10031-93-3

Basic information

• Product Name: ETHYL 4-PHENYLBUTYRATE
• Synonyms: benzenebutanoicacid,ethylester;Ethyl4-phenylbutanoate;4-Phenyl-butyric acid ethyl ester;ETHYL 4-PHENYLBUTYRATE;ETHYL G-PHENYLBUTYRATE;4-Phenylbutanoic acid ethyl ester;4-Phenylbutyric acid ethyl;ethyl 4-phenylbutanoat
• CAS NO: 10031-93-3
• Molecular Formula: C₁₂H₁₆O₂
• Molecular Weight: 192.25
• Mol File: 10031-93-3.mol
• Article Data: 65

Chemical Properties

• Boiling Point: 100°C/1mmHg(lit.)
• Flash Point: 114.4°C
• Appearance: /
• Density: 1.002g/cm³
• Vapor Pressure: 0.00476mmHg at 25°C
• Refractive Index: 1.4910 to 1.4950
• Storage Temp.: Sealed in dry,Room Temperature
• Solubility: Chloroform (Slightly), Ethyl Acetate (Slightly)
• CAS DataBase Reference: ETHYL 4-PHENYLBUTYRATE(CAS DataBase Reference)
• NIST Chemistry Reference: ETHYL 4-PHENYLBUTYRATE(10031-93-3)
• EPA Substance Registry System: ETHYL 4-PHENYLBUTYRATE(10031-93-3)

Safety Data

• Hazardous Substances Data: 10031-93-3(Hazardous Substances Data)

Usage

Description

ETHYL 4-PHENYLBUTYRATE, also known as Benzenebutanoic Acid Ethyl Ester, is an organic compound with a sweet, fruity, plum-like odor and a cooked plum–prune taste. It is characterized by its ester functional group and is derived from the esterification of 4-phenylbutyric acid with ethanol.

Uses

Used in Pharmaceutical Industry:
ETHYL 4-PHENYLBUTYRATE is used as a synthetic intermediate for the development of thiazolium salts, which possess potent antimalarial activity. These salts are crucial in the creation of new and effective treatments for malaria, a disease that affects millions of people worldwide.
Used in Research and Development:
ETHYL 4-PHENYLBUTYRATE is used as a key compound in the preparation of novel lactate dehydrogenase A (LDH-A) inhibitors. These inhibitors are essential for LDH-related research, as they can help in understanding the role of LDH-A in various biological processes and its potential as a therapeutic target for certain diseases.
Used in Flavor and Fragrance Industry:
Due to its sweet, fruity, plum-like odor and cooked plum–prune taste, ETHYL 4-PHENYLBUTYRATE is utilized as a flavoring agent and fragrance component in the food, beverage, and cosmetic industries. It adds a unique and pleasant aroma to various products, enhancing their overall sensory experience for consumers.

Preparation

By esterification of ethanol with γ-phenylbutyric acid obtained by Grignard reaction from γ-bromopropylbenzene.

Synthesis Reference(s)

Journal of the American Chemical Society, 107, p. 1429, 1985 DOI: 10.1021/ja00291a063

InChI:InChI=1/C12H16O2/c1-2-14-12(13)10-6-9-11-7-4-3-5-8-11/h3-5,7-8H,2,6,9-10H2,1H3

Upstream product

• 6270-17-3 ethyl 3-benzoylpropanoate 
• 64-17-5 ethanol 
• 1821-12-1 4-Phenylbutyric acid 
• 14308-31-7 2,2-diethoxy-5-phenyl-2,3-dihydro-furan 
• 36240-47-8 diethyl 1-trimethylsilyloxy 2-propenyl phosphonate 
• 100-39-0 benzyl bromide 
• 591-50-4 iodobenzene 
• 104089-17-0 ethyl 4-(iodozincio)butanoate 
• 144499-11-6 Trifluoro-acetic acid 1-cyano-4-phenyl-1-(pyridin-2-ylsulfanyl)-butyl ester 
• 73706-60-2 1-tosyloxy-4-phenyl-2-butanone 
• 140-88-5 ethyl acrylate 
• 123133-12-0 1-chloro-1-fluoro-4-phenylbutyl phenyl sulfoxide 
• 620-05-3 iodomethylbenzene 
• 10341-89-6 Benzylquecksilberacetat 

Downstream Products

• 22339-61-3 γ-(p-succinylphenyl)butyric acid 
• 31067-15-9 1,1,4-triphenyl-1-butanol 
• 39181-61-8 4-phenylbutyric acid hydrazide 
• 3360-41-6 4-phenyl-butan-1-ol 
• 87157-79-7 4-(4-sulfo-phenyl)-butyric acid 
• 89326-67-0 4-(4-propionyl-phenyl)-butyric acid ethyl ester 
• 71665-59-3 4-(4-acetylphenyl)butyric acid ethyl ester 
• 54918-70-6 phenethyl-oxalacetic acid diethyl ester 
• 5469-48-7 phenethyl-fumaric acid 
• 103281-80-7 1,7-diphenyl-4-(3-phenyl-propyl)-heptan-4-ol 
• 6048-24-4 Triphenyl-<1-(γ-phenyl-butyryl)-butyliden>-phosphoran 
• 64740-40-5 phenyl (4-phenylbutyl) sulfide 
• 21895-10-3 4-phenyl<1,1-(2)H2>butanol 
• 27182-49-6 N-carbamimidoyl-4-phenyl-butyramide 

Relevant articles and documents

Facile reaction of o-carboranyllithium reagents with functionalized alkyl halides

Unlike the normal organolithium reagents, o-carboroanyllithium derivatives can tolerate many functional groups, such as ketones, nitriles and esters. This chemoselectivity is utilized in synthesizing a wide variety of o-carborane derivatives containing fu

Cobalt-catalyzed cross-coupling reactions of alkyl halides with aryl Grignard reagents and their application to sequential radical cyclization/cross-coupling reactions

Reactions of alkyl halides with arylmagnesium bromides in the presence of cobalt(II)(diphosphine) complexes are discussed. Treatment of 1-bromooctane with phenylmagnesium bromide with the aid of a catalytic amount of CoCl 2(dppp) [DPPP=1,3-bis(diphenylphosphino)propane] yielded octylbenzene in good yield. The reaction mechanism would include single electron transfer from an electron-rich cobalt complex to alkyl halide to generate the corresponding alkyl radical. The mechanism was justified by CoCl 2(dppe)-catalyzed [DPPE=1,2-bis(diphenylphosphino)ethane] sequential radical cyclization/cross-coupling reactions of 6-halo-1-hexene derivatives that yielded benzyl-substituted cyclopentane skeletons.

Homolytic Reactions of Ligated Boranes. Part 9. Overall Addition of Alkanes to Electron-deficient Alkenes by a Radical Chain Mechanism

Methyl bromoacetate and ethyl 2-bromopropanoate are reduced by Bun3P->BH3 or Bun3P->BH2Ph to methyl acetate and ethyl propanoate, respectively, in chlorobenzene at 80-110 deg C in the presence of dibenzoyl peroxide or t-butyl perbenzoate.Amine complexes of borane or phenylborane are much less effective reducing agents.The reductions may also be initiated photochemically and are inhibited by a phenolic radical scavenger.A homolytic chain mechanism is proposed in which the phosphine-boryl radical abstracts halogen from the bromo ester and is subsequently regenerated by reaction of an α-(alkoxycarbonyl)alkyl radical with the phosphine-borane.The latter propagation step, together with halogen abstraction from RI and addition of the derived alkyl radical to the C=C bond, is also involved in the chain reaction between Bun3P->BH2Ph, an alkyl iodide, and ethyl acrylate according to equation (A); Bun3P->BH3 reacts similarly but gives lower yields of ester.Reaction (A) proceeds smoothly at 110 deg C Bun3P->BH2Ph + RI + CH2=CHCO2Et -> RCH2CH2CO2Et + Bun3P->BHIPh (A) when initiated by t-butyl perbenzoate and moderate yields of isolated esters were obtained from n-butyl iodide, cyclohexyl iodide, and 3β-iodocholest-5-ene.This last iodide gives an epimeric mixture of 3α- and 3β-esters in total isolated yield of ca. 50 percent.Similar addition reactions take place between Bun3P->BH2Ph, BunI, and diethyl vinylphosphonate or phenyl vinyl sulphone.It is concluded that Bun3P->BH3 and particularly Bun3P->BH2Ph offer promise as alternatives to tin, mercury, and germanium hydrides in radical chain reactions of synthetic value.

One-step cross-coupling reaction of functionalized alkyl iodides with aryl halides by the use of an electrochemical method

Organozinc compounds of functionalized alkyl iodide carrying an alkoxycarbonyl, cyano or alkenyl group were prepared in high yields under mild conditions (0°C-r.t., 10min in DMF) by the reaction of iodides with an electrogenerated reactive zinc (EGZn). Cross-coupling of the organozinc compounds with various aryl halides in the presence of 5 mol% Pd(P(o- Tol)3)2Cl2 in THF gave the corresponding cross-coupled products in moderate to high yields. These cross-coupling reactions can be also achieved in one step and in one pot by the use of an electrochemical method utilizing a Pt cathode and Zn anode.

Microwave-assisted aqueous Krapcho decarboxylation

The Krapcho decarboxylation of alkyl malonate derivatives has been adapted to aqueous microwave conditions. Various salt additives were examined, and both the cation and the anion impacted the facility of the reaction. A strong correlation was found between the pKa of the anion and the reaction rate, suggesting a straightforward base-catalyzed hydrolysis. Lithium sulfate gave the best results, obviating the need for DMSO co-solvent. Georg Thieme Verlag Stuttgart · New York.

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Cu(II)-Catalyzed Olefin Migration and Prins Cyclization: Highly Diastereoselective Synthesis of Substituted Tetrahydropyrans

Metal-ligand complexes of Cu(OTf)2 with an appropriate bisphosphine ligand have been shown to effectively catalyze the formation of substituted tetrahydropyrans via a sequential olefin migration and Prins-type cyclization. This methodology provides convenient access to a variety of functionalized tetrahydropyrans in excellent diastereoselectivities and good to excellent yields.

Vinylation of benzylic quaternary ammonium salts catalyzed by palladium

The palladium-catalyzed vinylation of benzylic tributylammonium salts with a variety of olefins has been studied. A possible free radical mechanism is proposed.

Synthesis of 1-(3-phenylpropyl)-4-(pyridinylmethoxy)-[1,2,4]triazolo[4,3-a] quinoxalines

Starting from 2,3-dichloroquinoxaline, a synthetic strategy for the preparation of 1-(3-phenylpropyl)-4-(pyridinylmethoxy)[1,2,4]triazolo[4,3-a]quinoxalines is described.

Ring opening of cyclopropanecarboxylates using samarium(ii) diiodide (SmI2)-HMPA-THF system

Cyclopropane ring of 2- and 2,3-substituted cyclopropanecarboxylates (1) was regioselectively cleaved using SmI2-HMPA-THF system in the presence of tert-BuOH to give 4- and 3,4-substituted butyrates (2) in moderate to good yields.

Ruthenium pincer complex-catalyzed heterocycle compatible alkoxycarbonylation of alkyl iodides: Substrate keeps the catalyst active

The electron pair of the heteroatom in heterocycles will coordinate with metal catalysts and decrease or even inhibit their catalytic activity consequently. In this work, a pincer ruthenium-catalyzed heterocycle compatible alkoxycarbonylation of alkyl iodides has been developed. Benefitting from the pincer ligand, a variety of heterocycles, such as thiophenes, morpholine, unprotected indoles, pyrrole, pyridine, pyrimidine, furan, thiazole, pyrazole, benzothiadiazole, and triazole, are compatible here. This journal is

Copper catalyzed C(sp3)-H bond alkylation via photoinduced ligand-to-metal charge transfer

Utilizing catalytic CuCl2 we report the functionalization of numerous feedstock chemicals via the coupling of unactivated C(sp3)-H bonds with electron-deficient olefins. The active cuprate catalyst undergoes Ligand-to-Metal Charge Transfer (LMCT) to enable the generation of a chlorine radical which acts as a powerful hydrogen atom transfer reagent capable of abstracting strong electron-rich C(sp3)-H bonds. Of note is that the chlorocuprate catalyst is an exceedingly mild oxidant (0.5 V vs SCE) and that a proposed protodemetalation mechanism offers a broad scope of electron-deficient olefins, offering high diastereoselectivity in the case of endocyclic alkenes. The coupling of chlorine radical generation with Cu reduction through LMCT enables the generation of a highly active HAT reagent in an operationally simple and atom economical protocol.

Mechanical metal activation for Ni-catalyzed, Mn-mediated cross-electrophile coupling between aryl and alkyl bromides

Liquid-assisted grinding has been successfully applied to eliminate the requirements of chemical activators and anhydrous solvents in nickel-catalyzed, manganese-mediated cross-electrophile coupling between aryl and alkyl bromides. In addition to the traditional reaction parameters, mechanical ones,e.g.the rotational speed of mill, the filling degree of jar and ball size, have been found to affect the catalytic efficiency remarkably, implying the involvement of the regeneration of nickel(0) species in the rate-determining steps. A combined evaluation of the reaction and mechanical parameters led to an optimal condition under which a variety ofn-alky aromatics with various functional groups could be readily obtained in good yields with a 1 mol% catalyst loading. The practical application of liquid-assisted grinding-enabled aryl/alkyl cross-electrophile coupling has been demonstrated in the gram-scale synthesis of 6-methoxytetralone.