86340-05-8Relevant articles and documents
Pharmacochemistry of the furoxan ring: Recent developments
Calvino,Di Stilo,Fruttero,Gasco,Sorba,Gasco
, p. 321 - 334 (2007/10/02)
In the present work recent results obtained in the pharmacochemistry of the furoxan system are reported. In particular, after a brief description of the salient points of the furoxan chemistry, the synthesis and the properties of a series of Nifedipine and Prazosin analogues, containing this heterocyclic system, are described. Since we observed that a few furoxan derivatives are able to elicit both a dose-dependent rise in platelet cGMP levels and to promote a dose-dependent inhibition of AA-induced [Ca++] rise, and that many substituted furoxans show potent vasodilating and antiaggregatory activity, the possibility of using the furoxan system as a lead in the design of new vasodilators is also discussed.
Heterocyclic Rearrangements. Synthesis and Reactivity of Oximes of Some 3-Acylisoxazoles. A Reinvestigation
Vivona, Nicolo,Macaluso, Gabriella,Frenna, Vincenzo
, p. 483 - 486 (2007/10/02)
The oximation reaction of some 3-acylisoxazoles with hydroxylamine hydrochloride and the geometry of the product oximes were reinvestigated. 3-Benzoylisoxazoles gave mixtures of (E)- and (Z)-isomers, whereas 3-acetylisoxazoles gave (E)-isomers only.The base-induced rearrangement of 3-acylisoxazole oximes to 1,2,5-oxadiazoles (furazans) was reinvestigated and was shown to depend on the geometry of the oximes since, when treated with aqueous potassium hydroxide, only (Z)-oximes readily rearranged.On the basis of our findings, some discrepancies in the literature have been corrected.
