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Dayang Chem (Hangzhou) Co.,Ltd.

Dayangchem's R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. DayangChem can provide different quantities

Benzomorpholine

Cas:5735-53-5

Min.Order:1 Kilogram

FOB Price: $3.0

Type:Lab/Research institutions

inquiry

Zhuozhou Wenxi import and Export Co., Ltd

WITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et

Pharmaceutical Grade CAS 5735-53-5 with competitive price

Cas:5735-53-5

Min.Order:1 Kilogram

FOB Price: $139.0 / 210.0

Type:Trading Company

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Shanghai Upbio Tech Co.,Ltd

1.In No Less 10 years exporting experience. you can 100% received goods 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Upbio is Specializ

2H-1,4-Benzoxazine,3,4-dihydro-

Cas:5735-53-5

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Shandong Hanjiang Chemical Co., Ltd.

Hello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by emai

2H-1,4-Benzoxazine,3,4-dihydro-

Cas:5735-53-5

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Triumph International Development Limilted

Lorcaserin(856681-05-5)is an orally administered agent and a selective 5-HT2C receptor agonist for the treatment of obesity. It had been approved for marketing in US by FDA on 27 June in 2012. In clinical studies, lorcaserin h

Benzomorpholine

Cas:5735-53-5

Min.Order:100 Metric Ton

Negotiable

Type:Lab/Research institutions

inquiry

Taizhou Crene Biotechnology co.ltd

Our company provides one-stop services of research - development - production for a variety of special prouducts. Not only do we make effective use of our strong technological strength, but also establish of cooperative relations with several well-

Benzomorpholine 5735-53-5

Cas:5735-53-5

Min.Order:100 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Hangzhou J&H Chemical Co., Ltd.

J&H CHEM R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. J&H CHEM has some Manufacturing base in Jia

2H-1,4-Benzoxazine,3,4-dihydro-

Cas:5735-53-5

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Shanghai Massive Chemical Technology Co., Ltd.

Massive Chemical is certified with ISO9001 and ISO14001 manufacturer for this product. We will offer all documents as requirement for the materials which includes, Certificate of Analysis, Material Safety Data Sheet, and Method of Analysis and

Benzomorpholine

Cas:5735-53-5

Min.Order:1 Gram

FOB Price: $1.0

Type:Lab/Research institutions

inquiry

Henan Wentao Chemical Product Co., Ltd.

1)quick response within 12 hours; 2)quality guarantee: all products are strictly tested by our qc, confirmed by qa and approved by third party lab in china, usa, canada, germany, uk, italy, france etc. 3) oem/odm available; 4) rea

BenzomorpholineCAS NO.:5735-53-5

Cas:5735-53-5

Min.Order:1 Gram

FOB Price: $2.0

Type:Lab/Research institutions

inquiry

HANGZHOU TIANYE CHEMICALS CO., LTD.

We product this chemical more than 10 years . We are very experience to export it to many countries, Our superior & stable quality , competitive price gain warm reception from our customers. Product Name:Benzomorpholine CAS No:5735-53-5 Synon

Benzomorpholine

Cas:5735-53-5

Min.Order:1 Gram

Negotiable

Type:Trading Company

inquiry

Shanghai Minstar Chemical Co., Ltd

Benzomorpholine Chemical Properties Boiling point 85°C/0.75mm density 1.095±0.06 g/cm3(Predicted) refractive index 1.60 pka 4.37±0.20(Predicted) Water Solubility Sparingly soluble in water.(0.26 g/L) (25°C),

3,4-Dihydro-2H-1,4-benzoxazine

Cas:5735-53-5

Min.Order:1 Gram

FOB Price: $66.0

Type:Lab/Research institutions

inquiry

EAST CHEMSOURCES LIMITED

factory?direct?saleAppearance:White Powder Storage:Store In Dry, Cool And Ventilated Place Package:25kg/drum, also according to the clients requirement Application:It is widely used as a thickener, emulsifier and stabilizer Transportation:By Sea Or B

Benzomorpholine

Cas:5735-53-5

Min.Order:1 Kilogram

FOB Price: $18.0 / 20.0

Type:Trading Company

inquiry

Hangzhou Huarong Pharm Co., Ltd.

We Huarong Pharm can provide Customized Synthesis & Process R&D & APIs and intermediates Production & Quality Research & Registration Application, especially our GMP validation service which complies with SFDA, FDA, WHO and EU EMPA. O

Benzomorpholine

Cas:5735-53-5

Min.Order:0

Negotiable

Type:Trading Company

inquiry

Shandong Mopai Biotechnology Co., LTD

Shandong Mopai Biotechnology Co., LTD is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemicals. W

Benzomorpholine

Cas:5735-53-5

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

KAISA GROUP INC

1.Applied in food field.it can improve the immune system and prolong life. 2.Appliedin cosmetic field.it can improve the skin care. 3.Applied in pharmaceutical field.it can treat various dieases. 4.Our product quality assurance will make our customer

Benzomorpholine

Cas:5735-53-5

Min.Order:1 Metric Ton

FOB Price: $1.5

Type:Trading Company

inquiry

Bluecrystal chem-union

We are a Union of chemistry in China, consists of chemists,engineers, laboratories,factories in China. We organize surplus capacity of R&D and production as well as custom synthesis for chemical products and chemical business project. We are supp

Benzomorpholine

Cas:5735-53-5

Min.Order:1 Metric Ton

FOB Price: $1.0

Type:Trading Company

inquiry

Win-Win chemical Co.Ltd

Stock products, own laboratory Package:Grams, Kilograms Application:For R&D Transportation:According to customer request Port:Shanghai

Benzomorpholine cas no. 5735-53-5 98%

Cas:5735-53-5

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

GIHI CHEMICALS CO.,LIMITED

Lower price, sample is available,SDS test documents are available,large stock in warehouseAppearance:White powder Storage:Sealed and preserved Package:200/Kilograms Application:Fine chemical intermediates, used as the main raw material for the synthe

Benzomorpholine

Cas:5735-53-5

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Kono Chem Co.,Ltd

high purity lowest priceAppearance:solid or liquid Storage:in sealed air resistant place Package:drum and bag Application:for pharma use Transportation:by sea or air Port:Beijing or Guangzhou

Benzomorpholine

Cas:5735-53-5

Min.Order:0

Negotiable

Type:Other

inquiry

Hangzhou Dingyan Chem Co., Ltd

R & D enterprises have their own stock in stockAppearance:To be subject to the object Package:Customized Application:pharmaceutical intermediates Transportation:Air Port:Shanghai;Guangzhou

3,4-dihydro-2H-benzo[b][1,4]oxazine

Cas:5735-53-5

Min.Order:0

Negotiable

Type:Manufacturers

inquiry

Shanghai Acmec Biochemical Technology Co., Ltd.

Acmec is a leading manufacturer and supplier of biochemical reagents and life science products. We have over 40,000 items in stock (real-time inventory) and offer discounted prices to registered members of the online store ( www.acmec.com.cn ) Appea

Acmec Benzomorpholine 25g

Cas:5735-53-5

Min.Order:1 bottle

Negotiable

Type:Lab/Research institutions

inquiry

Henan Allgreen Chemical Co.,Ltd

high quality Storage:Sealed, dry, microtherm , avoid light and smell. Package:According to the demand of customer Application:Organic synthesis Transportation:by air or by sea

Benzomorpholine

Cas:5735-53-5

Min.Order:0

Negotiable

Type:Manufacturers

inquiry

Henan Tianfu Chemical Co., Ltd.

1.Our services:A.Supply sampleB.The packing also can be according the customers` requirmentC.Any inquiries will be replied within 24 hoursD.we provide Commerical Invoice, Packing List, Bill of loading, COA , Health certificate and Origin certificate.

2H-1,4-Benzoxazine,3,4-dihydro-

Cas:5735-53-5

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Nanjing Fred Technology Co.,Ltd.

Fredchem focus on CRO/CMO business and its own R&D of API/Intermediates Package:Kilograms/MT Application:Pharmaceutical field Transportation:According to customer request Port:Shanghai

Benzomorpholine

Cas:5735-53-5

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Hebei Sankai Chemical Technology Co., Ltd

1. Product advantages? High purity, all above 98.5%, no impurities after dissolution? We will test each batch to ensure quality? OEM and private brand services designed for free? Various cap colors available? We can also provide MT1 peptide powder2.

Benzomorpholine

Cas:5735-53-5

Min.Order:0

Negotiable

Type:Trading Company

inquiry

Antimex Chemical Limied

Ansciep Chemical is a professional enterprise manufacturing and distributing fine chemicals and speciality chemicals. We have been dedicated to heterocycle compounds and phenyl rings for tens of years. This is our mature product for export. Our quali

3,4-Dihydro-2H-1,4-benzoxazine

Cas:5735-53-5

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Hubei Langyou International Trading Co., Ltd

Benzomorpholine Application:Benzomorpholine

Benzomorpholine

Cas:5735-53-5

Min.Order:0

Negotiable

Type:Other

inquiry

Guangdong Juda Chemical Industrial Co.,Limited

Appearance:solid or liquid Storage:sealed in cool and dry place Package:As customer's requested Application:Pharma Intermediate Transportation:by courier/air/sea Port:Any port in China

Benzomorpholine CAS No.5735-53-5

Cas:5735-53-5

Min.Order:0

Negotiable

Type:Trading Company

inquiry

BOC Sciences

We are committed to providing our customers with the best products and services at the most competitive prices.Appearance:white powder Storage:Room temperature with sealed well Package:according to the clients requirement Application:Use as primary a

Benzomorpholine

Cas:5735-53-5

Min.Order:0

Negotiable

Type:Trading Company

inquiry

Changchun Artel lmport and Export trade company

Supply top quality products with a reasonable price Application:api

5735-53-5

Cas:5735-53-5

Min.Order:0

Negotiable

Type:Trading Company

inquiry

Synthetic route

1-(2H-benzo[b][1,4]oxazin-4(3H)-yl)ethanone
70801-52-4

1-(2H-benzo[b][1,4]oxazin-4(3H)-yl)ethanone

1,4-benzoxazine
5735-53-5

1,4-benzoxazine

Conditions
ConditionsYield
With sodium bis(2-methoxyethoxy)aluminium dihydride In toluene at -40℃; for 1.16667h;100%
With sodium triethylborohydride In tetrahydrofuran at 80℃; for 12h; Inert atmosphere; Schlenk technique; Glovebox; Sealed tube;81%
With sodium triethylborohydride In tetrahydrofuran at 80℃; for 6h; Inert atmosphere; Schlenk technique; High pressure; Sealed tube;81%
(2,3-dihydro-4H-benzo[b][1,4]oxazin-4-yl)(phenyl)methanone
19202-00-7

(2,3-dihydro-4H-benzo[b][1,4]oxazin-4-yl)(phenyl)methanone

A

1,4-benzoxazine
5735-53-5

1,4-benzoxazine

B

benzaldehyde
100-52-7

benzaldehyde

Conditions
ConditionsYield
With sodium bis(2-methoxyethoxy)aluminium dihydride In ethyl acetate; benzene at -40℃;A 100%
B 100%
2-(2-aminophenoxy)ethan-1-ol
42876-07-3

2-(2-aminophenoxy)ethan-1-ol

1,4-benzoxazine
5735-53-5

1,4-benzoxazine

Conditions
ConditionsYield
With [RuCl2(N-heterocyclic carbene)(bis[2-(diphenylphosphino)ethyl]amine)]; hydrogen; caesium carbonate In toluene; butan-1-ol at 120℃; under 22502.3 Torr; for 6h; Schlenk technique; Autoclave;100%
3,4-dihydro-3-oxo-2H-1,4-benzoxazine
5466-88-6

3,4-dihydro-3-oxo-2H-1,4-benzoxazine

1,4-benzoxazine
5735-53-5

1,4-benzoxazine

Conditions
ConditionsYield
With [RuCl2(N-heterocyclic carbene)(bis[2-(diphenylphosphino)ethyl]amine)]; hydrogen; caesium carbonate In toluene; butan-1-ol at 120℃; under 22502.3 Torr; for 6h; Schlenk technique; Autoclave;98%
With lithium aluminium tetrahydride In tetrahydrofuran at 0 - 20℃; for 2h; Inert atmosphere;92%
Stage #1: 3,4-dihydro-3-oxo-2H-1,4-benzoxazine With lithium aluminium tetrahydride In tetrahydrofuran Heating / reflux;
Stage #2: With sodium hydroxide; water In tetrahydrofuran
79%
1-(2H-benzo[b][1,4]oxazin-4(3H)-yl)ethanone
70801-52-4

1-(2H-benzo[b][1,4]oxazin-4(3H)-yl)ethanone

A

4-ethyl-3,4-dihydro-2H-benzo[b][1,4]oxazine
82756-78-3

4-ethyl-3,4-dihydro-2H-benzo[b][1,4]oxazine

B

1,4-benzoxazine
5735-53-5

1,4-benzoxazine

Conditions
ConditionsYield
With triethyl borane; Triethoxysilane; sodium hydroxide In hexane at 80℃; for 6h; Reagent/catalyst; Solvent; Inert atmosphere; Sealed tube;A 7%
B 90%
With Triethoxysilane; sodium triethylborohydride In hexane at 80℃; for 6h; Schlenk technique; Glovebox; Sealed tube; Inert atmosphere;A 90%
B n/a
With Triethoxysilane; sodium triethylborohydride In hexane at 80℃; for 6h; Inert atmosphere; Schlenk technique; High pressure; Sealed tube;A 90%
B n/a
2-(2-nitrophenoxy)acetonitrile
31507-30-9

2-(2-nitrophenoxy)acetonitrile

1,4-benzoxazine
5735-53-5

1,4-benzoxazine

Conditions
ConditionsYield
With palladium 10% on activated carbon; hydrogen; toluene-4-sulfonic acid In ethanol at 50℃; under 37503.8 Torr; for 2h;88%
With polymethylhydrosiloxane; palladium dihydroxide In ethanol at 20℃; for 0.5h;73%
2-<(2-bromophenyl)amino>ethanol
87762-20-7

2-<(2-bromophenyl)amino>ethanol

1,4-benzoxazine
5735-53-5

1,4-benzoxazine

Conditions
ConditionsYield
With racemic-2-(di-tert-butylphosphino)-1,1′-binaphthyl; palladium diacetate; caesium carbonate In toluene at 50℃; for 24h;87%
With racemic-2-(di-tert-butylphosphino)-1,1′-binaphthyl; palladium diacetate; caesium carbonate In toluene at 50℃; for 24h;87%
4-(p-toluenesulfonyl)-3,4-dihydro-2H-benzoxazine
438013-84-4

4-(p-toluenesulfonyl)-3,4-dihydro-2H-benzoxazine

1,4-benzoxazine
5735-53-5

1,4-benzoxazine

Conditions
ConditionsYield
With naphthalene; tetraethylammonium bromide In N,N-dimethyl-formamide at 0℃; Inert atmosphere; Electrolysis;87%
tert-butyl (2-phenoxyethyl)(tosyloxy)carbamate

tert-butyl (2-phenoxyethyl)(tosyloxy)carbamate

1,4-benzoxazine
5735-53-5

1,4-benzoxazine

Conditions
ConditionsYield
With bis{rhodium[3,3'-(1,3-phenylene)bis(2,2-dimethylpropanoic acid)]}; trifluoroacetic acid In 2,2,2-trifluoroethanol at 0 - 20℃; for 17h; regioselective reaction;82%
With Rh2(esp)2; trifluoroacetic acid In 2,2,2-trifluoroethanol at 20℃; for 17h; Inert atmosphere;82%
benzofuran-3(2H)-one oxime
82415-84-7

benzofuran-3(2H)-one oxime

1,4-benzoxazine
5735-53-5

1,4-benzoxazine

Conditions
ConditionsYield
Stage #1: benzofuran-3(2H)-one oxime With diisobutylaluminium hydride In hexane; dichloromethane at 0 - 20℃; Inert atmosphere;
Stage #2: With sodium fluoride In hexane; dichloromethane; water at 0℃; for 0.5h;
80%
Stage #1: benzofuran-3(2H)-one oxime With diisobutylaluminium hydride In hexane; dichloromethane at 0 - 20℃; Inert atmosphere;
Stage #2: With water; sodium fluoride In hexane; dichloromethane at 0℃; for 0.5h; Inert atmosphere; regioselective reaction;
80%
With diisobutylaluminium hydride In dichloromethane at 0 - 20℃;80%
ethylene dibromide
106-93-4

ethylene dibromide

2-amino-phenol
95-55-6

2-amino-phenol

1,4-benzoxazine
5735-53-5

1,4-benzoxazine

Conditions
ConditionsYield
With potassium carbonate In N,N-dimethyl-formamide at 125℃; for 15h;73%
With potassium carbonate In N,N-dimethyl-formamide at 125℃; for 15h;65%
With potassium carbonate In dimethyl sulfoxide at 80℃;62%
2-amino-phenol
95-55-6

2-amino-phenol

(2-bromoethyl)(diphenyl)sulfonium trifluoromethanesulfonate

(2-bromoethyl)(diphenyl)sulfonium trifluoromethanesulfonate

1,4-benzoxazine
5735-53-5

1,4-benzoxazine

Conditions
ConditionsYield
Stage #1: 2-amino-phenol With sodium hydride In dichloromethane at 0℃; for 0.0833333h; Inert atmosphere;
Stage #2: (2-bromoethyl)(diphenyl)sulfonium trifluoromethanesulfonate In dichloromethane at 25 - 30℃; for 15h; Inert atmosphere;
68%
2-allyloxy-1-nitrobenzene
55339-51-0

2-allyloxy-1-nitrobenzene

A

1,4-benzoxazine
5735-53-5

1,4-benzoxazine

B

4-methyl-3,4-dihydro-2H-benzo[b][1,4]oxazine
77901-22-5

4-methyl-3,4-dihydro-2H-benzo[b][1,4]oxazine

Conditions
ConditionsYield
Stage #1: 2-allyloxy-1-nitrobenzene With ozone In methanol at -78℃;
Stage #2: With hydrogen; nitrobenzene; palladium on activated charcoal In methanol at 25℃; under 3040 Torr; for 6h;
A 66%
B n/a
1-(2-chloroethoxy)-2-nitrobenzene
102236-25-9

1-(2-chloroethoxy)-2-nitrobenzene

1,4-benzoxazine
5735-53-5

1,4-benzoxazine

Conditions
ConditionsYield
Stage #1: 1-(2-chloroethoxy)-2-nitrobenzene With platinum(IV) oxide; hydrogen; sodium acetate In ethyl acetate at 25℃; under 7500.75 Torr; for 2h;
Stage #2: With triethylamine; sodium iodide In ethyl acetate for 16h; Reflux;
37%
4-acetyl-4H-1,4-benzoxazine
70801-51-3

4-acetyl-4H-1,4-benzoxazine

A

4-ethyl-3,4-dihydro-2H-benzo[b][1,4]oxazine
82756-78-3

4-ethyl-3,4-dihydro-2H-benzo[b][1,4]oxazine

B

1,4-benzoxazine
5735-53-5

1,4-benzoxazine

Conditions
ConditionsYield
With lithium aluminium tetrahydride; hydrogen; palladium on activated charcoal 1.) Et2O, 20 deg C, 30 min, 2.) ethanol; Yield given. Multistep reaction. Yields of byproduct given;
2-<β-chloro-ethylamino>-phenol

2-<β-chloro-ethylamino>-phenol

1,4-benzoxazine
5735-53-5

1,4-benzoxazine

Conditions
ConditionsYield
With sodium hydroxide
ethylene dibromide
106-93-4

ethylene dibromide

2-amino-phenol
95-55-6

2-amino-phenol

A

1,4-benzoxazine
5735-53-5

1,4-benzoxazine

B

2-aziridin-1-yl-phenol

2-aziridin-1-yl-phenol

Conditions
ConditionsYield
With potassium carbonate In dimethyl sulfoxide at 80℃; for 8h; Title compound not separated from byproducts;
2-(2-chlorophenoxy)ethylamine
26378-53-0

2-(2-chlorophenoxy)ethylamine

1,4-benzoxazine
5735-53-5

1,4-benzoxazine

Conditions
ConditionsYield
With sodium hydride; tert-butyl alcohol; 1,3-bis[2,6-bis(1-methylethyl)phenyl]-1,3-dihydro-2H-imidazol-2-ylidene monohydrochloride; palladium diacetate In 1,4-dioxane for 4h;
4-(tert-butoxycarbonyl)-3,4-dihydro-2H-1,4-benzoxazine
212180-23-9

4-(tert-butoxycarbonyl)-3,4-dihydro-2H-1,4-benzoxazine

1,4-benzoxazine
5735-53-5

1,4-benzoxazine

Conditions
ConditionsYield
With hydrogenchloride In acetonitrile
Stage #1: 4-(tert-butoxycarbonyl)-3,4-dihydro-2H-1,4-benzoxazine With trifluoroacetic acid In dichloromethane at 20℃;
Stage #2: With sodium hydrogencarbonate In dichloromethane; water
1-(2-bromoethoxy)-2-chlorobenzene
18800-26-5

1-(2-bromoethoxy)-2-chlorobenzene

1,4-benzoxazine
5735-53-5

1,4-benzoxazine

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1.1: NaN3 / dimethylformamide / 2.5 h / 110 °C
2.1: PPh3 / tetrahydrofuran / 15 h / 20 °C
2.2: 63 percent / H2O / tetrahydrofuran / 3 h / 20 °C
3.1: N,N'-bis(2,6-diisopropylphenyl)dihydroimidazol-2-ylidene*HCl; NaH; t-BuOH / Pd(OAc)2 / dioxane / 4 h
View Scheme
2-monochlorophenol
95-57-8

2-monochlorophenol

(+-)-ethylphosphonic acid ethyl ester chloride

(+-)-ethylphosphonic acid ethyl ester chloride

1,4-benzoxazine
5735-53-5

1,4-benzoxazine

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1.1: aq. NaOH / 6 h / 100 °C
2.1: NaN3 / dimethylformamide / 2.5 h / 110 °C
3.1: PPh3 / tetrahydrofuran / 15 h / 20 °C
3.2: 63 percent / H2O / tetrahydrofuran / 3 h / 20 °C
4.1: N,N'-bis(2,6-diisopropylphenyl)dihydroimidazol-2-ylidene*HCl; NaH; t-BuOH / Pd(OAc)2 / dioxane / 4 h
View Scheme
1-(2-azidoethoxy)-2-chlorobenzene
66443-61-6

1-(2-azidoethoxy)-2-chlorobenzene

1,4-benzoxazine
5735-53-5

1,4-benzoxazine

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1.1: PPh3 / tetrahydrofuran / 15 h / 20 °C
1.2: 63 percent / H2O / tetrahydrofuran / 3 h / 20 °C
2.1: N,N'-bis(2,6-diisopropylphenyl)dihydroimidazol-2-ylidene*HCl; NaH; t-BuOH / Pd(OAc)2 / dioxane / 4 h
View Scheme
N-(2-(tert-butyldimethylsiloxy)-ethyl)-2-bromoaniline
325147-53-3

N-(2-(tert-butyldimethylsiloxy)-ethyl)-2-bromoaniline

1,4-benzoxazine
5735-53-5

1,4-benzoxazine

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 96 percent / TBAF / tetrahydrofuran / 1 h
2: 87 percent / Pd(OAc)2; Cs2CO3; 2-(di-tert-butylphosphanyl)-1,1'-binaphthyl / toluene / 24 h / 50 °C
View Scheme
Multi-step reaction with 2 steps
1: 96 percent / TBAF / tetrahydrofuran / 1 h
2: 87 percent / Pd(OAc)2; di-tert-butyl-[2-(1,1'-binnaphthyl)]phosphine; Cs2CO3 / toluene / 24 h / 50 °C
View Scheme
2-amino-phenol
95-55-6

2-amino-phenol

1,4-benzoxazine
5735-53-5

1,4-benzoxazine

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1.1: sodium hydrogencarbonate; N-benzyl-N,N,N-triethylammonium chloride / chloroform / 11 h / 0 - 55 °C
2.1: lithium aluminium tetrahydride / tetrahydrofuran / 20 °C / Reflux
2.2: 0 °C
View Scheme
Multi-step reaction with 3 steps
1: potassium carbonate / water; tetrahydrofuran / 1 h / -10 °C
2: potassium tert-butylate / dichloromethane; isopropyl alcohol / 1 h / 0 - 20 °C
3: lithium aluminium tetrahydride / tetrahydrofuran / 16 h / 0 - 20 °C
View Scheme
Multi-step reaction with 2 steps
1: potassium carbonate / acetonitrile / 20 h / Reflux
2: lithium aluminium tetrahydride / tetrahydrofuran / 2 h / 0 - 20 °C / Inert atmosphere
View Scheme
Multi-step reaction with 2 steps
1: potassium carbonate / acetonitrile / 80 °C
2: lithium aluminium tetrahydride / tetrahydrofuran / 0 °C / Inert atmosphere
View Scheme
3-oxo-2,3-dihydrobenzo[b]furan
7169-34-8

3-oxo-2,3-dihydrobenzo[b]furan

1,4-benzoxazine
5735-53-5

1,4-benzoxazine

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: methanesulfonic acid; sodium azide / 1.25 h / 0 - 20 °C
2: lithium aluminium tetrahydride / diethyl ether; tetrahydrofuran / 16 h / Reflux
View Scheme
N-(2-hydroxyphenyl)-2-chloroacetamide
10147-68-9

N-(2-hydroxyphenyl)-2-chloroacetamide

1,4-benzoxazine
5735-53-5

1,4-benzoxazine

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: potassium tert-butylate / dichloromethane; isopropyl alcohol / 1 h / 0 - 20 °C
2: lithium aluminium tetrahydride / tetrahydrofuran / 16 h / 0 - 20 °C
View Scheme
2-hydroxynitrobenzene
88-75-5

2-hydroxynitrobenzene

1,4-benzoxazine
5735-53-5

1,4-benzoxazine

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: acetic acid; iron / ethanol; water
2: potassium carbonate / acetonitrile / 20 h / Reflux
3: lithium aluminium tetrahydride / tetrahydrofuran / 2 h / 0 - 20 °C / Inert atmosphere
View Scheme
Multi-step reaction with 2 steps
1.1: potassium carbonate / 1-methyl-pyrrolidin-2-one / 16 h / 120 °C
2.1: toluene-4-sulfonic acid; palladium 10% on activated carbon; hydrogen / 1,4-dioxane / 25 - 100 °C / 22502.3 Torr
2.2: 2 h / 50 °C / 30003 Torr
View Scheme
Multi-step reaction with 2 steps
1.1: potassium carbonate / acetonitrile / 2.5 h / Reflux
2.1: hydrogen; platinum(IV) oxide; sodium acetate / ethyl acetate / 2 h / 25 °C / 7500.75 Torr
2.2: 16 h / Reflux
View Scheme
1-(2-bromoethoxy)-2-nitrobenzene
18800-37-8

1-(2-bromoethoxy)-2-nitrobenzene

1,4-benzoxazine
5735-53-5

1,4-benzoxazine

Conditions
ConditionsYield
Stage #1: 1-(2-bromoethoxy)-2-nitrobenzene With platinum(IV) oxide; hydrogen; sodium acetate In ethyl acetate at 25℃; under 7500.75 Torr; for 18h;
Stage #2: With triethylamine In ethyl acetate for 6h; Reflux;
2,2-Diethoxy-1-(o-nitrophenoxy)ethan
61144-93-2

2,2-Diethoxy-1-(o-nitrophenoxy)ethan

1,4-benzoxazine
5735-53-5

1,4-benzoxazine

Conditions
ConditionsYield
Stage #1: 2,2-Diethoxy-1-(o-nitrophenoxy)ethan With palladium 10% on activated carbon; hydrogen; toluene-4-sulfonic acid In 1,4-dioxane at 25 - 100℃; under 22502.3 Torr;
Stage #2: With hydrogenchloride; hydrogen In 1,4-dioxane; water at 50℃; under 30003 Torr; for 2h;
1,4-benzoxazine
5735-53-5

1,4-benzoxazine

chloroacetyl chloride
79-04-9

chloroacetyl chloride

2-chloro-1-(2,3-dihydro-4H-benzo[b][1,4]oxazin-4-yl)ethan-1-one
22178-82-1

2-chloro-1-(2,3-dihydro-4H-benzo[b][1,4]oxazin-4-yl)ethan-1-one

Conditions
ConditionsYield
With pyridine In benzene Ambient temperature;100%
With triethylamine In tetrahydrofuran at 20℃; for 2h; Inert atmosphere;76%
With TEA In chloroform at 20℃; for 18h;
1,4-benzoxazine
5735-53-5

1,4-benzoxazine

ethyl bromoacetate
105-36-2

ethyl bromoacetate

(2,3-dihydro-benzo[1,4]oxazin-4-yl)-acetic acid ethyl ester
903161-55-7

(2,3-dihydro-benzo[1,4]oxazin-4-yl)-acetic acid ethyl ester

Conditions
ConditionsYield
With potassium carbonate; sodium iodide In N,N-dimethyl-formamide at 125℃;99%
3-chlorothiophene
17249-80-8

3-chlorothiophene

1,4-benzoxazine
5735-53-5

1,4-benzoxazine

4-(thiophen-3-yl)-3,4-dihydro-2H-benzo[b][1,4]oxazine

4-(thiophen-3-yl)-3,4-dihydro-2H-benzo[b][1,4]oxazine

Conditions
ConditionsYield
With 2-dicyclohexylphosphino-2′,6′-diisopropoxybiphenyl; potassium carbonate; ruphos In tert-Amyl alcohol at 110℃; for 20h; Schlenk technique; Inert atmosphere;98%
With 2-dicyclohexylphosphino-2′,6′-diisopropoxybiphenyl; potassium carbonate; ruphos In tert-Amyl alcohol at 110℃; for 20h; Inert atmosphere;98%
(1-cyanopropyl)(4-methoxyphenyl)carbamic chloride

(1-cyanopropyl)(4-methoxyphenyl)carbamic chloride

1,4-benzoxazine
5735-53-5

1,4-benzoxazine

N-(1-cyanopropyl)-N-(4-methoxyphenyl)-2,3-dihydro-4H-benzo[b][1,4]oxazine-4-carboxamide

N-(1-cyanopropyl)-N-(4-methoxyphenyl)-2,3-dihydro-4H-benzo[b][1,4]oxazine-4-carboxamide

Conditions
ConditionsYield
With 2,6-dimethylpyridine; potassium iodide In acetonitrile at 120℃; for 4h; Microwave irradiation;98%
formaldehyd
50-00-0

formaldehyd

C12H12N2O

C12H12N2O

1,4-benzoxazine
5735-53-5

1,4-benzoxazine

C21H21N3O2

C21H21N3O2

Conditions
ConditionsYield
With C38H38N4O2Rh(1+)*F6P(1-) In acetonitrile at 20℃; for 17h; Mannich Aminomethylation; enantioselective reaction;96%
chlorodifluoroacetic anhydride
2834-23-3

chlorodifluoroacetic anhydride

1,4-benzoxazine
5735-53-5

1,4-benzoxazine

1-(2H-benzo[b][1,4]oxazin-4(3H)-yl)-2-chloro-2,2-difluoroethanone

1-(2H-benzo[b][1,4]oxazin-4(3H)-yl)-2-chloro-2,2-difluoroethanone

Conditions
ConditionsYield
With dmap; triethylamine In dichloromethane at 0 - 20℃; for 12h; Inert atmosphere;95%
1,4-benzoxazine
5735-53-5

1,4-benzoxazine

2,3-dihydro-4H-benzo[b][1,4]oxazine-4-carbaldehyde

2,3-dihydro-4H-benzo[b][1,4]oxazine-4-carbaldehyde

Conditions
ConditionsYield
In acetonitrile for 12h; Formylation;93%
(1-cyanopent-4-en-1-yl)(4-methoxyphenyl)carbamic chloride

(1-cyanopent-4-en-1-yl)(4-methoxyphenyl)carbamic chloride

1,4-benzoxazine
5735-53-5

1,4-benzoxazine

N-(1-cyanopent-4-en-1-yl)-N-(4-methoxyphenyl)-2,3-dihydro-4H-benzo[b][1,4]oxazine-4-carboxamide

N-(1-cyanopent-4-en-1-yl)-N-(4-methoxyphenyl)-2,3-dihydro-4H-benzo[b][1,4]oxazine-4-carboxamide

Conditions
ConditionsYield
With 2,6-dimethylpyridine; potassium iodide In acetonitrile at 120℃; for 4h; Microwave irradiation;93%
C13H12N2O3

C13H12N2O3

1,4-benzoxazine
5735-53-5

1,4-benzoxazine

C20H21N3O2

C20H21N3O2

Conditions
ConditionsYield
With bis[dichloro(pentamethylcyclopentadienyl)iridium(III)] In chloroform at 25℃; for 12h; Inert atmosphere; Sealed tube;93%
dichloroacethyl chloride
79-36-7

dichloroacethyl chloride

1,4-benzoxazine
5735-53-5

1,4-benzoxazine

N-dichloroacetyl-3,4-dihydro-2H-1,4-benzoxazine
98730-07-5

N-dichloroacetyl-3,4-dihydro-2H-1,4-benzoxazine

Conditions
ConditionsYield
With sodium carbonate In benzene at 25℃;92%
carbon dioxide
124-38-9

carbon dioxide

1,4-benzoxazine
5735-53-5

1,4-benzoxazine

4-methyl-3,4-dihydro-2H-benzo[b][1,4]oxazine
77901-22-5

4-methyl-3,4-dihydro-2H-benzo[b][1,4]oxazine

Conditions
ConditionsYield
With cyclopentadienyl iron(II) dicarbonyl dimer; phenylsilane; triphenylphosphine In acetonitrile at 100℃; under 760.051 Torr; for 36h; Schlenk technique; Sealed tube;92%
With diphenylsilane; [1,3-bis(2,4,6-trimethylphenyl)imidazol]-2-ylidene In N,N-dimethyl-formamide at 50℃; under 760.051 Torr; chemoselective reaction;64%
1,4-benzoxazine
5735-53-5

1,4-benzoxazine

prop-1-yne
74-99-7

prop-1-yne

4,4,6-trimethyl-2,3-dihydro-4H-1-oxa-3a-aza-phenalene

4,4,6-trimethyl-2,3-dihydro-4H-1-oxa-3a-aza-phenalene

Conditions
ConditionsYield
With ammonium hexafluorophosphate; dodecacarbonyl-triangulo-triruthenium In benzene at 95℃; for 24h;90%
Methyl 4-(bromomethyl)benzoate
2417-72-3

Methyl 4-(bromomethyl)benzoate

1,4-benzoxazine
5735-53-5

1,4-benzoxazine

C17H17NO3

C17H17NO3

Conditions
ConditionsYield
With potassium carbonate In N,N-dimethyl-formamide at 80℃; for 6h;89.7%
1,4-benzoxazine
5735-53-5

1,4-benzoxazine

erythro-3-(2H-benzo[b][1,4]oxazin-4(3H)-yl)-3-phenylpropane-1,2-diol

erythro-3-(2H-benzo[b][1,4]oxazin-4(3H)-yl)-3-phenylpropane-1,2-diol

Conditions
ConditionsYield
With tungsten hexa-ethoxide In acetonitrile at 55℃; for 24h; stereospecific reaction;89%
4-(2-cyclopropyl-5-oxazolyl)benzenesulfonyl chloride

4-(2-cyclopropyl-5-oxazolyl)benzenesulfonyl chloride

1,4-benzoxazine
5735-53-5

1,4-benzoxazine

4-((4-(2-cyclopropanyloxazol-5-yl)phenyl)sulfonyl)-3,4-dihydrobenzo[b][1,4]oxazine

4-((4-(2-cyclopropanyloxazol-5-yl)phenyl)sulfonyl)-3,4-dihydrobenzo[b][1,4]oxazine

Conditions
ConditionsYield
With pyridine In dichloromethane at 20℃; for 2h;88%
1,4-benzoxazine
5735-53-5

1,4-benzoxazine

trans ethyl 3-phenyloxirane-2-carboxylate

trans ethyl 3-phenyloxirane-2-carboxylate

ethyl (2RS,3RS)-3-(2,3-dihydro-4H-1,4-benzoxazin-4-yl)-2-hydroxy-3-phenylpropanoate

ethyl (2RS,3RS)-3-(2,3-dihydro-4H-1,4-benzoxazin-4-yl)-2-hydroxy-3-phenylpropanoate

Conditions
ConditionsYield
at 135℃; for 12h;87%
at 135℃; for 12h;87%
1,4-benzoxazine
5735-53-5

1,4-benzoxazine

benzenesulfonyl chloride
98-09-9

benzenesulfonyl chloride

4-(phenylsulfonyl)-3,4-dihydro-2Hbenzo[b][1,4]oxazine
1090557-10-0

4-(phenylsulfonyl)-3,4-dihydro-2Hbenzo[b][1,4]oxazine

Conditions
ConditionsYield
With triethylamine In benzene at 20℃; for 12h; Inert atmosphere;87%
1,1,1,3',3',3'-hexafluoro-propanol
920-66-1

1,1,1,3',3',3'-hexafluoro-propanol

1,4-benzoxazine
5735-53-5

1,4-benzoxazine

2-(3,4-dihydro-2H-benzo[b][1,4]oxazin-7-yl)-1,1,1,3,3,3-hexafluoropropan-2-ol
71280-80-3

2-(3,4-dihydro-2H-benzo[b][1,4]oxazin-7-yl)-1,1,1,3,3,3-hexafluoropropan-2-ol

Conditions
ConditionsYield
With piperidin-1-yl benzoate; copper(II) acetate tetrahydrate at 70℃; for 5h;87%
With [2,2]bipyridinyl; oxygen; copper(II) bis(trifluoromethanesulfonate); sodium carbonate at 50℃; under 760.051 Torr; for 3.5h; Schlenk technique; Green chemistry; regiospecific reaction;63%
C15H12FNO2
1479051-52-9

C15H12FNO2

1,4-benzoxazine
5735-53-5

1,4-benzoxazine

1-(3,4-dihydro-2H-1,4-benzoxazin-4-yl)-3-(6-fluoro-9H-carbazol-2-yloxy)-2-propanol
1479050-56-0

1-(3,4-dihydro-2H-1,4-benzoxazin-4-yl)-3-(6-fluoro-9H-carbazol-2-yloxy)-2-propanol

Conditions
ConditionsYield
In isopropyl alcohol Reflux;86%
1,4-benzoxazine
5735-53-5

1,4-benzoxazine

1,1'-carbonyldiimidazole
530-62-1

1,1'-carbonyldiimidazole

(2,3-dihydro-4H-benzo[b][1,4]oxazin-4-yl)(1H-imidazol-1-yl)methanone

(2,3-dihydro-4H-benzo[b][1,4]oxazin-4-yl)(1H-imidazol-1-yl)methanone

Conditions
ConditionsYield
In dichloromethane at 20℃; for 6h; Cooling with ice;86%
1,4-benzoxazine
5735-53-5

1,4-benzoxazine

Cyclohexanecarboxylic acid
98-89-5

Cyclohexanecarboxylic acid

4-cyclohexyl-3,4-dihydro-2H-benzo[b][1,4]oxazine

4-cyclohexyl-3,4-dihydro-2H-benzo[b][1,4]oxazine

Conditions
ConditionsYield
With 9-(2-chlorophenyl)acridine; di-tert-butyl peroxide; copper(II) hexafluoroacetylacetonate at 35℃; for 36h; Inert atmosphere; Irradiation;86%
carbon dioxide
124-38-9

carbon dioxide

1,4-benzoxazine
5735-53-5

1,4-benzoxazine

2,3-dihydro-4H-benzo[b][1,4]oxazine-4-carbaldehyde

2,3-dihydro-4H-benzo[b][1,4]oxazine-4-carbaldehyde

Conditions
ConditionsYield
With cyclopentadienyl iron(II) dicarbonyl dimer; tributylphosphine; phenylsilane In acetonitrile at 30℃; under 760.051 Torr; for 24h; Schlenk technique; Sealed tube;85%

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