100421-52-1 Usage
Description
2-Thiophenecarboxylic acid, 3-fluoro-, methyl ester (9CI) is an organic compound that belongs to the class of thiophenecarboxylic acids. It is characterized by the presence of a fluorine atom at the 3-position and a methyl ester group at the 2-position. 2-Thiophenecarboxylicacid,3-fluoro-,methylester(9CI) is known for its potential applications in the synthesis of various heterocyclic compounds.
Uses
Used in Pharmaceutical Industry:
2-Thiophenecarboxylic acid, 3-fluoro-, methyl ester (9CI) is used as a key intermediate in the synthesis of five-membered heterocyclic compounds, specifically as STING agonists. These STING agonists play a crucial role in modulating the immune response and have potential applications in the development of novel therapeutics for various diseases, including cancer and infectious diseases.
In the preparation of five-membered heterocyclic compounds, 2-Thiophenecarboxylic acid, 3-fluoro-, methyl ester (9CI) serves as a valuable building block due to its unique structural features. The presence of the fluorine atom and the methyl ester group allows for further functionalization and modification, enabling the synthesis of a wide range of biologically active compounds with diverse properties and applications.
Check Digit Verification of cas no
The CAS Registry Mumber 100421-52-1 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,0,0,4,2 and 1 respectively; the second part has 2 digits, 5 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 100421-52:
(8*1)+(7*0)+(6*0)+(5*4)+(4*2)+(3*1)+(2*5)+(1*2)=51
51 % 10 = 1
So 100421-52-1 is a valid CAS Registry Number.
InChI:InChI=1/C6H5FO2S/c1-9-6(8)5-4(7)2-3-10-5/h2-3H,1H3
100421-52-1Relevant articles and documents
A facile and improved synthesis of 3-fluorothiophene
Pomerantz, Martin,Turkman, Nashaat
, p. 2333 - 2336 (2008)
A new efficient and convenient route to 3-fluorothiophene in four steps and 49% overall yield is reported. The fluorine atom was successfully introduced into the thiophene ring in 67% yield using the Schiemann reaction on 2-methoxycarbonylthiophene-3-diazonium tetrafluoroborate. The product, methyl 3-fluorothiophene-2-carboxylate was saponified and the 3-fluorothiophene-2- carboxylic acid was decarboxylated to afford 3-fluorothiophene in 93% yield. Georg Thieme Verlag Stuttgart.
FACTOR XIa INHIBITORS
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Page/Page column 54, (2016/11/02)
The present invention provides a compound of Formula (I); and pharmaceutical compositions comprising one or more said compounds, and methods for using said compounds for treating or preventing thromboses, embolisms, hypercoagulability or fibrotic changes. The compounds are selective Factor XIa inhibitors or dual inhibitors of Factor XIa and plasma kallikrein.
Ring fluorinated thiophenes: Applications to liquid crystal synthesis
Kiryanov, Andre A.,Seed, Alexander J.,Sampson, Paul
, p. 8797 - 8800 (2007/10/03)
Ring fluorinated thiophenes were synthesized via a Balz-Schiemann fluorination approach and were successfully employed in the synthesis of liquid crystals using regioselective electrophilic bromination and regioselective Suzuki coupling chemistry.