10147-68-9

Basic information

• Product Name: 2-HYDROXY CHLOROACETOANILIDE
• Synonyms: 2-HYDROXY CHLOROACETOANILIDE;2-chloro-N-(2-hydroxyphenyl)acetaMide;2-CHLORO-2'-HYDROXYACETANILIDE
• CAS NO: 10147-68-9
• Molecular Formula: C₈H₈ClNO₂
• Molecular Weight: 185.61
• Mol File: 10147-68-9.mol
• Article Data: 16

Chemical Properties

• Boiling Point: 376.7°C at 760 mmHg
• Flash Point: 181.6°C
• Appearance: /
• Density: 1.402g/cm³
• Vapor Pressure: 3.28E-06mmHg at 25°C
• Refractive Index: 1.632
• CAS DataBase Reference: 2-HYDROXY CHLOROACETOANILIDE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-HYDROXY CHLOROACETOANILIDE(10147-68-9)
• EPA Substance Registry System: 2-HYDROXY CHLOROACETOANILIDE(10147-68-9)

Safety Data

• Hazardous Substances Data: 10147-68-9(Hazardous Substances Data)

Usage

General Description

2-HYDROXY CHLOROACETOANILIDE, also known as chloroacetanilide, is a chemical compound with the molecular formula C8H8ClNO2. It is a white crystalline solid that is commonly used as an intermediate in the synthesis of pharmaceuticals, pesticides, and dyes. It is a derivative of acetanilide, with a chloro and hydroxyl group attached to the phenyl ring. It has both analgesic and antipyretic properties, and has been used in the development of various pain relief medications. However, it is also known to have potential toxic effects and therefore should be handled and used with caution.

InChI:InChI=1/C8H8ClNO2/c9-5-8(12)10-6-3-1-2-4-7(6)11/h1-4,11H,5H2,(H,10,12)

Upstream product

• 79-04-9 chloroacetyl chloride 
• 95-55-6 2-amino-phenol 
• 24265-34-7 2-nitrophenyl 2-chloroacetate 

Downstream Products

• 5428-96-6 carbamoylsulfanyl-acetic acid-(2-hydroxy-anilide) 
• 5466-88-6 3,4-dihydro-3-oxo-2H-1,4-benzoxazine 
• 73037-92-0 1-acetoxy-2-(2-chloro-acetylamino)-benzene 
• 106477-59-2 phenylsulfanyl-acetic acid-(2-hydroxy-anilide) 
• 102880-97-7 2-[(4-chloro-phenylsulfanyl)-methyl]-benzoxazole 
• 37161-45-8 1-chloroacetoxy-2-(2-chloro-acetylamino)-benzene 
• 41014-43-1 2-(chloromethyl)benzoxazole 
• 100725-46-0 2-(phenylsulfanylmethyl)benzoxazole 
• 916337-57-0 C₁₀H₁₂ClNO₃ 
• 1393643-64-5 C₂₂H₂₃N₅O₂S 
• 1393644-05-7 C₁₁H₁₂ClNO₃ 
• 1577212-61-3 N-(2-hydroxyphenyl)-2-((1-mesityl-1H-imidazo[4,5-c]pyridin-2-yl)thio)acetamide 
• 1577212-62-4 N-(2-hydroxyphenyl)-2-((3-mesityl-3H-imidazo[4,5-b]pyridine-2-yl)thio)acetamide 
• 5735-53-5 1,4-benzoxazine 

Relevant articles and documents

The syntheses of nonnucleoside, HIV-1 reverse transcriptase inhibitors containing a CF2 group: The SRN1 reactions of 2-(bromodifluoromethyl)benzoxazole with the anions derived from heterocyclic thiols and phenolic compounds

In an effort to prepare new fluorine-containing compounds which are active against HIV, the SRN1 reactions of 2-(bromodifluoromethyl)benzoxazole (5) with the anions of heterocyclic thiols and phenolic compounds were carried out. The products (6

SYNTHESIS OF 2-(4-ARYL-1E,3E-BUTADIENYL)BENZOXAZOLES BY THE HORNER-WADSWORTH-EMMONS REACTION

2-(4-Aryl-1E,3E-butadienyl)benzoxazole derivatives were synthesized by the Horner-Wadsworth-Emmons reaction of 2-phosphorylmethylbenzoxazoles with cinnamaldehydes in fair to good yield.

Synthesis, Molecular Docking and Biological Evaluation of 2-Aryloxy-N-Phenylacetamide and N′-(2-Aryloxyoxyacetyl) Benzohydrazide Derivatives as Potential Antibacterial Agents

A new class of 2-aryloxy-N-phenylacetamide and N′-(2-aryloxyoxyacetyl) benzohydrazide derivatives with different active moieties were synthesized and screened for their antibacterial activity. Structural characterization of synthesized compounds was perfo

Synthesis, antimicrobial, antioxidant and docking study of novel 2H-1,4-Benzoxazin-3(4H)-One derivatives

A NOVEL series of 1,4-benzoxazinone derivatives were synthesized and characterized using FT-IR , 1H-NMR, 13C-NMR and Mass spectroscopy. These compounds were in vitro screened against several bacterial species gram positive and gram negative as well as Candida albicans and found exhibiting moderate to potent activity. The antioxidant study was confirmed for the synthesized derivatives against 1,1-diphenyl-2-picryl hydrazyl (DPPH) radical. Docking study for the potent compound 8 against glucosamine-6-phosphate synthase , the target enzyme for the antimicrobial agents was explored to explain the interactions of the discovered hits with in the amino acid residues of the enzyme active side. The docking parameters enhanced the activity of new compound as promising antimicrobial agents.