100638-26-4

Basic information

• Product Name: 3-CHLORO-N-(3-FLUOROPHENYL)PROPANAMIDE
• Synonyms: 3-CHLORO-N-(3-FLUOROPHENYL)PROPANAMIDE;3-chloro-N-(3-fluorophenyl)propanamide(SALTDATA: FREE);Propanamide, 3-chloro-N-(3-fluorophenyl)-
• CAS NO: 100638-26-4
• Molecular Formula: C₉H₉ClFNO
• Molecular Weight: 201.63
• Mol File: 100638-26-4.mol
• Article Data: 17

Chemical Properties

• Boiling Point: 350.4°C at 760 mmHg
• Flash Point: 165.7°C
• Appearance: /
• Density: 1.304g/cm³
• Vapor Pressure: 4.41E-05mmHg at 25°C
• Refractive Index: 1.56
• CAS DataBase Reference: 3-CHLORO-N-(3-FLUOROPHENYL)PROPANAMIDE(CAS DataBase Reference)
• NIST Chemistry Reference: 3-CHLORO-N-(3-FLUOROPHENYL)PROPANAMIDE(100638-26-4)
• EPA Substance Registry System: 3-CHLORO-N-(3-FLUOROPHENYL)PROPANAMIDE(100638-26-4)

Safety Data

• HazardClass: IRRITANT
• Hazardous Substances Data: 100638-26-4(Hazardous Substances Data)

Usage

General Description

3-CHLORO-N-(3-FLUOROPHENYL)PROPANAMIDE is a chemical compound with the molecular formula C9H10ClFNO. It is a white solid that is classified as an amide. 3-CHLORO-N-(3-FLUOROPHENYL)PROPANAMIDE is used in the pharmaceutical industry as an intermediate in the synthesis of various drugs and pharmaceutical products. Its chemical structure contains a chloro group, a fluorophenyl group, and a propanamide group, making it useful in the production of pharmaceutical compounds with diverse properties and applications. 3-CHLORO-N-(3-FLUOROPHENYL)PROPANAMIDE is typically handled and stored according to standard safety measures for handling chemical compounds.

InChI:InChI=1/C9H9ClFNO/c10-5-4-9(13)12-8-3-1-2-7(11)6-8/h1-3,6H,4-5H2,(H,12,13)

Upstream product

• 372-19-0 meta-fluoroaniline 
• 625-36-5 2-chloropropionyl chloride 

Downstream Products

• 53098-51-4 5-Fluor-2,4-dinitro-β-chlorpropionanilid 
• 4590-52-7 7-fluoro-3,4-dihydro-1H-quinolin-2-one 
• 939758-75-5 7-fluoro-1,2,3,4-tetrahydroquinoline 
• 1384850-32-1 3-(7-fluoro-1,2,3,4-tetrahydroquinolin-1-yl)-2-(4-fluorophenyl)quinoxaline-6-carboxylic acid 
• 1384850-72-9 methyl 3-(7-fluoro-1,2,3,4-tetrahydroquinolin-1-yl)-2-(4-fluorophenyl)quinoxaline-6-carboxylate 
• 1156389-00-2 6-bromo-7-fluoro-3,4-dihydroquinolin-2(1H)-one 
• 116434-95-8 5-fluoro-3,4-dihydro-1H-quinolin-2-one 
• 1444511-93-6 diethyl [N-(3-fluorophenyl)carbamoyl]ethylphosphonate 
• 1444512-38-2 [N-(3-fluorophenyl)carbamoyl]ethylphosphonic acid 
• 1444512-87-1 sodium hydrogen [N-(3-fluorophenyl)carbamoyl]ethylphosphonate 

Relevant articles and documents

TETRAHYDROQUINOLINO DERIVATIVES FOR THE TREATMENT OF METASTATIC AND CHEMORESISTANT CANCERS

Disclosed herein are compounds of Structural Formula I. Compounds of Structural Formula I inhibit aldehyde dehydrogenase isoform Ia3 (ALDHIa3) and are useful for treating cancer, for example, metastatic or chemoresistant cancer, such as metastatic cancer resistant to chemotherapy. Also disclosed herein are compositions comprising compounds of Structural Formula I and uses of compounds of Structural Formula I for treating cancer, for example, metastatic or chemoresistant cancer.

Triazole derivative having HSP90 (Heat Shock Protein) inhibiting activity, as well as preparation method and application of triazole derivative

The invention discloses a triazole derivative having an HSP90 (Heat Shock Protein) inhibiting activity, as well as a preparation method and an application of the triazole derivative. Specifically, the invention relates to the triazole derivative having a structure as shown in a formula (I), a stereisomer of the triazole derivative and a pharmaceutically acceptable salt, wherein the definition of each substituent group in the formula (I) and the definition in a description are the same. The compound with a novel structure has the HSP90 inhibiting activity, can be used to cure cancers, neurodegenerative disorders, inflammation diseases, autoimmune diseases, ischemic brain injuries and the like, and has a broad application prospect.

NEW DIHYDROQUINOLINE PYRAZOLYL COMPOUNDS AS ALDOSTERONE SYNTHASE INHIBITORS

The invention provides novel compounds having the general formula (I) wherein R1, R2, R3, R4, R5, R6, R7, R8, R10, R11, R12, R13, R14, R15, R16, R17 and m are as described herein, compositions including the compounds and methods of using the compounds.