52783-83-2

Basic information

• Product Name: 4-ACETOXY-2-BROMO-5-METHOXYBENZALDEHYDE 98
• Synonyms: 4-ACETOXY-2-BROMO-5-METHOXYBENZALDEHYDE 98;4-Acetoxy-2-bromo-5-methoxybenzaldehyde 98%;5-bromo-4-formyl-2-methoxyphenyl acetate(SALTDATA: FREE);4-(acetyloxy)-2-broMo-5-Methoxy-Benzaldehyde;6-BroMovanillin Acetate
• CAS NO: 52783-83-2
• Molecular Formula: C₁₀H₉BrO₄
• Molecular Weight: 273.0811
• Product Categories: Aldehydes;blocks;Bromides
• Mol File: 52783-83-2.mol
• Article Data: 11

Chemical Properties

• Melting Point: 110-113
• Boiling Point: 336.4 °C at 760 mmHg
• Flash Point: 157.2 °C
• Appearance: /
• Density: 1.526 g/cm³
• Vapor Pressure: 0.000113mmHg at 25°C
• Refractive Index: 1.57
• Storage Temp.: Keep Cold
• Solubility: Chloroform, DCM, Ethyl Acetate
• CAS DataBase Reference: 4-ACETOXY-2-BROMO-5-METHOXYBENZALDEHYDE 98(CAS DataBase Reference)
• NIST Chemistry Reference: 4-ACETOXY-2-BROMO-5-METHOXYBENZALDEHYDE 98(52783-83-2)
• EPA Substance Registry System: 4-ACETOXY-2-BROMO-5-METHOXYBENZALDEHYDE 98(52783-83-2)

Safety Data

• Hazard Codes: Xi
• Hazardous Substances Data: 52783-83-2(Hazardous Substances Data)

Usage

Uses

6-Bromovanillin Acetate is used in the synthesis of BMS-593214, a potent, selective FVIIa inhibitor.

InChI:InChI=1/C10H9BrO4/c1-6(13)15-10-4-8(11)7(5-12)3-9(10)14-2/h3-5H,1-2H3

Upstream product

• 881-68-5 vanillin acetate 
• 121-33-5 vanillin 

Downstream Products

• 60632-40-8 6-bromovanillin 
• 161196-87-8 2-bromo-4-hydroxy-5-methoxybenzonitrile 
• 90050-65-0 2-Bromo-4-hydroxy-5-methoxybenzoic acid 
• 40705-22-4 4-benzyloxy-6-bromo-3-methoxybenzaldehyde 
• 127027-59-2 Ethyl-6-(benzyloxy)-7-methoxyindol-2-carboxylat 
• 127027-65-0 Ethyl-6-(benzyloxy)-4-bromo-7-methoxyindol-2-carboxylat 
• 127027-70-7 6-(Benzyloxy)-7-methoxy-4-nitro-1H-indol-2-carbonsaeure-ethylester 
• 127027-63-8 Ethyl-2-azido-3-hydroxy-3-<2'-bromo-4'-(benzyloxy)-5'-methoxyphenyl>propanoat 
• 499217-06-0 4-Hydroxy-5-methoxy-2-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-benzaldehyde 
• 864717-15-7 2-bromo-5-methoxy-4-[(4-nitrophenyl)methoxy]benzaldehyde 
• 1350809-54-9 5-methoxy-2-methyl-4-[(4-nitrophenyl)methoxy]benzaldehyde 
• 1350809-53-8 2-ethenyl-5-methoxy-4-[(4-nitrophenyl)methoxy]benzaldehyde 
• 1350809-55-0 2-ethyl-5-methoxy-4-[(4-nitrophenyl)methoxy]benzaldehyde 
• 1429310-01-9 C₃₈H₃₃N₃O₄ 

Relevant articles and documents

Structure and biological evaluation of (E)-5-bromo-2-methoxy-4-((phenylimino)methyl)phenol derivatives as antibacterial agents

Three (E)-5-bromo-2-methoxy-4-((phenylimino)methyl)phenol derivatives (1-3) are synthesized and characterized by elemental analysis and single-crystal X-ray diffraction. The antibacterial activities of compounds 1-3 against Escherichia coli, Pseudomonas aeruginosa, Bacillus subtilis, and Staphylococcus aureus are evaluated by the MTT method.

cGAS ANTAGONIST COMPOUNDS

Disclosed are novel compounds of Formula (I) that are cGAS antagonists, methods of preparation of the compounds, pharmaceutical compositions comprising the compounds, and their use in medical therapy.

Exploring the formation and recognition of an important G-quadruplex in a HIF1α promoter and its transcriptional inhibition by a benzo[c]phenanthridine derivative

Four putative G-quadruplex sequences (PGSs) in the HIF1α promoter and the 5′UTR were evaluated for their G-quadruplex-forming potential using ESI-MS, CD, FRET, DMS footprinting, and a polymerase stop assay. An important G-quadruplex (S1) has been proven to inhibit HIF1α transcription by blocking AP2 binding. A benzo[c]phenanthridine derivative was found to target the S1 G-quadruplex and induce its conformational conversion from antiparallel to parallel orientation. The transcriptional suppression of HIF1α by this compound was demonstrated using western blotting, Q-RT-PCR, luciferase assay, and ChIP. Our new findings provided a novel strategy for HIF1α regulation and potential insight for cancer therapy.