1015758-92-5

Basic information

• Product Name: 2-(4-fluorobenzyl)-pyridine N-oxide
• Synonyms: 2-(4-fluorobenzyl)-pyridine N-oxide
• CAS NO: 1015758-92-5
• Molecular Weight: 203.216
• Mol File: 1015758-92-5.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: 2-(4-fluorobenzyl)-pyridine N-oxide(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(4-fluorobenzyl)-pyridine N-oxide(1015758-92-5)
• EPA Substance Registry System: 2-(4-fluorobenzyl)-pyridine N-oxide(1015758-92-5)

Safety Data

• Hazardous Substances Data: 1015758-92-5(Hazardous Substances Data)

Upstream product

• 931-19-1 2-methylpyridine N-oxide 
• 460-00-4 1-Bromo-4-fluorobenzene 
• 941279-81-8 2,4-dimethyl-3-(pyridin-2-ylmethyl)pentan-3-ol 
• 109-06-8 α-picoline 
• 694-59-7 pyridine N-oxide 
• 352-11-4 1-chloromethyl-4-fluorobenzene 
• 1201921-86-9 C₁₃H₂₁NO₂ 
• 457-61-4 2-(4-fluorobenzyl)pyridine 

Relevant articles and documents

Acylation of 2-benzylpyridine N-oxides and subsequent in situ [3,3]-sigamatropic rearrangement reaction

An effective method for the acylation of 2-benzylpyridine N-oxides and their fast in situ [3,3]-sigmatropic rearrangement was reported. This transformation has a wide substrate scope under mild conditions, giving moderate to excellent yields. The application for the synthesis of chiral phenyl-2-pyridylmethanol products was briefly explored. Furthermore, an interesting example of tandem substitution and in situ [3,3]-sigamatropic rearrangement of 2-benzylpyridine N-oxide with benzenecarboximidoyl chloride was reported.

Palladium-catalyzed (N-oido-2-pyridinyl)methyl transfer from 2-(2-Hydroxyalkyl)pyridine N-oxide to aryl halides by β-carbon elimination

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Site-selective sp2 and benzylic sp3 palladium-catalyzed direct arylation

Palladium-catalyzed site selective arylation reactions of both sp2 and benzylic sp3 sites on azine and diazine N-oxide substrates are described that occur in good to excellent yield and with complete selectivity for reaction at the desired position. These studies have uncovered the need to properly control the metal to ligand ratio in sp2 arylation and necessitated a complete reinvestigation of all reaction parameters for sp3 arylation. From these studies, the choice of base emerged as a pivotal component for site selectivity, pointing to its intimate involvement in the mechanism of direct arylation. These site selective reactions have been validated in both divergent and sequential derivatizations of heterocyclic compounds represent an attractive alternative to other routes to this class of molecule. Copyright