5735-53-5Relevant articles and documents
Lithiation of N-protected-dihydro-1,4-benzoxazines
Lu, Yansong J.,Hu, Bin,Prashad, Mahavir,Kabadi, Shaum,Repic, Oljan,Blacklock, Thomas J.
, p. 1125 - 1127 (2006)
Lithiation of N-protected-2,3-dihydro-1,4-benzoxazines is described. Lithiation of N-(tert-butoxycarbonyl)-2,3-dihydro-1,4-benzoxazine (1) with BuLi/TMEDA occurred in the α-position to nitrogen on the heterocyclic ring, leading to the unexpected ring-opened product 3. On the other hand, lithiation of N-methyl-2,3-dihydro-1,4-benzoxazine (4) took place at the oxygen-adjacent orito-position of the aromatic ring.
Silicon hydrogenation reaction method of organic boron and inorganic alkali catalysis amide (by machine translation)
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Paragraph 0107-0113; 0130-0133, (2020/08/18)
The method is characterized in that organic boron and inorganic bases are used as catalysts, silane is used as a reducing agent, primary amide is reduced to primary amine or dehydration dinitrile, the secondary amide is reduced to a secondary amine or aldimine, and the tertiary amide is reduced to tertiary amine. The method has the advantages of simple operation, mild reaction conditions, wide substrate universality, good functional group compatibility and the like, and has the characteristics of good stability, cheap and accessible catalyst, simple and convenient operation, high practicality and the like. (by machine translation)
Design, synthesis, and bioevaluation of substituted phenyl isoxazole analogues as herbicide safeners
Fu, Ying,Gao, Shuang,Gao, Ying-Chao,Guo, Ke-Liang,Li, Juan-Juan,Wang, Zi-Wei,Ye, Fei,Zhao, Li-Xia
, p. 10550 - 10559 (2020/11/05)
Herbicide safeners enhance herbicide detoxification in crops without affecting target weed sensitivity. To enhance crop tolerance to the toxicity-related stress caused by the herbicide acetochlor (ACT), a new class of substituted phenyl isoxazole derivatives was designed by an intermediate derivatization method as herbicide safeners. Microwave-assisted synthesis was used to prepare the phenyl isoxazole analogues, and all of the structures were confirmed via IR, 1H NMR, 13C NMR, and HRMS. Compound I-1 was further characterized by X-ray diffraction analysis. Bioassay results showed that most of the obtained compounds provided varying degrees of safening against ACT-induced injury by increasing the corn growth recovery, glutathione content, and glutathione S-transferase activity. In particular, compound I-20 showed excellent safener activity against ACT toxicity, comparable to that of the commercial safener benoxacor. Gaussian calculations have been performed and the results indicated that the nucleophilic ability of compound I-20 is higher than that of benoxacor, thus the activity is higher than that of benoxacor. These findings demonstrate that phenyl isoxazole derivatives possess great potential for protective management in cornfields.