1014717-75-9Relevant articles and documents
Total synthesis of biologically active 20S-hydroxyvitamin D3
Wang, Qinghui,Lin, Zongtao,Kim, Tae-Kang,Slominski, Andrzej T.,Miller, Duane D.,Li, Wei
, p. 153 - 162 (2015)
A total synthetic strategy of 20S-hydroxyVitamin D3 [20S-(OH)D3] involving modified synthesis of key intermediates 7 and 12, Grignard reaction to stereoselectively generate 20S-OH and Wittig-Horner coupling to establish D3 framework, was completed in 16 steps with an overall yield of 0.4%. The synthetic 20S-(OH)D3 activated Vitamin D receptor (VDR) and initiated the expression of downstream genes. In addition, 20S-(OH)D3 showed similar inhibitory potency as calcitriol [1,25(OH)2D3] on proliferation of melanoma cells.