3672-49-9

Basic information

• Product Name: phenyl(5-phenyl-1,2-oxazol-3-yl)methanone
• CAS NO: 3672-49-9
• Molecular Formula: C₁₆H₁₁NO₂
• Molecular Weight: 249.264
• Mol File: 3672-49-9.mol
• Article Data: 31

Chemical Properties

• Boiling Point: 455.6°C at 760 mmHg
• Flash Point: 229.4°C
• Density: 1.193g/cm³
• Vapor Pressure: 1.73E-08mmHg at 25°C
• Refractive Index: 1.595
• CAS DataBase Reference: phenyl(5-phenyl-1,2-oxazol-3-yl)methanone(CAS DataBase Reference)
• NIST Chemistry Reference: phenyl(5-phenyl-1,2-oxazol-3-yl)methanone(3672-49-9)
• EPA Substance Registry System: phenyl(5-phenyl-1,2-oxazol-3-yl)methanone(3672-49-9)

Safety Data

• Hazardous Substances Data: 3672-49-9(Hazardous Substances Data)

Upstream product

• 4937-87-5 N-hydroxy-2-oxo-2-phenylethanimidoyl chloride 
• 536-74-3 phenylacetylene 
• 495-71-6 phenacylacetophenone 
• 7064-02-0 phenyl (5-phenyl-4,5-dihydroisoxazol-3-yl)methanone 
• 33193-65-6 2-methoxy-1,4-diphenyl-but-2-ene-1,4-dione 
• 1087-09-8 1,4-diphenyl-but-2-yne-1,4-dione 
• 20913-05-7 (Benzoylmethylene)triphenylphosphorane 
• 86340-05-8 3-benzoyl-5-phenylisoxazole oxime 
• 87613-29-4 (Z)-3-benzoyl-5-phenylisoxazole phenylhydrazone 
• 614-21-1 2-nitroacetophenone 
• 98304-59-7 (E)-1-(cis-2,3-diphenylaziridinyl)-1,2-dibenzoylethylene 
• 532-54-7 oxo-phenyl-acetaldehyde oxime 
• 7697-37-2 nitric acid 
• 32147-16-3 meso-2,3-dibromo-1,4-diphenyl-1,4-butanedione 

Downstream Products

• 101291-06-9 N⁽³⁾,5-diphenylizoxazole-3-carboxamide 
• 875249-33-5 [5-(4-nitro-phenyl)-isoxazol-3-yl]-phenyl ketone 
• 31970-74-8 phenyl(5-phenyloxazol-2-yl)methanone 
• 31879-47-7 2-benzoyl-3-oxo-3-phenylpropanenitrile 
• 15231-17-1 N-benzoylbenzoylacetamide 
• 119441-65-5 N-(4-Methoxy-phenyl)-N'-[1-phenyl-1-(5-phenyl-isoxazol-3-yl)-meth-(Z)-ylidene]-hydrazine 
• 119441-66-6 N-(4-Nitro-phenyl)-N'-[1-phenyl-1-(5-phenyl-isoxazol-3-yl)-meth-(Z)-ylidene]-hydrazine 
• 87613-32-9 1-methyl-2-phenyl-3-(2,5-diphenyl-1,2,3-triazol-4-yl)indole 
• 87613-31-8 N-Methyl-N-phenyl-N'-[1-phenyl-1-(5-phenyl-isoxazol-3-yl)-meth-(E)-ylidene]-hydrazine 
• 31879-39-7 2,4-diphenyl-5-phenacyl-1,2,3-triazole 
• 87613-29-4 (Z)-3-benzoyl-5-phenylisoxazole phenylhydrazone 
• 87613-30-7 (E)-3-benzoyl-5-phenylisoxazole phenylhydrazone 
• 86340-05-8 3-benzoyl-5-phenylisoxazole oxime 
• 844-69-9 1-phenyl-2-(4-phenyl-1,2,5-oxadiazol-3-yl)ethanone 

Relevant articles and documents

Tert-Butyl Nitrite-Mediated Domino Synthesis of Isoxazolines and Isoxazoles from Terminal Aryl Alkenes and Alkynes

A sequential construction of C-C, C-O, C = N, and C = O bonds from alkenes leading to the direct synthesis of isoxazolines in the presence of tert-butyl nitrite, quinoline, and the Sc(OTf)3 catalyst in DCE at 80 °C has been accomplished. An unprecedented three consecutive C-H functionalizations of two styrenes are involved in this isoxazoline synthesis. In this radical-mediated reaction, one-half of the aryl alkene is converted into an intermediate 2-nitroketone, which serves as a 1,3-dipolarophile and undergoes cycloaddition with the other half of the unreacted aromatic terminal alkene. The use of an alkyne in lieu of an alkene leads to the formation of isoxazole under identical reaction conditions.

1,2,5-Oxadiazole (Furazan) derivatives from benzoylnitromethane and dipolarophiles in the presence of DABCO: Structure and intermediates

Furazan (1,2,5-oxadiazole) derivatives are obtained along with isoxazolines from the reaction of benzoylnitromethane with dipolarophiles in the presence of DABCO. Furazans are shown to derive from the intermediate dibenzoylfuroxan (3,4-dibenzoyl-1,2,5-oxa

Synthesis of 3-Acyl-Isoxazoles via Radical 5-endo trig Cyclization of β,γ-Unsaturated Ketones with NaNO2

Here we report a facile cyclization reaction of β,γ-unsaturated ketones with NaNO2 under mild conditions to construct 3-acyl-isoxazoles. This transformation is realized via nitrosation of the activated methylene, radical 5-endo trig cyclization

A Facile Approach to the Synthesis of 3-Acylisoxazole Derivatives with Reusable Solid Acid Catalysts

Nitrile oxides were formed from nitro ketones using silica gel-supported sodium hydrogen sulfate (NaHSO4/SiO2) or Amberlyst 15 as solid acid catalyst, and then the corresponding 3-acylisoxaszoles were obtained by reacting with alkynes via the 1,3-dipolar [3+2] cycloaddition. These heterogeneous catalysts are easily separable from the reaction mixture and reused. This synthetic method provides a facile, efficient, and reusable production of 3-acylisoxazoles.

Iron Nitrate-Mediated Selective Synthesis of 3-Acyl-1,2,4-oxadiazoles from Alkynes and Nitriles: The Dual Roles of Iron Nitrate

A direct strategy for the selective synthesis of 3-acyl-1,2,4-oxadiazoles from alkynes and nitriles has been developed under iron(III) nitrate-mediated conditions. The mechanism includes three sequential procedures: Iron(III) nitrate-mediated nitration of