
Orita, Akihiro,Miwa, Kai,Uehara, Genta,Otera, Junzo
, p. 2136 - 2144 (2008/09/19)
In order to improve redundant synthetic processes, the integration of a solventless reaction has proved to be useful for gaining high reaction mass efficiency (RME) as well as reducing the amount of solvents. This concept was applied to synthesis of PA-82
Process for preparing for imidazopyran derivatives
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Page/Page column 7, (2010/10/20)
A novel process for preparing imidazopyran derivatives of the formula: wherein R1 is halogen atom, hydrogen atom, C1 to C3 alkyl group, aryl group, or aryl group substituted by C1 to C3 alkyl group, b
