101291-06-9

Basic information

• Product Name: 3-Isoxazolecarboxamide, N,5-diphenyl-
• CAS NO: 101291-06-9
• Molecular Formula: C16H12N2O2
• Molecular Weight: 264.283
• Mol File: 101291-06-9.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 3-Isoxazolecarboxamide, N,5-diphenyl-(CAS DataBase Reference)
• NIST Chemistry Reference: 3-Isoxazolecarboxamide, N,5-diphenyl-(101291-06-9)
• EPA Substance Registry System: 3-Isoxazolecarboxamide, N,5-diphenyl-(101291-06-9)

Safety Data

• Hazardous Substances Data: 101291-06-9(Hazardous Substances Data)

Upstream product

• 3672-49-9 phenyl(5-phenyl-1,2-oxazol-3-yl)methanone 
• 412028-64-9 2-anilino-2-oxoethanehydroxymoyl chloride 
• 536-74-3 phenylacetylene 
• 51677-09-9 methyl 5-phenylisoxazole-3-carboxylate 
• 20577-73-5 methyl 4-phenyl-2,4-dioxobutanoate 
• 14441-90-8 5-phenyl-3-isoxazolecarboxylic acid 
• 62-53-3 aniline 
• 220898-58-8 N⁽¹⁾-phenyl-2-amino-2-hydroxyiminoacetamide 
• 107402-60-8 N-Phenyl-α-methoxycarbonyl-α-nitroacetamide 

Downstream Products

• 14441-90-8 5-phenyl-3-isoxazolecarboxylic acid 

Relevant articles and documents

Synthesis of novel 5-substituted isoxazole-3-carboxamide derivatives and cytotoxicity studies on lung cancer cell line

A series of novel 5-substituted isoxazole-3-carboxamide derivatives 6 have been prepared by coupling of 5-substituted isoxazole-3-carboxylic acids 3 with substituted-3-benzyloxyaniline 5 using DCC/HOBT as coupling agent. The products 6 have been evaluated for cytotoxicity on A549 lung cancer cell line and compounds 6a, 6b, 6e, 6j are found to show moderate proliferative activity and low cytotoxicity.

Synthesis of Isoxazoline-3-carboxanilides and Isoxazole-3-carboxanilides by Thermolysis of α-Methoxycarbonyl-α-nitroacetanilides in the Presence of Dipolarophiles

Isoxazoline-3-carboxanilides (5) and isoxazole-3-carboxanilides (6) were prepared in 20-63percent yields by thermolysis of α-methoxycarbonyl-α-nitroacetanilides (3) in the presence of dipolarophiles.