1004551-40-9 Usage
General Description
C31H27N3O4, also known as thalidomide, is a pharmaceutical compound with a complex chemical structure. It consists of 31 carbon atoms, 27 hydrogen atoms, 3 nitrogen atoms, and 4 oxygen atoms. Thalidomide has been used as a sedative and antiemetic drug, but it is most infamous for its teratogenic effects, causing severe birth defects when taken during pregnancy. Despite these dangerous side effects, thalidomide has also shown promise in the treatment of certain cancers and autoimmune diseases, and it continues to be used in some medical settings under strict regulations and monitoring. Its chemical makeup allows it to interact with various biological systems, leading to both its therapeutic potential and its harmful effects.
Check Digit Verification of cas no
The CAS Registry Mumber 1004551-40-9 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,0,0,4,5,5 and 1 respectively; the second part has 2 digits, 4 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 1004551-40:
(9*1)+(8*0)+(7*0)+(6*4)+(5*5)+(4*5)+(3*1)+(2*4)+(1*0)=89
89 % 10 = 9
So 1004551-40-9 is a valid CAS Registry Number.
1004551-40-9Relevant articles and documents
Discovery and gram-scale synthesis of BMS-593214, a potent, selective FVIIa inhibitor
Priestley, E. Scott,De Lucca, Indawati,Zhou, Jinglan,Zhou, Jiacheng,Saiah, Eddine,Stanton, Robert,Robinson, Leslie,Luettgen, Joseph M.,Wei, Anzhi,Wen, Xiao,Knabb, Robert M.,Wong, Pancras C.,Wexler, Ruth R.
, p. 2432 - 2435 (2013/05/09)
A 6-amidinotetrahydroquinoline screening hit was driven to a structurally novel, potent, and selective FVIIa inhibitor through a combination of library synthesis and rational design. An efficient gram-scale synthesis of the active enantiomer BMS-593214 was developed, which required significant optimization of the key Povarov annulation. Importantly, BMS-593214 showed antithrombotic efficacy in a rabbit arterial thrombosis model. A crystal structure of BMS-593214 bound to FVIIa highlights key contacts with Asp 189, Lys 192, and the S2 pocket.
