101441-97-8

Basic information

• Product Name: 2-mesityl-4H-benzo[d][1,3]oxazin-4-one
• Synonyms: 2-mesityl-4H-benzo[d][1,3]oxazin-4-one
• CAS NO: 101441-97-8
• Molecular Weight: 265.312
• Mol File: 101441-97-8.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 2-mesityl-4H-benzo[d][1,3]oxazin-4-one(CAS DataBase Reference)
• NIST Chemistry Reference: 2-mesityl-4H-benzo[d][1,3]oxazin-4-one(101441-97-8)
• EPA Substance Registry System: 2-mesityl-4H-benzo[d][1,3]oxazin-4-one(101441-97-8)

Safety Data

• Hazardous Substances Data: 101441-97-8(Hazardous Substances Data)

Upstream product

• 615-36-1 2-bromoaniline 
• 938-18-1 mesitylene-2-carboxylic acid chloride 
• 50-00-0 formaldehyd 
• 1016769-45-1 N-(2-bromophenyl)-2,4,6-trimethylbenzamide 
• 2346-67-0 2-(2,4,6-trimethylbenzoyl)-benzoic acid 

Relevant articles and documents

Palladium-catalyzed carbonylative synthesis of benzoxazinones from N -(o -bromoaryl)amides using paraformaldehyde as the carbonyl source

Carbonylation reactions have been widely used in organic synthesis. However, the manipulation of toxic and pressurized carbon monoxide limited their applications in organic laboratories. The search for alternative carbonyl sources as an important method for carbonylative organic synthesis is spreading. Herein, a series of substituted benzoxazinones were synthesized from N-(o-bromoaryl)amides by palladium-catalyzed carbonylation with paraformaldehyde as the carbonyl source, which is inexpensive, stable, and easy to use. Notably, this is the first example of using paraformaldehyde as the CO source in palladium-catalyzed carbonylative synthesis of heterocycles.