32431-84-8

Basic information

• Product Name: 2-Thiophenecarboxylic acid, 3-fluoro-
• Synonyms: 2-Thiophenecarboxylicacid,3-fluoro-(8CI,9CI);3-Fluoro-2-thiophenecarboxylic acid;2-Carboxy-3-fluorothiophene;2-Thiophenecarboxylic acid, 3-fluoro-;3-Fluor
• CAS NO: 32431-84-8
• Molecular Formula: C₅H₃FO₂S
• Molecular Weight: 146.1395232
• Product Categories: CARBOXYLICACID;Heterocyclic Building Blocks
• Mol File: 32431-84-8.mol
• Article Data: 13

Chemical Properties

• Melting Point: 175.0 to 179.0 °C
• Boiling Point: 263.819 °C at 760 mmHg
• Flash Point: 113.4℃
• Appearance: /
• Density: 1.527
• Vapor Pressure: 0.00506mmHg at 25°C
• Refractive Index: 1.573
• Storage Temp.: 0-10°C
• Solubility: soluble in Methanol
• PKA: 3.22±0.10(Predicted)
• CAS DataBase Reference: 2-Thiophenecarboxylic acid, 3-fluoro-(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Thiophenecarboxylic acid, 3-fluoro-(32431-84-8)
• EPA Substance Registry System: 2-Thiophenecarboxylic acid, 3-fluoro-(32431-84-8)

Safety Data

• Hazardous Substances Data: 32431-84-8(Hazardous Substances Data)

Usage

General Description

3-Fluoro-2-thiophenecarboxylic acid is a type of chemical compound primarily known for being utilized within scientific and medical research settings. This particular compound exists in a solid state under normal conditions and is identifiable through its specific systematic name of 3-Fluorothiophene-2-carboxylic acid. Commonly found in the subclass of thiophene carboxylic acids and derivatives, this chemical substance is quite prominent in the world of chemistry due to its prevalent use. The compound exhibits strong acidic properties, offering a plethora of uses, such as in chemical synthesis and various laboratory applications. However, 3-Fluoro-2-thiophenecarboxylic acid is noted for its potential hazards, including skin and eye irritation, prompting strict guidelines for handling and storage.

InChI:InChI=1/C5H3FO2S/c6-3-1-2-9-4(3)5(7)8/h1-2H,(H,7,8)

Upstream product

• 100421-52-1 methyl 3-fluorothiophene-2-carboxylate 
• 154499-46-4 2-cyano-3-fluorothiophene 
• 527-72-0 2-thiophenylcarboxylic acid 
• 147123-67-9 3-chlorothiophene-2-carbonitrile 
• 22288-78-4 Methyl 3-aminothiophene-2-carboxylate 
• 109-72-8 n-butyllithium 
• 133745-75-2 N-fluorobis(benzenesulfon)imide 

Downstream Products

• 3093-88-7 3-fluorothiophene 
• 614729-70-3 (3-fluorothiophen-2-yl)methanol 
• 395664-56-9 methyl 4-bromo-3-fluorothiophene-2-carboxylate 
• 100421-52-1 methyl 3-fluorothiophene-2-carboxylate 
• 32431-83-7 3-fluorothiophene-2-carbaldehyde 
• 83933-19-1 3-fluorothiophen-2-carboxamide 

Relevant articles and documents

A facile synthesis of 3-fluorothiophene-2-carboxylic acid

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Fluorinated Dithienylethene-Naphthalenediimide Copolymers for High-Mobility n-Channel Field-Effect Transistors

We develop two donor-acceptor copolymers based on a fluorinated dithienylethene building block, namely PNFDTE1 and PNFDTE2, in which naphthalenediimide (NDI) acts as an acceptor unit. Thermogravimetric analysis displayed both copolymers having good thermal stability with high decomposition temperatures over 400 °C. Broad absorption spectra were observed in the UV-vis-NIR region, with the absorption maxima being 720 and 724 nm for PNFDTE1 and PNFDTE2, respectively. Cyclic voltammetry tests exhibited deep-lying lowest unoccupied molecular orbital energy levels of ca. -4.0 eV. Two-dimensional grazing incidence X-ray diffraction patterns showed that different packing modes for two polymers result in the variation in charge transport properties. Backbone fluorination effectively decreases electron injection barrier, thereby facilitating electron mobility. An impressive electron mobility of 3.20 cm2 V-1 s-1 was achieved in air for PNFDTE1-based polymer field-effect transistors fabricated on the poly(ethylene terephthalate) substrate. The mobility value is almost the highest for NDI-containing polymers on the flexible substrate. This work provides a guideline for design and synthesis of fluorinated semiconductors that enables control of charge-transport polarity.

CATHEPSIN CYSTEINE PROTEASE INHIBITORS FOR THE TREATMENT OF VARIOUS DISEASES

The present invention relates to compounds capable of inhibiting and/or decreasing the activity of one or more cathepsins, thereby treating and/or preventing various disease states associated with one or more cysteine proteases including, but not limited