100491-30-3 Usage
Chemical structure
A type of ethyl ester containing a naphthyridine-3-carboxylic acid core structure with a chloro and fluoro substituent on the 7th and 6th positions, respectively, and a 4-fluorophenyl group on the 1st position.
Functional groups
Ethyl ester, naphthyridine-3-carboxylic acid, chloro, fluoro, and 4-fluorophenyl.
Molecular weight
Approximately 369.74 g/mol
Appearance
Likely a solid or crystalline substance, though specific appearance may vary.
Solubility
Solubility may vary depending on the solvent, but it is likely soluble in organic solvents such as ethanol, methanol, or dimethyl sulfoxide (DMSO).
Stability
Stable under normal temperature and pressure, but may be sensitive to light, heat, or moisture.
Reactivity
May undergo various chemical reactions, such as hydrolysis, esterification, or substitution reactions, depending on the reaction conditions and reagents used.
Synthesis
Often used as a building block for the synthesis of various pharmaceutical compounds.
Biological activity
May have biological activities and potential applications in drug discovery and development, but specific uses and properties may vary depending on the context and the specific chemical reactions it is involved in.
Safety
As with any chemical, appropriate safety precautions should be taken when handling, such as wearing gloves, protective eyewear, and a lab coat. Additionally, it should be stored in a well-ventilated area and away from incompatible substances.
Regulatory status
Regulatory status may vary depending on the country and intended use, so it is essential to consult local regulations and guidelines for proper handling and disposal.
Check Digit Verification of cas no
The CAS Registry Mumber 100491-30-3 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,0,0,4,9 and 1 respectively; the second part has 2 digits, 3 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 100491-30:
(8*1)+(7*0)+(6*0)+(5*4)+(4*9)+(3*1)+(2*3)+(1*0)=73
73 % 10 = 3
So 100491-30-3 is a valid CAS Registry Number.
100491-30-3Relevant articles and documents
Synthesis and structure-activity relationships of novel 7-substituted 1,4-dihydro-4-oxo-1-(2-thiazolyl)-1,8-naphthyridine-3-carboxylic acids as antitumor agents. Part 1
Tomita, Kyoji,Tsuzuki, Yasunori,Shibamori, Koh-ichiro,Tashima, Masanori,Kajikawa, Fumie,Sato, Yuji,Kashimoto, Shigeki,Chiba, Katsumi,Hino, Katsuhiko
, p. 5564 - 5575 (2007/10/03)
In an attempt to search for clinically useful antitumor agents, we have discovered that a series of 1,7-disubstituted-6-fluoro-1,4-dihydro-4-oxo-1,8-naphthyridine-3-carboxylic acids possessed moderate cytotoxic activity. We investigated the structure-acti
Synthesis and Structure-Activity Relationships of New Arylfluoronaphthyridine Antibacterial Agents
Chu, Daniel T. W.,Fernandes, Prabhavathi B.,Claiborne, Akiyo K.,Gracey, Eugene H.,Pernet, Andre G.
, p. 2364 - 2369 (2007/10/02)
Novel arylfluoro-1,4-dihydro-4-oxo-1,8-naphthyridine-3-carboxylic acid have been prepared and their antibacterial activity evaluated.These derivatives are characterized by having a fluorine atom at 6-position, substituted amino groups at the 7-position, and substituted phenyl groups at the 1-position.The in vitro antibacterial potency is greatest when the 1-substituent is either p-fluorophenyl or o,p-difluorophenyl and the 7-substituent is a 3-amino-1-pyrrolidinyl group. 1-(2,4-Difluorophenyl)-6-fluoro-7-(3-amino-1-pyrrolidinyl)-1,4-dihydro-4-oxo-1,8-naphthyridine-3-carboxylic acid (38) was found to possess excellent in vitro potency and in vivo efficacy.
