103855-01-2

Basic information

• Product Name: Propanoic acid, 2-[(3,5-dichlorophenyl)hydrazono]-, ethyl ester
• CAS NO: 103855-01-2
• Molecular Formula: C11H12Cl2N2O2
• Molecular Weight: 275.134
• Mol File: 103855-01-2.mol
• Article Data: 8

Chemical Properties

• CAS DataBase Reference: Propanoic acid, 2-[(3,5-dichlorophenyl)hydrazono]-, ethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: Propanoic acid, 2-[(3,5-dichlorophenyl)hydrazono]-, ethyl ester(103855-01-2)
• EPA Substance Registry System: Propanoic acid, 2-[(3,5-dichlorophenyl)hydrazono]-, ethyl ester(103855-01-2)

Safety Data

• Hazardous Substances Data: 103855-01-2(Hazardous Substances Data)

Upstream product

• 617-35-6 2-oxo-propionic acid ethyl ester 
• 39943-56-1 3,5-dichlorophenylhydrazine 
• 64-17-5 ethanol 
• 63352-99-8 (3,5-dichlorophenyl)hydrazine hydrochloride 
• 127-17-3 2-oxo-propionic acid 
• 626-43-7 3,5-Dichloroaniline 
• 609-14-3 2-acetylpropanoic acid ethyl ester 

Downstream Products

• 1447607-01-3 ethyl 1-(3,5-dichlorophenyl)-4-formyl-1H-pyrazole-3-carboxylate 
• 205646-86-2 ethyl (Z)-4,6-dichloro-3-[2-(3-aminophenyl)2-cyanoethenyl]-1H-indole-2-carboxylate 
• 1099474-22-2 ethyl (Z)-4,6-dichloro-3-[(3-amino-2-aminophenyl)-3-oxo-1-propenyl]-1H-indole-2-carboxylate 
• 205646-84-0 ethyl (Z)-4,6-dichloro-3-[2-cyano-2-(3-nitrophenyl)-ethenyl]-1H-indole-2-carboxylate 
• 1473450-60-0 NITD-304 
• 101861-63-6 4,6-dichloro-1H-indole-2-carboxylic acid 
• 101495-18-5 4,6-dichloro-1H-indole 
• 53995-82-7 4,6-dichloro-indole-2-carboxylic acid,ethyl ester 
• 496956-05-9 4,6-dichloro-3-{[3-(4-methoxyphenyl)-2,4-dioxo-1-imidazolidinyl]methyl}indole-2-carboxylic acid ethyl ester 
• 153435-96-2 ethyl-3-formyl-4,6-dichloro-indole-2-carboxylate 
• 1335466-09-5 C₂₃H₂₀Cl₂⁽¹⁸⁾FN₃O₅ 
• 1335466-07-3 C₂₃H₂₀Cl₂⁽¹⁸⁾FN₃O₅ 

Relevant articles and documents

From Cells to Mice to Target: Characterization of NEU-1053 (SB-443342) and Its Analogues for Treatment of Human African Trypanosomiasis

Human African trypanosomiasis is a neglected tropical disease that is lethal if left untreated. Existing therapeutics have limited efficacy and severe associated toxicities. 2-(2-(((3-((1H-Benzo[d]imidazol-2-yl)amino)propyl)amino)methyl)-4,6-dichloro-1H-indol-1-yl)ethan-1-ol (NEU-1053) has recently been identified from a high-throughput screen of >42,000 compounds as a highly potent and fast-acting trypanocidal agent capable of curing a bloodstream infection of Trypanosoma brucei in mice. We have designed a library of analogues to probe the structure-activity relationship and improve the predicted central nervous system (CNS) exposure of NEU-1053. We report the activity of these inhibitors of T. brucei, the efficacy of NEU-1053 in a murine CNS model of infection, and identification of the target of NEU-1053 via X-ray crystallography.

INDOLE CARBOXAMIDE DERIVATIVES AND USES THEREOF

A compound of Formula (I) is provided that has been shown to be useful for treating a disease, disorder or syndrome that is mediated by the transportation of essential molecules in the mmpL3 pathway: (I) wherein R1, R2, R3, R4, R5 and R6 are as defined herein.

SUBSTITUTED INDOLE COMPOUND

Disclosed is an excellent LXR modulator. A compound represented by the general formula (I): (I) wherein R1, R2, R3 and R4: H, an alkyl which may be substituted, OH, an alkoxy which may be substituted, an amino which may be substituted, a halogeno, a phenyl or the like; R5: H or an alkyl; R6: -COR8 (wherein R8: an alkoxy which may be substituted, a phenyloxy which may be substituted, an amino which may be substituted, or the like), -SO2R9 (wherein R9: an alkyl which may be substituted, a phenyl which may be substituted or a heterocyclyl which may be substituted), or an alkyl which may be substituted; R7: -X2R10 [wherein R10: -COR11 (where R11: OH, an alkoxy which may be substituted or an amino which may be substituted), -SO2R12 (where R12: an alkyl which may be substituted or amino which may be substituted), -N(R13)COR14 (where R13: H or an alkyl which may be substituted; R14: H or an alkyl which may be substituted), -N(R13)SO2R15 (where R13: as defined above; R15: an alkyl which may be substituted) or tetrazol-5-yl; and X2: a single bond or an alkylene which may be substituted]; X1: a methylene which may be substituted; Y1: a phenyl which may be substituted or a heterocyclyl which may be substituted; and Y2: an aryl which may be substituted, a heterocyclyl which may be substituted or the like], or the like.