4590-52-7

Basic information

• Product Name: NISTC4590527
• Synonyms: NISTC4590527;7-Fluoro-3,4-dihydroquinolin-2(1H)-one;7-fluoro-3,4-dihydro-2(1H)-Quinolinone;7-Fluoro-3,4-dihydroquinolin-2(1H);2(1H)-Quinolinone, 7-fluoro-3,4-dihydro-
• CAS NO: 4590-52-7
• Molecular Formula: C₉H₈FNO
• Molecular Weight: 165.1643232
• Mol File: 4590-52-7.mol
• Article Data: 22

Chemical Properties

• Boiling Point: 305.8°Cat760mmHg
• Flash Point: 138.7°C
• Appearance: /
• Density: 1.241g/cm³
• Vapor Pressure: 0.000804mmHg at 25°C
• Refractive Index: 1.542
• Storage Temp.: Sealed in dry,Room Temperature
• PKA: 14.01±0.20(Predicted)
• CAS DataBase Reference: NISTC4590527(CAS DataBase Reference)
• NIST Chemistry Reference: NISTC4590527(4590-52-7)
• EPA Substance Registry System: NISTC4590527(4590-52-7)

Safety Data

• Hazardous Substances Data: 4590-52-7(Hazardous Substances Data)

Usage

Uses

7-Fluoro-3,4-dihydroquinolin-2(1H)-one is a useful reagent in the multicomponent one-pot synthesis of 3,4-dihydroquinolinones.

InChI:InChI=1/C9H8FNO/c10-7-3-1-6-2-4-9(12)11-8(6)5-7/h1,3,5H,2,4H2,(H,11,12)

Upstream product

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• 313545-72-1 2-chloro-4-fluorophenylboronic acid 
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• 364-78-3 2-nitro-4-fluoroaniline 

Downstream Products

• 939758-75-5 7-fluoro-1,2,3,4-tetrahydroquinoline 
• 148136-14-5 7-fluoroquinolin-2(1H)-one 
• 1384850-32-1 3-(7-fluoro-1,2,3,4-tetrahydroquinolin-1-yl)-2-(4-fluorophenyl)quinoxaline-6-carboxylic acid 
• 1384850-72-9 methyl 3-(7-fluoro-1,2,3,4-tetrahydroquinolin-1-yl)-2-(4-fluorophenyl)quinoxaline-6-carboxylate 
• 1156389-00-2 6-bromo-7-fluoro-3,4-dihydroquinolin-2(1H)-one 

Relevant articles and documents

Dehydrogenative and Redox-Neutral N-Heterocyclization of Aminoalcohols Catalyzed by Manganese Pincer Complexes

A new manganese catalyzed heterocyclization of aminoalcohols has been accomplished. A wide range of heterocycles were synthesized, including 1,2,3,4-tetrahydroquinolines, dihydroquinolinones, and 2,3,4,5-tetrahydro-1H-benzo[b]azepines. The reaction is performed under mild reaction conditions using air and moisture stable manganese catalysts. The desired heterocycles were obtained in good to excellent yields.

DIACYLGLYCEROL KINASE MODULATING COMPOUNDS

The present disclosure provides diacylglycerol kinase modulating compounds, and pharmaceutical compositions thereof, for treating cancer, including solid tumors, and viral infections, such as HIV or hepatitis B virus infection. The compounds can be used alone or in combination with other agents.

TETRAHYDROQUINOLINO DERIVATIVES FOR THE TREATMENT OF METASTATIC AND CHEMORESISTANT CANCERS

Disclosed herein are compounds of Structural Formula I. Compounds of Structural Formula I inhibit aldehyde dehydrogenase isoform Ia3 (ALDHIa3) and are useful for treating cancer, for example, metastatic or chemoresistant cancer, such as metastatic cancer resistant to chemotherapy. Also disclosed herein are compositions comprising compounds of Structural Formula I and uses of compounds of Structural Formula I for treating cancer, for example, metastatic or chemoresistant cancer.