148136-14-5

Basic information

• Product Name: 2-HYDROXY-7-FLUOROQUINOLINE
• Synonyms: 2-HYDROXY-7-FLUOROQUINOLINE;7-fluoroquinolin-2(1H)-one;7-fluoro-1,2-dihydroquinolin-2-one;EOS-60813
• CAS NO: 148136-14-5
• Molecular Formula: C9H6FNO
• Molecular Weight: 163.15
• Mol File: 148136-14-5.mol
• Article Data: 14

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 2-HYDROXY-7-FLUOROQUINOLINE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-HYDROXY-7-FLUOROQUINOLINE(148136-14-5)
• EPA Substance Registry System: 2-HYDROXY-7-FLUOROQUINOLINE(148136-14-5)

Safety Data

• Hazardous Substances Data: 148136-14-5(Hazardous Substances Data)

Usage

General Description

2-Hydroxy-7-fluoroquinoline is a chemical compound with the molecular formula C9H6FN0. It is a fluorine-substituted quinoline derivative, and it belongs to the class of heterocyclic compounds. The compound has a hydroxyl group and a fluorine atom attached to a quinoline ring, which imparts specific chemical and biological properties to the molecule. 2-Hydroxy-7-fluoroquinoline has potential applications in medicinal chemistry, particularly as a building block for the synthesis of pharmaceuticals and agrochemicals. It is also of interest for its chemical reactivity and potential use as a ligand in coordination chemistry and catalysis.

Upstream product

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Relevant articles and documents

Palladium-catalyzed synthesis of quinolin-2(1: H)-ones: the unexpected reactivity of azodicarboxylate

Quinolin-2(1H)-one is a useful structure unit present in a wide range of natural products and pharmaceuticals. A Pd(ii)-catalyzed synthesis of quinolin-2(1H)-ones from quinoline N-oxides was developed with azodicarboxylates which act as both the activating agent and oxidant. The reaction proceeded under mild conditions and no protection against air and moisture was needed.

Oxidative Aromatization of 3,4-Dihydroquinolin-2(1 H)-ones to Quinolin-2(1 H)-ones Using Transition-Metal-Activated Persulfate Salts

Inorganic persulfate salts were identified as efficient reagents for the oxidative aromatization of 3,4-dihydroquinolin-2(1H)-ones through the activation of readily available transition metals, such as iron and copper. The feasible protocol conforming to the requirement of green chemistry was utilized in the preparation of the key intermediate (7-(4-chlorobutoxy)quinolin-2(1H)-one 2) of brexpiprazole in 80% isolated yield on a 100 g scale, and different quinolin-2(1H)-one derivatives with various functional groups were demonstrated in 52-89% yields.

Tetrahydroquinoline analogues as muscarinic agonists

The present invention relates to tetrahydroquinoline compounds as muscarinic receptor agonists; compositions comprising the same; methods of inhibiting an activity of a muscarinic receptor with said compounds; methods of treating a disease condition associated with a muscarinic receptor using said compounds; and methods for identifying a subject suitable for treatment using said compounds.