2346-67-0Relevant articles and documents
Palladium-catalyzed chemoselective decarboxylative ortho acylation of benzoic acids with α-oxocarboxylic acids
Miao, Jinmin,Ge, Haibo
supporting information, p. 2930 - 2933 (2013/07/26)
Palladium-catalyzed chemoselective decarboxylative cross coupling of benzoic acids with α-oxocarboxylic acids was realized via an arene sp 2 C-H functionalization process. This work represents the first example of transition-metal-catalyzed cro
Synthesis and antimicrobial ealuation of some annelated phthalazine deriaties and acyclo C-nucleosides from 1-chloro-4-(2,4,6-trimethylphenyl) phthalazine precursor
El-Hashash, Maher Abdel Aziz,Soliman, Ahmed Youssef,El-Shamy, Ibrahim Essam
scheme or table, p. 347 - 366 (2012/06/30)
A highly efficient and ersatile synthetic approach to the synthesis of annelated phthalazine deriaties iz. 1,2,4-triazolo[3,4-a]phthalazine 11a,b, 14, 18, 19a,b, 29-31, 33, 1,2,4-triazino[3,4-a]phthalazine 25a,b-28, 1,3,5-triazino[4,3-a]phthalazine 22, tetrazolo[5,1-a] phthalazine 23, imidazophthalazine 9a,b,15, and pyrimidinophthlazine 6, 10, 16, 17, 20 is presented. Moreoer, acyclo C -nucleoside and double headed acyclo C-nucleoside of 1,2,4-triazolo[3,4-a]phthalazine 12, 13 were obtained ia heterocyclization reaction of 1-chloro-4-(2,4,6-trimethylphenyl)phthalazine (4) with gluconic acid hydrazide and galactaric acid bis hydrazide, respectiely. The new compounds were synthesized with the objectie of studying their antimicrobial actiity. TUeBITAK.
Isoquinolinamine and phthalazinamine derivatives: corticotropin-releasing factor receptor CRF1 specific ligands
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Page column 14-15, (2010/01/30)
Disclosed are compounds that are highly selective partial agonists or antagonists at human CRF1receptors that are useful in the diagnosis and treatment of treating stress related disorders such as post traumatic stress disorder (PTSD) as well as depression, headache and anxiety. The compounds have the formula or the pharmaceutically acceptable salts thereof wherein Ar, R1, R2, R3, R4and W are various organic and inorganic substituents.