125520-55-0

Basic information

• Product Name: 1,2,5-Oxadiazole-3-carboxylic acid, 4-phenyl-, 2-oxide
• CAS NO: 125520-55-0
• Molecular Formula: C9H6N2O4
• Molecular Weight: 206.158
• Mol File: 125520-55-0.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 1,2,5-Oxadiazole-3-carboxylic acid, 4-phenyl-, 2-oxide(CAS DataBase Reference)
• NIST Chemistry Reference: 1,2,5-Oxadiazole-3-carboxylic acid, 4-phenyl-, 2-oxide(125520-55-0)
• EPA Substance Registry System: 1,2,5-Oxadiazole-3-carboxylic acid, 4-phenyl-, 2-oxide(125520-55-0)

Safety Data

• Hazardous Substances Data: 125520-55-0(Hazardous Substances Data)

Upstream product

• 104-54-1 3-Phenylpropenol 
• 135733-31-2 4-(hydroxymethyl)-3-phenylfuroxan 
• 135733-35-6 3-phenyl-4-furoxancarbaldehyde 
• 135733-30-1 3-(hydroxymethyl)-4-phenylfuroxan 
• 135733-34-5 4-phenylfuroxan-3-carboxaldehyde 

Downstream Products

• 1361949-88-3 C₁₇H₁₂N₄O₅ 
• 1361949-56-5 C₉H₈N₄O₃ 
• 125520-58-3 methyl 4-phenyl-3-furoxancarboxylate 
• 125520-64-1 methyl 3-phenyl-4-furoxancarboxylate 
• 125520-61-8 3-phenyl-4-furoxancarboxylic acid 
• 125520-60-7 3-phenyl-4-furoxancarboxamide 
• 125520-59-4 4-phenyl-3-furoxancarboxamide 
• 125520-63-0 3-phenyl-4-cyano-furoxan 
• 125520-62-9 4-phenyl-3-furoxancarbonitrile 
• 86340-05-8 3-benzoyl-5-phenylisoxazole oxime 
• 3672-49-9 phenyl(5-phenyl-1,2-oxazol-3-yl)methanone 
• 125520-57-2 N-Hydroxy-2-[(E)-hydroxyimino]-2,N'-diphenyl-acetamidine 
• 125520-56-1 N-Hydroxy-2-[(Z)-hydroxyimino]-2,N'-diphenyl-acetamidine 
• 1456-22-0 3-phenyl-4H-[1,2,4]oxadiazol-5-one 

Relevant articles and documents

Design, Synthesis, and in vitro Evaluation of P2X7 Antagonists

The P2X7 receptor is a promising target for the treatment of various diseases due to its significant role in inflammation and immune cell signaling. This work describes the design, synthesis, and in vitro evaluation of a series of novel derivatives bearing diverse scaffolds as potent P2X7 antagonists. Our approach was based on structural modifications of reported (adamantan-1-yl)methylbenzamides able to inhibit the receptor activation. The adamantane moieties and the amide bond were replaced, and the replacements were evaluated by a ligand-based pharmacophore model. The antagonistic potency of the synthesized analogues was assessed by two-electrode voltage clamp experiments, using Xenopus laevis oocytes that express the human P2X7 receptor. SAR studies suggested that the replacement of the adamantane ring by an aryl-cyclohexyl moiety afforded the most potent antagonists against the activation of the P2X7 cation channel, with analogue 2-chloro-N-[1-(3-(nitrooxymethyl)phenyl)cyclohexyl)methyl]benzamide (56) exhibiting the best potency with an IC50 value of 0.39 μΜ.

Unsymmetrically Substituted Furoxans, XIII. Phenylfuroxancarbaldehydes and Related Compounds

The synthesis and structure of two isomeric phenylfuroxancarbaldehydes 7a and 7b, of the phenylfurazancarbaldehyde 6 and of the corresponding alcohols 3a, 3b and 5 are reported.Thermal equilibration of the furoxan derivatives and their oxidation to the co