101495-18-5 Usage
Description
4,6-Dichloro-1H-indole is a dichlorinated indole, a type of organic compound characterized by the presence of two chlorine atoms at the 4th and 6th positions of the indole ring. It is known for its potential in the synthesis of various biologically active compounds.
Uses
Used in Pharmaceutical Industry:
4,6-Dichloro-1H-indole is used as a key intermediate in the synthesis of biologically active compounds for the pharmaceutical industry. Its application is primarily due to its ability to inhibit the reuptake of neurotransmitters such as serotonin, norepinephrine, and dopamine, which can be beneficial in the treatment of various neurological and psychiatric disorders.
Additionally, 4,6-Dichloro-1H-indole is used as a precursor in the development of tryptase inhibitors. Tryptase is an enzyme found in mast cells, and its inhibition can be useful in the treatment of conditions such as asthma, allergic reactions, and inflammatory diseases.
Check Digit Verification of cas no
The CAS Registry Mumber 101495-18-5 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,0,1,4,9 and 5 respectively; the second part has 2 digits, 1 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 101495-18:
(8*1)+(7*0)+(6*1)+(5*4)+(4*9)+(3*5)+(2*1)+(1*8)=95
95 % 10 = 5
So 101495-18-5 is a valid CAS Registry Number.
InChI:InChI=1/C8H5Cl2N/c9-5-3-7(10)6-1-2-11-8(6)4-5/h1-4,11H
101495-18-5Relevant articles and documents
Preparation method for 4,6-dichloroindole
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, (2019/01/17)
The invention discloses a preparation method for 4,6-dichloroindole. The preparation method comprises the following specific steps: in an acidic condition of 3,5-dichloroaniline, carrying out a diazo-reaction on sodium nitrite and then carrying out a condensation reaction with ethyl pyruvate to obtain ethyl-2-(2-(3,5-dichlorophenyl) hydrazono) propionic acid; carrying out ring formation on the ethyl-2-(2-(3,5-dichlorophenyl) hydrazono) propionic acid under the action of lewis acid to obtain 4,6-dichlorindole ethyl formate; hydrolyzing the 4,6-dichlorindole ethyl formate under action of lithium hydroxide to obtain 4,6-dichloroindolecarboxylic acid; and carrying out decarboxylation on the 4,6-dichloroindolecarboxylic acid to obtain 4,6-dichloroindole. The synthetic process of the inventionis more economic, environmentally friendly, efficient and simple.
Erratum: Continuous-flow synthesis of monoarylated acetaldehydes using aryldiazonium salts (Journal of the American Chemical Society (2012) 134 (2466-12469))
Chernyak, Natalia,Buchwald, Stephen L.
, p. 18147 - 18147,1 (2020/10/15)
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