864717-15-7Relevant articles and documents
A new method for induced fit docking (genius) and its application to virtual screening of novel HCV NS3-4A protease inhibitors
Takaya, Daisuke,Yamashita, Atsuya,Kamijo, Kazue,Gomi, Junko,Ito, Masahiko,Maekawa, Shinya,Enomoto, Nobuyuki,Sakamoto, Naoya,Watanabe, Yoshiaki,Arai, Ryoichi,Umeyama, Hideaki,Honma, Teruki,Matsumoto, Takehisa,Yokoyama, Shigeyuki
, p. 6892 - 6905 (2011)
Hepatitis C virus (HCV) is an etiologic agent of chronic liver disease, and approximately 170 million people worldwide are infected with the virus. HCV NS3-4A serine protease is essential for the replication of this virus, and thus has been investigated as an attractive target for anti-HCV drugs. In this study, we developed our new induced-fit docking program (genius), and applied it to the discovery of a new class of NS3-4A protease inhibitors (IC50 = 1-10 μM including high selectivity index). The new inhibitors thus identified were modified, based on the docking models, and revealed preliminary structure-activity relationships. Moreover, the genius in silico screening performance was validated by using an enrichment factor. We believe our designed scaffold could contribute to the improvement of HCV chemotherapy.
